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Protein

Olfactory receptor 2A2

Gene

OR2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. olfactory receptor activity Source: InterPro
  2. taste receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of taste Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A2
Alternative name(s):
Olfactory receptor 2A17
Olfactory receptor OR7-11
Gene namesi
Name:OR2A2
Synonyms:OR2A17P, OR2A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8230. OR2A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 2A2PRO_0000150453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6IF42.

PTM databases

PhosphoSiteiQ6IF42.

Expressioni

Gene expression databases

CleanExiHS_OR2A2.
GenevestigatoriQ6IF42.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386209.

Structurei

3D structure databases

ProteinModelPortaliQ6IF42.
SMRiQ6IF42. Positions 6-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148596.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF42.
KOiK04257.
OMAiNLMNQKR.
OrthoDBiEOG793B85.
PhylomeDBiQ6IF42.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL
60 70 80 90 100
DSKLHTPMYF FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT
110 120 130 140 150
FLYLAFAVTE CLILVVMSYD RYVAICHPFQ YTVIMSWRVC TILVLTSWSC
160 170 180 190 200
GFALSLVHEI LLLRLPFCGP RDVNHLFCEI LSVLKLACAD TWVNQVVIFA
210 220 230 240 250
TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC SSHLCVVGLF
260 270 280 290 300
FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL
310
HRALQRKRSM RTVYGLCL
Length:318
Mass (Da):35,820
Last modified:December 20, 2005 - v2
Checksum:iCCF412640B5AD8DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51Q → K.
Corresponds to variant rs10230228 [ dbSNP | Ensembl ].
VAR_059982
Natural varianti210 – 2101L → P.
Corresponds to variant rs10252253 [ dbSNP | Ensembl ].
VAR_053128
Natural varianti280 – 2801F → L.1 Publication
Corresponds to variant rs2961149 [ dbSNP | Ensembl ].
VAR_059983

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065695 Genomic DNA. Translation: BAC05918.1.
AC091768 Genomic DNA. No translation available.
BC136742 mRNA. Translation: AAI36743.1.
BK004420 Genomic DNA. Translation: DAA04818.1.
CCDSiCCDS43671.1.
RefSeqiNP_001005480.2. NM_001005480.2.
UniGeneiHs.553841.

Genome annotation databases

EnsembliENST00000408979; ENSP00000386209; ENSG00000221989.
GeneIDi442361.
KEGGihsa:442361.
UCSCiuc011ktz.2. human.

Polymorphism databases

DMDMi84029381.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065695 Genomic DNA. Translation: BAC05918.1.
AC091768 Genomic DNA. No translation available.
BC136742 mRNA. Translation: AAI36743.1.
BK004420 Genomic DNA. Translation: DAA04818.1.
CCDSiCCDS43671.1.
RefSeqiNP_001005480.2. NM_001005480.2.
UniGeneiHs.553841.

3D structure databases

ProteinModelPortaliQ6IF42.
SMRiQ6IF42. Positions 6-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386209.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6IF42.

Polymorphism databases

DMDMi84029381.

Proteomic databases

PRIDEiQ6IF42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408979; ENSP00000386209; ENSG00000221989.
GeneIDi442361.
KEGGihsa:442361.
UCSCiuc011ktz.2. human.

Organism-specific databases

CTDi442361.
GeneCardsiGC07P143806.
HGNCiHGNC:8230. OR2A2.
neXtProtiNX_Q6IF42.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148596.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF42.
KOiK04257.
OMAiNLMNQKR.
OrthoDBiEOG793B85.
PhylomeDBiQ6IF42.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A2.
GenomeRNAii442361.
NextBioi111033.
PROiQ6IF42.

Gene expression databases

CleanExiHS_OR2A2.
GenevestigatoriQ6IF42.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-280.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2A2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF42
Secondary accession number(s): B2RN85, Q8NGT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: February 4, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.