Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cytoskeletal 1b

Gene

Krt77

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei420 – 4201Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 1b
Alternative name(s):
Cytokeratin-1B
Short name:
CK-1B
Embryonic type II keratin-1
Keratin-77
Short name:
K77
Type-II keratin Kb39
Gene namesi
Name:Krt77
Synonyms:Krt1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3588209. Krt77.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Keratin, type II cytoskeletal 1bPRO_0000063712Add
BLAST

Post-translational modificationi

Undergoes deimination of some arginine residues (citrullination).1 Publication

Keywords - PTMi

Citrullination

Proteomic databases

MaxQBiQ6IFZ6.
PaxDbiQ6IFZ6.
PRIDEiQ6IFZ6.

PTM databases

iPTMnetiQ6IFZ6.
PhosphoSiteiQ6IFZ6.

Expressioni

Tissue specificityi

Expressed in stratified epithelia.1 Publication

Gene expression databases

BgeeiQ6IFZ6.
CleanExiMM_KRT77.
ExpressionAtlasiQ6IFZ6. baseline and differential.
GenevisibleiQ6IFZ6. MM.

Interactioni

Protein-protein interaction databases

BioGridi240430. 7 interactions.
STRINGi10090.ENSMUSP00000085311.

Structurei

3D structure databases

ProteinModelPortaliQ6IFZ6.
SMRiQ6IFZ6. Positions 164-305, 333-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 166166HeadAdd
BLAST
Regioni167 – 476310RodAdd
BLAST
Regioni167 – 20236Coil 1AAdd
BLAST
Regioni203 – 22119Linker 1Add
BLAST
Regioni222 – 31392Coil 1BAdd
BLAST
Regioni314 – 33724Linker 12Add
BLAST
Regioni338 – 476139Coil 2Add
BLAST
Regioni477 – 56892TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVT1. Eukaryota.
ENOG4111ACY. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IFZ6.
KOiK07605.
OMAiTNTSHRR.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ6IFZ6.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 3 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQFSSQSA FSSRSRRAYS SRSSSGFGGG RQALVSVSQS RRYGGDYGGG
60 70 80 90 100
FSSRSLYSLG GSKSIFGNLV GRSASGFCQS RGPGGGFGGG IGGGIGGGRG
110 120 130 140 150
FGGGGFGGGY GGGGRFGGGF GGAGFGFGGF GPSYPPGGIH EVTINQSLLE
160 170 180 190 200
PLHLEVDPEI QRVKTQEREQ IKTLNNKFAS FIDKVRFLEQ QNQVLQTKWE
210 220 230 240 250
LLQQVNTSTR TSSLEPVFEE FISQLQRQVD VLTTEQLRQN TEIRNMQDVV
260 270 280 290 300
EDYKNKYEDE INKRTNAEND FVVLKKDVDA AFMGKSDLQS KVDTLYGEIN
310 320 330 340 350
FLKYLFDTEL SQIQTHVSDT NVILSMDNNR SLDLDSIIDA VRAQYEIIAQ
360 370 380 390 400
KSKDEAEALY QTKYQELQIT AGKHGDDLKN SKMEISELNR NIQRLRAEIA
410 420 430 440 450
NIKKQVEGMH GLISDAEERG ERALQNAKQK LQDMEEALQQ AKEDLAKLLR
460 470 480 490 500
DYQAMLGAKL SLDVEIATYR QLLEGEESRM SGALQSQVSI SVQSSQVTIG
510 520 530 540 550
GGGGGSGSYS GSSRGGGGGG GGTGSRGGGG GGGGSSYVSS SRSATKYGSG
560 570
GGSSRTQILQ TSTHSSRRHV VE
Length:572
Mass (Da):61,359
Last modified:July 5, 2004 - v1
Checksum:i4D6A8BEC8E250096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01098975 Genomic DNA. No translation available.
CAAA01098987 Genomic DNA. No translation available.
BK005256 mRNA. Translation: DAA05633.1.
BK003993 mRNA. Translation: DAA02234.1.
CCDSiCCDS27865.1.
RefSeqiNP_001003667.1. NM_001003667.1.
UniGeneiMm.292992.

Genome annotation databases

EnsembliENSMUST00000087996; ENSMUSP00000085311; ENSMUSG00000067594.
GeneIDi406220.
KEGGimmu:406220.
UCSCiuc007xud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01098975 Genomic DNA. No translation available.
CAAA01098987 Genomic DNA. No translation available.
BK005256 mRNA. Translation: DAA05633.1.
BK003993 mRNA. Translation: DAA02234.1.
CCDSiCCDS27865.1.
RefSeqiNP_001003667.1. NM_001003667.1.
UniGeneiMm.292992.

3D structure databases

ProteinModelPortaliQ6IFZ6.
SMRiQ6IFZ6. Positions 164-305, 333-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240430. 7 interactions.
STRINGi10090.ENSMUSP00000085311.

PTM databases

iPTMnetiQ6IFZ6.
PhosphoSiteiQ6IFZ6.

Proteomic databases

MaxQBiQ6IFZ6.
PaxDbiQ6IFZ6.
PRIDEiQ6IFZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087996; ENSMUSP00000085311; ENSMUSG00000067594.
GeneIDi406220.
KEGGimmu:406220.
UCSCiuc007xud.1. mouse.

Organism-specific databases

CTDi374454.
MGIiMGI:3588209. Krt77.

Phylogenomic databases

eggNOGiENOG410IVT1. Eukaryota.
ENOG4111ACY. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IFZ6.
KOiK07605.
OMAiTNTSHRR.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ6IFZ6.
TreeFamiTF317854.

Miscellaneous databases

PROiQ6IFZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IFZ6.
CleanExiMM_KRT77.
ExpressionAtlasiQ6IFZ6. baseline and differential.
GenevisibleiQ6IFZ6. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 3 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 187-198, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "Prediction of a coding sequence for a novel type II keratin from N-terminal sequences of mouse epidermal proteins site-specifically deiminated in embryonic development."
    Senshu T., Ishida-Yamamoto A., Takahashi H., Iizuka H.
    J. Dermatol. Sci. 37:41-48(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION, CITRULLINATION.
    Strain: C57BL/6JImported.
    Tissue: EpidermisImported.
  4. "Comprehensive analysis of keratin gene clusters in humans and rodents."
    Hesse M., Zimek A., Weber K., Magin T.M.
    Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart and Pancreas.

Entry informationi

Entry nameiK2C1B_MOUSE
AccessioniPrimary (citable) accession number: Q6IFZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.