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Q6IF42

- OR2A2_HUMAN

UniProt

Q6IF42 - OR2A2_HUMAN

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Protein

Olfactory receptor 2A2

Gene
OR2A2, OR2A17P, OR2A2P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A2
Alternative name(s):
Olfactory receptor 2A17
Olfactory receptor OR7-11
Gene namesi
Name:OR2A2
Synonyms:OR2A17P, OR2A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8230. OR2A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed predictionAdd
BLAST
Transmembranei25 – 4824Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7822Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9921Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 11920Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15719Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini158 – 19437Extracellular Reviewed predictionAdd
BLAST
Transmembranei195 – 21824Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 23517Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29120Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 31019Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 2A2PRO_0000150453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6IF42.

PTM databases

PhosphoSiteiQ6IF42.

Expressioni

Gene expression databases

CleanExiHS_OR2A2.
GenevestigatoriQ6IF42.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386209.

Structurei

3D structure databases

ProteinModelPortaliQ6IF42.
SMRiQ6IF42. Positions 6-289.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148596.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF42.
KOiK04257.
OMAiWIFSLFY.
OrthoDBiEOG793B85.
PhylomeDBiQ6IF42.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF42-1 [UniParc]FASTAAdd to Basket

« Hide

MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL    50
DSKLHTPMYF FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT 100
FLYLAFAVTE CLILVVMSYD RYVAICHPFQ YTVIMSWRVC TILVLTSWSC 150
GFALSLVHEI LLLRLPFCGP RDVNHLFCEI LSVLKLACAD TWVNQVVIFA 200
TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC SSHLCVVGLF 250
FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL 300
HRALQRKRSM RTVYGLCL 318
Length:318
Mass (Da):35,820
Last modified:December 20, 2005 - v2
Checksum:iCCF412640B5AD8DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51Q → K.
Corresponds to variant rs10230228 [ dbSNP | Ensembl ].
VAR_059982
Natural varianti210 – 2101L → P.
Corresponds to variant rs10252253 [ dbSNP | Ensembl ].
VAR_053128
Natural varianti280 – 2801F → L.1 Publication
Corresponds to variant rs2961149 [ dbSNP | Ensembl ].
VAR_059983

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065695 Genomic DNA. Translation: BAC05918.1.
AC091768 Genomic DNA. No translation available.
BC136742 mRNA. Translation: AAI36743.1.
BK004420 Genomic DNA. Translation: DAA04818.1.
CCDSiCCDS43671.1.
RefSeqiNP_001005480.2. NM_001005480.2.
UniGeneiHs.553841.

Genome annotation databases

EnsembliENST00000408979; ENSP00000386209; ENSG00000221989.
GeneIDi442361.
KEGGihsa:442361.
UCSCiuc011ktz.2. human.

Polymorphism databases

DMDMi84029381.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065695 Genomic DNA. Translation: BAC05918.1 .
AC091768 Genomic DNA. No translation available.
BC136742 mRNA. Translation: AAI36743.1 .
BK004420 Genomic DNA. Translation: DAA04818.1 .
CCDSi CCDS43671.1.
RefSeqi NP_001005480.2. NM_001005480.2.
UniGenei Hs.553841.

3D structure databases

ProteinModelPortali Q6IF42.
SMRi Q6IF42. Positions 6-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386209.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q6IF42.

Polymorphism databases

DMDMi 84029381.

Proteomic databases

PRIDEi Q6IF42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408979 ; ENSP00000386209 ; ENSG00000221989 .
GeneIDi 442361.
KEGGi hsa:442361.
UCSCi uc011ktz.2. human.

Organism-specific databases

CTDi 442361.
GeneCardsi GC07P143806.
HGNCi HGNC:8230. OR2A2.
neXtProti NX_Q6IF42.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148596.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q6IF42.
KOi K04257.
OMAi WIFSLFY.
OrthoDBi EOG793B85.
PhylomeDBi Q6IF42.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2A2.
GenomeRNAii 442361.
NextBioi 111033.
PROi Q6IF42.

Gene expression databases

CleanExi HS_OR2A2.
Genevestigatori Q6IF42.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-280.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2A2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF42
Secondary accession number(s): B2RN85, Q8NGT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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