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Q6IE81

- JADE1_HUMAN

UniProt

Q6IE81 - JADE1_HUMAN

Protein

Protein Jade-1

Gene

JADE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 25351PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 37160PHD-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA polymerase II transcription coactivator activity Source: MGI
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. chromatin organization Source: Reactome
    3. histone H3 acetylation Source: UniProtKB
    4. histone H4-K12 acetylation Source: UniProtKB
    5. histone H4-K5 acetylation Source: UniProtKB
    6. histone H4-K8 acetylation Source: UniProtKB
    7. negative regulation of cell growth Source: UniProtKB
    8. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: GOC
    10. response to stress Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Jade-1
    Alternative name(s):
    Jade family PHD finger protein 1
    PHD finger protein 17
    Gene namesi
    Name:JADE1
    Synonyms:KIAA1807, PHF17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:30027. JADE1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. histone acetyltransferase complex Source: UniProtKB
    3. intercellular bridge Source: HPA
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProtKB
    6. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134925124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842Protein Jade-1PRO_0000253529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 891Phosphoserine1 Publication
    Modified residuei92 – 921Phosphothreonine2 Publications
    Modified residuei603 – 6031Phosphoserine3 Publications
    Modified residuei609 – 6091N6-acetyllysineBy similarity
    Modified residuei743 – 7431Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6IE81.
    PaxDbiQ6IE81.
    PRIDEiQ6IE81.

    PTM databases

    PhosphoSiteiQ6IE81.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.2 Publications

    Gene expression databases

    ArrayExpressiQ6IE81.
    BgeeiQ6IE81.
    CleanExiHS_PHF17.
    GenevestigatoriQ6IE81.

    Organism-specific databases

    HPAiHPA020016.
    HPA048865.

    Interactioni

    Subunit structurei

    Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5.3 Publications

    Protein-protein interaction databases

    BioGridi123029. 17 interactions.
    IntActiQ6IE81. 7 interactions.
    MINTiMINT-2876566.
    STRINGi9606.ENSP00000226319.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IE81.
    SMRiQ6IE81. Positions 201-250, 255-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi544 – 5507Poly-Ser

    Domaini

    The 2 PHD-type zinc fingers are required for transcriptional activity.

    Sequence similaritiesi

    Belongs to the JADE family.Curated
    Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 25351PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 37160PHD-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5141.
    HOVERGENiHBG053585.
    InParanoidiQ6IE81.
    KOiK11347.
    OMAiEAHEGAC.
    OrthoDBiEOG738044.
    PhylomeDBiQ6IE81.
    TreeFamiTF316118.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF10513. EPL1. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6IE81-1) [UniParc]FASTAAdd to Basket

    Also known as: JADE1L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT    50
    DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV 100
    VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW 150
    LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY 200
    DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC 250
    ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI 300
    TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK 350
    TILAENDEVK FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF 400
    ASLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL 450
    YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE 500
    RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS GVPSSCSSSS 550
    LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL 600
    QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG 650
    VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA 700
    ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQTAVKVPTT PASPVKNWGG 750
    FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG LGRVPAKERA KSKLKSDNEN 800
    DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL AS 842
    Length:842
    Mass (Da):95,533
    Last modified:July 5, 2004 - v1
    Checksum:i239FC2229CE25FFD
    GO
    Isoform 2 (identifier: Q6IE81-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         99-110: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:830
    Mass (Da):94,114
    Checksum:i3F136EE584113837
    GO
    Isoform 3 (identifier: Q6IE81-3) [UniParc]FASTAAdd to Basket

    Also known as: JADE1S

    The sequence of this isoform differs from the canonical sequence as follows:
         503-509: RNLTYMV → MIDTDTL
         510-842: Missing.

    Show »
    Length:509
    Mass (Da):58,370
    Checksum:iED47BFCFAE89A24F
    GO

    Sequence cautioni

    The sequence BAB15371.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC11335.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti662 – 6621N → S.
    Corresponds to variant rs6855813 [ dbSNP | Ensembl ].
    VAR_053777

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei99 – 11012Missing in isoform 2. 1 PublicationVSP_021045Add
    BLAST
    Alternative sequencei503 – 5097RNLTYMV → MIDTDTL in isoform 3. 3 PublicationsVSP_021046
    Alternative sequencei510 – 842333Missing in isoform 3. 3 PublicationsVSP_021047Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF520952 mRNA. Translation: AAM95612.1.
    AK027620 mRNA. Translation: BAB55239.1.
    AK026132 mRNA. Translation: BAB15371.1. Different initiation.
    AK074986 mRNA. Translation: BAC11335.1. Different initiation.
    AK127326 mRNA. Translation: BAC86931.1.
    AC108024 Genomic DNA. Translation: AAY40997.1.
    AC093783 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05171.1.
    CH471056 Genomic DNA. Translation: EAX05173.1.
    CH471056 Genomic DNA. Translation: EAX05175.1.
    CH471056 Genomic DNA. Translation: EAX05176.1.
    BC032376 mRNA. Translation: AAH32376.1.
    AB058710 mRNA. Translation: BAB47436.1.
    BN000287 mRNA. Translation: CAE30500.1.
    CCDSiCCDS34062.1. [Q6IE81-1]
    CCDS47134.1. [Q6IE81-3]
    RefSeqiNP_001274366.1. NM_001287437.1. [Q6IE81-2]
    NP_001274368.1. NM_001287439.1. [Q6IE81-1]
    NP_001274369.1. NM_001287440.1. [Q6IE81-1]
    NP_001274370.1. NM_001287441.1. [Q6IE81-3]
    NP_001274371.1. NM_001287442.1. [Q6IE81-1]
    NP_001274372.1. NM_001287443.1. [Q6IE81-1]
    NP_079176.2. NM_024900.4. [Q6IE81-3]
    NP_955352.1. NM_199320.3. [Q6IE81-1]
    XP_005263289.1. XM_005263232.1. [Q6IE81-1]
    UniGeneiHs.12420.

