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Protein

Olfactory receptor 2T2

Gene

OR2T2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T2
Alternative name(s):
Olfactory receptor OR1-43
Gene namesi
Name:OR2T2
Synonyms:OR2T2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14725. OR2T2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 293Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini294 – 324CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi401992.
OpenTargetsiENSG00000196240.
ENSG00000275754.
ENSG00000276821.
PharmGKBiPA32202.

Polymorphism and mutation databases

BioMutaiOR2T2.
DMDMi74762309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504971 – 324Olfactory receptor 2T2Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IF00.
PeptideAtlasiQ6IF00.
PRIDEiQ6IF00.

PTM databases

iPTMnetiQ6IF00.
PhosphoSitePlusiQ6IF00.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343062.

Structurei

3D structure databases

ProteinModelPortaliQ6IF00.
SMRiQ6IF00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICX. Eukaryota.
ENOG41113GT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF00.
KOiK04257.
OMAiITHPTFP.
OrthoDBiEOG090A087F.
PhylomeDBiQ6IF00.
TreeFamiTF337295.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IF00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA IVFSIFVVAI TANLVMILLI
60 70 80 90 100
HMDSRLHTPM YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV
110 120 130 140 150
QIFLYLTLIG GEFFLLGLMA YDRYVAVCNP LRYPLLMNRR VCLFMVVGSW
160 170 180 190 200
VGGSLDGFML TPVTMSFPFC RSREINHFFC EIPAVLKLSC TDTSLYETLM
210 220 230 240 250
YACCVLMLLI PLSVISVSYT HILLTVHRMN SAEGRRKAFA TCSSHIMVVS
260 270 280 290 300
VFYGAAFYTN VLPHSYHTPE KDKVVSAFYT ILTPMLNPLI YSLRNKDVAA
310 320
ALRKVLGRCG SSQSIRVATV IRKG
Length:324
Mass (Da):36,228
Last modified:July 5, 2004 - v1
Checksum:iAF11D073719A994A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BC136961 mRNA. Translation: AAI36962.1.
BC136962 mRNA. Translation: AAI36963.1.
BK004462 Genomic DNA. Translation: DAA04860.1.
CCDSiCCDS31116.1.
RefSeqiNP_001004136.1. NM_001004136.1.
UniGeneiHs.554482.

Genome annotation databases

EnsembliENST00000342927; ENSP00000343062; ENSG00000196240.
ENST00000610282; ENSP00000482837; ENSG00000276821.
ENST00000616594; ENSP00000481002; ENSG00000275754.
GeneIDi401992.
KEGGihsa:401992.
UCSCiuc001iek.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BC136961 mRNA. Translation: AAI36962.1.
BC136962 mRNA. Translation: AAI36963.1.
BK004462 Genomic DNA. Translation: DAA04860.1.
CCDSiCCDS31116.1.
RefSeqiNP_001004136.1. NM_001004136.1.
UniGeneiHs.554482.

3D structure databases

ProteinModelPortaliQ6IF00.
SMRiQ6IF00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343062.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6IF00.
PhosphoSitePlusiQ6IF00.

Polymorphism and mutation databases

BioMutaiOR2T2.
DMDMi74762309.

Proteomic databases

PaxDbiQ6IF00.
PeptideAtlasiQ6IF00.
PRIDEiQ6IF00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342927; ENSP00000343062; ENSG00000196240.
ENST00000610282; ENSP00000482837; ENSG00000276821.
ENST00000616594; ENSP00000481002; ENSG00000275754.
GeneIDi401992.
KEGGihsa:401992.
UCSCiuc001iek.1. human.

Organism-specific databases

CTDi401992.
DisGeNETi401992.
GeneCardsiOR2T2.
HGNCiHGNC:14725. OR2T2.
neXtProtiNX_Q6IF00.
OpenTargetsiENSG00000196240.
ENSG00000275754.
ENSG00000276821.
PharmGKBiPA32202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICX. Eukaryota.
ENOG41113GT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF00.
KOiK04257.
OMAiITHPTFP.
OrthoDBiEOG090A087F.
PhylomeDBiQ6IF00.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T2.
GenomeRNAii401992.
PROiQ6IF00.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF00
Secondary accession number(s): B2RNM1, B9EH01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.