Q6IE81 (JADE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Jade-1

Alternative name(s):
PHD finger protein 17

Gene names

Name:	PHF17
Synonyms:	JADE1, KIAA1807

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	842 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Ref.8 Ref.9 Ref.10
Subunit structure	Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Isoform 3 interacts with VHL and KAT5. Ref.1 Ref.8 Ref.10
Subcellular location	Cytoplasm. Nucleus Ref.1 Ref.8.
Tissue specificity	Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. Ref.1 Ref.9
Domain	The 2 PHD-type zinc fingers are required for transcriptional activity.
Sequence similarities	Belongs to the JADE family. Contains 2 PHD-type zinc fingers.
Sequence caution	The sequence BAB15371.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11335.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Non-traceable author statement Ref.1. Source: UniProtKB histone H3 acetylation Inferred from direct assay Ref.10. Source: UniProtKB histone H4-K12 acetylation Inferred from direct assay Ref.10. Source: UniProtKB histone H4-K5 acetylation Inferred from direct assay Ref.10. Source: UniProtKB histone H4-K8 acetylation Inferred from direct assay Ref.10. Source: UniProtKB negative regulation of cell growth Non-traceable author statement Ref.1. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to stress Non-traceable author statement Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	histone acetyltransferase complex Inferred from direct assay Ref.10. Source: UniProtKB mitochondrion Inferred from direct assay. Source: HPA
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6IE81-1)

Also known as: JADE1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6IE81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6IE81-3)

Also known as: JADE1S;

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 842	842	Protein Jade-1		PRO_0000253529
Regions
	Zinc finger	203 – 253	51	PHD-type 1
	Zinc finger	312 – 371	60	PHD-type 2; atypical
	Compositional bias	544 – 550	7	Poly-Ser
Amino acid modifications
	Modified residue	89	1	Phosphoserine Ref.11
	Modified residue	92	1	Phosphothreonine Ref.11 Ref.12
	Modified residue	603	1	Phosphoserine Ref.12 Ref.13 Ref.14
	Modified residue	743	1	Phosphoserine Ref.14
Natural variations
	Alternative sequence	99 – 110	12	Missing in isoform 2.		VSP_021045
	Alternative sequence	503 – 509	7	RNLTYMV → MIDTDTL in isoform 3.		VSP_021046
	Alternative sequence	510 – 842	333	Missing in isoform 3.		VSP_021047
	Natural variant	662	1	N → S. Corresponds to variant rs6855813 [ dbSNP | Ensembl ].		VAR_053777

