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Protein

Olfactory receptor 52W1

Gene

OR52W1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52W1
Alternative name(s):
Olfactory receptor OR11-71
Gene namesi
Name:OR52W1
Synonyms:OR52W1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15239. OR52W1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 59CytoplasmicSequence analysis8
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 104ExtracellularSequence analysisAdd BLAST24
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 144CytoplasmicSequence analysisAdd BLAST19
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 201ExtracellularSequence analysisAdd BLAST36
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 242CytoplasmicSequence analysisAdd BLAST20
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 279ExtracellularSequence analysisAdd BLAST16
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 320CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175485.
PharmGKBiPA32453.

Polymorphism and mutation databases

BioMutaiOR52W1.
DMDMi205525921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507921 – 320Olfactory receptor 52W1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IF63.
PeptideAtlasiQ6IF63.
PRIDEiQ6IF63.

PTM databases

iPTMnetiQ6IF63.
PhosphoSitePlusiQ6IF63.

Expressioni

Gene expression databases

CleanExiHS_OR52W1.

Interactioni

Protein-protein interaction databases

BioGridi125694. 1 interactor.
STRINGi9606.ENSP00000309673.

Structurei

3D structure databases

ProteinModelPortaliQ6IF63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKBE. Eukaryota.
ENOG411157G. LUCA.
GeneTreeiENSGT00810000125632.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ6IF63.
KOiK04257.
OMAiLQLPTRE.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ6IF63.
TreeFamiTF343679.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETLQLNST FLHPNFFILT GFPGLGSAQT WLTLVFGPIY LLALLGNGAL
60 70 80 90 100
PAVVWIDSTL HQPMFLLLAI LAATDLGLAT SIAPGLLAVL WLGPRSVPYA
110 120 130 140 150
VCLVQMFFVH ALTAMESGVL LAMACDRAAA IGRPLHYPVL VTKACVGYAA
160 170 180 190 200
LALALKAVAI VVPFPLLVAK FEHFQAKTIG HTYCAHMAVV ELVVGNTQAT
210 220 230 240 250
NLYGLALSLA ISGMDILGIT GSYGLIAHAV LQLPTREAHA KAFGTCSSHI
260 270 280 290 300
CVILAFYIPG LFSYLTHRFG HHTVPKPVHI LLSNIYLLLP PALNPLIYGA
310 320
RTKQIRDRLL ETFTFRKSPL
Length:320
Mass (Da):34,414
Last modified:July 22, 2008 - v2
Checksum:iB3E2EF68C32733B2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044514239H → R.Corresponds to variant rs10839531dbSNPEnsembl.1
Natural variantiVAR_044515254L → Q.Corresponds to variant rs11040799dbSNPEnsembl.1
Natural variantiVAR_044516266T → A.1 PublicationCorresponds to variant rs325609dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065511 Genomic DNA. Translation: BAC05759.1.
AC036216 Genomic DNA. No translation available.
BC137225 mRNA. Translation: AAI37226.1.
BK004399 Genomic DNA. Translation: DAA04797.1.
CCDSiCCDS31407.1.
RefSeqiNP_001005178.1. NM_001005178.1.
UniGeneiHs.553570.

Genome annotation databases

EnsembliENST00000311352; ENSP00000309673; ENSG00000175485.
GeneIDi120787.
KEGGihsa:120787.
UCSCiuc010qzz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065511 Genomic DNA. Translation: BAC05759.1.
AC036216 Genomic DNA. No translation available.
BC137225 mRNA. Translation: AAI37226.1.
BK004399 Genomic DNA. Translation: DAA04797.1.
CCDSiCCDS31407.1.
RefSeqiNP_001005178.1. NM_001005178.1.
UniGeneiHs.553570.

3D structure databases

ProteinModelPortaliQ6IF63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125694. 1 interactor.
STRINGi9606.ENSP00000309673.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6IF63.
PhosphoSitePlusiQ6IF63.

Polymorphism and mutation databases

BioMutaiOR52W1.
DMDMi205525921.

Proteomic databases

PaxDbiQ6IF63.
PeptideAtlasiQ6IF63.
PRIDEiQ6IF63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311352; ENSP00000309673; ENSG00000175485.
GeneIDi120787.
KEGGihsa:120787.
UCSCiuc010qzz.3. human.

Organism-specific databases

CTDi120787.
GeneCardsiOR52W1.
HGNCiHGNC:15239. OR52W1.
neXtProtiNX_Q6IF63.
OpenTargetsiENSG00000175485.
PharmGKBiPA32453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKBE. Eukaryota.
ENOG411157G. LUCA.
GeneTreeiENSGT00810000125632.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ6IF63.
KOiK04257.
OMAiLQLPTRE.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ6IF63.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52W1.
GenomeRNAii120787.
PROiQ6IF63.

Gene expression databases

CleanExiHS_OR52W1.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52W1_HUMAN
AccessioniPrimary (citable) accession number: Q6IF63
Secondary accession number(s): Q8NH78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.