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Protein

Keratin, type I cytoskeletal 14

Gene

Krt14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei371StutterBy similarity1

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • intermediate filament bundle assembly Source: UniProtKB
  • response to ionizing radiation Source: RGD
  • response to zinc ion Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-446107 Type I hemidesmosome assembly
R-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 14
Alternative name(s):
Cytokeratin-14
Short name:
CK-14
Keratin-14
Short name:
K14
Type I keratin Ka14
Gene namesi
Name:Krt14
Synonyms:Ka14Imported, Krt1-14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1307463 Krt14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636551 – 485Keratin, type I cytoskeletal 14Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi374InterchainBy similarity
Modified residuei448PhosphoserineBy similarity1

Post-translational modificationi

A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.By similarity
Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6IFV1
PRIDEiQ6IFV1

PTM databases

iPTMnetiQ6IFV1
PhosphoSitePlusiQ6IFV1

Expressioni

Tissue specificityi

Expressed in most cells of squamous cell carcinomas, in spinous and suprabasal cells around the branching papillary region of papillomas, and weakly in a few proliferative cells of hyperplastic tissue.1 Publication

Gene expression databases

BgeeiENSRNOG00000003899
ExpressionAtlasiQ6IFV1 baseline
GenevisibleiQ6IFV1 RN

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. disulfide-linked keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins (By similarity). Interacts with EPPK1 (By similarity). Interacts with KLHL24 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6IFV1, 1 interactor
STRINGi10116.ENSRNOP00000005285

Structurei

3D structure databases

ProteinModelPortaliQ6IFV1
SMRiQ6IFV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 433IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 121HeadBy similarityAdd BLAST121
Regioni122 – 157Coil 1ABy similarityAdd BLAST36
Regioni158 – 175Linker 1By similarityAdd BLAST18
Regioni176 – 267Coil 1BBy similarityAdd BLAST92
Regioni268 – 290Linker 12By similarityAdd BLAST23
Regioni291 – 429Coil 2By similarityAdd BLAST139
Regioni430 – 485TailBy similarityAdd BLAST56
Regioni432 – 485Interaction with Type I keratins and keratin filamentsBy similarityAdd BLAST54

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ6IFV1
KOiK07604
OMAiSYASNGL
OrthoDBiEOG091G087I
PhylomeDBiQ6IFV1
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IFV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCSRQFTS SSSMKGSCGI GGGSSRMSSV LAGGSCRAPS TYGGMSRFSS
60 70 80 90 100
AGAYAVGSGY GGGFSSSSFG GGFGGGIGGG IGGGLGGGIG GGFGGGIGGG
110 120 130 140 150
FGGGIGSGFG GGLGDGLLVG SEKVTMQNLN DRLATYLDKV RALEEANSDL
160 170 180 190 200
EVKIRDWYQR QRPTEIKDYS PYFKTIEDLK SKILAATVDN ANVLLQIDNA
210 220 230 240 250
RLAADDFRTK FETEQSLRIN VESDINGLRR VLDELTLARA DLEMQIESLK
260 270 280 290 300
EELAYLKKNH EEEMASMRGQ VGGDVNVEMD AAPGVDLSRI LNEMRDQYEK
310 320 330 340 350
MAEKNRKDAE DWFFTKTEEL NREVATNSEL VQSGKSEISE LRRTMQNLEI
360 370 380 390 400
ELQSQLSMKA SLENNLEETK GRYCMQLAQI QEMIGSVEEQ LAQLRCEMEQ
410 420 430 440 450
QNQEYKILLD VKTRLEQEIA TYRRLLEGED AHLSSAQFSS SSQFSSGSQS
460 470 480
SRDVTSTNRQ IRTKVMDVHD GKVVSTHEQV LRTKN
Length:485
Mass (Da):52,684
Last modified:July 5, 2004 - v1
Checksum:iC12CC69E59CD8DBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77I → L in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti81I → F in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti84G → R in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti88 – 107Missing in BAA22371 (PubMed:8950218).CuratedAdd BLAST20
Sequence conflicti205 – 207DDF → NDL in BAA22371 (PubMed:8950218).Curated3
Sequence conflicti211 – 215FETEQ → YDNET in BAA22371 (PubMed:8950218).Curated5
Sequence conflicti219 – 220IN → QL in BAA22371 (PubMed:8950218).Curated2
Sequence conflicti227G → N in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti230R → C in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti237 – 238LA → MS in BAA22371 (PubMed:8950218).Curated2
Sequence conflicti250K → T in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti265 – 271ASMRGQV → LALRVRL in BAA22371 (PubMed:8950218).Curated7
Sequence conflicti300K → Q in BAA22371 (PubMed:8950218).Curated1
Sequence conflicti309 – 317AEDWFFTKT → VEAWLEATS in BAA22371 (PubMed:8950218).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073469 Genomic DNA No translation available.
D63774 mRNA Translation: BAA22371.1
BK004047 mRNA Translation: DAA04481.1
RefSeqiNP_001008751.1, NM_001008751.1
UniGeneiRn.145931
Rn.153972

Genome annotation databases

EnsembliENSRNOT00000005285; ENSRNOP00000005285; ENSRNOG00000003899
GeneIDi287701
KEGGirno:287701
UCSCiRGD:1307463 rat

Similar proteinsi

Entry informationi

Entry nameiK1C14_RAT
AccessioniPrimary (citable) accession number: Q6IFV1
Secondary accession number(s): O35813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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