Q6IF42 (OR2A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2A2

Alternative name(s):
Olfactory receptor 2A17
Olfactory receptor OR7-11

Gene names

Name:	OR2A2
Synonyms:	OR2A17P, OR2A2P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Olfactory receptor 2A2		PRO_0000150453
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 48	24	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 78	22	Helical; Name=2; Potential
	Topological domain	79 – 99	21	Extracellular Potential
	Transmembrane	100 – 119	20	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 157	19	Helical; Name=4; Potential
	Topological domain	158 – 194	37	Extracellular Potential
	Transmembrane	195 – 218	24	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 310	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	5	1	Q → K. Corresponds to variant rs10230228 [ dbSNP | Ensembl ].		VAR_059982
	Natural variant	210	1	L → P. Corresponds to variant rs10252253 [ dbSNP | Ensembl ].		VAR_053128
	Natural variant	280	1	F → L. Ref.2 Corresponds to variant rs2961149 [ dbSNP | Ensembl ].		VAR_059983

Sequences

	Sequence		Length	Mass (Da)
	Q6IF42 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: CCF412640B5AD8DC	FASTA	318	35,820
	10 20 30 40 50 60 MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL DSKLHTPMYF 70 80 90 100 110 120 FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT FLYLAFAVTE CLILVVMSYD 130 140 150 160 170 180 RYVAICHPFQ YTVIMSWRVC TILVLTSWSC GFALSLVHEI LLLRLPFCGP RDVNHLFCEI 190 200 210 220 230 240 LSVLKLACAD TWVNQVVIFA TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC 250 260 270 280 290 300 SSHLCVVGLF FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL 310 HRALQRKRSM RTVYGLCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-280.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065695 Genomic DNA. Translation: BAC05918.1. AC091768 Genomic DNA. No translation available. BC136742 mRNA. Translation: AAI36743.1. BK004420 Genomic DNA. Translation: DAA04818.1.
IPI	IPI00386374.
RefSeq	NP_001005480.2. NM_001005480.2.
UniGene	Hs.553841.
3D structure databases
ProteinModelPortal	Q6IF42.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000386209.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q6IF42.
Polymorphism databases
DMDM	84029381.
Proteomic databases
PRIDE	Q6IF42.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000408979; ENSP00000386209; ENSG00000221989.
GeneID	442361.
KEGG	hsa:442361.
UCSC	uc011ktz.2. human.
Organism-specific databases
CTD	442361.
GeneCards	GC07P143806.
HGNC	HGNC:8230. OR2A2.
neXtProt	NX_Q6IF42.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148596.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q6IF42.
KO	K04257.
OMA	NLMNQKR.
OrthoDB	EOG4ZKJMV.
PhylomeDB	Q6IF42.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR2A2.
Genevestigator	Q6IF42.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	442361.
NextBio	111033.

Entry information

Entry name

OR2A2_HUMAN

Accession

Primary (citable) accession number: Q6IF42
Secondary accession number(s): B2RN85, Q8NGT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.