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Q6IF42

- OR2A2_HUMAN

UniProt

Q6IF42 - OR2A2_HUMAN

Protein

Olfactory receptor 2A2

Gene

OR2A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2A2
    Alternative name(s):
    Olfactory receptor 2A17
    Olfactory receptor OR7-11
    Gene namesi
    Name:OR2A2
    Synonyms:OR2A17P, OR2A2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:8230. OR2A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Olfactory receptor 2A2PRO_0000150453Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6IF42.

    PTM databases

    PhosphoSiteiQ6IF42.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2A2.
    GenevestigatoriQ6IF42.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386209.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IF42.
    SMRiQ6IF42. Positions 6-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148596.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ6IF42.
    KOiK04257.
    OMAiWIFSLFY.
    OrthoDBiEOG793B85.
    PhylomeDBiQ6IF42.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IF42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL    50
    DSKLHTPMYF FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT 100
    FLYLAFAVTE CLILVVMSYD RYVAICHPFQ YTVIMSWRVC TILVLTSWSC 150
    GFALSLVHEI LLLRLPFCGP RDVNHLFCEI LSVLKLACAD TWVNQVVIFA 200
    TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC SSHLCVVGLF 250
    FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL 300
    HRALQRKRSM RTVYGLCL 318
    Length:318
    Mass (Da):35,820
    Last modified:December 20, 2005 - v2
    Checksum:iCCF412640B5AD8DC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51Q → K.
    Corresponds to variant rs10230228 [ dbSNP | Ensembl ].
    VAR_059982
    Natural varianti210 – 2101L → P.
    Corresponds to variant rs10252253 [ dbSNP | Ensembl ].
    VAR_053128
    Natural varianti280 – 2801F → L.1 Publication
    Corresponds to variant rs2961149 [ dbSNP | Ensembl ].
    VAR_059983

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065695 Genomic DNA. Translation: BAC05918.1.
    AC091768 Genomic DNA. No translation available.
    BC136742 mRNA. Translation: AAI36743.1.
    BK004420 Genomic DNA. Translation: DAA04818.1.
    CCDSiCCDS43671.1.
    RefSeqiNP_001005480.2. NM_001005480.2.
    UniGeneiHs.553841.

    Genome annotation databases

    EnsembliENST00000408979; ENSP00000386209; ENSG00000221989.
    GeneIDi442361.
    KEGGihsa:442361.
    UCSCiuc011ktz.2. human.

    Polymorphism databases

    DMDMi84029381.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065695 Genomic DNA. Translation: BAC05918.1 .
    AC091768 Genomic DNA. No translation available.
    BC136742 mRNA. Translation: AAI36743.1 .
    BK004420 Genomic DNA. Translation: DAA04818.1 .
    CCDSi CCDS43671.1.
    RefSeqi NP_001005480.2. NM_001005480.2.
    UniGenei Hs.553841.

    3D structure databases

    ProteinModelPortali Q6IF42.
    SMRi Q6IF42. Positions 6-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386209.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6IF42.

    Polymorphism databases

    DMDMi 84029381.

    Proteomic databases

    PRIDEi Q6IF42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408979 ; ENSP00000386209 ; ENSG00000221989 .
    GeneIDi 442361.
    KEGGi hsa:442361.
    UCSCi uc011ktz.2. human.

    Organism-specific databases

    CTDi 442361.
    GeneCardsi GC07P143806.
    HGNCi HGNC:8230. OR2A2.
    neXtProti NX_Q6IF42.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148596.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q6IF42.
    KOi K04257.
    OMAi WIFSLFY.
    OrthoDBi EOG793B85.
    PhylomeDBi Q6IF42.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2A2.
    GenomeRNAii 442361.
    NextBioi 111033.
    PROi Q6IF42.

    Gene expression databases

    CleanExi HS_OR2A2.
    Genevestigatori Q6IF42.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-280.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2A2_HUMAN
    AccessioniPrimary (citable) accession number: Q6IF42
    Secondary accession number(s): B2RN85, Q8NGT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3