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Q6IEZ7 (OR2T5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2T5
Alternative name(s):
Olfactory receptor OR1-62
Gene names
Name:OR2T5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 2T5
PRO_0000150500

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5324Helical; Name=1; Potential
Topological domain54 – 618Cytoplasmic Potential
Transmembrane62 – 8322Helical; Name=2; Potential
Topological domain84 – 10421Extracellular Potential
Transmembrane105 – 12420Helical; Name=3; Potential
Topological domain125 – 14319Cytoplasmic Potential
Transmembrane144 – 16219Helical; Name=4; Potential
Topological domain163 – 19937Extracellular Potential
Transmembrane200 – 22324Helical; Name=5; Potential
Topological domain224 – 24017Cytoplasmic Potential
Transmembrane241 – 26323Helical; Name=6; Potential
Topological domain264 – 27613Extracellular Potential
Transmembrane277 – 29620Helical; Name=7; Potential
Topological domain297 – 31519Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation91N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 193 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IEZ7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C6D2BB5AC283F38A

FASTA31535,595
        10         20         30         40         50         60 
MANITRMANH TGKLDFILMG LFRRSKHPAL LSVVIFVVFL KALSGNAVLI LLIHCDAHLH 

        70         80         90        100        110        120 
SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE CGMQMFLYLT LAGSEFFLLA 

       130        140        150        160        170        180 
TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS GCWFLGSVDG FMLTPITMSF PFCRSWEIHH 

       190        200        210        220        230        240 
FFCEVPAVTI LSCSDTSLYE TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK 

       250        260        270        280        290        300 
AFATCSSHLT VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD 

       310 
VMGALKKMLT VRFVL 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1.
RefSeqNP_001004697.1. NM_001004697.1.
UniGeneHs.553808.

3D structure databases

ProteinModelPortalQ6IEZ7.
SMRQ6IEZ7. Positions 28-227, 281-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000355429.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ6IEZ7.

Polymorphism databases

DMDM74762308.

Proteomic databases

PRIDEQ6IEZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366473; ENSP00000355429; ENSG00000203661.
GeneID401993.
KEGGhsa:401993.
UCSCuc001iem.1. human.

Organism-specific databases

CTD401993.
GeneCardsGC01P248651.
H-InvDBHIX0200060.
HGNCHGNC:15017. OR2T5.
neXtProtNX_Q6IEZ7.
PharmGKBPA32205.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ6IEZ7.
KOK04257.
OMAVETIMYL.
OrthoDBEOG7W9RV2.
PhylomeDBQ6IEZ7.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ6IEZ7.
CleanExHS_OR2T5.
GenevestigatorQ6IEZ7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi401993.
NextBio107256.
PROQ6IEZ7.

Entry information

Entry nameOR2T5_HUMAN
AccessionPrimary (citable) accession number: Q6IEZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries