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Q6IF99

- O10K2_HUMAN

UniProt

Q6IF99 - O10K2_HUMAN

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Protein

Olfactory receptor 10K2

Gene

OR10K2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10K2
Alternative name(s):
Olfactory receptor OR1-4
Gene namesi
Name:OR10K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14826. OR10K2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 10K2PRO_0000150712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IF99.
PRIDEiQ6IF99.

Expressioni

Gene expression databases

CleanExiHS_OR10K2.
GenevestigatoriQ6IF99.

Organism-specific databases

HPAiHPA059125.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324251.

Structurei

3D structure databases

ProteinModelPortaliQ6IF99.
SMRiQ6IF99. Positions 26-133.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40813.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF99.
KOiK04257.
OMAiVASHHTH.
OrthoDBiEOG7WMCK8.
PhylomeDBiQ6IF99.
TreeFamiTF337249.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF99 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERVNETVVR EVIFLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV
60 70 80 90 100
LDRALHIPMY FFLAILSCSE ICYTFIIVPK MLVDLLSQKK TISFLGCAIQ
110 120 130 140 150
MFSFLFLGCS HSFLLAVMGY DRYIAICNPL RYSVLMGHGV CMGLVAAACA
160 170 180 190 200
CGFTVAQIIT SLVFHLPFYS SNQLHHFFCD IAPVLKLASH HNHFSQIVIF
210 220 230 240 250
MLCTLVLAIP LLLILVSYVH ILSAILQFPS TLGRCKAFST CVSHLIIVTV
260 270 280 290 300
HYGCASFIYL RPQSNYSSSQ DALISVSYTI ITPLFNPMIY SLRNKEFKSA
310
LCKIVRRTIS LL
Length:312
Mass (Da):35,029
Last modified:July 5, 2004 - v1
Checksum:i1161372C7CB7CE90
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081A → T.
Corresponds to variant rs12240099 [ dbSNP | Ensembl ].
VAR_053283

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL121986 Genomic DNA. Translation: CAI10868.1.
BK004363 Genomic DNA. Translation: DAA04761.1.
CCDSiCCDS30896.1.
RefSeqiNP_001004476.1. NM_001004476.1.
UniGeneiHs.626815.

Genome annotation databases

EnsembliENST00000314902; ENSP00000324251; ENSG00000180708.
GeneIDi391107.
KEGGihsa:391107.
UCSCiuc010pii.2. human.

Polymorphism databases

DMDMi74762319.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL121986 Genomic DNA. Translation: CAI10868.1 .
BK004363 Genomic DNA. Translation: DAA04761.1 .
CCDSi CCDS30896.1.
RefSeqi NP_001004476.1. NM_001004476.1.
UniGenei Hs.626815.

3D structure databases

ProteinModelPortali Q6IF99.
SMRi Q6IF99. Positions 26-133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000324251.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 74762319.

Proteomic databases

PaxDbi Q6IF99.
PRIDEi Q6IF99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314902 ; ENSP00000324251 ; ENSG00000180708 .
GeneIDi 391107.
KEGGi hsa:391107.
UCSCi uc010pii.2. human.

Organism-specific databases

CTDi 391107.
GeneCardsi GC01M158388.
HGNCi HGNC:14826. OR10K2.
HPAi HPA059125.
neXtProti NX_Q6IF99.
PharmGKBi PA31989.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40813.
GeneTreei ENSGT00760000119043.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q6IF99.
KOi K04257.
OMAi VASHHTH.
OrthoDBi EOG7WMCK8.
PhylomeDBi Q6IF99.
TreeFami TF337249.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10K2.
GenomeRNAii 391107.
NextBioi 104331.
PROi Q6IF99.

Gene expression databases

CleanExi HS_OR10K2.
Genevestigatori Q6IF99.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10K2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3