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Q6IEY1

- OR4F3_HUMAN

UniProt

Q6IEY1 - OR4F3_HUMAN

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Protein

Olfactory receptor 4F3/4F16/4F29

Gene

OR4F3

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F3/4F16/4F29
Alternative name(s):
Olfactory receptor OR1-1
Gene namesi
Name:OR4F3
AND
Name:OR4F16
AND
Name:OR4F29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1, UP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:15079. OR4F16.
HGNC:31275. OR4F29.
HGNC:8300. OR4F3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 4F3/4F16/4F29PRO_0000150551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6IEY1.

PTM databases

PhosphoSiteiQ6IEY1.

Expressioni

Gene expression databases

BgeeiQ6IEY1.
CleanExiHS_OR4F16.
GenevestigatoriQ6IEY1.

Organism-specific databases

HPAiHPA047705.

Structurei

3D structure databases

ProteinModelPortaliQ6IEY1.
SMRiQ6IEY1. Positions 17-295.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
BLAST
Topological domaini290 – 31223CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116959.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ6IEY1.
KOiK04257.
OMAiSVWKYSS.
OrthoDBiEOG75XGMH.
PhylomeDBiQ6IEY1.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNILIVFSVT
60 70 80 90 100
TDPHLHSPMY FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ
110 120 130 140 150
IFFIHVVGGV EMVLLIAMAF DRYVALCKPL HYLTIMSPRM CLSFLAVAWT
160 170 180 190 200
LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD LPRLLRLACT DTYRLQFMVT
210 220 230 240 250
VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL SAHSTVVLLF
260 270 280 290 300
FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
310
VCKQLVIYKR IS
Length:312
Mass (Da):35,074
Last modified:July 5, 2004 - v1
Checksum:i08285B196DC638FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732372 Genomic DNA. Translation: CAI22294.1.
BC137547 mRNA. Translation: AAI37548.1.
BK004481 Genomic DNA. Translation: DAA04879.1.
CCDSiCCDS41221.1.
CCDS43415.1.
CCDS72675.1.
RefSeqiNP_001005221.2. NM_001005221.2.
NP_001005224.1. NM_001005224.1.
NP_001005277.1. NM_001005277.1.
UniGeneiHs.632360.
Hs.722724.

Genome annotation databases

EnsembliENST00000332831; ENSP00000329982; ENSG00000273547.
ENST00000426406; ENSP00000409316; ENSG00000278566.
ENST00000456475; ENSP00000394282; ENSG00000230178.
GeneIDi26683.
729759.
81399.
KEGGihsa:26683.
hsa:729759.
hsa:81399.
UCSCiuc010nxu.2. human.

Polymorphism databases

DMDMi74762307.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Human Olfactory Receptor Data Exploratorium (HORDE)
Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732372 Genomic DNA. Translation: CAI22294.1 .
BC137547 mRNA. Translation: AAI37548.1 .
BK004481 Genomic DNA. Translation: DAA04879.1 .
CCDSi CCDS41221.1.
CCDS43415.1.
CCDS72675.1.
RefSeqi NP_001005221.2. NM_001005221.2.
NP_001005224.1. NM_001005224.1.
NP_001005277.1. NM_001005277.1.
UniGenei Hs.632360.
Hs.722724.

3D structure databases

ProteinModelPortali Q6IEY1.
SMRi Q6IEY1. Positions 17-295.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q6IEY1.

Polymorphism databases

DMDMi 74762307.

Proteomic databases

PRIDEi Q6IEY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332831 ; ENSP00000329982 ; ENSG00000273547 .
ENST00000426406 ; ENSP00000409316 ; ENSG00000278566 .
ENST00000456475 ; ENSP00000394282 ; ENSG00000230178 .
GeneIDi 26683.
729759.
81399.
KEGGi hsa:26683.
hsa:729759.
hsa:81399.
UCSCi uc010nxu.2. human.

Organism-specific databases

CTDi 26683.
729759.
81399.
GeneCardsi GC01M000622.
GC01P000367.
GC05P180794.
HGNCi HGNC:15079. OR4F16.
HGNC:31275. OR4F29.
HGNC:8300. OR4F3.
HPAi HPA047705.
neXtProti NX_Q6IEY1.
PharmGKBi PA32284.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116959.
GeneTreei ENSGT00760000118815.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q6IEY1.
KOi K04257.
OMAi SVWKYSS.
OrthoDBi EOG75XGMH.
PhylomeDBi Q6IEY1.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4F16.
OR4F3.
NextBioi 49041.
PROi Q6IEY1.

Gene expression databases

Bgeei Q6IEY1.
CleanExi HS_OR4F16.
Genevestigatori Q6IEY1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4F3_HUMAN
AccessioniPrimary (citable) accession number: Q6IEY1
Secondary accession number(s): B2RPQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3