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Q6IEZ7

- OR2T5_HUMAN

UniProt

Q6IEZ7 - OR2T5_HUMAN

Protein

Olfactory receptor 2T5

Gene

OR2T5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2T5
    Alternative name(s):
    Olfactory receptor OR1-62
    Gene namesi
    Name:OR2T5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15017. OR2T5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32205.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 2T5PRO_0000150500Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ6IEZ7.

    PTM databases

    PhosphoSiteiQ6IEZ7.

    Expressioni

    Gene expression databases

    BgeeiQ6IEZ7.
    CleanExiHS_OR2T5.
    GenevestigatoriQ6IEZ7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IEZ7.
    SMRiQ6IEZ7. Positions 28-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini54 – 618CytoplasmicSequence Analysis
    Topological domaini84 – 10421ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 24017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31519CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5324Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12420Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16219Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22324Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26323Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ6IEZ7.
    KOiK04257.
    OMAiHRMNSAT.
    OrthoDBiEOG7W9RV2.
    PhylomeDBiQ6IEZ7.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IEZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANITRMANH TGKLDFILMG LFRRSKHPAL LSVVIFVVFL KALSGNAVLI    50
    LLIHCDAHLH SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE 100
    CGMQMFLYLT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS 150
    GCWFLGSVDG FMLTPITMSF PFCRSWEIHH FFCEVPAVTI LSCSDTSLYE 200
    TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK AFATCSSHLT 250
    VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD 300
    VMGALKKMLT VRFVL 315
    Length:315
    Mass (Da):35,595
    Last modified:July 5, 2004 - v1
    Checksum:iC6D2BB5AC283F38A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138089 Genomic DNA. No translation available.
    BK004465 Genomic DNA. Translation: DAA04863.1.
    CCDSiCCDS31118.1.
    RefSeqiNP_001004697.1. NM_001004697.1.
    UniGeneiHs.553808.

    Genome annotation databases

    EnsembliENST00000366473; ENSP00000355429; ENSG00000203661.
    GeneIDi401993.
    KEGGihsa:401993.
    UCSCiuc001iem.1. human.

    Polymorphism databases

    DMDMi74762308.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138089 Genomic DNA. No translation available.
    BK004465 Genomic DNA. Translation: DAA04863.1 .
    CCDSi CCDS31118.1.
    RefSeqi NP_001004697.1. NM_001004697.1.
    UniGenei Hs.553808.

    3D structure databases

    ProteinModelPortali Q6IEZ7.
    SMRi Q6IEZ7. Positions 28-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355429.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6IEZ7.

    Polymorphism databases

    DMDMi 74762308.

    Proteomic databases

    PRIDEi Q6IEZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366473 ; ENSP00000355429 ; ENSG00000203661 .
    GeneIDi 401993.
    KEGGi hsa:401993.
    UCSCi uc001iem.1. human.

    Organism-specific databases

    CTDi 401993.
    GeneCardsi GC01P248651.
    H-InvDB HIX0200060.
    HGNCi HGNC:15017. OR2T5.
    neXtProti NX_Q6IEZ7.
    PharmGKBi PA32205.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q6IEZ7.
    KOi K04257.
    OMAi HRMNSAT.
    OrthoDBi EOG7W9RV2.
    PhylomeDBi Q6IEZ7.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 401993.
    NextBioi 107256.
    PROi Q6IEZ7.

    Gene expression databases

    Bgeei Q6IEZ7.
    CleanExi HS_OR2T5.
    Genevestigatori Q6IEZ7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2T5_HUMAN
    AccessioniPrimary (citable) accession number: Q6IEZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3