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Protein

Protein Jade-1

Gene

JADE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 253PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri255 – 289C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri313 – 369PHD-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

  • RNA polymerase II transcription coactivator activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • histone H3 acetylation Source: UniProtKB
  • histone H4-K12 acetylation Source: UniProtKB
  • histone H4-K5 acetylation Source: UniProtKB
  • histone H4-K8 acetylation Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene namesi
Name:JADE1
Synonyms:KIAA1807, PHF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30027. JADE1.

Subcellular locationi

GO - Cellular componenti

  • ciliary basal body Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: GO_Central
  • histone acetyltransferase complex Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79960.
OpenTargetsiENSG00000077684.
PharmGKBiPA134925124.

Polymorphism and mutation databases

DMDMi74748786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535291 – 842Protein Jade-1Add BLAST842

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei609N6-acetyllysineBy similarity1
Modified residuei703PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6IE81.
MaxQBiQ6IE81.
PaxDbiQ6IE81.
PeptideAtlasiQ6IE81.
PRIDEiQ6IE81.

PTM databases

iPTMnetiQ6IE81.
PhosphoSitePlusiQ6IE81.

Expressioni

Tissue specificityi

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.2 Publications

Gene expression databases

BgeeiENSG00000077684.
CleanExiHS_PHF17.
ExpressionAtlasiQ6IE81. baseline and differential.
GenevisibleiQ6IE81. HS.

Organism-specific databases

HPAiHPA020016.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5. Interacts with NPHP4.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC94Q9BW853EBI-954672,EBI-10300345
NPHP4O751614EBI-954672,EBI-4281852

Protein-protein interaction databases

BioGridi123029. 24 interactors.
IntActiQ6IE81. 16 interactors.
MINTiMINT-2876566.
STRINGi9606.ENSP00000226319.

Structurei

3D structure databases

ProteinModelPortaliQ6IE81.
SMRiQ6IE81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi544 – 550Poly-Ser7

Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similaritiesi

Belongs to the JADE family.Curated
Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 253PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri255 – 289C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri313 – 369PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0954. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOVERGENiHBG053585.
InParanoidiQ6IE81.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG091G0T5C.
PhylomeDBiQ6IE81.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IE81-1) [UniParc]FASTAAdd to basket
Also known as: JADE1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT
60 70 80 90 100
DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV
110 120 130 140 150
VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW
160 170 180 190 200
LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY
210 220 230 240 250
DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC
260 270 280 290 300
ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI
310 320 330 340 350
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK
360 370 380 390 400
TILAENDEVK FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF
410 420 430 440 450
ASLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL
460 470 480 490 500
YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE
510 520 530 540 550
RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS GVPSSCSSSS
560 570 580 590 600
LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL
610 620 630 640 650
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG
660 670 680 690 700
VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA
710 720 730 740 750
ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQTAVKVPTT PASPVKNWGG
760 770 780 790 800
FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG LGRVPAKERA KSKLKSDNEN
810 820 830 840
DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS
Length:842
Mass (Da):95,533
Last modified:July 5, 2004 - v1
Checksum:i239FC2229CE25FFD
GO
Isoform 2 (identifier: Q6IE81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.

Note: No experimental confirmation available.
Show »
Length:830
Mass (Da):94,114
Checksum:i3F136EE584113837
GO
Isoform 3 (identifier: Q6IE81-3) [UniParc]FASTAAdd to basket
Also known as: JADE1S

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Show »
Length:509
Mass (Da):58,370
Checksum:iED47BFCFAE89A24F
GO

Sequence cautioni

The sequence BAB15371 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11335 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053777662N → S.Corresponds to variant rs6855813dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02104599 – 110Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_021046503 – 509RNLTYMV → MIDTDTL in isoform 3. 3 Publications7
Alternative sequenceiVSP_021047510 – 842Missing in isoform 3. 3 PublicationsAdd BLAST333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA. Translation: AAM95612.1.
AK027620 mRNA. Translation: BAB55239.1.
AK026132 mRNA. Translation: BAB15371.1. Different initiation.
AK074986 mRNA. Translation: BAC11335.1. Different initiation.
AK127326 mRNA. Translation: BAC86931.1.
AC108024 Genomic DNA. Translation: AAY40997.1.
AC093783 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05171.1.
CH471056 Genomic DNA. Translation: EAX05173.1.
CH471056 Genomic DNA. Translation: EAX05175.1.
CH471056 Genomic DNA. Translation: EAX05176.1.
BC032376 mRNA. Translation: AAH32376.1.
AB058710 mRNA. Translation: BAB47436.1.
BN000287 mRNA. Translation: CAE30500.1.
CCDSiCCDS34062.1. [Q6IE81-1]
CCDS47134.1. [Q6IE81-3]
CCDS75191.1. [Q6IE81-2]
RefSeqiNP_001274366.1. NM_001287437.1. [Q6IE81-2]
NP_001274368.1. NM_001287439.1. [Q6IE81-1]
NP_001274369.1. NM_001287440.1. [Q6IE81-1]
NP_001274370.1. NM_001287441.1. [Q6IE81-3]
NP_001274371.1. NM_001287442.1. [Q6IE81-1]
NP_001274372.1. NM_001287443.1. [Q6IE81-1]
NP_079176.2. NM_024900.4. [Q6IE81-3]
NP_955352.1. NM_199320.3. [Q6IE81-1]
XP_005263289.1. XM_005263232.1. [Q6IE81-1]
UniGeneiHs.12420.

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684. [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684. [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684. [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684. [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684. [Q6IE81-1]
ENST00000610919; ENSP00000483219; ENSG00000077684. [Q6IE81-1]
ENST00000611140; ENSP00000482212; ENSG00000077684. [Q6IE81-1]
GeneIDi79960.
KEGGihsa:79960.
UCSCiuc003igj.5. human. [Q6IE81-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA. Translation: AAM95612.1.
AK027620 mRNA. Translation: BAB55239.1.
AK026132 mRNA. Translation: BAB15371.1. Different initiation.
AK074986 mRNA. Translation: BAC11335.1. Different initiation.
AK127326 mRNA. Translation: BAC86931.1.
AC108024 Genomic DNA. Translation: AAY40997.1.
AC093783 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05171.1.
CH471056 Genomic DNA. Translation: EAX05173.1.
CH471056 Genomic DNA. Translation: EAX05175.1.
CH471056 Genomic DNA. Translation: EAX05176.1.
BC032376 mRNA. Translation: AAH32376.1.
AB058710 mRNA. Translation: BAB47436.1.
BN000287 mRNA. Translation: CAE30500.1.
CCDSiCCDS34062.1. [Q6IE81-1]
CCDS47134.1. [Q6IE81-3]
CCDS75191.1. [Q6IE81-2]
RefSeqiNP_001274366.1. NM_001287437.1. [Q6IE81-2]
NP_001274368.1. NM_001287439.1. [Q6IE81-1]
NP_001274369.1. NM_001287440.1. [Q6IE81-1]
NP_001274370.1. NM_001287441.1. [Q6IE81-3]
NP_001274371.1. NM_001287442.1. [Q6IE81-1]
NP_001274372.1. NM_001287443.1. [Q6IE81-1]
NP_079176.2. NM_024900.4. [Q6IE81-3]
NP_955352.1. NM_199320.3. [Q6IE81-1]
XP_005263289.1. XM_005263232.1. [Q6IE81-1]
UniGeneiHs.12420.

3D structure databases

ProteinModelPortaliQ6IE81.
SMRiQ6IE81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123029. 24 interactors.
IntActiQ6IE81. 16 interactors.
MINTiMINT-2876566.
STRINGi9606.ENSP00000226319.

PTM databases

iPTMnetiQ6IE81.
PhosphoSitePlusiQ6IE81.

Polymorphism and mutation databases

DMDMi74748786.

Proteomic databases

EPDiQ6IE81.
MaxQBiQ6IE81.
PaxDbiQ6IE81.
PeptideAtlasiQ6IE81.
PRIDEiQ6IE81.

Protocols and materials databases

DNASUi79960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684. [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684. [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684. [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684. [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684. [Q6IE81-1]
ENST00000610919; ENSP00000483219; ENSG00000077684. [Q6IE81-1]
ENST00000611140; ENSP00000482212; ENSG00000077684. [Q6IE81-1]
GeneIDi79960.
KEGGihsa:79960.
UCSCiuc003igj.5. human. [Q6IE81-1]

Organism-specific databases

CTDi79960.
DisGeNETi79960.
GeneCardsiJADE1.
H-InvDBHIX0004498.
HGNCiHGNC:30027. JADE1.
HPAiHPA020016.
MIMi610514. gene.
neXtProtiNX_Q6IE81.
OpenTargetsiENSG00000077684.
PharmGKBiPA134925124.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0954. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOVERGENiHBG053585.
InParanoidiQ6IE81.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG091G0T5C.
PhylomeDBiQ6IE81.
TreeFamiTF316118.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

GeneWikiiPHF17.
GenomeRNAii79960.
PROiQ6IE81.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077684.
CleanExiHS_PHF17.
ExpressionAtlasiQ6IE81. baseline and differential.
GenevisibleiQ6IE81. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJADE1_HUMAN
AccessioniPrimary (citable) accession number: Q6IE81
Secondary accession number(s): D3DNY0
, D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.