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Protein

Keratin, type II cytoskeletal 4

Gene

Krt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei395StutterSequence analysis1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 4
Alternative name(s):
Cytokeratin-4
Short name:
CK-4
Keratin-4
Short name:
K4
Type-II keratin Kb4
Gene namesi
Name:Krt4By similarity
Synonyms:Kb4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359272 Krt4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637241 – 536Keratin, type II cytoskeletal 4Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ6IG00
PRIDEiQ6IG00

PTM databases

iPTMnetiQ6IG00
PhosphoSitePlusiQ6IG00

Expressioni

Gene expression databases

BgeeiENSRNOG00000032332
ExpressionAtlasiQ6IG00 baseline and differential
GenevisibleiQ6IG00 RN

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-4 is generally associated with keratin-13.

Protein-protein interaction databases

IntActiQ6IG00, 1 interactor
STRINGi10116.ENSRNOP00000012943

Structurei

3D structure databases

ProteinModelPortaliQ6IG00
SMRiQ6IG00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 457IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 145HeadSequence analysisAdd BLAST145
Regioni146 – 181Coil 1ASequence analysisAdd BLAST36
Regioni182 – 200Linker 1Sequence analysisAdd BLAST19
Regioni201 – 293Coil 1BSequence analysisAdd BLAST93
Regioni294 – 316Linker 12Sequence analysisAdd BLAST23
Regioni317 – 454Coil 2Sequence analysisAdd BLAST138
Regioni455 – 524TailSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 117Gly-richSequence analysisAdd BLAST108
Compositional biasi471 – 511Gly-richSequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGG3 Eukaryota
ENOG410ZE7B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ6IG00
KOiK07605
OMAiQQCVRGG
OrthoDBiEOG091G09KR
PhylomeDBiQ6IG00

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IG00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRQSSVRG VSRGFSSGSA VAGGVKRVAF SSASMSGGAG RCSSGGFGSR
60 70 80 90 100
SLYNLGGHKS ISMSVAGSCQ GGGYGGAGGF GVGGYGAGFG AGGFGGGFGG
110 120 130 140 150
SFNGRGGPGF PVCPAGGIQE VTINQSLLTP LQVEIDPEIQ KIRTAEREQI
160 170 180 190 200
KTLNNKFASF IDKVRFLEQQ NKVLETKWNL LQQQTTTTSP RNLDPFFETY
210 220 230 240 250
INALRKNLDT LSNDKGRLQS ELKLMQDSVE DFKTKYEEEI NKRTAAENDF
260 270 280 290 300
VVLKKDVDAA YMIKVELEAK MESLKDEINF MRVLYEAELS QMQTHVSDTS
310 320 330 340 350
VVLSMDNNRN LDLDGIIAEV RAQYEEIARK SKAEVESWYQ IKVQQLQMSA
360 370 380 390 400
DQHGDSLKST KNEISELNRM IQRIRSEIEN IKKQTLQASV ADAEQRGELA
410 420 430 440 450
LKDAYTKRAD LETALQKAKE DLARLMRDYQ ELMNVKLALD VEIATYRKLL
460 470 480 490 500
EGEECRMSGE CKSAVSISVV GGSASIGGSG GIGLGLGSGF GSGSCSGSGF
510 520 530
GFGGGIYGSS GTKITSSATI TKRSPRTRQD PDGLQP
Length:536
Mass (Da):57,667
Last modified:July 5, 2004 - v1
Checksum:i5D1AC47FA0477DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03057015 Genomic DNA No translation available.
BK003985 mRNA Translation: DAA02230.1
RefSeqiNP_001008806.1, NM_001008806.1
UniGeneiRn.100688
Rn.229128

Genome annotation databases

EnsembliENSRNOT00000012943; ENSRNOP00000012943; ENSRNOG00000032332
GeneIDi315323
KEGGirno:315323
UCSCiRGD:1359272 rat

Similar proteinsi

Entry informationi

Entry nameiK2C4_RAT
AccessioniPrimary (citable) accession number: Q6IG00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health