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Q6IF00 (OR2T2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2T2
Alternative name(s):
Olfactory receptor OR1-43
Gene names
Name:OR2T2
Synonyms:OR2T2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Olfactory receptor 2T2
PRO_0000150497

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 5024Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10121Extracellular Potential
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 15919Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 22024Helical; Name=5; Potential
Topological domain221 – 23717Cytoplasmic Potential
Transmembrane238 – 26023Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29320Helical; Name=7; Potential
Topological domain294 – 32431Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IF00 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: AF11D073719A994A

FASTA32436,228
        10         20         30         40         50         60 
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA IVFSIFVVAI TANLVMILLI HMDSRLHTPM 

        70         80         90        100        110        120 
YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV QIFLYLTLIG GEFFLLGLMA 

       130        140        150        160        170        180 
YDRYVAVCNP LRYPLLMNRR VCLFMVVGSW VGGSLDGFML TPVTMSFPFC RSREINHFFC 

       190        200        210        220        230        240 
EIPAVLKLSC TDTSLYETLM YACCVLMLLI PLSVISVSYT HILLTVHRMN SAEGRRKAFA 

       250        260        270        280        290        300 
TCSSHIMVVS VFYGAAFYTN VLPHSYHTPE KDKVVSAFYT ILTPMLNPLI YSLRNKDVAA 

       310        320 
ALRKVLGRCG SSQSIRVATV IRKG 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC138089 Genomic DNA. No translation available.
BC136961 mRNA. Translation: AAI36962.1.
BC136962 mRNA. Translation: AAI36963.1.
BK004462 Genomic DNA. Translation: DAA04860.1.
CCDSCCDS31116.1.
RefSeqNP_001004136.1. NM_001004136.1.
UniGeneHs.554482.

3D structure databases

ProteinModelPortalQ6IF00.
SMRQ6IF00. Positions 30-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000343062.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ6IF00.

Polymorphism databases

DMDM74762309.

Proteomic databases

PaxDbQ6IF00.
PRIDEQ6IF00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342927; ENSP00000343062; ENSG00000196240.
GeneID401992.
KEGGhsa:401992.
UCSCuc001iek.1. human.

Organism-specific databases

CTD401992.
GeneCardsGC01P248616.
HGNCHGNC:14725. OR2T2.
neXtProtNX_Q6IF00.
PharmGKBPA32202.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG151052.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ6IF00.
KOK04257.
OMAFTMSFPY.
OrthoDBEOG71K63J.
PhylomeDBQ6IF00.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ6IF00.
GenevestigatorQ6IF00.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2T2.
GenomeRNAi401992.
NextBio107250.
PROQ6IF00.

Entry information

Entry nameOR2T2_HUMAN
AccessionPrimary (citable) accession number: Q6IF00
Secondary accession number(s): B2RNM1, B9EH01
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries