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Protein

Keratin, type II cytoskeletal 1b

Gene

Krt77

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei420Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 1b
Alternative name(s):
Cytokeratin-1B
Short name:
CK-1B
Embryonic type II keratin-1
Keratin-77
Short name:
K77
Type-II keratin Kb39
Gene namesi
Name:Krt77
Synonyms:Krt1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3588209. Krt77.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637121 – 572Keratin, type II cytoskeletal 1bAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Omega-N-methylarginineCombined sources1
Modified residuei99Omega-N-methylarginineCombined sources1
Modified residuei526Omega-N-methylarginineCombined sources1
Modified residuei542Omega-N-methylarginineCombined sources1

Post-translational modificationi

Undergoes deimination of some arginine residues (citrullination).1 Publication

Keywords - PTMi

Citrullination, Methylation

Proteomic databases

PaxDbiQ6IFZ6.
PRIDEiQ6IFZ6.

PTM databases

iPTMnetiQ6IFZ6.
PhosphoSitePlusiQ6IFZ6.

Expressioni

Tissue specificityi

Expressed in stratified epithelia.1 Publication

Gene expression databases

BgeeiENSMUSG00000067594.
CleanExiMM_KRT77.
ExpressionAtlasiQ6IFZ6. baseline and differential.
GenevisibleiQ6IFZ6. MM.

Interactioni

Protein-protein interaction databases

BioGridi240430. 7 interactors.
STRINGi10090.ENSMUSP00000085311.

Structurei

3D structure databases

ProteinModelPortaliQ6IFZ6.
SMRiQ6IFZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 166HeadAdd BLAST166
Regioni167 – 476RodAdd BLAST310
Regioni167 – 202Coil 1AAdd BLAST36
Regioni203 – 221Linker 1Add BLAST19
Regioni222 – 313Coil 1BAdd BLAST92
Regioni314 – 337Linker 12Add BLAST24
Regioni338 – 476Coil 2Add BLAST139
Regioni477 – 568TailAdd BLAST92

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVT1. Eukaryota.
ENOG4111ACY. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IFZ6.
KOiK07605.
OMAiHVSISVQ.
OrthoDBiEOG091G09KR.
PhylomeDBiQ6IFZ6.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 3 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQFSSQSA FSSRSRRAYS SRSSSGFGGG RQALVSVSQS RRYGGDYGGG
60 70 80 90 100
FSSRSLYSLG GSKSIFGNLV GRSASGFCQS RGPGGGFGGG IGGGIGGGRG
110 120 130 140 150
FGGGGFGGGY GGGGRFGGGF GGAGFGFGGF GPSYPPGGIH EVTINQSLLE
160 170 180 190 200
PLHLEVDPEI QRVKTQEREQ IKTLNNKFAS FIDKVRFLEQ QNQVLQTKWE
210 220 230 240 250
LLQQVNTSTR TSSLEPVFEE FISQLQRQVD VLTTEQLRQN TEIRNMQDVV
260 270 280 290 300
EDYKNKYEDE INKRTNAEND FVVLKKDVDA AFMGKSDLQS KVDTLYGEIN
310 320 330 340 350
FLKYLFDTEL SQIQTHVSDT NVILSMDNNR SLDLDSIIDA VRAQYEIIAQ
360 370 380 390 400
KSKDEAEALY QTKYQELQIT AGKHGDDLKN SKMEISELNR NIQRLRAEIA
410 420 430 440 450
NIKKQVEGMH GLISDAEERG ERALQNAKQK LQDMEEALQQ AKEDLAKLLR
460 470 480 490 500
DYQAMLGAKL SLDVEIATYR QLLEGEESRM SGALQSQVSI SVQSSQVTIG
510 520 530 540 550
GGGGGSGSYS GSSRGGGGGG GGTGSRGGGG GGGGSSYVSS SRSATKYGSG
560 570
GGSSRTQILQ TSTHSSRRHV VE
Length:572
Mass (Da):61,359
Last modified:July 5, 2004 - v1
Checksum:i4D6A8BEC8E250096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01098975 Genomic DNA. No translation available.
CAAA01098987 Genomic DNA. No translation available.
BK005256 mRNA. Translation: DAA05633.1.
BK003993 mRNA. Translation: DAA02234.1.
CCDSiCCDS27865.1.
RefSeqiNP_001003667.1. NM_001003667.1.
UniGeneiMm.292992.

Genome annotation databases

EnsembliENSMUST00000087996; ENSMUSP00000085311; ENSMUSG00000067594.
GeneIDi406220.
KEGGimmu:406220.
UCSCiuc007xud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01098975 Genomic DNA. No translation available.
CAAA01098987 Genomic DNA. No translation available.
BK005256 mRNA. Translation: DAA05633.1.
BK003993 mRNA. Translation: DAA02234.1.
CCDSiCCDS27865.1.
RefSeqiNP_001003667.1. NM_001003667.1.
UniGeneiMm.292992.

3D structure databases

ProteinModelPortaliQ6IFZ6.
SMRiQ6IFZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240430. 7 interactors.
STRINGi10090.ENSMUSP00000085311.

PTM databases

iPTMnetiQ6IFZ6.
PhosphoSitePlusiQ6IFZ6.

Proteomic databases

PaxDbiQ6IFZ6.
PRIDEiQ6IFZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087996; ENSMUSP00000085311; ENSMUSG00000067594.
GeneIDi406220.
KEGGimmu:406220.
UCSCiuc007xud.1. mouse.

Organism-specific databases

CTDi374454.
MGIiMGI:3588209. Krt77.

Phylogenomic databases

eggNOGiENOG410IVT1. Eukaryota.
ENOG4111ACY. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IFZ6.
KOiK07605.
OMAiHVSISVQ.
OrthoDBiEOG091G09KR.
PhylomeDBiQ6IFZ6.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IFZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067594.
CleanExiMM_KRT77.
ExpressionAtlasiQ6IFZ6. baseline and differential.
GenevisibleiQ6IFZ6. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 3 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C1B_MOUSE
AccessioniPrimary (citable) accession number: Q6IFZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.