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Protein

Keratin, type I cytoskeletal 17

Gene

Krt17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.By similarity

GO - Molecular functioni

  • MHC class II receptor activity Source: Ensembl
  • structural constituent of cytoskeleton Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
Cytokeratin-17
Short name:
CK-17
Keratin-17
Short name:
K17
Type I keratin Ka17
Gene namesi
Name:Krt17By similarity
Synonyms:Ka17Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1303181. Krt17.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cell periphery Source: Ensembl
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: Ensembl
  • intermediate filament Source: RGD
  • keratin filament Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003105791 – 433Keratin, type I cytoskeletal 17Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei32PhosphoserineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei44Phosphoserine; by RPS6KA1By similarity1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei323PhosphoserineBy similarity1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6IFU8.
PRIDEiQ6IFU8.

PTM databases

iPTMnetiQ6IFU8.
PhosphoSitePlusiQ6IFU8.

Expressioni

Gene expression databases

ExpressionAtlasiQ6IFU8. baseline and differential.
GenevisibleiQ6IFU8. RN.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B). Interacts with TRADD and SFN (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005382.

Structurei

3D structure databases

ProteinModelPortaliQ6IFU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 83HeadAdd BLAST83
Regioni84 – 392RodSequence analysisAdd BLAST309
Regioni84 – 120Coil 1ASequence analysisAdd BLAST37
Regioni121 – 138Linker 1Sequence analysisAdd BLAST18
Regioni139 – 230Coil 1BSequence analysisAdd BLAST92
Regioni231 – 250Linker 12Sequence analysisAdd BLAST20
Regioni251 – 392Coil 2Sequence analysisAdd BLAST142
Regioni393 – 433TailSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 62Ser-richSequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFU8.
KOiK07604.
PhylomeDBiQ6IFU8.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTIRQFTS SSSIKGSSGL GGGSSRTSCR LSGSLGAGSC RLGSASGLGS
60 70 80 90 100
ALGGNSYSSC YSFGTGSGYG GNFGGVDGLL AGGEKATMQN LNDRLASYLD
110 120 130 140 150
KVRALEEANT ELEVKIRDWY QKQAPGPARD YSAYYQTIED LKNKILVATV
160 170 180 190 200
DNASILLQID NARLAADDFR TKFETEQALR MSVEADINGL RRVLDELTLA
210 220 230 240 250
RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS
260 270 280 290 300
RILSEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI
310 320 330 340 350
SELRRTMQAL EIELQSQLSM KASLEGSLAE TENRYCVQLS QIQGLIGSVE
360 370 380 390 400
EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKP
410 420 430
KEPVTTRQVR TIVEEVQDGK VISSREQVHQ TTR
Length:433
Mass (Da):48,123
Last modified:July 5, 2004 - v1
Checksum:i7CB5C921841382D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073469 Genomic DNA. No translation available.
BC100058 mRNA. Translation: AAI00059.1.
BK004050 mRNA. Translation: DAA04484.1.
RefSeqiNP_997710.1. NM_212545.2.
UniGeneiRn.106755.

Genome annotation databases

EnsembliENSRNOT00000005382; ENSRNOP00000005382; ENSRNOG00000026371.
GeneIDi287702.
KEGGirno:287702.
UCSCiRGD:1303181. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073469 Genomic DNA. No translation available.
BC100058 mRNA. Translation: AAI00059.1.
BK004050 mRNA. Translation: DAA04484.1.
RefSeqiNP_997710.1. NM_212545.2.
UniGeneiRn.106755.

3D structure databases

ProteinModelPortaliQ6IFU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005382.

PTM databases

iPTMnetiQ6IFU8.
PhosphoSitePlusiQ6IFU8.

Proteomic databases

PaxDbiQ6IFU8.
PRIDEiQ6IFU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005382; ENSRNOP00000005382; ENSRNOG00000026371.
GeneIDi287702.
KEGGirno:287702.
UCSCiRGD:1303181. rat.

Organism-specific databases

CTDi3872.
RGDi1303181. Krt17.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6IFU8.
KOiK07604.
PhylomeDBiQ6IFU8.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IFU8.

Gene expression databases

ExpressionAtlasiQ6IFU8. baseline and differential.
GenevisibleiQ6IFU8. RN.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C17_RAT
AccessioniPrimary (citable) accession number: Q6IFU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.