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Q6IEI0

- HXB2A_TAKRU

UniProt

Q6IEI0 - HXB2A_TAKRU

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Protein

Homeobox protein Hox-B2a

Gene

hoxb2a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 23260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2a
Gene namesi
Name:hoxb2a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Homeobox protein Hox-B2aPRO_0000265977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000025073.

Structurei

3D structure databases

ProteinModelPortaliQ6IEI0.
SMRiQ6IEI0. Positions 173-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 1146Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG70923.
InParanoidiQ6IEI0.
KOiK09302.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE SFQTSSIKES TVIPPPFEHT
60 70 80 90 100
IPSLSPCAAS QPRPTARNQQ NRRNSNTNGI QTHQRAAQQP CPPGQAPATA
110 120 130 140 150
TAAGPMAPEF PWMKEKKSSK KSSKPGSSSG GGAPILPPSS ASPSPTASGY
160 170 180 190 200
ASASIESPTD QSQAGLDAGG AGSRRLRTAY TNTQLLELEK EFHFNKYLCR
210 220 230 240 250
PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTHHRDGSGG GNDSNEPGGF
260 270 280 290 300
EPLEGADASS PYSSQPLEAS GTGESESEQG SSNPSSAAYA SDSGDNAQST
310 320 330 340 350
AEEGGLLGCP DRQSLSAVSG SSATHLHPLT ATNSSDNQAP LQLNRTGPEP
360 370 380 390 400
SFSEQRDSSI PSATAALPDL TLFATDACLS PSLQSSLDSP VDFSEEDFDL
410
FTSTLCTIDL QHLNF
Length:415
Mass (Da):44,044
Last modified:July 5, 2004 - v1
Checksum:i1F0246C6ECD070EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK005104 Genomic DNA. Translation: DAA05216.1.
DQ481665 Genomic DNA. Translation: ABF22418.1.
RefSeqiXP_003964308.1. XM_003964259.1.

Genome annotation databases

GeneIDi101073209.
KEGGitru:101073209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK005104 Genomic DNA. Translation: DAA05216.1 .
DQ481665 Genomic DNA. Translation: ABF22418.1 .
RefSeqi XP_003964308.1. XM_003964259.1.

3D structure databases

ProteinModelPortali Q6IEI0.
SMRi Q6IEI0. Positions 173-231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000025073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101073209.
KEGGi tru:101073209.

Organism-specific databases

CTDi 30338.

Phylogenomic databases

eggNOGi NOG70923.
InParanoidi Q6IEI0.
KOi K09302.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes."
    Hadrys T., Prince V.E., Hunter M., Baker R., Rinkwitz S.
    J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXB2A_TAKRU
AccessioniPrimary (citable) accession number: Q6IEI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3