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Protein

Keratin, type II cytoskeletal 4

Gene

Krt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei395StutterSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 4
Alternative name(s):
Cytokeratin-4
Short name:
CK-4
Keratin-4
Short name:
K4
Type-II keratin Kb4
Gene namesi
Name:Krt4By similarity
Synonyms:Kb4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359272. Krt4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637241 – 536Keratin, type II cytoskeletal 4Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ6IG00.
PRIDEiQ6IG00.

PTM databases

iPTMnetiQ6IG00.
PhosphoSitePlusiQ6IG00.

Expressioni

Gene expression databases

BgeeiENSRNOG00000032332.
ExpressionAtlasiQ6IG00. baseline and differential.
GenevisibleiQ6IG00. RN.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-4 is generally associated with keratin-13.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012943.

Structurei

3D structure databases

ProteinModelPortaliQ6IG00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 145HeadSequence analysisAdd BLAST145
Regioni146 – 454RodSequence analysisAdd BLAST309
Regioni146 – 181Coil 1ASequence analysisAdd BLAST36
Regioni182 – 200Linker 1Sequence analysisAdd BLAST19
Regioni201 – 293Coil 1BSequence analysisAdd BLAST93
Regioni294 – 316Linker 12Sequence analysisAdd BLAST23
Regioni317 – 454Coil 2Sequence analysisAdd BLAST138
Regioni455 – 524TailSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 117Gly-richSequence analysisAdd BLAST108
Compositional biasi471 – 511Gly-richSequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGG3. Eukaryota.
ENOG410ZE7B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IG00.
KOiK07605.
OMAiQQCVRGG.
OrthoDBiEOG091G09KR.
PhylomeDBiQ6IG00.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IG00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRQSSVRG VSRGFSSGSA VAGGVKRVAF SSASMSGGAG RCSSGGFGSR
60 70 80 90 100
SLYNLGGHKS ISMSVAGSCQ GGGYGGAGGF GVGGYGAGFG AGGFGGGFGG
110 120 130 140 150
SFNGRGGPGF PVCPAGGIQE VTINQSLLTP LQVEIDPEIQ KIRTAEREQI
160 170 180 190 200
KTLNNKFASF IDKVRFLEQQ NKVLETKWNL LQQQTTTTSP RNLDPFFETY
210 220 230 240 250
INALRKNLDT LSNDKGRLQS ELKLMQDSVE DFKTKYEEEI NKRTAAENDF
260 270 280 290 300
VVLKKDVDAA YMIKVELEAK MESLKDEINF MRVLYEAELS QMQTHVSDTS
310 320 330 340 350
VVLSMDNNRN LDLDGIIAEV RAQYEEIARK SKAEVESWYQ IKVQQLQMSA
360 370 380 390 400
DQHGDSLKST KNEISELNRM IQRIRSEIEN IKKQTLQASV ADAEQRGELA
410 420 430 440 450
LKDAYTKRAD LETALQKAKE DLARLMRDYQ ELMNVKLALD VEIATYRKLL
460 470 480 490 500
EGEECRMSGE CKSAVSISVV GGSASIGGSG GIGLGLGSGF GSGSCSGSGF
510 520 530
GFGGGIYGSS GTKITSSATI TKRSPRTRQD PDGLQP
Length:536
Mass (Da):57,667
Last modified:July 5, 2004 - v1
Checksum:i5D1AC47FA0477DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03057015 Genomic DNA. No translation available.
BK003985 mRNA. Translation: DAA02230.1.
RefSeqiNP_001008806.1. NM_001008806.1.
UniGeneiRn.100688.
Rn.229128.

Genome annotation databases

EnsembliENSRNOT00000012943; ENSRNOP00000012943; ENSRNOG00000032332.
GeneIDi315323.
KEGGirno:315323.
UCSCiRGD:1359272. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03057015 Genomic DNA. No translation available.
BK003985 mRNA. Translation: DAA02230.1.
RefSeqiNP_001008806.1. NM_001008806.1.
UniGeneiRn.100688.
Rn.229128.

3D structure databases

ProteinModelPortaliQ6IG00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012943.

PTM databases

iPTMnetiQ6IG00.
PhosphoSitePlusiQ6IG00.

Proteomic databases

PaxDbiQ6IG00.
PRIDEiQ6IG00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012943; ENSRNOP00000012943; ENSRNOG00000032332.
GeneIDi315323.
KEGGirno:315323.
UCSCiRGD:1359272. rat.

Organism-specific databases

CTDi3851.
RGDi1359272. Krt4.

Phylogenomic databases

eggNOGiENOG410IGG3. Eukaryota.
ENOG410ZE7B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IG00.
KOiK07605.
OMAiQQCVRGG.
OrthoDBiEOG091G09KR.
PhylomeDBiQ6IG00.

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IG00.

Gene expression databases

BgeeiENSRNOG00000032332.
ExpressionAtlasiQ6IG00. baseline and differential.
GenevisibleiQ6IG00. RN.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C4_RAT
AccessioniPrimary (citable) accession number: Q6IG00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.