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Q6IF00

- OR2T2_HUMAN

UniProt

Q6IF00 - OR2T2_HUMAN

Protein

Olfactory receptor 2T2

Gene

OR2T2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2T2
    Alternative name(s):
    Olfactory receptor OR1-43
    Gene namesi
    Name:OR2T2
    Synonyms:OR2T2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14725. OR2T2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32202.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Olfactory receptor 2T2PRO_0000150497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6IF00.
    PRIDEiQ6IF00.

    PTM databases

    PhosphoSiteiQ6IF00.

    Expressioni

    Gene expression databases

    BgeeiQ6IF00.
    GenevestigatoriQ6IF00.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000343062.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IF00.
    SMRiQ6IF00. Positions 30-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 32431CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151052.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ6IF00.
    KOiK04257.
    OMAiFTMSFPY.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ6IF00.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IF00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA IVFSIFVVAI TANLVMILLI    50
    HMDSRLHTPM YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV 100
    QIFLYLTLIG GEFFLLGLMA YDRYVAVCNP LRYPLLMNRR VCLFMVVGSW 150
    VGGSLDGFML TPVTMSFPFC RSREINHFFC EIPAVLKLSC TDTSLYETLM 200
    YACCVLMLLI PLSVISVSYT HILLTVHRMN SAEGRRKAFA TCSSHIMVVS 250
    VFYGAAFYTN VLPHSYHTPE KDKVVSAFYT ILTPMLNPLI YSLRNKDVAA 300
    ALRKVLGRCG SSQSIRVATV IRKG 324
    Length:324
    Mass (Da):36,228
    Last modified:July 5, 2004 - v1
    Checksum:iAF11D073719A994A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138089 Genomic DNA. No translation available.
    BC136961 mRNA. Translation: AAI36962.1.
    BC136962 mRNA. Translation: AAI36963.1.
    BK004462 Genomic DNA. Translation: DAA04860.1.
    CCDSiCCDS31116.1.
    RefSeqiNP_001004136.1. NM_001004136.1.
    UniGeneiHs.554482.

    Genome annotation databases

    EnsembliENST00000342927; ENSP00000343062; ENSG00000196240.
    GeneIDi401992.
    KEGGihsa:401992.
    UCSCiuc001iek.1. human.

    Polymorphism databases

    DMDMi74762309.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138089 Genomic DNA. No translation available.
    BC136961 mRNA. Translation: AAI36962.1 .
    BC136962 mRNA. Translation: AAI36963.1 .
    BK004462 Genomic DNA. Translation: DAA04860.1 .
    CCDSi CCDS31116.1.
    RefSeqi NP_001004136.1. NM_001004136.1.
    UniGenei Hs.554482.

    3D structure databases

    ProteinModelPortali Q6IF00.
    SMRi Q6IF00. Positions 30-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000343062.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6IF00.

    Polymorphism databases

    DMDMi 74762309.

    Proteomic databases

    PaxDbi Q6IF00.
    PRIDEi Q6IF00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342927 ; ENSP00000343062 ; ENSG00000196240 .
    GeneIDi 401992.
    KEGGi hsa:401992.
    UCSCi uc001iek.1. human.

    Organism-specific databases

    CTDi 401992.
    GeneCardsi GC01P248616.
    HGNCi HGNC:14725. OR2T2.
    neXtProti NX_Q6IF00.
    PharmGKBi PA32202.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151052.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q6IF00.
    KOi K04257.
    OMAi FTMSFPY.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q6IF00.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2T2.
    GenomeRNAii 401992.
    NextBioi 107250.
    PROi Q6IF00.

    Gene expression databases

    Bgeei Q6IF00.
    Genevestigatori Q6IF00.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2T2_HUMAN
    AccessioniPrimary (citable) accession number: Q6IF00
    Secondary accession number(s): B2RNM1, B9EH01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3