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Protein

Keratin, type I cytoskeletal 27

Gene

Krt27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 27
Alternative name(s):
Cytokeratin-27
Short name:
CK-27
Keratin-27
Short name:
K27
Type I inner root sheath-specific keratin-K25irs3
Type I keratin KA40
Gene namesi
Name:Krt27By similarity
Synonyms:Ka40Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359115. Krt27.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127031 – 449Keratin, type I cytoskeletal 27Add BLAST449

Proteomic databases

PaxDbiQ6IFW8.
PRIDEiQ6IFW8.

PTM databases

iPTMnetiQ6IFW8.
PhosphoSitePlusiQ6IFW8.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015740.

Structurei

3D structure databases

ProteinModelPortaliQ6IFW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 73HeadSequence analysisAdd BLAST73
Regioni74 – 385RodSequence analysisAdd BLAST312
Regioni74 – 109Coil 1ASequence analysisAdd BLAST36
Regioni110 – 131Linker 1Sequence analysisAdd BLAST22
Regioni132 – 223Coil 1BSequence analysisAdd BLAST92
Regioni224 – 246Linker 12Sequence analysisAdd BLAST23
Regioni247 – 385Coil 2Sequence analysisAdd BLAST139
Regioni386 – 449TailSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 60Gly-richSequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFW8.
KOiK07604.
OMAiSRVHTME.
OrthoDBiEOG091G087I.
PhylomeDBiQ6IFW8.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRFSSASR RLGSVRLSSP GAALGAGNTC GVPGIGSGFS CAFGGSSLAG
60 70 80 90 100
GLGMGGASCG AFTVNEHGLL SGNEKVTMQN LNDRLASYLE NVQALEEANA
110 120 130 140 150
DLEQKIKDWY EKFGPGSCRG LDHDYSRYFP IIDDLRTQII SATAQNANIV
160 170 180 190 200
LQNDNARLTA DDFRMKYENE LALHQSVDAD INGLRRVLDE LTLCRTDLEV
210 220 230 240 250
QLETLSEELA YLKKNHEEEM QALQCAAGGN VNVEMNAAPG VDLTVLLNNM
260 270 280 290 300
RAEYEALAEQ NRRDAEAWFQ EKSASLQQQI SDDAGATTSA RNELTEMKRT
310 320 330 340 350
LQTLEIELQS LLAMKHSLEC SLTETEGNYC TQLAQIQAQI SALEEQLHQV
360 370 380 390 400
RTETEGQKLE YEQLLNVKAH LEKEIETYCL LIGGDEGSCV KSKGQGGPGN
410 420 430 440
QTKDSPKTAI VKTVVEELDP RGKVLSSRVH TLEEKSTKVN NKNEQRIPS
Length:449
Mass (Da):49,109
Last modified:July 5, 2004 - v1
Checksum:iFD863F380DDBAD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073900 Genomic DNA. No translation available.
BK004030 mRNA. Translation: DAA04464.1.
RefSeqiNP_001008824.1. NM_001008824.1.
UniGeneiRn.162195.

Genome annotation databases

EnsembliENSRNOT00000015740; ENSRNOP00000015740; ENSRNOG00000011628.
GeneIDi450229.
KEGGirno:450229.
UCSCiRGD:1359115. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073900 Genomic DNA. No translation available.
BK004030 mRNA. Translation: DAA04464.1.
RefSeqiNP_001008824.1. NM_001008824.1.
UniGeneiRn.162195.

3D structure databases

ProteinModelPortaliQ6IFW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015740.

PTM databases

iPTMnetiQ6IFW8.
PhosphoSitePlusiQ6IFW8.

Proteomic databases

PaxDbiQ6IFW8.
PRIDEiQ6IFW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015740; ENSRNOP00000015740; ENSRNOG00000011628.
GeneIDi450229.
KEGGirno:450229.
UCSCiRGD:1359115. rat.

Organism-specific databases

CTDi342574.
RGDi1359115. Krt27.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFW8.
KOiK07604.
OMAiSRVHTME.
OrthoDBiEOG091G087I.
PhylomeDBiQ6IFW8.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IFW8.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C27_RAT
AccessioniPrimary (citable) accession number: Q6IFW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.