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (JADE1L) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 239FC2229CE25FFD	FASTA	842	95,533
	10 20 30 40 50 60 MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD 70 80 90 100 110 120 SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV VSEEKSLMFI RPKKYIVSSG 130 140 150 160 170 180 SEPPELGYVD IRTLADSVCR YDLNDMDAAW LELTNEEFKE MGMPELDEYT MERVLEEFEQ 190 200 210 220 230 240 RCYDNMNHAI ETEEGLGIEY DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV 250 260 270 280 290 300 PEGSWLCRTC ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI 310 320 330 340 350 360 TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK TILAENDEVK 370 380 390 400 410 420 FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF ASLEQNREEA HRVSVRKQKL 430 440 450 460 470 480 QQLEDEFYTF VNLLDVARAL RLPEEVVDFL YQYWKLKRKV NFNKPLITPK KDEEDNLAKR 490 500 510 520 530 540 EQDVLFRRLQ LFTHLRQDLE RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS 550 560 570 580 590 600 GVPSSCSSSS LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL 610 620 630 640 650 660 QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG VVMPDHGKRR 670 680 690 700 710 720 DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA ATSPGVGQSA PGTRKEIVPK 730 740 750 760 770 780 CNGSLIKVNY NQTAVKVPTT PASPVKNWGG FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG 790 800 810 820 830 840 LGRVPAKERA KSKLKSDNEN DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS
	Isoform 2 [UniParc]. Checksum: 3F136EE584113837	FASTA	830	94,114
	10 20 30 40 50 60 MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD 70 80 90 100 110 120 SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARP KKYIVSSGSE PPELGYVDIR 130 140 150 160 170 180 TLADSVCRYD LNDMDAAWLE LTNEEFKEMG MPELDEYTME RVLEEFEQRC YDNMNHAIET 190 200 210 220 230 240 EEGLGIEYDE DVVCDVCQSP DGEDGNEMVF CDKCNICVHQ ACYGILKVPE GSWLCRTCAL 250 260 270 280 290 300 GVQPKCLLCP KKGGAMKPTR SGTKWVHVSC ALWIPEVSIG SPEKMEPITK VSHIPSSRWA 310 320 330 340 350 360 LVCSLCNEKF GASIQCSVKN CRTAFHVTCA FDRGLEMKTI LAENDEVKFK SYCPKHSSHR 370 380 390 400 410 420 KPEESLGKGA AQENGAPECS PRNPLEPFAS LEQNREEAHR VSVRKQKLQQ LEDEFYTFVN 430 440 450 460 470 480 LLDVARALRL PEEVVDFLYQ YWKLKRKVNF NKPLITPKKD EEDNLAKREQ DVLFRRLQLF 490 500 510 520 530 540 THLRQDLERV RNLTYMVTRR EKIKRSVCKV QEQIFNLYTK LLEQERVSGV PSSCSSSSLE 550 560 570 580 590 600 NMLLFNSPSV GPDAPKIEDL KWHSAFFRKQ MGTSLVHSLK KPHKRDPLQN SPGSEGKTLL 610 620 630 640 650 660 KQPDLCGRRE GMVVPESFLG LEKTFAEARL ISAQQKNGVV MPDHGKRRDN RFHCDLIKGD 670 680 690 700 710 720 LKDKSFKQSH KPLRSTDVSQ RHLDNTRAAT SPGVGQSAPG TRKEIVPKCN GSLIKVNYNQ 730 740 750 760 770 780 TAVKVPTTPA SPVKNWGGFR IPKKGERQQQ GEAHDGACHQ HSDYPYLGLG RVPAKERAKS 790 800 810 820 830 KLKSDNENDG YVPDVEMSDS ESEASEKKCI HTSSTISRRT DIIRRSILAS
	Isoform 3 (JADE1S) [UniParc]. Checksum: ED47BFCFAE89A24F	FASTA	509	58,370
	10 20 30 40 50 60 MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD 70 80 90 100 110 120 SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV VSEEKSLMFI RPKKYIVSSG 130 140 150 160 170 180 SEPPELGYVD IRTLADSVCR YDLNDMDAAW LELTNEEFKE MGMPELDEYT MERVLEEFEQ 190 200 210 220 230 240 RCYDNMNHAI ETEEGLGIEY DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV 250 260 270 280 290 300 PEGSWLCRTC ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI 310 320 330 340 350 360 TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK TILAENDEVK 370 380 390 400 410 420 FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF ASLEQNREEA HRVSVRKQKL 430 440 450 460 470 480 QQLEDEFYTF VNLLDVARAL RLPEEVVDFL YQYWKLKRKV NFNKPLITPK KDEEDNLAKR 490 500 EQDVLFRRLQ LFTHLRQDLE RVMIDTDTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1." Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T. J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH VHL, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Hippocampus.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Cervix.
[6]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-842. Tissue: Brain.
[7]	"Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development." Tzouanacou E., Tweedie S., Wilson V. Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 1).
[8]	"von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity." Panchenko M.V., Zhou M.I., Cohen H.T. J. Biol. Chem. 279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KAT5, SUBCELLULAR LOCATION, FUNCTION.
[9]	"Jade-1, a candidate renal tumor suppressor that promotes apoptosis." Zhou M.I., Foy R.L., Chitalia V.C., Zhao J., Panchenko M.V., Wang H., Cohen H.T. Proc. Natl. Acad. Sci. U.S.A. 102:11035-11040(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[10]	"ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation." Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J. Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND THR-92, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-603, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603 AND SER-743, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF520952 mRNA. Translation: AAM95612.1. AK027620 mRNA. Translation: BAB55239.1. AK026132 mRNA. Translation: BAB15371.1. Different initiation. AK074986 mRNA. Translation: BAC11335.1. Different initiation. AK127326 mRNA. Translation: BAC86931.1. AC108024 Genomic DNA. Translation: AAY40997.1. AC093783 Genomic DNA. No translation available. CH471056 Genomic DNA. Translation: EAX05171.1. CH471056 Genomic DNA. Translation: EAX05173.1. CH471056 Genomic DNA. Translation: EAX05175.1. CH471056 Genomic DNA. Translation: EAX05176.1. BC032376 mRNA. Translation: AAH32376.1. AB058710 mRNA. Translation: BAB47436.1. BN000287 mRNA. Translation: CAE30500.1.
IPI	IPI00395424. IPI00399252. IPI00789745.
RefSeq	NP_079176.2. NM_024900.3. NP_955352.1. NM_199320.2.
UniGene	Hs.12420.
3D structure databases
ProteinModelPortal	Q6IE81.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6IE81. 2 interactions.
MINT	MINT-2876566.
STRING	9606.ENSP00000226319.
PTM databases
PhosphoSite	Q6IE81.
Polymorphism databases
DMDM	74748786.
Proteomic databases
PaxDb	Q6IE81.
PRIDE	Q6IE81.
Protocols and materials databases
DNASU	79960.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000226319; ENSP00000226319; ENSG00000077684. ENST00000413543; ENSP00000404211; ENSG00000077684. ENST00000452328; ENSP00000388015; ENSG00000077684. ENST00000511647; ENSP00000423737; ENSG00000077684. ENST00000512960; ENSP00000425730; ENSG00000077684.
GeneID	79960.
KEGG	hsa:79960.
UCSC	uc003igj.3. human. uc003igk.3. human. uc003igl.3. human.
Organism-specific databases
CTD	79960.
GeneCards	GC04P129730.
H-InvDB	HIX0004498.
HGNC	HGNC:30027. PHF17.
HPA	HPA020016.
MIM	610514. gene.
neXtProt	NX_Q6IE81.
PharmGKB	PA134925124.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5141.
HOVERGEN	HBG053585.
InParanoid	Q6IE81.
KO	K11347.
OMA	EAHEGAC.
OrthoDB	EOG4BP1B2.
Gene expression databases
ArrayExpress	Q6IE81.
Bgee	Q6IE81.
CleanEx	HS_PHF17.
Genevestigator	Q6IE81.
GermOnline	ENSG00000077684. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR019542. Enhancer_polycomb-like_N. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF10513. EPL1. 1 hit. [Graphical view]
SMART	SM00249. PHD. 2 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PHF17. human.
GenomeRNAi	79960.
NextBio	69955.
SOURCE	Search...

Entry information

Entry name

JADE1_HUMAN

Accession

Primary (citable) accession number: Q6IE81
Secondary accession number(s): D3DNY0 , D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.