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Q6IE81 (JADE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
Gene names
Name:JADE1
Synonyms:KIAA1807, PHF17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Ref.8 Ref.9 Ref.10

Subunit structure

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5. Ref.1 Ref.8 Ref.10

Subcellular location

Cytoplasm. Nucleus Ref.1 Ref.8.

Tissue specificity

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. Ref.1 Ref.9

Domain

The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similarities

Belongs to the JADE family.

Contains 2 PHD-type zinc fingers.

Sequence caution

The sequence BAB15371.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC11335.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processApoptosis
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionActivator
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Non-traceable author statement Ref.1. Source: UniProtKB

chromatin organization

Traceable author statement. Source: Reactome

histone H3 acetylation

Inferred from direct assay Ref.10. Source: UniProtKB

histone H4-K12 acetylation

Inferred from direct assay Ref.10. Source: UniProtKB

histone H4-K5 acetylation

Inferred from direct assay Ref.10. Source: UniProtKB

histone H4-K8 acetylation

Inferred from direct assay Ref.10. Source: UniProtKB

negative regulation of G1/S transition of mitotic cell cycle

Inferred from direct assay PubMed 23001567. Source: MGI

negative regulation of cell growth

Non-traceable author statement Ref.1. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 23001567. Source: GOC

response to stress

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

histone acetyltransferase complex

Inferred from direct assay Ref.10. Source: UniProtKB

intercellular bridge

Inferred from direct assay. Source: HPA

nucleoplasm

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay Ref.1. Source: UniProtKB

plasma membrane

Inferred from direct assay PubMed 23001567. Source: MGI

   Molecular_functionRNA polymerase II transcription coactivator activity

Inferred from direct assay PubMed 23001567. Source: MGI

protein binding

Inferred from physical interaction Ref.1. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6IE81-1)

Also known as: JADE1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6IE81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6IE81-3)

Also known as: JADE1S;

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842Protein Jade-1
PRO_0000253529

Regions

Zinc finger203 – 25351PHD-type 1
Zinc finger312 – 37160PHD-type 2; atypical
Compositional bias544 – 5507Poly-Ser

Amino acid modifications

Modified residue891Phosphoserine Ref.11
Modified residue921Phosphothreonine Ref.11 Ref.13
Modified residue6031Phosphoserine Ref.13 Ref.14 Ref.15
Modified residue6091N6-acetyllysine By similarity
Modified residue7431Phosphoserine Ref.15

Natural variations

Alternative sequence99 – 11012Missing in isoform 2.
VSP_021045
Alternative sequence503 – 5097RNLTYMV → MIDTDTL in isoform 3.
VSP_021046
Alternative sequence510 – 842333Missing in isoform 3.
VSP_021047
Natural variant6621N → S.
Corresponds to variant rs6855813 [ dbSNP | Ensembl ].
VAR_053777

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (JADE1L) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 239FC2229CE25FFD

FASTA84295,533
        10         20         30         40         50         60 
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD 

        70         80         90        100        110        120 
SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV VSEEKSLMFI RPKKYIVSSG 

       130        140        150        160        170        180 
SEPPELGYVD IRTLADSVCR YDLNDMDAAW LELTNEEFKE MGMPELDEYT MERVLEEFEQ 

       190        200        210        220        230        240 
RCYDNMNHAI ETEEGLGIEY DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV 

       250        260        270        280        290        300 
PEGSWLCRTC ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI 

       310        320        330        340        350        360 
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK TILAENDEVK 

       370        380        390        400        410        420 
FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF ASLEQNREEA HRVSVRKQKL 

       430        440        450        460        470        480 
QQLEDEFYTF VNLLDVARAL RLPEEVVDFL YQYWKLKRKV NFNKPLITPK KDEEDNLAKR 

       490        500        510        520        530        540 
EQDVLFRRLQ LFTHLRQDLE RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS 

       550        560        570        580        590        600 
GVPSSCSSSS LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL 

       610        620        630        640        650        660 
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG VVMPDHGKRR 

       670        680        690        700        710        720 
DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA ATSPGVGQSA PGTRKEIVPK 

       730        740        750        760        770        780 
CNGSLIKVNY NQTAVKVPTT PASPVKNWGG FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG 

       790        800        810        820        830        840 
LGRVPAKERA KSKLKSDNEN DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL 


AS 

« Hide

Isoform 2 [UniParc].

Checksum: 3F136EE584113837
Show »

FASTA83094,114
Isoform 3 (JADE1S) [UniParc].

