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Protein

Olfactory receptor 2T2

Gene

OR2T2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T2
Alternative name(s):
Olfactory receptor OR1-43
Gene namesi
Name:OR2T2
Synonyms:OR2T2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14725. OR2T2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 32431CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 2T2PRO_0000150497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IF00.
PRIDEiQ6IF00.

PTM databases

PhosphoSiteiQ6IF00.

Expressioni

Gene expression databases

BgeeiQ6IF00.
GenevestigatoriQ6IF00.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343062.

Structurei

3D structure databases

ProteinModelPortaliQ6IF00.
SMRiQ6IF00. Positions 30-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151052.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF00.
KOiK04257.
OMAiFTMSFPY.
OrthoDBiEOG71K63J.
PhylomeDBiQ6IF00.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IF00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA IVFSIFVVAI TANLVMILLI
60 70 80 90 100
HMDSRLHTPM YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV
110 120 130 140 150
QIFLYLTLIG GEFFLLGLMA YDRYVAVCNP LRYPLLMNRR VCLFMVVGSW
160 170 180 190 200
VGGSLDGFML TPVTMSFPFC RSREINHFFC EIPAVLKLSC TDTSLYETLM
210 220 230 240 250
YACCVLMLLI PLSVISVSYT HILLTVHRMN SAEGRRKAFA TCSSHIMVVS
260 270 280 290 300
VFYGAAFYTN VLPHSYHTPE KDKVVSAFYT ILTPMLNPLI YSLRNKDVAA
310 320
ALRKVLGRCG SSQSIRVATV IRKG
Length:324
Mass (Da):36,228
Last modified:July 5, 2004 - v1
Checksum:iAF11D073719A994A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BC136961 mRNA. Translation: AAI36962.1.
BC136962 mRNA. Translation: AAI36963.1.
BK004462 Genomic DNA. Translation: DAA04860.1.
CCDSiCCDS31116.1.
RefSeqiNP_001004136.1. NM_001004136.1.
UniGeneiHs.554482.

Genome annotation databases

EnsembliENST00000342927; ENSP00000343062; ENSG00000196240.
ENST00000610282; ENSP00000482837; ENSG00000276821.
ENST00000616594; ENSP00000481002; ENSG00000275754.
GeneIDi401992.
KEGGihsa:401992.
UCSCiuc001iek.1. human.

Polymorphism databases

DMDMi74762309.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BC136961 mRNA. Translation: AAI36962.1.
BC136962 mRNA. Translation: AAI36963.1.
BK004462 Genomic DNA. Translation: DAA04860.1.
CCDSiCCDS31116.1.
RefSeqiNP_001004136.1. NM_001004136.1.
UniGeneiHs.554482.

3D structure databases

ProteinModelPortaliQ6IF00.
SMRiQ6IF00. Positions 30-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343062.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6IF00.

Polymorphism databases

DMDMi74762309.

Proteomic databases

PaxDbiQ6IF00.
PRIDEiQ6IF00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342927; ENSP00000343062; ENSG00000196240.
ENST00000610282; ENSP00000482837; ENSG00000276821.
ENST00000616594; ENSP00000481002; ENSG00000275754.
GeneIDi401992.
KEGGihsa:401992.
UCSCiuc001iek.1. human.

Organism-specific databases

CTDi401992.
GeneCardsiGC01P248616.
HGNCiHGNC:14725. OR2T2.
neXtProtiNX_Q6IF00.
PharmGKBiPA32202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG151052.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IF00.
KOiK04257.
OMAiFTMSFPY.
OrthoDBiEOG71K63J.
PhylomeDBiQ6IF00.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T2.
GenomeRNAii401992.
NextBioi107250.
PROiQ6IF00.

Gene expression databases

BgeeiQ6IF00.
GenevestigatoriQ6IF00.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2T2_HUMAN
AccessioniPrimary (citable) accession number: Q6IF00
Secondary accession number(s): B2RNM1, B9EH01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.