Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cytoskeletal 15

Gene

Krt15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: RGD

GO - Biological processi

  • intermediate filament-based process Source: RGD
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
Type I keratin Ka15
Gene namesi
Name:Krt15By similarity
Synonyms:Ka15Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1303044. Krt15.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • intermediate filament Source: RGD
  • keratin filament Source: RGD
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636591 – 447Keratin, type I cytoskeletal 15Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei290PhosphothreonineCombined sources1
Modified residuei312PhosphothreonineCombined sources1
Modified residuei421PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IFV3.
PRIDEiQ6IFV3.

PTM databases

iPTMnetiQ6IFV3.
PhosphoSitePlusiQ6IFV3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014099.
GenevisibleiQ6IFV3. RN.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019037.

Structurei

3D structure databases

ProteinModelPortaliQ6IFV3.
SMRiQ6IFV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 93HeadSequence analysisAdd BLAST93
Regioni94 – 402RodSequence analysisAdd BLAST309
Regioni94 – 129Coil 1ASequence analysisAdd BLAST36
Regioni130 – 148Linker 1Sequence analysisAdd BLAST19
Regioni149 – 240Coil 1BSequence analysisAdd BLAST92
Regioni241 – 260Linker 12Sequence analysisAdd BLAST20
Regioni261 – 402Coil 2Sequence analysisAdd BLAST142
Regioni403 – 447TailSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 92Gly-richSequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFV3.
KOiK07604.
OMAiVEAWFFS.
OrthoDBiEOG091G087I.
PhylomeDBiQ6IFV3.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTFLQTSS TFGSGSTRGG SLRVGGGSFG GGSLYGGGGS RSISASSARF
60 70 80 90 100
VSSGAGVGFG GGMSCGFGGG FGGGFGGGFG DFGGGDGGLL SGNEKVTMQN
110 120 130 140 150
LNDRLASYLD KVRALEEANT ELEVKIRDWY QKQSPASPDR DYSHYFKTME
160 170 180 190 200
EIRDKILAAT IDNSRVILEI DNARLAADDF RLKYENELAL RQGVEADING
210 220 230 240 250
LRRVLDELTL ARTDLEMQIE QLNEELAYLK KNHEEEMKEF SSQLAGQVNV
260 270 280 290 300
EMDAAPGVDL TRMLAEMREQ YEAIAEKNRR DVEAWFFSKT EELNKEVASN
310 320 330 340 350
TEMIQTSKTE ITDLRRTLQG LEIELQSQLS MKAGLENSLA EVECRYATQL
360 370 380 390 400
QQIQGLITGL ETQLSELRCE MEAQNQEYNM LLDIKTRLEQ EISTYRNLLE
410 420 430 440
GQDAKMAAIG VREASLRGGS SGGGSNFHIS VEESVDGKVV SSRKRES
Length:447
Mass (Da):48,870
Last modified:July 5, 2004 - v1
Checksum:iCD16F2D55F193671
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073341 Genomic DNA. No translation available.
BC101868 mRNA. Translation: AAI01869.1.
BK004045 mRNA. Translation: DAA04479.1.
RefSeqiNP_001004022.1. NM_001004022.2.
UniGeneiRn.153568.

Genome annotation databases

EnsembliENSRNOT00000019037; ENSRNOP00000019037; ENSRNOG00000014099.
GeneIDi287700.
KEGGirno:287700.
UCSCiRGD:1303044. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073341 Genomic DNA. No translation available.
BC101868 mRNA. Translation: AAI01869.1.
BK004045 mRNA. Translation: DAA04479.1.
RefSeqiNP_001004022.1. NM_001004022.2.
UniGeneiRn.153568.

3D structure databases

ProteinModelPortaliQ6IFV3.
SMRiQ6IFV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019037.

PTM databases

iPTMnetiQ6IFV3.
PhosphoSitePlusiQ6IFV3.

Proteomic databases

PaxDbiQ6IFV3.
PRIDEiQ6IFV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019037; ENSRNOP00000019037; ENSRNOG00000014099.
GeneIDi287700.
KEGGirno:287700.
UCSCiRGD:1303044. rat.

Organism-specific databases

CTDi3866.
RGDi1303044. Krt15.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFV3.
KOiK07604.
OMAiVEAWFFS.
OrthoDBiEOG091G087I.
PhylomeDBiQ6IFV3.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IFV3.

Gene expression databases

BgeeiENSRNOG00000014099.
GenevisibleiQ6IFV3. RN.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C15_RAT
AccessioniPrimary (citable) accession number: Q6IFV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.