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Q6IE82

- JADE3_MOUSE

UniProt

Q6IE82 - JADE3_MOUSE

Protein

Protein Jade-3

Gene

Jade3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri200 – 25051PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone H3 acetylation Source: UniProtKB
    2. histone H4-K12 acetylation Source: UniProtKB
    3. histone H4-K5 acetylation Source: UniProtKB
    4. histone H4-K8 acetylation Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Jade-3
    Alternative name(s):
    Jade family PHD finger protein 3
    PHD finger protein 16
    Gene namesi
    Name:Jade3
    Synonyms:Kiaa0215, Phf16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2148019. Jade3.

    Subcellular locationi

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 823823Protein Jade-3PRO_0000253534Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301N6-acetyllysineBy similarity
    Modified residuei32 – 321N6-acetyllysine1 Publication
    Modified residuei35 – 351N6-acetyllysine1 Publication
    Modified residuei38 – 381N6-acetyllysineBy similarity
    Modified residuei566 – 5661PhosphoserineBy similarity
    Modified residuei601 – 6011N6-acetyllysine1 Publication
    Modified residuei638 – 6381N6-acetyllysineBy similarity
    Modified residuei735 – 7351N6-acetyllysine1 Publication
    Modified residuei774 – 7741PhosphoserineBy similarity
    Modified residuei776 – 7761PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6IE82.
    PRIDEiQ6IE82.

    PTM databases

    PhosphoSiteiQ6IE82.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6IE82.
    BgeeiQ6IE82.
    CleanExiMM_PHF16.
    GenevestigatoriQ6IE82.

    Interactioni

    Subunit structurei

    Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000111042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IE82.
    SMRiQ6IE82. Positions 198-248, 302-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the JADE family.Curated
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri200 – 25051PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5141.
    GeneTreeiENSGT00740000115415.
    HOGENOMiHOG000220882.
    HOVERGENiHBG053585.
    InParanoidiA1L3T5.
    OMAiASVCRYD.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF10513. EPL1. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IE82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRHRPVSSS ESSDECPSTS FTSSSMYRKK SKNPKEQKKS AEVFRKDLIS    50
    AMKIPDSHHV NPDSYYLFTD TWKEEWEKGV QVPANPDSVP TPSLRIISEK 100
    VKEMLFVRPR KYIRCSSPES AEPGYINTLE QAASTCRYDL DDMDIFWLQE 150
    LNEDLGEMGY GPIDETLMEK TIEVLERHCH ENMNHAIETV EGLGIEYDED 200
    VICDVCRSPD SEEGNDMVFC DKCNVCVHQA CYGILKIPEG SWLCRSCVLG 250
    IYPQCVLCPK KGGAMKTTRT GTKWAHVSCA LWIPEVSIAC PERMEPVTKI 300
    SHIPPSRWAL VCNLCKLKTG ACIQCSVKSC ITAFHVTCAF EHGLEMKTIL 350
    DEGDEVKFKS FCLKHSQNKP KLGDAEYHHH RVAEQSQAKS EKTSLRAQKL 400
    RELEEEFYTL VQVEDVAKEM ELSAFTVDFI YNYWKLKRKS NFNKPLIPPK 450
    EEEENGLVQP KEESIHTRMR MFMHLRQDLE RVRNLCYMIS RREKLKLSHT 500
    KVQEQIFGLQ VQLINEEITE GLSLTNALEN SLFYPPPRIT LKLKMPKSTS 550
    EDCKDSSTET EHQLSSPGSS SPGHSKRSPQ MPEEPLDMNV KIYPRYPLES 600
    KSNCLQTSRS HSRCETKSSS PTPRAPSAEF YHGQSLGKPL ALQAALHGQV 650
    SIGNGKNQPN SRVSSSNGLE GNWSGNITQK VNSSEVCYDQ ESMLSSHLPS 700
    PGNIRKSSME HFSRSFKEAT NTWVKPTEDL QYCVKPTKNV SSKEQLWGRQ 750
    LLRRPTGRAS YQETDGYCPD LEPSDSEAEG EGSKETPRVK RESSDRENPS 800
    HDSARECHGK TKTHPHSHSS MQR 823
    Length:823
    Mass (Da):93,455
    Last modified:July 5, 2004 - v1
    Checksum:iE3841F26478D703A
    GO

    Sequence cautioni

    The sequence BAC97901.1 differs from that shown. Reason: Frameshift at position 32.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129091 mRNA. Translation: BAC97901.1. Frameshift.
    BC130270 mRNA. Translation: AAI30271.1.
    BN000286 mRNA. Translation: CAE30499.1.
    RefSeqiNP_955021.2. NM_199317.2.
    XP_006527703.1. XM_006527640.1.
    UniGeneiMm.281517.

    Genome annotation databases

    EnsembliENSMUST00000043693; ENSMUSP00000048529; ENSMUSG00000037315.
    GeneIDi382207.
    KEGGimmu:382207.
    UCSCiuc009ssz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129091 mRNA. Translation: BAC97901.1 . Frameshift.
    BC130270 mRNA. Translation: AAI30271.1 .
    BN000286 mRNA. Translation: CAE30499.1 .
    RefSeqi NP_955021.2. NM_199317.2.
    XP_006527703.1. XM_006527640.1.
    UniGenei Mm.281517.

    3D structure databases

    ProteinModelPortali Q6IE82.
    SMRi Q6IE82. Positions 198-248, 302-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000111042.

    PTM databases

    PhosphoSitei Q6IE82.

    Proteomic databases

    PaxDbi Q6IE82.
    PRIDEi Q6IE82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043693 ; ENSMUSP00000048529 ; ENSMUSG00000037315 .
    GeneIDi 382207.
    KEGGi mmu:382207.
    UCSCi uc009ssz.1. mouse.

    Organism-specific databases

    CTDi 9767.
    MGIi MGI:2148019. Jade3.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5141.
    GeneTreei ENSGT00740000115415.
    HOGENOMi HOG000220882.
    HOVERGENi HBG053585.
    InParanoidi A1L3T5.
    OMAi ASVCRYD.

    Miscellaneous databases

    NextBioi 403117.
    PROi Q6IE82.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6IE82.
    Bgeei Q6IE82.
    CleanExi MM_PHF16.
    Genevestigatori Q6IE82.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF10513. EPL1. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
      Tzouanacou E., Tweedie S., Wilson V.
      Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
      Strain: C57BL/6.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-35; LYS-601 AND LYS-735, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiJADE3_MOUSE
    AccessioniPrimary (citable) accession number: Q6IE82
    Secondary accession number(s): A1L3T5, Q6ZQG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3