Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-B2a

Gene

hoxb2a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 23260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2a
Gene namesi
Name:hoxb2a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226 Componenti: Unplaced

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Homeobox protein Hox-B2aPRO_0000265977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000025073.

Structurei

3D structure databases

SMRiQ6IEI0. Positions 173-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 1146Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG70923.
InParanoidiQ6IEI0.
KOiK09302.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IEI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE SFQTSSIKES TVIPPPFEHT
60 70 80 90 100
IPSLSPCAAS QPRPTARNQQ NRRNSNTNGI QTHQRAAQQP CPPGQAPATA
110 120 130 140 150
TAAGPMAPEF PWMKEKKSSK KSSKPGSSSG GGAPILPPSS ASPSPTASGY
160 170 180 190 200
ASASIESPTD QSQAGLDAGG AGSRRLRTAY TNTQLLELEK EFHFNKYLCR
210 220 230 240 250
PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTHHRDGSGG GNDSNEPGGF
260 270 280 290 300
EPLEGADASS PYSSQPLEAS GTGESESEQG SSNPSSAAYA SDSGDNAQST
310 320 330 340 350
AEEGGLLGCP DRQSLSAVSG SSATHLHPLT ATNSSDNQAP LQLNRTGPEP
360 370 380 390 400
SFSEQRDSSI PSATAALPDL TLFATDACLS PSLQSSLDSP VDFSEEDFDL
410
FTSTLCTIDL QHLNF
Length:415
Mass (Da):44,044
Last modified:July 5, 2004 - v1
Checksum:i1F0246C6ECD070EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005104 Genomic DNA. Translation: DAA05216.1.
DQ481665 Genomic DNA. Translation: ABF22418.1.
RefSeqiXP_003964308.1. XM_003964259.1.

Genome annotation databases

GeneIDi101073209.
KEGGitru:101073209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005104 Genomic DNA. Translation: DAA05216.1.
DQ481665 Genomic DNA. Translation: ABF22418.1.
RefSeqiXP_003964308.1. XM_003964259.1.

3D structure databases

SMRiQ6IEI0. Positions 173-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000025073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101073209.
KEGGitru:101073209.

Organism-specific databases

CTDi30338.

Phylogenomic databases

eggNOGiNOG70923.
InParanoidiQ6IEI0.
KOiK09302.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes."
    Hadrys T., Prince V.E., Hunter M., Baker R., Rinkwitz S.
    J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXB2A_TAKRU
AccessioniPrimary (citable) accession number: Q6IEI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.