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Protein

Olfactory receptor 2A2

Gene

OR2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A2
Alternative name(s):
Olfactory receptor 2A17
Olfactory receptor OR7-11
Gene namesi
Name:OR2A2
Synonyms:OR2A17P, OR2A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221989.2.
HGNCiHGNC:8230. OR2A2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR2A2.
DMDMi84029381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504531 – 318Olfactory receptor 2A2Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IF42.
PRIDEiQ6IF42.

PTM databases

iPTMnetiQ6IF42.
PhosphoSitePlusiQ6IF42.

Expressioni

Gene expression databases

CleanExiHS_OR2A2.
ExpressionAtlasiQ6IF42. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi138235. 2 interactors.
STRINGi9606.ENSP00000386209.

Structurei

3D structure databases

ProteinModelPortaliQ6IF42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHV. Eukaryota.
ENOG410Z9E8. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF42.
KOiK04257.
OMAiLVYMVPD.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ6IF42.
TreeFamiTF337251.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030782. OR2A2.
PANTHERiPTHR26453:SF82. PTHR26453:SF82. 1 hit.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IF42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL
60 70 80 90 100
DSKLHTPMYF FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT
110 120 130 140 150
FLYLAFAVTE CLILVVMSYD RYVAICHPFQ YTVIMSWRVC TILVLTSWSC
160 170 180 190 200
GFALSLVHEI LLLRLPFCGP RDVNHLFCEI LSVLKLACAD TWVNQVVIFA
210 220 230 240 250
TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC SSHLCVVGLF
260 270 280 290 300
FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL
310
HRALQRKRSM RTVYGLCL
Length:318
Mass (Da):35,820
Last modified:December 20, 2005 - v2
Checksum:iCCF412640B5AD8DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0599825Q → K. Corresponds to variant dbSNP:rs10230228Ensembl.1
Natural variantiVAR_053128210L → P. Corresponds to variant dbSNP:rs10252253Ensembl.1
Natural variantiVAR_059983280F → L1 PublicationCorresponds to variant dbSNP:rs2961149Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065695 Genomic DNA. Translation: BAC05918.1.
AC091768 Genomic DNA. No translation available.
BC136742 mRNA. Translation: AAI36743.1.
BK004420 Genomic DNA. Translation: DAA04818.1.
CCDSiCCDS43671.1.
RefSeqiNP_001005480.2. NM_001005480.2.
UniGeneiHs.553841.

Genome annotation databases

EnsembliENST00000408979; ENSP00000386209; ENSG00000221989.
GeneIDi442361.
KEGGihsa:442361.
UCSCiuc011ktz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2A2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF42
Secondary accession number(s): B2RN85, Q8NGT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 25, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families