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Protein

Olfactory receptor 4C11

Gene

OR4C11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C11
Alternative name(s):
Olfactory receptor OR11-136
Gene namesi
Name:OR4C11
Synonyms:OR4C11P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172188.4
HGNCiHGNC:15167 OR4C11
neXtProtiNX_Q6IEV9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 310CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32253

Polymorphism and mutation databases

BioMutaiOR4C11
DMDMi74762306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505321 – 310Olfactory receptor 4C11Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IEV9
PeptideAtlasiQ6IEV9
PRIDEiQ6IEV9
ProteomicsDBi66415

PTM databases

iPTMnetiQ6IEV9
PhosphoSitePlusiQ6IEV9

Expressioni

Gene expression databases

BgeeiENSG00000172188
CleanExiHS_OR4C11
ExpressionAtlasiQ6IEV9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306651

Structurei

3D structure databases

ProteinModelPortaliQ6IEV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFW9 Eukaryota
ENOG411142U LUCA
GeneTreeiENSGT00910000144096
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ6IEV9
KOiK04257
OMAiLIFYMGT
OrthoDBiEOG091G0CY9
PhylomeDBiQ6IEV9
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IEV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQNNSVPEF ILLGLTQDPL RQKIVFVIFL IFYMGTVVGN MLIIVTIKSS
60 70 80 90 100
RTLGSPMYFF LFYLSFADSC FSTSTAPRLI VDALSEKKII TYNECMTQVF
110 120 130 140 150
ALHLFGCMEI FVLILMAVDR YVAICKPLRY PTIMSQQVCI ILIVLAWIGS
160 170 180 190 200
LIHSTAQIIL ALRLPFCGPY LIDHYCCDLQ PLLKLACMDT YMINLLLVSN
210 220 230 240 250
SGAICSSSFM ILIISYIVIL HSLRNHSAKG KKKALSACTS HIIVVILFFG
260 270 280 290 300
PCIFIYTRPP TTFPMDKMVA VFYTIGTPFL NPLIYTLRNA EVKNAMRKLW
310
HGKIISENKG
Length:310
Mass (Da):35,003
Last modified:July 5, 2004 - v1
Checksum:i10435F9D98FAC123
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0575438P → T1 PublicationCorresponds to variant dbSNP:rs491160Ensembl.1
Natural variantiVAR_05754415L → I1 PublicationCorresponds to variant dbSNP:rs11230346Ensembl.1
Natural variantiVAR_057545277T → P1 PublicationCorresponds to variant dbSNP:rs2456022Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065774 Genomic DNA Translation: BAC05994.1
BC140727 mRNA Translation: AAI40728.1
BK004503 Genomic DNA Translation: DAA04901.1
CCDSiCCDS31503.1
RefSeqiNP_001004700.2, NM_001004700.2
UniGeneiHs.553620

Genome annotation databases

EnsembliENST00000302231; ENSP00000306651; ENSG00000172188
ENST00000641580; ENSP00000492971; ENSG00000172188
GeneIDi219429
KEGGihsa:219429
UCSCiuc010rii.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4CB_HUMAN
AccessioniPrimary (citable) accession number: Q6IEV9
Secondary accession number(s): B9EIL4, Q8NGL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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