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Protein

Protein Jade-1

Gene

JADE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 25351PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 37160PHD-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II transcription coactivator activity Source: MGI
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB
  2. chromatin organization Source: Reactome
  3. histone H3 acetylation Source: UniProtKB
  4. histone H4-K12 acetylation Source: UniProtKB
  5. histone H4-K5 acetylation Source: UniProtKB
  6. histone H4-K8 acetylation Source: UniProtKB
  7. negative regulation of cell growth Source: UniProtKB
  8. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: GOC
  10. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene namesi
Name:JADE1
Synonyms:KIAA1807, PHF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:30027. JADE1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. histone acetyltransferase complex Source: UniProtKB
  3. intercellular bridge Source: HPA
  4. nucleoplasm Source: HPA
  5. nucleus Source: UniProtKB
  6. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134925124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Protein Jade-1PRO_0000253529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891Phosphoserine1 Publication
Modified residuei92 – 921Phosphothreonine2 Publications
Modified residuei603 – 6031Phosphoserine3 Publications
Modified residuei609 – 6091N6-acetyllysineBy similarity
Modified residuei743 – 7431Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6IE81.
PaxDbiQ6IE81.
PRIDEiQ6IE81.

PTM databases

PhosphoSiteiQ6IE81.

Expressioni

Tissue specificityi

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.2 Publications

Gene expression databases

BgeeiQ6IE81.
CleanExiHS_PHF17.
ExpressionAtlasiQ6IE81. baseline and differential.
GenevestigatoriQ6IE81.

Organism-specific databases

HPAiHPA020016.
HPA048865.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5.3 Publications

Protein-protein interaction databases

BioGridi123029. 21 interactions.
IntActiQ6IE81. 7 interactions.
MINTiMINT-2876566.
STRINGi9606.ENSP00000226319.

Structurei

3D structure databases

ProteinModelPortaliQ6IE81.
SMRiQ6IE81. Positions 201-250, 305-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi544 – 5507Poly-Ser

Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similaritiesi

Belongs to the JADE family.Curated
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 25351PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 37160PHD-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5141.
GeneTreeiENSGT00740000114866.
HOVERGENiHBG053585.
InParanoidiQ6IE81.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG738044.
PhylomeDBiQ6IE81.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IE81-1) [UniParc]FASTAAdd to basket

Also known as: JADE1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT
60 70 80 90 100
DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV
110 120 130 140 150
VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW
160 170 180 190 200
LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY
210 220 230 240 250
DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC
260 270 280 290 300
ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI
310 320 330 340 350
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK
360 370 380 390 400
TILAENDEVK FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF
410 420 430 440 450
ASLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL
460 470 480 490 500
YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE
510 520 530 540 550
RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS GVPSSCSSSS
560 570 580 590 600
LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL
610 620 630 640 650
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG
660 670 680 690 700
VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA
710 720 730 740 750
ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQTAVKVPTT PASPVKNWGG
760 770 780 790 800
FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG LGRVPAKERA KSKLKSDNEN
810 820 830 840
DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS
Length:842
Mass (Da):95,533
Last modified:July 5, 2004 - v1
Checksum:i239FC2229CE25FFD
GO
Isoform 2 (identifier: Q6IE81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.

Note: No experimental confirmation available.

Show »
Length:830
Mass (Da):94,114
Checksum:i3F136EE584113837
GO
Isoform 3 (identifier: Q6IE81-3) [UniParc]FASTAAdd to basket

Also known as: JADE1S

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Show »
Length:509
Mass (Da):58,370
Checksum:iED47BFCFAE89A24F
GO

Sequence cautioni

The sequence BAB15371.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11335.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti662 – 6621N → S.
Corresponds to variant rs6855813 [ dbSNP | Ensembl ].
VAR_053777

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei99 – 11012Missing in isoform 2. 1 PublicationVSP_021045Add
BLAST
Alternative sequencei503 – 5097RNLTYMV → MIDTDTL in isoform 3. 3 PublicationsVSP_021046
Alternative sequencei510 – 842333Missing in isoform 3. 3 PublicationsVSP_021047Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA. Translation: AAM95612.1.
AK027620 mRNA. Translation: BAB55239.1.
AK026132 mRNA. Translation: BAB15371.1. Different initiation.
AK074986 mRNA. Translation: BAC11335.1. Different initiation.
AK127326 mRNA. Translation: BAC86931.1.
AC108024 Genomic DNA. Translation: AAY40997.1.
AC093783 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05171.1.
CH471056 Genomic DNA. Translation: EAX05173.1.
CH471056 Genomic DNA. Translation: EAX05175.1.
CH471056 Genomic DNA. Translation: EAX05176.1.
BC032376 mRNA. Translation: AAH32376.1.
AB058710 mRNA. Translation: BAB47436.1.
BN000287 mRNA. Translation: CAE30500.1.
CCDSiCCDS34062.1. [Q6IE81-1]
CCDS47134.1. [Q6IE81-3]
CCDS75191.1. [Q6IE81-2]
RefSeqiNP_001274366.1. NM_001287437.1. [Q6IE81-2]
NP_001274368.1. NM_001287439.1. [Q6IE81-1]
NP_001274369.1. NM_001287440.1. [Q6IE81-1]
NP_001274370.1. NM_001287441.1. [Q6IE81-3]
NP_001274371.1. NM_001287442.1. [Q6IE81-1]
NP_001274372.1. NM_001287443.1. [Q6IE81-1]
NP_079176.2. NM_024900.4. [Q6IE81-3]
NP_955352.1. NM_199320.3. [Q6IE81-1]
XP_005263289.1. XM_005263232.1. [Q6IE81-1]
UniGeneiHs.12420.

