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Protein

Olfactory receptor 2T5

Gene

OR2T5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T5
Alternative name(s):
Olfactory receptor OR1-62
Gene namesi
Name:OR2T5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15017. OR2T5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 53Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini54 – 61CytoplasmicSequence analysis8
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 104ExtracellularSequence analysisAdd BLAST21
Transmembranei105 – 124Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 162Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 223Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini224 – 240CytoplasmicSequence analysisAdd BLAST17
Transmembranei241 – 263Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini264 – 276ExtracellularSequence analysisAdd BLAST13
Transmembranei277 – 296Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini297 – 315CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi401993.
OpenTargetsiENSG00000203661.
ENSG00000273827.
ENSG00000275102.
PharmGKBiPA32205.

Polymorphism and mutation databases

BioMutaiOR2T5.
DMDMi74762308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505001 – 315Olfactory receptor 2T5Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IEZ7.
PRIDEiQ6IEZ7.

PTM databases

iPTMnetiQ6IEZ7.
PhosphoSitePlusiQ6IEZ7.

Expressioni

Gene expression databases

CleanExiHS_OR2T5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355429.

Structurei

3D structure databases

ProteinModelPortaliQ6IEZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IEZ7.
KOiK04257.
OMAiLITIHRR.
OrthoDBiEOG091G0DUZ.
PhylomeDBiQ6IEZ7.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANITRMANH TGKLDFILMG LFRRSKHPAL LSVVIFVVFL KALSGNAVLI
60 70 80 90 100
LLIHCDAHLH SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE
110 120 130 140 150
CGMQMFLYLT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS
160 170 180 190 200
GCWFLGSVDG FMLTPITMSF PFCRSWEIHH FFCEVPAVTI LSCSDTSLYE
210 220 230 240 250
TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK AFATCSSHLT
260 270 280 290 300
VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD
310
VMGALKKMLT VRFVL
Length:315
Mass (Da):35,595
Last modified:July 5, 2004 - v1
Checksum:iC6D2BB5AC283F38A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1.
CCDSiCCDS31118.1.
RefSeqiNP_001004697.1. NM_001004697.1.
UniGeneiHs.553808.

Genome annotation databases

EnsembliENST00000366473; ENSP00000355429; ENSG00000203661.
ENST00000611272; ENSP00000480545; ENSG00000273827.
ENST00000620813; ENSP00000480714; ENSG00000275102.
GeneIDi401993.
KEGGihsa:401993.
UCSCiuc001iem.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1.
CCDSiCCDS31118.1.
RefSeqiNP_001004697.1. NM_001004697.1.
UniGeneiHs.553808.

3D structure databases

ProteinModelPortaliQ6IEZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355429.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6IEZ7.
PhosphoSitePlusiQ6IEZ7.

Polymorphism and mutation databases

BioMutaiOR2T5.
DMDMi74762308.

Proteomic databases

PaxDbiQ6IEZ7.
PRIDEiQ6IEZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366473; ENSP00000355429; ENSG00000203661.
ENST00000611272; ENSP00000480545; ENSG00000273827.
ENST00000620813; ENSP00000480714; ENSG00000275102.
GeneIDi401993.
KEGGihsa:401993.
UCSCiuc001iem.1. human.

Organism-specific databases

CTDi401993.
DisGeNETi401993.
GeneCardsiOR2T5.
H-InvDBHIX0200060.
HGNCiHGNC:15017. OR2T5.
neXtProtiNX_Q6IEZ7.
OpenTargetsiENSG00000203661.
ENSG00000273827.
ENSG00000275102.
PharmGKBiPA32205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IEZ7.
KOiK04257.
OMAiLITIHRR.
OrthoDBiEOG091G0DUZ.
PhylomeDBiQ6IEZ7.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii401993.
PROiQ6IEZ7.

Gene expression databases

CleanExiHS_OR2T5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T5_HUMAN
AccessioniPrimary (citable) accession number: Q6IEZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.