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Q6IE82 (JADE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Jade-3
Alternative name(s):
Jade family PHD finger protein 3
PHD finger protein 16
Gene names
Name:Jade3
Synonyms:Kiaa0215, Phf16
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length823 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo By similarity.

Subunit structure

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 By similarity.

Sequence similarities

Belongs to the JADE family.

Contains 1 PHD-type zinc finger.

Sequence caution

The sequence BAC97901.1 differs from that shown. Reason: Frameshift at position 32.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 823823Protein Jade-3
PRO_0000253534

Regions

Zinc finger200 – 25051PHD-type

Amino acid modifications

Modified residue301N6-acetyllysine By similarity
Modified residue321N6-acetyllysine Ref.4
Modified residue351N6-acetyllysine Ref.4
Modified residue381N6-acetyllysine By similarity
Modified residue5661Phosphoserine By similarity
Modified residue6011N6-acetyllysine Ref.4
Modified residue6381N6-acetyllysine By similarity
Modified residue7351N6-acetyllysine Ref.4
Modified residue7741Phosphoserine By similarity
Modified residue7761Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IE82 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E3841F26478D703A

FASTA82393,455
        10         20         30         40         50         60 
MKRHRPVSSS ESSDECPSTS FTSSSMYRKK SKNPKEQKKS AEVFRKDLIS AMKIPDSHHV 

        70         80         90        100        110        120 
NPDSYYLFTD TWKEEWEKGV QVPANPDSVP TPSLRIISEK VKEMLFVRPR KYIRCSSPES 

       130        140        150        160        170        180 
AEPGYINTLE QAASTCRYDL DDMDIFWLQE LNEDLGEMGY GPIDETLMEK TIEVLERHCH 

       190        200        210        220        230        240 
ENMNHAIETV EGLGIEYDED VICDVCRSPD SEEGNDMVFC DKCNVCVHQA CYGILKIPEG 

       250        260        270        280        290        300 
SWLCRSCVLG IYPQCVLCPK KGGAMKTTRT GTKWAHVSCA LWIPEVSIAC PERMEPVTKI 

       310        320        330        340        350        360 
SHIPPSRWAL VCNLCKLKTG ACIQCSVKSC ITAFHVTCAF EHGLEMKTIL DEGDEVKFKS 

       370        380        390        400        410        420 
FCLKHSQNKP KLGDAEYHHH RVAEQSQAKS EKTSLRAQKL RELEEEFYTL VQVEDVAKEM 

       430        440        450        460        470        480 
ELSAFTVDFI YNYWKLKRKS NFNKPLIPPK EEEENGLVQP KEESIHTRMR MFMHLRQDLE 

       490        500        510        520        530        540 
RVRNLCYMIS RREKLKLSHT KVQEQIFGLQ VQLINEEITE GLSLTNALEN SLFYPPPRIT 

       550        560        570        580        590        600 
LKLKMPKSTS EDCKDSSTET EHQLSSPGSS SPGHSKRSPQ MPEEPLDMNV KIYPRYPLES 

       610        620        630        640        650        660 
KSNCLQTSRS HSRCETKSSS PTPRAPSAEF YHGQSLGKPL ALQAALHGQV SIGNGKNQPN 

       670        680        690        700        710        720 
SRVSSSNGLE GNWSGNITQK VNSSEVCYDQ ESMLSSHLPS PGNIRKSSME HFSRSFKEAT 

       730        740        750        760        770        780 
NTWVKPTEDL QYCVKPTKNV SSKEQLWGRQ LLRRPTGRAS YQETDGYCPD LEPSDSEAEG 

       790        800        810        820 
EGSKETPRVK RESSDRENPS HDSARECHGK TKTHPHSHSS MQR 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
Tzouanacou E., Tweedie S., Wilson V.
Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
Strain: C57BL/6.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-35; LYS-601 AND LYS-735, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129091 mRNA. Translation: BAC97901.1. Frameshift.
BC130270 mRNA. Translation: AAI30271.1.
BN000286 mRNA. Translation: CAE30499.1.
RefSeqNP_955021.2. NM_199317.2.
XP_006527703.1. XM_006527640.1.
UniGeneMm.281517.

3D structure databases

ProteinModelPortalQ6IE82.
SMRQ6IE82. Positions 198-248, 302-347.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000111042.

PTM databases

PhosphoSiteQ6IE82.

Proteomic databases

PaxDbQ6IE82.
PRIDEQ6IE82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043693; ENSMUSP00000048529; ENSMUSG00000037315.
GeneID382207.
KEGGmmu:382207.
UCSCuc009ssz.1. mouse.

Organism-specific databases

CTD9767.
MGIMGI:2148019. Jade3.
RougeSearch...

Phylogenomic databases

eggNOGCOG5141.
GeneTreeENSGT00740000115415.
HOGENOMHOG000220882.
HOVERGENHBG053585.
InParanoidA1L3T5.
OMAASVCRYD.

Gene expression databases

ArrayExpressQ6IE82.
BgeeQ6IE82.
CleanExMM_PHF16.
GenevestigatorQ6IE82.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF10513. EPL1. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio403117.
PROQ6IE82.
SOURCESearch...

Entry information

Entry nameJADE3_MOUSE
AccessionPrimary (citable) accession number: Q6IE82
Secondary accession number(s): A1L3T5, Q6ZQG2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot