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Protein

Keratin, type I cytoskeletal 13

Gene

Krt13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to retinoic acid Source: RGD
  • cytoskeleton organization Source: Ensembl
  • response to radiation Source: RGD
  • tongue morphogenesis Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Type I keratin Ka13
Gene namesi
Name:Krt13By similarity
Synonyms:Ka13Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1302937. Krt13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Keratin, type I cytoskeletal 13PRO_0000063649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei42 – 421PhosphoserineBy similarity
Modified residuei50 – 501PhosphoserineBy similarity

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6IFV4.
PRIDEiQ6IFV4.

PTM databases

PhosphoSiteiQ6IFV4.

Expressioni

Gene expression databases

GenevisibleiQ6IFV4. RN.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-13 is generally associated with keratin-4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018851.

Structurei

3D structure databases

ProteinModelPortaliQ6IFV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9595HeadSequence analysisAdd
BLAST
Regioni96 – 404309RodSequence analysisAdd
BLAST
Regioni96 – 13136CoilSequence analysisAdd
BLAST
Regioni132 – 15019Linker 1Sequence analysisAdd
BLAST
Regioni151 – 24292Coil 1BSequence analysisAdd
BLAST
Regioni243 – 26523Linker 12Sequence analysisAdd
BLAST
Regioni266 – 404139Coil 2Sequence analysisAdd
BLAST
Regioni405 – 43834TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 9482Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFV4.
KOiK07604.
OMAiEEWFHSK.
OrthoDBiEOG091G087I.
PhylomeDBiQ6IFV4.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS TCSSRFVTGG SSGGYGGGMS
60 70 80 90 100
CGFGGGAGGG YGGGFGGGFG GSCGGGFGGG FGDFGSVDGG LLSGNEKITM
110 120 130 140 150
QNLNDRLASY LEKVRALEAA NADLEVKIRD WHLKQSPTSP ERDYSAYYKT
160 170 180 190 200
IEELRIKILE ATTDNNRIVL EIDNARLAAD DFRLKYENEL ALRQSVEADI
210 220 230 240 250
NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK EFSNQAVGQV
260 270 280 290 300
NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEAWFQA KSAELNKEVS
310 320 330 340 350
SNAAMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL
360 370 380 390 400
QLQQIQALIS SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL
410 420 430
LEGQDAKMTG FNTGGNSTTT SNTSTSPSTS GRPDFRKY
Length:438
Mass (Da):47,729
Last modified:July 5, 2004 - v1
Checksum:iCFCE10BC2431519A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073341 Genomic DNA. No translation available.
BK004044 mRNA. Translation: DAA04478.1.
RefSeqiNP_001004021.1. NM_001004021.1.
UniGeneiRn.102517.

Genome annotation databases

EnsembliENSRNOT00000018851; ENSRNOP00000018851; ENSRNOG00000014070.
GeneIDi287699.
KEGGirno:287699.
UCSCiRGD:1302937. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073341 Genomic DNA. No translation available.
BK004044 mRNA. Translation: DAA04478.1.
RefSeqiNP_001004021.1. NM_001004021.1.
UniGeneiRn.102517.

3D structure databases

ProteinModelPortaliQ6IFV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018851.

PTM databases

PhosphoSiteiQ6IFV4.

Proteomic databases

PaxDbiQ6IFV4.
PRIDEiQ6IFV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018851; ENSRNOP00000018851; ENSRNOG00000014070.
GeneIDi287699.
KEGGirno:287699.
UCSCiRGD:1302937. rat.

Organism-specific databases

CTDi3860.
RGDi1302937. Krt13.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFV4.
KOiK07604.
OMAiEEWFHSK.
OrthoDBiEOG091G087I.
PhylomeDBiQ6IFV4.
TreeFamiTF332742.

Miscellaneous databases

PROiQ6IFV4.

Gene expression databases

GenevisibleiQ6IFV4. RN.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C13_RAT
AccessioniPrimary (citable) accession number: Q6IFV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.