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Protein

Olfactory receptor 10K2

Gene

OR10K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10K2
Alternative name(s):
Olfactory receptor OR1-4
Gene namesi
Name:OR10K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14826. OR10K2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi391107.
OpenTargetsiENSG00000180708.
PharmGKBiPA31989.

Polymorphism and mutation databases

BioMutaiOR10K2.
DMDMi74762319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507121 – 312Olfactory receptor 10K2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IF99.
PeptideAtlasiQ6IF99.
PRIDEiQ6IF99.

Expressioni

Gene expression databases

CleanExiHS_OR10K2.
ExpressionAtlasiQ6IF99. baseline and differential.

Organism-specific databases

HPAiHPA059125.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324251.

Structurei

3D structure databases

ProteinModelPortaliQ6IF99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0G. Eukaryota.
ENOG41117G5. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF99.
KOiK04257.
OMAiVASHHTH.
OrthoDBiEOG091G0CYL.
PhylomeDBiQ6IF99.
TreeFamiTF337249.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVNETVVR EVIFLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV
60 70 80 90 100
LDRALHIPMY FFLAILSCSE ICYTFIIVPK MLVDLLSQKK TISFLGCAIQ
110 120 130 140 150
MFSFLFLGCS HSFLLAVMGY DRYIAICNPL RYSVLMGHGV CMGLVAAACA
160 170 180 190 200
CGFTVAQIIT SLVFHLPFYS SNQLHHFFCD IAPVLKLASH HNHFSQIVIF
210 220 230 240 250
MLCTLVLAIP LLLILVSYVH ILSAILQFPS TLGRCKAFST CVSHLIIVTV
260 270 280 290 300
HYGCASFIYL RPQSNYSSSQ DALISVSYTI ITPLFNPMIY SLRNKEFKSA
310
LCKIVRRTIS LL
Length:312
Mass (Da):35,029
Last modified:July 5, 2004 - v1
Checksum:i1161372C7CB7CE90
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053283208A → T.Corresponds to variant rs12240099dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121986 Genomic DNA. Translation: CAI10868.1.
BK004363 Genomic DNA. Translation: DAA04761.1.
CCDSiCCDS30896.1.
RefSeqiNP_001004476.1. NM_001004476.1.
UniGeneiHs.626815.

Genome annotation databases

EnsembliENST00000314902; ENSP00000324251; ENSG00000180708.
GeneIDi391107.
KEGGihsa:391107.
UCSCiuc010pii.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121986 Genomic DNA. Translation: CAI10868.1.
BK004363 Genomic DNA. Translation: DAA04761.1.
CCDSiCCDS30896.1.
RefSeqiNP_001004476.1. NM_001004476.1.
UniGeneiHs.626815.

3D structure databases

ProteinModelPortaliQ6IF99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324251.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10K2.
DMDMi74762319.

Proteomic databases

PaxDbiQ6IF99.
PeptideAtlasiQ6IF99.
PRIDEiQ6IF99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314902; ENSP00000324251; ENSG00000180708.
GeneIDi391107.
KEGGihsa:391107.
UCSCiuc010pii.2. human.

Organism-specific databases

CTDi391107.
DisGeNETi391107.
GeneCardsiOR10K2.
HGNCiHGNC:14826. OR10K2.
HPAiHPA059125.
neXtProtiNX_Q6IF99.
OpenTargetsiENSG00000180708.
PharmGKBiPA31989.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0G. Eukaryota.
ENOG41117G5. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF99.
KOiK04257.
OMAiVASHHTH.
OrthoDBiEOG091G0CYL.
PhylomeDBiQ6IF99.
TreeFamiTF337249.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10K2.
GenomeRNAii391107.
PROiQ6IF99.

Gene expression databases

CleanExiHS_OR10K2.
ExpressionAtlasiQ6IF99. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10K2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.