ID   SN12L_HUMAN             Reviewed;         588 AA.
AC   Q6IEE8; F5H6G3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 4.
DT   24-JAN-2024, entry version 126.
DE   RecName: Full=Schlafen family member 12-like;
GN   Name=SLFN12L; Synonyms=SLFN5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   IDENTIFICATION (ISOFORM 1).
RX   PubMed=14569139; DOI=10.1136/jmg.40.10.e116;
RA   Kehrer-Sawatzki H., Tinschert S., Jenne D.E.;
RT   "Heterogeneity of breakpoints in non-LCR-mediated large constitutional
RT   deletions of the 17q11.2 NF1 tumour suppressor region.";
RL   J. Med. Genet. 40:E116-E116(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6IEE8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6IEE8-2; Sequence=VSP_040137;
CC   -!- SIMILARITY: Belongs to the Schlafen family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD80167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AK172761; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC015911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BN000147; CAD80167.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001182719.1; NM_001195790.1.
DR   RefSeq; XP_016879494.1; XM_017024005.1.
DR   RefSeq; XP_016879495.1; XM_017024006.1.
DR   RefSeq; XP_016879496.1; XM_017024007.1.
DR   AlphaFoldDB; Q6IEE8; -.
DR   SMR; Q6IEE8; -.
DR   BioGRID; 131188; 3.
DR   IntAct; Q6IEE8; 3.
DR   STRING; 9606.ENSP00000354412; -.
DR   iPTMnet; Q6IEE8; -.
DR   PhosphoSitePlus; Q6IEE8; -.
DR   BioMuta; SLFN12L; -.
DR   DMDM; 313104287; -.
DR   jPOST; Q6IEE8; -.
DR   MassIVE; Q6IEE8; -.
DR   MaxQB; Q6IEE8; -.
DR   PaxDb; 9606-ENSP00000437635; -.
DR   PeptideAtlas; Q6IEE8; -.
DR   ProteomicsDB; 27182; -.
DR   ProteomicsDB; 66410; -. [Q6IEE8-1]
DR   ProteomicsDB; 66411; -. [Q6IEE8-2]
DR   Antibodypedia; 7340; 68 antibodies from 13 providers.
DR   DNASU; 100506736; -.
DR   GeneID; 100506736; -.
DR   KEGG; hsa:100506736; -.
DR   UCSC; uc002hjn.4; human. [Q6IEE8-1]
DR   AGR; HGNC:33920; -.
DR   CTD; 100506736; -.
DR   DisGeNET; 100506736; -.
DR   GeneCards; SLFN12L; -.
DR   HGNC; HGNC:33920; SLFN12L.
DR   MIM; 614956; gene.
DR   neXtProt; NX_Q6IEE8; -.
DR   PharmGKB; PA162403886; -.
DR   VEuPathDB; HostDB:ENSG00000205045; -.
DR   eggNOG; ENOG502RU3F; Eukaryota.
DR   HOGENOM; CLU_034558_0_0_1; -.
DR   InParanoid; Q6IEE8; -.
DR   OMA; VKMGGYT; -.
DR   OrthoDB; 5398472at2759; -.
DR   TreeFam; TF337168; -.
DR   PathwayCommons; Q6IEE8; -.
DR   SignaLink; Q6IEE8; -.
DR   BioGRID-ORCS; 100506736; 16 hits in 1139 CRISPR screens.
DR   ChiTaRS; SLFN12L; human.
DR   GenomeRNAi; 100506736; -.
DR   Pharos; Q6IEE8; Tbio.
DR   PRO; PR:Q6IEE8; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q6IEE8; Protein.
DR   ExpressionAtlas; Q6IEE8; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.950.30; Schlafen, AAA domain; 1.
DR   InterPro; IPR031450; Poxin-SLFN/SLFN_N.
DR   InterPro; IPR029684; Schlafen.
DR   InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR   InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR   InterPro; IPR048729; SLFN_GTPase-like.
DR   PANTHER; PTHR12155; SCHLAFEN; 1.
DR   PANTHER; PTHR12155:SF46; SCHLAFEN FAMILY MEMBER 12-LIKE; 1.
DR   Pfam; PF17057; B3R; 1.
DR   Pfam; PF04326; SLFN_AlbA_2; 1.
DR   Pfam; PF21026; SLFN_GTPase-like; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..588
FT                   /note="Schlafen family member 12-like"
FT                   /id="PRO_0000336097"
FT   TRANSMEM        566..586
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..4
FT                   /note="MDLA -> MAMKIMEKIRNVFHCEAHRILYICESQFLRNFI (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_040137"
FT   VARIANT         275
FT                   /note="L -> S (in dbSNP:rs12451679)"
FT                   /id="VAR_043551"
FT   VARIANT         373
FT                   /note="A -> G (in dbSNP:rs2304967)"
FT                   /id="VAR_043552"
FT   VARIANT         430
FT                   /note="C -> Y (in dbSNP:rs777316634)"
FT                   /id="VAR_043553"
FT   VARIANT         518
FT                   /note="Y -> S (in dbSNP:rs3744372)"
FT                   /id="VAR_043554"
FT   CONFLICT        Q6IEE8-2:13
FT                   /note="F -> S (in Ref. 1; AK172761)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   588 AA;  67096 MW;  C8B7C194140C6A50 CRC64;
     MDLARKEFLR GNGLAAGKMN ISIDLDTNYA ELVLNVGRVT LGENNRKKMK DCQLRKQQNE
     NVSRAVCALL NSGGGVIKAE VENKGYSYKK DGIGLDLENS FSNMLPFVPN FLDFMQNGNY
     FHIFVKSWSL ETSGPQIATL SSSLYKRDVT SAKVMNASAA LEFLKDMEKT GGRAYLRPEF
     PAKRACVDVQ EESNMEALAA DFFNRTELGY KEKLTFTEST HVEIKNFSTE KLLQRITEIL
     PQYVSAFANT DGGYLFVGLN EDKEVIGFKA EKSYLTKLEE VTKNSIGKLP VHHFCVEKGT
     INYLCKFLGV YDKGRLCGYV YALRVERFCC AVFAKKPDSW HVKDNRVKQL TEKEWIQFMV
     DSEPVCEELP SPASTSSPVS QSYPLREYIN FKIQPLRYHL PGLSEKITCA PKTFCRNLFS
     QHEGLKQLIC EEMGSVNKGS LIFSRSWSLD LGLQENHKVL CDALLISQDK PPVLYTFHMV
     QDEEFKDYST QTAQTLKQKL AKIGGYTKKV CVMTKIFYLS PEGKTSCQYD LNSQVIYPES
     YYWTTAQTMK DLEKALSNIL PKENQIFLFV CLFRFCLFVC WFVCFFLR
//