    Genome annotation databases

    EnsembliENST00000226319; ENSP00000226319; ENSG00000077684. [Q6IE81-1]
    ENST00000413543; ENSP00000404211; ENSG00000077684. [Q6IE81-3]
    ENST00000452328; ENSP00000388015; ENSG00000077684. [Q6IE81-2]
    ENST00000511647; ENSP00000423737; ENSG00000077684. [Q6IE81-3]
    ENST00000512960; ENSP00000425730; ENSG00000077684. [Q6IE81-1]
    GeneIDi79960.
    KEGGihsa:79960.
    UCSCiuc003igj.3. human. [Q6IE81-3]
    uc003igk.3. human. [Q6IE81-1]
    uc003igl.3. human. [Q6IE81-2]

    Polymorphism databases

    DMDMi74748786.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF520952 mRNA. Translation: AAM95612.1 .
    AK027620 mRNA. Translation: BAB55239.1 .
    AK026132 mRNA. Translation: BAB15371.1 . Different initiation.
    AK074986 mRNA. Translation: BAC11335.1 . Different initiation.
    AK127326 mRNA. Translation: BAC86931.1 .
    AC108024 Genomic DNA. Translation: AAY40997.1 .
    AC093783 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05171.1 .
    CH471056 Genomic DNA. Translation: EAX05173.1 .
    CH471056 Genomic DNA. Translation: EAX05175.1 .
    CH471056 Genomic DNA. Translation: EAX05176.1 .
    BC032376 mRNA. Translation: AAH32376.1 .
    AB058710 mRNA. Translation: BAB47436.1 .
    BN000287 mRNA. Translation: CAE30500.1 .
    CCDSi CCDS34062.1. [Q6IE81-1 ]
    CCDS47134.1. [Q6IE81-3 ]
    RefSeqi NP_001274366.1. NM_001287437.1. [Q6IE81-2 ]
    NP_001274368.1. NM_001287439.1. [Q6IE81-1 ]
    NP_001274369.1. NM_001287440.1. [Q6IE81-1 ]
    NP_001274370.1. NM_001287441.1. [Q6IE81-3 ]
    NP_001274371.1. NM_001287442.1. [Q6IE81-1 ]
    NP_001274372.1. NM_001287443.1. [Q6IE81-1 ]
    NP_079176.2. NM_024900.4. [Q6IE81-3 ]
    NP_955352.1. NM_199320.3. [Q6IE81-1 ]
    XP_005263289.1. XM_005263232.1. [Q6IE81-1 ]
    UniGenei Hs.12420.

    3D structure databases

    ProteinModelPortali Q6IE81.
    SMRi Q6IE81. Positions 201-250, 255-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123029. 17 interactions.
    IntActi Q6IE81. 7 interactions.
    MINTi MINT-2876566.
    STRINGi 9606.ENSP00000226319.

    PTM databases

    PhosphoSitei Q6IE81.

    Polymorphism databases

    DMDMi 74748786.

    Proteomic databases

    MaxQBi Q6IE81.
    PaxDbi Q6IE81.
    PRIDEi Q6IE81.

    Protocols and materials databases

    DNASUi 79960.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226319 ; ENSP00000226319 ; ENSG00000077684 . [Q6IE81-1 ]
    ENST00000413543 ; ENSP00000404211 ; ENSG00000077684 . [Q6IE81-3 ]
    ENST00000452328 ; ENSP00000388015 ; ENSG00000077684 . [Q6IE81-2 ]
    ENST00000511647 ; ENSP00000423737 ; ENSG00000077684 . [Q6IE81-3 ]
    ENST00000512960 ; ENSP00000425730 ; ENSG00000077684 . [Q6IE81-1 ]
    GeneIDi 79960.
    KEGGi hsa:79960.
    UCSCi uc003igj.3. human. [Q6IE81-3 ]
    uc003igk.3. human. [Q6IE81-1 ]
    uc003igl.3. human. [Q6IE81-2 ]

    Organism-specific databases

    CTDi 79960.
    GeneCardsi GC04P129730.
    H-InvDB HIX0004498.
    HGNCi HGNC:30027. JADE1.
    HPAi HPA020016.
    HPA048865.
    MIMi 610514. gene.
    neXtProti NX_Q6IE81.
    PharmGKBi PA134925124.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5141.
    HOVERGENi HBG053585.
    InParanoidi Q6IE81.
    KOi K11347.
    OMAi EAHEGAC.
    OrthoDBi EOG738044.
    PhylomeDBi Q6IE81.
    TreeFami TF316118.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi PHF17. human.
    GeneWikii PHF17.
    GenomeRNAii 79960.
    NextBioi 69955.
    PROi Q6IE81.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6IE81.
    Bgeei Q6IE81.
    CleanExi HS_PHF17.
    Genevestigatori Q6IE81.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF10513. EPL1. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
      Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
      J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH VHL, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Hippocampus.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Cervix.
    6. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-842.
      Tissue: Brain.
    7. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
      Tzouanacou E., Tweedie S., Wilson V.
      Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 1).
    8. "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."
      Panchenko M.V., Zhou M.I., Cohen H.T.
      J. Biol. Chem. 279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KAT5, SUBCELLULAR LOCATION, FUNCTION.
    9. Cited for: TISSUE SPECIFICITY, FUNCTION.
    10. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
      Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
      Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
    11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND THR-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603 AND SER-743, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiJADE1_HUMAN
    AccessioniPrimary (citable) accession number: Q6IE81
    Secondary accession number(s): D3DNY0
    , D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3