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Protein

Olfactory receptor 4C11

Gene

OR4C11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C11
Alternative name(s):
Olfactory receptor OR11-136
Gene namesi
Name:OR4C11
Synonyms:OR4C11P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15167. OR4C11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 310CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172188.
PharmGKBiPA32253.

Polymorphism and mutation databases

BioMutaiOR4C11.
DMDMi74762306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505321 – 310Olfactory receptor 4C11Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IEV9.
PeptideAtlasiQ6IEV9.
PRIDEiQ6IEV9.

PTM databases

iPTMnetiQ6IEV9.
PhosphoSitePlusiQ6IEV9.

Expressioni

Gene expression databases

CleanExiHS_OR4C11.
ExpressionAtlasiQ6IEV9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306651.

Structurei

3D structure databases

ProteinModelPortaliQ6IEV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFW9. Eukaryota.
ENOG411142U. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ6IEV9.
KOiK04257.
OMAiWHGKIIS.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ6IEV9.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQNNSVPEF ILLGLTQDPL RQKIVFVIFL IFYMGTVVGN MLIIVTIKSS
60 70 80 90 100
RTLGSPMYFF LFYLSFADSC FSTSTAPRLI VDALSEKKII TYNECMTQVF
110 120 130 140 150
ALHLFGCMEI FVLILMAVDR YVAICKPLRY PTIMSQQVCI ILIVLAWIGS
160 170 180 190 200
LIHSTAQIIL ALRLPFCGPY LIDHYCCDLQ PLLKLACMDT YMINLLLVSN
210 220 230 240 250
SGAICSSSFM ILIISYIVIL HSLRNHSAKG KKKALSACTS HIIVVILFFG
260 270 280 290 300
PCIFIYTRPP TTFPMDKMVA VFYTIGTPFL NPLIYTLRNA EVKNAMRKLW
310
HGKIISENKG
Length:310
Mass (Da):35,003
Last modified:July 5, 2004 - v1
Checksum:i10435F9D98FAC123
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0575438P → T.1 PublicationCorresponds to variant rs491160dbSNPEnsembl.1
Natural variantiVAR_05754415L → I.1 PublicationCorresponds to variant rs11230346dbSNPEnsembl.1
Natural variantiVAR_057545277T → P.1 PublicationCorresponds to variant rs2456022dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065774 Genomic DNA. Translation: BAC05994.1.
BC140727 mRNA. Translation: AAI40728.1.
BK004503 Genomic DNA. Translation: DAA04901.1.
CCDSiCCDS31503.1.
RefSeqiNP_001004700.2. NM_001004700.2.
UniGeneiHs.553620.

Genome annotation databases

EnsembliENST00000302231; ENSP00000306651; ENSG00000172188.
GeneIDi219429.
KEGGihsa:219429.
UCSCiuc010rii.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065774 Genomic DNA. Translation: BAC05994.1.
BC140727 mRNA. Translation: AAI40728.1.
BK004503 Genomic DNA. Translation: DAA04901.1.
CCDSiCCDS31503.1.
RefSeqiNP_001004700.2. NM_001004700.2.
UniGeneiHs.553620.

3D structure databases

ProteinModelPortaliQ6IEV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306651.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6IEV9.
PhosphoSitePlusiQ6IEV9.

Polymorphism and mutation databases

BioMutaiOR4C11.
DMDMi74762306.

Proteomic databases

PaxDbiQ6IEV9.
PeptideAtlasiQ6IEV9.
PRIDEiQ6IEV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302231; ENSP00000306651; ENSG00000172188.
GeneIDi219429.
KEGGihsa:219429.
UCSCiuc010rii.2. human.

Organism-specific databases

CTDi219429.
GeneCardsiOR4C11.
HGNCiHGNC:15167. OR4C11.
neXtProtiNX_Q6IEV9.
OpenTargetsiENSG00000172188.
PharmGKBiPA32253.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFW9. Eukaryota.
ENOG411142U. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ6IEV9.
KOiK04257.
OMAiWHGKIIS.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ6IEV9.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4C11.
GenomeRNAii219429.
PROiQ6IEV9.

Gene expression databases

CleanExiHS_OR4C11.
ExpressionAtlasiQ6IEV9. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4CB_HUMAN
AccessioniPrimary (citable) accession number: Q6IEV9
Secondary accession number(s): B9EIL4, Q8NGL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.