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Protein

Olfactory receptor 2T5

Gene

OR2T5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T5
Alternative name(s):
Olfactory receptor OR1-62
Gene namesi
Name:OR2T5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15017. OR2T5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5324Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini54 – 618CytoplasmicSequence Analysis
Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini84 – 10421ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12420Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16219Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22324Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 24017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26323Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini264 – 27613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29620Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini297 – 31519CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32205.

Polymorphism and mutation databases

BioMutaiOR2T5.
DMDMi74762308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 2T5PRO_0000150500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6IEZ7.

PTM databases

PhosphoSiteiQ6IEZ7.

Expressioni

Gene expression databases

BgeeiQ6IEZ7.
CleanExiHS_OR2T5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355429.

Structurei

3D structure databases

ProteinModelPortaliQ6IEZ7.
SMRiQ6IEZ7. Positions 28-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IEZ7.
KOiK04257.
OMAiVETIMYL.
OrthoDBiEOG7W9RV2.
PhylomeDBiQ6IEZ7.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANITRMANH TGKLDFILMG LFRRSKHPAL LSVVIFVVFL KALSGNAVLI
60 70 80 90 100
LLIHCDAHLH SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE
110 120 130 140 150
CGMQMFLYLT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS
160 170 180 190 200
GCWFLGSVDG FMLTPITMSF PFCRSWEIHH FFCEVPAVTI LSCSDTSLYE
210 220 230 240 250
TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK AFATCSSHLT
260 270 280 290 300
VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD
310
VMGALKKMLT VRFVL
Length:315
Mass (Da):35,595
Last modified:July 5, 2004 - v1
Checksum:iC6D2BB5AC283F38A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1.
CCDSiCCDS31118.1.
RefSeqiNP_001004697.1. NM_001004697.1.
UniGeneiHs.553808.

Genome annotation databases

EnsembliENST00000366473; ENSP00000355429; ENSG00000203661.
ENST00000611272; ENSP00000480545; ENSG00000273827.
ENST00000620813; ENSP00000480714; ENSG00000275102.
GeneIDi401993.
KEGGihsa:401993.
UCSCiuc001iem.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
BK004465 Genomic DNA. Translation: DAA04863.1.
CCDSiCCDS31118.1.
RefSeqiNP_001004697.1. NM_001004697.1.
UniGeneiHs.553808.

3D structure databases

ProteinModelPortaliQ6IEZ7.
SMRiQ6IEZ7. Positions 28-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355429.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6IEZ7.

Polymorphism and mutation databases

BioMutaiOR2T5.
DMDMi74762308.

Proteomic databases

PRIDEiQ6IEZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366473; ENSP00000355429; ENSG00000203661.
ENST00000611272; ENSP00000480545; ENSG00000273827.
ENST00000620813; ENSP00000480714; ENSG00000275102.
GeneIDi401993.
KEGGihsa:401993.
UCSCiuc001iem.1. human.

Organism-specific databases

CTDi401993.
GeneCardsiGC01P248651.
H-InvDBHIX0200060.
HGNCiHGNC:15017. OR2T5.
neXtProtiNX_Q6IEZ7.
PharmGKBiPA32205.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ6IEZ7.
KOiK04257.
OMAiVETIMYL.
OrthoDBiEOG7W9RV2.
PhylomeDBiQ6IEZ7.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii401993.
NextBioi107256.
PROiQ6IEZ7.

Gene expression databases

BgeeiQ6IEZ7.
CleanExiHS_OR2T5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2T5_HUMAN
AccessioniPrimary (citable) accession number: Q6IEZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.