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Q6IEZ7

- OR2T5_HUMAN

UniProt

Q6IEZ7 - OR2T5_HUMAN

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Protein

Olfactory receptor 2T5

Gene
OR2T5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T5
Alternative name(s):
Olfactory receptor OR1-62
Gene namesi
Name:OR2T5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15017. OR2T5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular Reviewed predictionAdd
BLAST
Transmembranei30 – 5324Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini54 – 618Cytoplasmic Reviewed prediction
Transmembranei62 – 8322Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini84 – 10421Extracellular Reviewed predictionAdd
BLAST
Transmembranei105 – 12420Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini125 – 14319Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei144 – 16219Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini163 – 19937Extracellular Reviewed predictionAdd
BLAST
Transmembranei200 – 22324Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini224 – 24017Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei241 – 26323Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini264 – 27613Extracellular Reviewed predictionAdd
BLAST
Transmembranei277 – 29620Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini297 – 31519Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 2T5PRO_0000150500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi101 ↔ 193 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6IEZ7.

PTM databases

PhosphoSiteiQ6IEZ7.

Expressioni

Gene expression databases

BgeeiQ6IEZ7.
CleanExiHS_OR2T5.
GenevestigatoriQ6IEZ7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355429.

Structurei

3D structure databases

ProteinModelPortaliQ6IEZ7.
SMRiQ6IEZ7. Positions 28-227.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IEZ7.
KOiK04257.
OMAiHRMNSAT.
OrthoDBiEOG7W9RV2.
PhylomeDBiQ6IEZ7.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MANITRMANH TGKLDFILMG LFRRSKHPAL LSVVIFVVFL KALSGNAVLI    50
LLIHCDAHLH SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE 100
CGMQMFLYLT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS 150
GCWFLGSVDG FMLTPITMSF PFCRSWEIHH FFCEVPAVTI LSCSDTSLYE 200
TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK AFATCSSHLT 250
VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD 300
VMGALKKMLT VRFVL 315
Length:315
Mass (Da):35,595
Last modified:July 5, 2004 - v1
Checksum:iC6D2BB5AC283F38A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1.
CCDSiCCDS31118.1.
RefSeqiNP_001004697.1. NM_001004697.1.
UniGeneiHs.553808.

Genome annotation databases

EnsembliENST00000366473; ENSP00000355429; ENSG00000203661.
GeneIDi401993.
KEGGihsa:401993.
UCSCiuc001iem.1. human.

Polymorphism databases

DMDMi74762308.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1 .
CCDSi CCDS31118.1.
RefSeqi NP_001004697.1. NM_001004697.1.
UniGenei Hs.553808.

3D structure databases

ProteinModelPortali Q6IEZ7.
SMRi Q6IEZ7. Positions 28-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000355429.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q6IEZ7.

Polymorphism databases

DMDMi 74762308.

Proteomic databases

PRIDEi Q6IEZ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366473 ; ENSP00000355429 ; ENSG00000203661 .
GeneIDi 401993.
KEGGi hsa:401993.
UCSCi uc001iem.1. human.

Organism-specific databases

CTDi 401993.
GeneCardsi GC01P248651.
H-InvDB HIX0200060.
HGNCi HGNC:15017. OR2T5.
neXtProti NX_Q6IEZ7.
PharmGKBi PA32205.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q6IEZ7.
KOi K04257.
OMAi HRMNSAT.
OrthoDBi EOG7W9RV2.
PhylomeDBi Q6IEZ7.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 401993.
NextBioi 107256.
PROi Q6IEZ7.

Gene expression databases

Bgeei Q6IEZ7.
CleanExi HS_OR2T5.
Genevestigatori Q6IEZ7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2T5_HUMAN
AccessioniPrimary (citable) accession number: Q6IEZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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