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Protein

Olfactory receptor 7E24

Gene

OR7E24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7E24
Alternative name(s):
Olfactory receptor OR19-14
Gene namesi
Name:OR7E24
Synonyms:OR7E24P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8396. OR7E24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 728CytoplasmicSequence analysis
Transmembranei73 – 9321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini94 – 11724ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 21537ExtracellularSequence analysisAdd
BLAST
Transmembranei216 – 23520Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 25520CytoplasmicSequence analysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini277 – 28913ExtracellularSequence analysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini311 – 33929CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32675.

Polymorphism and mutation databases

BioMutaiOR7E24.
DMDMi74757943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Olfactory receptor 7E24PRO_0000281642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IFN5.
PRIDEiQ6IFN5.

PTM databases

iPTMnetiQ6IFN5.
PhosphoSiteiQ6IFN5.

Expressioni

Gene expression databases

BgeeiENSG00000237521.
GenevisibleiQ6IFN5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000387523.

Structurei

3D structure databases

ProteinModelPortaliQ6IFN5.
SMRiQ6IFN5. Positions 40-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB54. Eukaryota.
ENOG4111DP5. LUCA.
GeneTreeiENSGT00810000125431.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ6IFN5.
KOiK04257.
OMAiLKRCPSY.
OrthoDBiEOG091G0B53.
PhylomeDBiQ6IFN5.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFPILFFF FLKRCPSYTE PQNLTGVSEF LLLGLSEDPE LQPVLAGLFL
60 70 80 90 100
SMYLVTVLGN LLIILAVSSD SHLHTPMYFF LSNLSLADIG FTSTTVPKMI
110 120 130 140 150
VDMQTHSRVI SYEGCLTQMS FFVLFACMDD MLLSVMAYDR FVAICHPLHY
160 170 180 190 200
RIIMNPRLCG FLILLSFFIS LLDSQLHNLI MLQLTCFKDV DISNFFCDPS
210 220 230 240 250
QLLHLRCSDT FINEMVIYFM GAIFGCLPIS GILFSYYKIV SPILRVPTSD
260 270 280 290 300
GKYKAFSTCG SHLAVVCLFY GTGLVGYLSS AVLPSPRKSM VASVMYTVVT
310 320 330
PMLNPFIYSL RNKDIQSALC RLHGRIIKSH HLHPFCYMG
Length:339
Mass (Da):38,279
Last modified:July 5, 2004 - v1
Checksum:i529D5BAB05301A24
GO

Sequence cautioni

The sequence AAD03353 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931S → F.
Corresponds to variant rs12980833 [ dbSNP | Ensembl ].
VAR_053236
Natural varianti242 – 2421P → S.
Corresponds to variant rs2240928 [ dbSNP | Ensembl ].
VAR_053237

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006271 Genomic DNA. Translation: AAD03353.1. Sequence problems.
BC146920 mRNA. Translation: AAI46921.1.
BK004227 Genomic DNA. Translation: DAA04625.1.
CCDSiCCDS45955.1.
RefSeqiNP_001073404.1. NM_001079935.1.
UniGeneiHs.129832.

Genome annotation databases

EnsembliENST00000456448; ENSP00000387523; ENSG00000237521.
GeneIDi26648.
KEGGihsa:26648.
UCSCiuc002mlb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006271 Genomic DNA. Translation: AAD03353.1. Sequence problems.
BC146920 mRNA. Translation: AAI46921.1.
BK004227 Genomic DNA. Translation: DAA04625.1.
CCDSiCCDS45955.1.
RefSeqiNP_001073404.1. NM_001079935.1.
UniGeneiHs.129832.

3D structure databases

ProteinModelPortaliQ6IFN5.
SMRiQ6IFN5. Positions 40-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000387523.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6IFN5.
PhosphoSiteiQ6IFN5.

Polymorphism and mutation databases

BioMutaiOR7E24.
DMDMi74757943.

Proteomic databases

PaxDbiQ6IFN5.
PRIDEiQ6IFN5.

Protocols and materials databases

DNASUi26648.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456448; ENSP00000387523; ENSG00000237521.
GeneIDi26648.
KEGGihsa:26648.
UCSCiuc002mlb.2. human.

Organism-specific databases

CTDi26648.
GeneCardsiOR7E24.
HGNCiHGNC:8396. OR7E24.
neXtProtiNX_Q6IFN5.
PharmGKBiPA32675.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB54. Eukaryota.
ENOG4111DP5. LUCA.
GeneTreeiENSGT00810000125431.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ6IFN5.
KOiK04257.
OMAiLKRCPSY.
OrthoDBiEOG091G0B53.
PhylomeDBiQ6IFN5.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii26648.
PROiQ6IFN5.

Gene expression databases

BgeeiENSG00000237521.
GenevisibleiQ6IFN5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO7E24_HUMAN
AccessioniPrimary (citable) accession number: Q6IFN5
Secondary accession number(s): B9EJD9, Q9UPJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.