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684. [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684. [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684. [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684. [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684. [Q6IE81-1]
ENST00000610919; ENSP00000483219; ENSG00000077684. [Q6IE81-1]
ENST00000611140; ENSP00000482212; ENSG00000077684. [Q6IE81-1]
GeneIDi79960.
KEGGihsa:79960.
UCSCiuc003igj.3. human. [Q6IE81-3]
uc003igk.3. human. [Q6IE81-1]
uc003igl.3. human. [Q6IE81-2]

Polymorphism databases

DMDMi74748786.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520952 mRNA. Translation: AAM95612.1.
AK027620 mRNA. Translation: BAB55239.1.
AK026132 mRNA. Translation: BAB15371.1. Different initiation.
AK074986 mRNA. Translation: BAC11335.1. Different initiation.
AK127326 mRNA. Translation: BAC86931.1.
AC108024 Genomic DNA. Translation: AAY40997.1.
AC093783 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05171.1.
CH471056 Genomic DNA. Translation: EAX05173.1.
CH471056 Genomic DNA. Translation: EAX05175.1.
CH471056 Genomic DNA. Translation: EAX05176.1.
BC032376 mRNA. Translation: AAH32376.1.
AB058710 mRNA. Translation: BAB47436.1.
BN000287 mRNA. Translation: CAE30500.1.
CCDSiCCDS34062.1. [Q6IE81-1]
CCDS47134.1. [Q6IE81-3]
CCDS75191.1. [Q6IE81-2]
RefSeqiNP_001274366.1. NM_001287437.1. [Q6IE81-2]
NP_001274368.1. NM_001287439.1. [Q6IE81-1]
NP_001274369.1. NM_001287440.1. [Q6IE81-1]
NP_001274370.1. NM_001287441.1. [Q6IE81-3]
NP_001274371.1. NM_001287442.1. [Q6IE81-1]
NP_001274372.1. NM_001287443.1. [Q6IE81-1]
NP_079176.2. NM_024900.4. [Q6IE81-3]
NP_955352.1. NM_199320.3. [Q6IE81-1]
XP_005263289.1. XM_005263232.1. [Q6IE81-1]
UniGeneiHs.12420.

3D structure databases

ProteinModelPortaliQ6IE81.
SMRiQ6IE81. Positions 201-250, 305-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123029. 21 interactions.
IntActiQ6IE81. 7 interactions.
MINTiMINT-2876566.
STRINGi9606.ENSP00000226319.

PTM databases

PhosphoSiteiQ6IE81.

Polymorphism databases

DMDMi74748786.

Proteomic databases

MaxQBiQ6IE81.
PaxDbiQ6IE81.
PRIDEiQ6IE81.

Protocols and materials databases

DNASUi79960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226319; ENSP00000226319; ENSG00000077684. [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684. [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684. [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684. [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684. [Q6IE81-1]
ENST00000610919; ENSP00000483219; ENSG00000077684. [Q6IE81-1]
ENST00000611140; ENSP00000482212; ENSG00000077684. [Q6IE81-1]
GeneIDi79960.
KEGGihsa:79960.
UCSCiuc003igj.3. human. [Q6IE81-3]
uc003igk.3. human. [Q6IE81-1]
uc003igl.3. human. [Q6IE81-2]

Organism-specific databases

CTDi79960.
GeneCardsiGC04P129731.
H-InvDBHIX0004498.
HGNCiHGNC:30027. JADE1.
HPAiHPA020016.
HPA048865.
MIMi610514. gene.
neXtProtiNX_Q6IE81.
PharmGKBiPA134925124.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5141.
GeneTreeiENSGT00740000114866.
HOVERGENiHBG053585.
InParanoidiQ6IE81.
KOiK11347.
OMAiEAHEGAC.
OrthoDBiEOG738044.
PhylomeDBiQ6IE81.
TreeFamiTF316118.

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Miscellaneous databases

GeneWikiiPHF17.
GenomeRNAii79960.
NextBioi69955.
PROiQ6IE81.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IE81.
CleanExiHS_PHF17.
ExpressionAtlasiQ6IE81. baseline and differential.
GenevestigatoriQ6IE81.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
    Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
    J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH VHL, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Hippocampus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cervix.
  6. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-842.
    Tissue: Brain.
  7. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
    Tzouanacou E., Tweedie S., Wilson V.
    Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 1).
  8. "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."
    Panchenko M.V., Zhou M.I., Cohen H.T.
    J. Biol. Chem. 279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KAT5, SUBCELLULAR LOCATION, FUNCTION.
  9. Cited for: TISSUE SPECIFICITY, FUNCTION.
  10. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
    Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
    Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND THR-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603 AND SER-743, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJADE1_HUMAN
AccessioniPrimary (citable) accession number: Q6IE81
Secondary accession number(s): D3DNY0
, D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.