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Protein

Olfactory receptor 4A47

Gene

OR4A47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4A47
Alternative name(s):
Olfactory receptor OR11-113
Gene namesi
Name:OR4A47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:31266. OR4A47.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7722Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini288 – 30922CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952685.

Polymorphism and mutation databases

BioMutaiOR4A47.
DMDMi215273863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 4A47PRO_0000150527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IF82.
PRIDEiQ6IF82.

PTM databases

PhosphoSiteiQ6IF82.

Expressioni

Gene expression databases

CleanExiHS_OR4A47.

Organism-specific databases

HPAiHPA059763.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412752.

Structurei

3D structure databases

ProteinModelPortaliQ6IF82.
SMRiQ6IF82. Positions 23-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ82. Eukaryota.
ENOG41116C3. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ6IF82.
KOiK04257.
OMAiNTISFEY.
OrthoDBiEOG754HPT.
PhylomeDBiQ6IF82.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRKNVTDF VLLGFTQNPK EQKVLFVMFL LFYILTMVGN LLIVVTVTVS
60 70 80 90 100
ETLGSPMYFF LAGLSFIDII YSSSISPRLI SGLFFGNNSI SFQSCMAQLF
110 120 130 140 150
IEHIFGGSEV FLLLVMAYDC YVAICKPLHY LVIMRQWVCV VLLVVSWVGG
160 170 180 190 200
FLHSVFQLSI IYGLPFCGPN VIDHFFCDMY PLLKLVCTDT HAIGLLVVAN
210 220 230 240 250
GGLACTIVFL LLLISYGVIL HSLKNLSQKG RQKALSTCSS HMTVVVFFFV
260 270 280 290 300
PCIFMYARPA RTFPIDKSVS VFYTVITPML NPLIYTLRNS EMTSAMKKLW

RRDLISSST
Length:309
Mass (Da):34,760
Last modified:November 25, 2008 - v2
Checksum:i9E4EB0E0A3C0BCD7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821G → D.
Corresponds to variant rs12805819 [ dbSNP | Ensembl ].
VAR_047759
Natural varianti104 – 1041I → L.
Corresponds to variant rs7103557 [ dbSNP | Ensembl ].
VAR_047760
Natural varianti145 – 1451V → M.
Corresponds to variant rs7103992 [ dbSNP | Ensembl ].
VAR_047761
Natural varianti192 – 1921A → D.
Corresponds to variant rs7103932 [ dbSNP | Ensembl ].
VAR_047762

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134982 Genomic DNA. No translation available.
BK004380 Genomic DNA. Translation: DAA04778.1.
CCDSiCCDS31490.1.
RefSeqiNP_001005512.2. NM_001005512.2.
XP_006718293.1. XM_006718230.1.
UniGeneiHs.554532.

Genome annotation databases

EnsembliENST00000446524; ENSP00000412752; ENSG00000237388.
GeneIDi403253.
KEGGihsa:403253.
UCSCiuc010rhx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134982 Genomic DNA. No translation available.
BK004380 Genomic DNA. Translation: DAA04778.1.
CCDSiCCDS31490.1.
RefSeqiNP_001005512.2. NM_001005512.2.
XP_006718293.1. XM_006718230.1.
UniGeneiHs.554532.

3D structure databases

ProteinModelPortaliQ6IF82.
SMRiQ6IF82. Positions 23-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000412752.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6IF82.

Polymorphism and mutation databases

BioMutaiOR4A47.
DMDMi215273863.

Proteomic databases

PaxDbiQ6IF82.
PRIDEiQ6IF82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446524; ENSP00000412752; ENSG00000237388.
GeneIDi403253.
KEGGihsa:403253.
UCSCiuc010rhx.3. human.

Organism-specific databases

CTDi403253.
GeneCardsiOR4A47.
H-InvDBHIX0058972.
HGNCiHGNC:31266. OR4A47.
HPAiHPA059763.
neXtProtiNX_Q6IF82.
PharmGKBiPA134952685.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ82. Eukaryota.
ENOG41116C3. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ6IF82.
KOiK04257.
OMAiNTISFEY.
OrthoDBiEOG754HPT.
PhylomeDBiQ6IF82.
TreeFamiTF337350.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4A47.
GenomeRNAii403253.
NextBioi107665.
PROiQ6IF82.

Gene expression databases

CleanExiHS_OR4A47.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO4A47_HUMAN
AccessioniPrimary (citable) accession number: Q6IF82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 25, 2008
Last modified: May 11, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.