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Q6IEI0

- HXB2A_TAKRU

UniProt

Q6IEI0 - HXB2A_TAKRU

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Protein
Homeobox protein Hox-B2a
Gene
hoxb2a
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 23260Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2a
Gene namesi
Name:hoxb2a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Homeobox protein Hox-B2a
PRO_0000265977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000025073.

Structurei

3D structure databases

ProteinModelPortaliQ6IEI0.
SMRiQ6IEI0. Positions 173-231.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 1146Antp-type hexapeptide

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG70923.
InParanoidiQ6IEI0.
KOiK09302.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEI0-1 [UniParc]FASTAAdd to Basket

« Hide

MNFEFEREIG FINSQPSLAE CLTSFPAVLE SFQTSSIKES TVIPPPFEHT    50
IPSLSPCAAS QPRPTARNQQ NRRNSNTNGI QTHQRAAQQP CPPGQAPATA 100
TAAGPMAPEF PWMKEKKSSK KSSKPGSSSG GGAPILPPSS ASPSPTASGY 150
ASASIESPTD QSQAGLDAGG AGSRRLRTAY TNTQLLELEK EFHFNKYLCR 200
PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTHHRDGSGG GNDSNEPGGF 250
EPLEGADASS PYSSQPLEAS GTGESESEQG SSNPSSAAYA SDSGDNAQST 300
AEEGGLLGCP DRQSLSAVSG SSATHLHPLT ATNSSDNQAP LQLNRTGPEP 350
SFSEQRDSSI PSATAALPDL TLFATDACLS PSLQSSLDSP VDFSEEDFDL 400
FTSTLCTIDL QHLNF 415
Length:415
Mass (Da):44,044
Last modified:July 5, 2004 - v1
Checksum:i1F0246C6ECD070EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK005104 Genomic DNA. Translation: DAA05216.1.
DQ481665 Genomic DNA. Translation: ABF22418.1.
RefSeqiXP_003964308.1. XM_003964259.1.

Genome annotation databases

GeneIDi101073209.
KEGGitru:101073209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK005104 Genomic DNA. Translation: DAA05216.1 .
DQ481665 Genomic DNA. Translation: ABF22418.1 .
RefSeqi XP_003964308.1. XM_003964259.1.

3D structure databases

ProteinModelPortali Q6IEI0.
SMRi Q6IEI0. Positions 173-231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000025073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101073209.
KEGGi tru:101073209.

Organism-specific databases

CTDi 30338.

Phylogenomic databases

eggNOGi NOG70923.
InParanoidi Q6IEI0.
KOi K09302.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes."
    Hadrys T., Prince V.E., Hunter M., Baker R., Rinkwitz S.
    J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXB2A_TAKRU
AccessioniPrimary (citable) accession number: Q6IEI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi