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Protein

Protein Jade-3

Gene

Jade3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri200 – 25051PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-3
Alternative name(s):
Jade family PHD finger protein 3
PHD finger protein 16
Gene namesi
Name:Jade3
Synonyms:Kiaa0215, Phf16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2148019. Jade3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 823823Protein Jade-3PRO_0000253534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301N6-acetyllysineBy similarity
Modified residuei32 – 321N6-acetyllysineCombined sources
Modified residuei35 – 351N6-acetyllysineCombined sources
Modified residuei566 – 5661PhosphoserineBy similarity
Modified residuei578 – 5781PhosphoserineCombined sources
Modified residuei601 – 6011N6-acetyllysineCombined sources
Modified residuei608 – 6081PhosphoserineBy similarity
Modified residuei638 – 6381N6-acetyllysineBy similarity
Modified residuei735 – 7351N6-acetyllysineCombined sources
Modified residuei774 – 7741PhosphoserineCombined sources
Modified residuei776 – 7761PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6IE82.
PaxDbiQ6IE82.
PeptideAtlasiQ6IE82.
PRIDEiQ6IE82.

PTM databases

iPTMnetiQ6IE82.
PhosphoSiteiQ6IE82.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037315.
CleanExiMM_PHF16.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048529.

Structurei

3D structure databases

ProteinModelPortaliQ6IE82.
SMRiQ6IE82. Positions 198-248, 302-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JADE family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri200 – 25051PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0954. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ6IE82.
OMAiCHENMNH.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IE82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRHRPVSSS ESSDECPSTS FTSSSMYRKK SKNPKEQKKS AEVFRKDLIS
60 70 80 90 100
AMKIPDSHHV NPDSYYLFTD TWKEEWEKGV QVPANPDSVP TPSLRIISEK
110 120 130 140 150
VKEMLFVRPR KYIRCSSPES AEPGYINTLE QAASTCRYDL DDMDIFWLQE
160 170 180 190 200
LNEDLGEMGY GPIDETLMEK TIEVLERHCH ENMNHAIETV EGLGIEYDED
210 220 230 240 250
VICDVCRSPD SEEGNDMVFC DKCNVCVHQA CYGILKIPEG SWLCRSCVLG
260 270 280 290 300
IYPQCVLCPK KGGAMKTTRT GTKWAHVSCA LWIPEVSIAC PERMEPVTKI
310 320 330 340 350
SHIPPSRWAL VCNLCKLKTG ACIQCSVKSC ITAFHVTCAF EHGLEMKTIL
360 370 380 390 400
DEGDEVKFKS FCLKHSQNKP KLGDAEYHHH RVAEQSQAKS EKTSLRAQKL
410 420 430 440 450
RELEEEFYTL VQVEDVAKEM ELSAFTVDFI YNYWKLKRKS NFNKPLIPPK
460 470 480 490 500
EEEENGLVQP KEESIHTRMR MFMHLRQDLE RVRNLCYMIS RREKLKLSHT
510 520 530 540 550
KVQEQIFGLQ VQLINEEITE GLSLTNALEN SLFYPPPRIT LKLKMPKSTS
560 570 580 590 600
EDCKDSSTET EHQLSSPGSS SPGHSKRSPQ MPEEPLDMNV KIYPRYPLES
610 620 630 640 650
KSNCLQTSRS HSRCETKSSS PTPRAPSAEF YHGQSLGKPL ALQAALHGQV
660 670 680 690 700
SIGNGKNQPN SRVSSSNGLE GNWSGNITQK VNSSEVCYDQ ESMLSSHLPS
710 720 730 740 750
PGNIRKSSME HFSRSFKEAT NTWVKPTEDL QYCVKPTKNV SSKEQLWGRQ
760 770 780 790 800
LLRRPTGRAS YQETDGYCPD LEPSDSEAEG EGSKETPRVK RESSDRENPS
810 820
HDSARECHGK TKTHPHSHSS MQR
Length:823
Mass (Da):93,455
Last modified:July 5, 2004 - v1
Checksum:iE3841F26478D703A
GO

Sequence cautioni

The sequence BAC97901 differs from that shown. Reason: Frameshift at position 32. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129091 mRNA. Translation: BAC97901.1. Frameshift.
BC130270 mRNA. Translation: AAI30271.1.
BN000286 mRNA. Translation: CAE30499.1.
RefSeqiNP_955021.2. NM_199317.2.
UniGeneiMm.281517.

Genome annotation databases

EnsembliENSMUST00000043693; ENSMUSP00000048529; ENSMUSG00000037315.
GeneIDi382207.
KEGGimmu:382207.
UCSCiuc009ssz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129091 mRNA. Translation: BAC97901.1. Frameshift.
BC130270 mRNA. Translation: AAI30271.1.
BN000286 mRNA. Translation: CAE30499.1.
RefSeqiNP_955021.2. NM_199317.2.
UniGeneiMm.281517.

3D structure databases

ProteinModelPortaliQ6IE82.
SMRiQ6IE82. Positions 198-248, 302-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048529.

PTM databases

iPTMnetiQ6IE82.
PhosphoSiteiQ6IE82.

Proteomic databases

MaxQBiQ6IE82.
PaxDbiQ6IE82.
PeptideAtlasiQ6IE82.
PRIDEiQ6IE82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043693; ENSMUSP00000048529; ENSMUSG00000037315.
GeneIDi382207.
KEGGimmu:382207.
UCSCiuc009ssz.2. mouse.

Organism-specific databases

CTDi9767.
MGIiMGI:2148019. Jade3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0954. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ6IE82.
OMAiCHENMNH.

Miscellaneous databases

PROiQ6IE82.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037315.
CleanExiMM_PHF16.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJADE3_MOUSE
AccessioniPrimary (citable) accession number: Q6IE82
Secondary accession number(s): A1L3T5, Q6ZQG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.