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Protein

Olfactory receptor 5M10

Gene

OR5M10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5M10
Alternative name(s):
Olfactory receptor OR11-207
Gene namesi
Name:OR5M10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15290. OR5M10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31523CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32547.

Polymorphism and mutation databases

BioMutaiOR5M10.
DMDMi74762305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 5M10PRO_0000150608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IEU7.
PeptideAtlasiQ6IEU7.
PRIDEiQ6IEU7.

Expressioni

Gene expression databases

CleanExiHS_OR5M10.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000436004.

Structurei

3D structure databases

ProteinModelPortaliQ6IEU7.
SMRiQ6IEU7. Positions 29-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9DF. Eukaryota.
ENOG41117XS. LUCA.
GeneTreeiENSGT00810000125401.
HOVERGENiHBG017625.
InParanoidiQ6IEU7.
KOiK04257.
OMAiIQQMIRG.
OrthoDBiEOG71K63J.
PhylomeDBiQ6IEU7.
TreeFamiTF352751.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPNHTIVT EFILLGLTDD PVLEKILFGV FLAIYLITLA GNLCMILLIR
60 70 80 90 100
TNSQLQTPMY FFLGHLSFVD ICYSSNVTPN MLHNFLSEQK TISYAGCFTQ
110 120 130 140 150
CLLFIALVIT EFYFLASMAL DRYVAICSPL HYSSRMSKNI CISLVTVPYM
160 170 180 190 200
YGFLNGLSQT LLTFHLSFCG SLEINHFYCA DPPLIMLACS DTRVKKMAMF
210 220 230 240 250
VVAGFTLSSS LFIILLSYLF IFAAIFRIRS AEGRHKAFST CASHLTIVTL
260 270 280 290 300
FYGTLFCMYV RPPSEKSVEE SKIIAVFYTF LSPMLNPLIY SLRNRDVILA
310
IQQMIRGKSF CKIAV
Length:315
Mass (Da):35,592
Last modified:July 5, 2004 - v1
Checksum:iAAB69157FC5682C4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691V → L.2 Publications
Corresponds to variant rs10792043 [ dbSNP | Ensembl ].
VAR_053201
Natural varianti313 – 3131I → T.
Corresponds to variant rs10896488 [ dbSNP | Ensembl ].
VAR_053202

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002517 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73718.1.
BC140733 mRNA. Translation: AAI40734.1.
BK004515 Genomic DNA. Translation: DAA04913.1.
CCDSiCCDS53630.1.
RefSeqiNP_001004741.1. NM_001004741.1.
UniGeneiHs.553750.

Genome annotation databases

EnsembliENST00000526812; ENSP00000436004; ENSG00000254834.
GeneIDi390167.
KEGGihsa:390167.
UCSCiuc001niz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002517 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73718.1.
BC140733 mRNA. Translation: AAI40734.1.
BK004515 Genomic DNA. Translation: DAA04913.1.
CCDSiCCDS53630.1.
RefSeqiNP_001004741.1. NM_001004741.1.
UniGeneiHs.553750.

3D structure databases

ProteinModelPortaliQ6IEU7.
SMRiQ6IEU7. Positions 29-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000436004.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5M10.
DMDMi74762305.

Proteomic databases

PaxDbiQ6IEU7.
PeptideAtlasiQ6IEU7.
PRIDEiQ6IEU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526812; ENSP00000436004; ENSG00000254834.
GeneIDi390167.
KEGGihsa:390167.
UCSCiuc001niz.1. human.

Organism-specific databases

CTDi390167.
GeneCardsiOR5M10.
HGNCiHGNC:15290. OR5M10.
neXtProtiNX_Q6IEU7.
PharmGKBiPA32547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9DF. Eukaryota.
ENOG41117XS. LUCA.
GeneTreeiENSGT00810000125401.
HOVERGENiHBG017625.
InParanoidiQ6IEU7.
KOiK04257.
OMAiIQQMIRG.
OrthoDBiEOG71K63J.
PhylomeDBiQ6IEU7.
TreeFamiTF352751.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5M10.
GenomeRNAii390167.
PROiQ6IEU7.

Gene expression databases

CleanExiHS_OR5M10.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-69.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-69.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5MA_HUMAN
AccessioniPrimary (citable) accession number: Q6IEU7
Secondary accession number(s): B9EIL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.