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Protein

Olfactory receptor 6B2

Gene

OR6B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32030-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6B2
Alternative name(s):
Olfactory receptor OR2-1
Gene namesi
Name:OR6B2
Synonyms:OR6B2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:15041. OR6B2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi389090.
OpenTargetsiENSG00000182083.
PharmGKBiPA32577.

Polymorphism and mutation databases

BioMutaiOR6B2.
DMDMi84029382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506211 – 312Olfactory receptor 6B2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IFH4.
PeptideAtlasiQ6IFH4.
PRIDEiQ6IFH4.

Expressioni

Gene expression databases

BgeeiENSG00000182083.

Organism-specific databases

HPAiHPA047529.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384563.

Structurei

3D structure databases

ProteinModelPortaliQ6IFH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKF0. Eukaryota.
ENOG41113GD. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ6IFH4.
KOiK04257.
OMAiVVTPIIN.
OrthoDBiEOG091G0DAJ.
PhylomeDBiQ6IFH4.
TreeFamiTF337475.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IFH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGENVTKVS TFILVGLPTA PGLQYLLFLL FLLTYLFVLV ENLAIILIVW
60 70 80 90 100
SSTSLHRPMY YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ
110 120 130 140 150
LYFFSSLVCT ECVLLASMAY DRYVAICHPL RYHVLVTPGL CLQLVGFSFV
160 170 180 190 200
SGFTISMIKV CFISSVTFCG SNVLNHFFCD ISPILKLACT DFSTAELVDF
210 220 230 240 250
ILAFIILVFP LLATILSYWH ITLAVLRIPS ATGCWRAFST CASHLTVVTV
260 270 280 290 300
FYTALLFMYV RPQAIDSQSS NKLISAVYTV VTPIINPLIY CLRNKEFKDA
310
LKKALGLGQT SH
Length:312
Mass (Da):35,029
Last modified:December 20, 2005 - v2
Checksum:i56D388B1AF4799FA
GO

Sequence cautioni

The sequence DAA04686 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062047179C → R.Corresponds to variant rs10187574dbSNPEnsembl.1
Natural variantiVAR_062048227R → C.Corresponds to variant rs60841887dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065663 Genomic DNA. Translation: BAC05889.1.
CH471063 Genomic DNA. Translation: EAW71176.1.
BC137561 mRNA. Translation: AAI37562.1.
BC137562 mRNA. Translation: AAI37563.1.
BK004288 Genomic DNA. Translation: DAA04686.1. Different initiation.
CCDSiCCDS46559.1.
RefSeqiNP_001005853.1. NM_001005853.1.
UniGeneiHs.531343.

Genome annotation databases

EnsembliENST00000402971; ENSP00000384563; ENSG00000182083.
GeneIDi389090.
KEGGihsa:389090.
UCSCiuc010zoc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065663 Genomic DNA. Translation: BAC05889.1.
CH471063 Genomic DNA. Translation: EAW71176.1.
BC137561 mRNA. Translation: AAI37562.1.
BC137562 mRNA. Translation: AAI37563.1.
BK004288 Genomic DNA. Translation: DAA04686.1. Different initiation.
CCDSiCCDS46559.1.
RefSeqiNP_001005853.1. NM_001005853.1.
UniGeneiHs.531343.

3D structure databases

ProteinModelPortaliQ6IFH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384563.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR6B2.
DMDMi84029382.

Proteomic databases

PaxDbiQ6IFH4.
PeptideAtlasiQ6IFH4.
PRIDEiQ6IFH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402971; ENSP00000384563; ENSG00000182083.
GeneIDi389090.
KEGGihsa:389090.
UCSCiuc010zoc.3. human.

Organism-specific databases

CTDi389090.
DisGeNETi389090.
GeneCardsiOR6B2.
HGNCiHGNC:15041. OR6B2.
HPAiHPA047529.
neXtProtiNX_Q6IFH4.
OpenTargetsiENSG00000182083.
PharmGKBiPA32577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKF0. Eukaryota.
ENOG41113GD. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ6IFH4.
KOiK04257.
OMAiVVTPIIN.
OrthoDBiEOG091G0DAJ.
PhylomeDBiQ6IFH4.
TreeFamiTF337475.

Enzyme and pathway databases

BioCyciZFISH:G66-32030-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6B2.
GenomeRNAii389090.
PROiQ6IFH4.

Gene expression databases

BgeeiENSG00000182083.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR6B2_HUMAN
AccessioniPrimary (citable) accession number: Q6IFH4
Secondary accession number(s): B2RPR3, Q8NGW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.