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Q6IF42 (OR2A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2A2
Alternative name(s):
Olfactory receptor 2A17
Olfactory receptor OR7-11
Gene names
Name:OR2A2
Synonyms:OR2A17P, OR2A2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Olfactory receptor 2A2
PRO_0000150453

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7822Helical; Name=2; Potential
Topological domain79 – 9921Extracellular Potential
Transmembrane100 – 11920Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15719Helical; Name=4; Potential
Topological domain158 – 19437Extracellular Potential
Transmembrane195 – 21824Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31019Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential

Natural variations

Natural variant51Q → K.
Corresponds to variant rs10230228 [ dbSNP | Ensembl ].
VAR_059982
Natural variant2101L → P.
Corresponds to variant rs10252253 [ dbSNP | Ensembl ].
VAR_053128
Natural variant2801F → L. Ref.2
Corresponds to variant rs2961149 [ dbSNP | Ensembl ].
VAR_059983

Sequences

Sequence LengthMass (Da)Tools
Q6IF42 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: CCF412640B5AD8DC

FASTA31835,820
        10         20         30         40         50         60 
MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL DSKLHTPMYF 

        70         80         90        100        110        120 
FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT FLYLAFAVTE CLILVVMSYD 

       130        140        150        160        170        180 
RYVAICHPFQ YTVIMSWRVC TILVLTSWSC GFALSLVHEI LLLRLPFCGP RDVNHLFCEI 

       190        200        210        220        230        240 
LSVLKLACAD TWVNQVVIFA TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC 

       250        260        270        280        290        300 
SSHLCVVGLF FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL 

       310 
HRALQRKRSM RTVYGLCL 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-280.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065695 Genomic DNA. Translation: BAC05918.1.
AC091768 Genomic DNA. No translation available.
BC136742 mRNA. Translation: AAI36743.1.
BK004420 Genomic DNA. Translation: DAA04818.1.
RefSeqNP_001005480.2. NM_001005480.2.
UniGeneHs.553841.

3D structure databases

ProteinModelPortalQ6IF42.
SMRQ6IF42. Positions 6-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000386209.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ6IF42.

Polymorphism databases

DMDM84029381.

Proteomic databases

PRIDEQ6IF42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408979; ENSP00000386209; ENSG00000221989.
GeneID442361.
KEGGhsa:442361.
UCSCuc011ktz.2. human.

Organism-specific databases

CTD442361.
GeneCardsGC07P143806.
HGNCHGNC:8230. OR2A2.
neXtProtNX_Q6IF42.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148596.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ6IF42.
KOK04257.
OMAWIFSLFY.
OrthoDBEOG793B85.
PhylomeDBQ6IF42.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2A2.
GenevestigatorQ6IF42.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2A2.
GenomeRNAi442361.
NextBio111033.
PROQ6IF42.

Entry information

Entry nameOR2A2_HUMAN
AccessionPrimary (citable) accession number: Q6IF42
Secondary accession number(s): B2RN85, Q8NGT6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries