Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cytoskeletal 10

Gene

Krt10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin-10
Short name:
CK-10
Keratin-10
Short name:
K10
Type I keratin Ka10
Gene namesi
Name:Krt10By similarity
Synonyms:Ka10Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359092. Krt10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Keratin, type I cytoskeletal 10PRO_0000257991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei38 – 381PhosphoserineBy similarity
Modified residuei52 – 521PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IFW6.
PRIDEiQ6IFW6.

PTM databases

iPTMnetiQ6IFW6.

Expressioni

Gene expression databases

ExpressionAtlasiQ6IFW6. baseline and differential.
GenevisibleiQ6IFW6. RN.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.

Protein-protein interaction databases

BioGridi268782. 1 interaction.
STRINGi10116.ENSRNOP00000029821.

Structurei

3D structure databases

ProteinModelPortaliQ6IFW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 144144HeadSequence analysisAdd
BLAST
Regioni145 – 455311RodSequence analysisAdd
BLAST
Regioni145 – 18036Coil 1ASequence analysisAdd
BLAST
Regioni181 – 20121Linker 1Sequence analysisAdd
BLAST
Regioni202 – 29392Coil 1BSequence analysisAdd
BLAST
Regioni294 – 31623Linker 12Sequence analysisAdd
BLAST
Regioni317 – 455139Coil 2Sequence analysisAdd
BLAST
Regioni456 – 52671TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 143126Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJX. Eukaryota.
ENOG410YDXS. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFW6.
KOiK07604.
OMAiRSEYEAM.
OrthoDBiEOG7FV3Q8.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRFSSNSR QYSSARSGGG GGGGGGGSSI RVSSTKSSLG GGYSSGGFSG
60 70 80 90 100
GSFSRGSSSG GCFGGSSGGY GGFGGGSFGG GYGGGSFGGG YGGGSFGGGY
110 120 130 140 150
GGGSFGGGYG GGSFGGGSFG GGSFGGGSFG GGLGGDGGGL LSGNEKVTMQ
160 170 180 190 200
NLNDRLASYM NKVRDLEESN YELEGKIKEW YEKHGNSSQR EPRDYSKYYK
210 220 230 240 250
TIEDLKGQIV NLTTDNANVL LQIDNARLAA DDFRLKYENE VALRQSVEAD
260 270 280 290 300
INGLRRVLDE LTLSKADLEM QIESLTEELA YLKKNHEEEM KDLQNVSTGD
310 320 330 340 350
VNVEMNAAPG VDLTQLLNNM RNQYEQLAEK NRKDAEAWFN EKSKELTTEI
360 370 380 390 400
DSNIEQMSSH KSEITELRRT VQGLEIELQS QLALKQSLEA SLAETEGRYC
410 420 430 440 450
VQLSQIQSQI SALEEQLQQI RAETECQNAE YQQLLDIKTR LENEIQTYRS
460 470 480 490 500
LLEGEGGYVG NLQITLNCFP SEFHLAKLTQ TQGKTRGWKG SNTNKTRVIK
510 520
TIIEEVTPEG RVLSSMIESE TKKHFY
Length:526
Mass (Da):56,505
Last modified:July 5, 2004 - v1
Checksum:i0B0AB97DAADEA9EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074182 Genomic DNA. No translation available.
BK004032 mRNA. Translation: DAA04466.1.
RefSeqiNP_001008804.1. NM_001008804.1.
UniGeneiRn.125065.

Genome annotation databases

EnsembliENSRNOT00000036023; ENSRNOP00000029821; ENSRNOG00000030170.
GeneIDi450225.
KEGGirno:450225.
UCSCiRGD:1359092. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074182 Genomic DNA. No translation available.
BK004032 mRNA. Translation: DAA04466.1.
RefSeqiNP_001008804.1. NM_001008804.1.
UniGeneiRn.125065.

3D structure databases

ProteinModelPortaliQ6IFW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi268782. 1 interaction.
STRINGi10116.ENSRNOP00000029821.

PTM databases

iPTMnetiQ6IFW6.

Proteomic databases

PaxDbiQ6IFW6.
PRIDEiQ6IFW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036023; ENSRNOP00000029821; ENSRNOG00000030170.
GeneIDi450225.
KEGGirno:450225.
UCSCiRGD:1359092. rat.

Organism-specific databases

CTDi3858.
RGDi1359092. Krt10.

Phylogenomic databases

eggNOGiENOG410IGJX. Eukaryota.
ENOG410YDXS. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFW6.
KOiK07604.
OMAiRSEYEAM.
OrthoDBiEOG7FV3Q8.

Miscellaneous databases

NextBioi697157.
PROiQ6IFW6.

Gene expression databases

ExpressionAtlasiQ6IFW6. baseline and differential.
GenevisibleiQ6IFW6. RN.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway1 Publication.
  2. "Comprehensive analysis of keratin gene clusters in humans and rodents."
    Hesse M., Zimek A., Weber K., Magin T.M.
    Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiK1C10_RAT
AccessioniPrimary (citable) accession number: Q6IFW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.