Checksum: ED47BFCFAE89A24F
Show »

FASTA50958,370

References

« Hide 'large scale' references
[1]"The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH VHL, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Hippocampus.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Cervix.
[6]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-842.
Tissue: Brain.
[7]"Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
Tzouanacou E., Tweedie S., Wilson V.
Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1).
[8]"von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."
Panchenko M.V., Zhou M.I., Cohen H.T.
J. Biol. Chem. 279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KAT5, SUBCELLULAR LOCATION, FUNCTION.
[9]"Jade-1, a candidate renal tumor suppressor that promotes apoptosis."
Zhou M.I., Foy R.L., Chitalia V.C., Zhao J., Panchenko M.V., Wang H., Cohen H.T.
Proc. Natl. Acad. Sci. U.S.A. 102:11035-11040(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[10]"ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
[11]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND THR-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[14]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603 AND SER-743, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF520952 mRNA. Translation: AAM95612.1.
AK027620 mRNA. Translation: BAB55239.1.
AK026132 mRNA. Translation: BAB15371.1. Different initiation.
AK074986 mRNA. Translation: BAC11335.1. Different initiation.
AK127326 mRNA. Translation: BAC86931.1.
AC108024 Genomic DNA. Translation: AAY40997.1.
AC093783 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05171.1.
CH471056 Genomic DNA. Translation: EAX05173.1.
CH471056 Genomic DNA. Translation: EAX05175.1.
CH471056 Genomic DNA. Translation: EAX05176.1.
BC032376 mRNA. Translation: AAH32376.1.
AB058710 mRNA. Translation: BAB47436.1.
BN000287 mRNA. Translation: CAE30500.1.
CCDSCCDS34062.1. [Q6IE81-1]
CCDS47134.1. [Q6IE81-3]
RefSeqNP_001274366.1. NM_001287437.1. [Q6IE81-2]
NP_001274368.1. NM_001287439.1. [Q6IE81-1]
NP_001274369.1. NM_001287440.1. [Q6IE81-1]
NP_001274370.1. NM_001287441.1. [Q6IE81-3]
NP_001274371.1. NM_001287442.1. [Q6IE81-1]
NP_001274372.1. NM_001287443.1. [Q6IE81-1]
NP_079176.2. NM_024900.4. [Q6IE81-3]
NP_955352.1. NM_199320.3. [Q6IE81-1]
XP_005263289.1. XM_005263232.1. [Q6IE81-1]
UniGeneHs.12420.

3D structure databases

ProteinModelPortalQ6IE81.
SMRQ6IE81. Positions 201-250, 255-369.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123029. 17 interactions.
IntActQ6IE81. 7 interactions.
MINTMINT-2876566.
STRING9606.ENSP00000226319.

PTM databases

PhosphoSiteQ6IE81.

Polymorphism databases

DMDM74748786.

Proteomic databases

MaxQBQ6IE81.
PaxDbQ6IE81.
PRIDEQ6IE81.

Protocols and materials databases

DNASU79960.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000226319; ENSP00000226319; ENSG00000077684. [Q6IE81-1]
ENST00000413543; ENSP00000404211; ENSG00000077684. [Q6IE81-3]
ENST00000452328; ENSP00000388015; ENSG00000077684. [Q6IE81-2]
ENST00000511647; ENSP00000423737; ENSG00000077684. [Q6IE81-3]
ENST00000512960; ENSP00000425730; ENSG00000077684. [Q6IE81-1]
GeneID79960.
KEGGhsa:79960.
UCSCuc003igj.3. human. [Q6IE81-3]
uc003igk.3. human. [Q6IE81-1]
uc003igl.3. human. [Q6IE81-2]

Organism-specific databases

CTD79960.
GeneCardsGC04P129730.
H-InvDBHIX0004498.
HGNCHGNC:30027. JADE1.
HPAHPA020016.
HPA048865.
MIM610514. gene.
neXtProtNX_Q6IE81.
PharmGKBPA134925124.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5141.
HOVERGENHBG053585.
InParanoidQ6IE81.
KOK11347.
OMAEAHEGAC.
OrthoDBEOG738044.
PhylomeDBQ6IE81.
TreeFamTF316118.

Enzyme and pathway databases

ReactomeREACT_172623. Chromatin organization.

Gene expression databases

ArrayExpressQ6IE81.
BgeeQ6IE81.
CleanExHS_PHF17.
GenevestigatorQ6IE81.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF10513. EPL1. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPHF17. human.
GeneWikiPHF17.
GenomeRNAi79960.
NextBio69955.
PROQ6IE81.
SOURCESearch...

Entry information

Entry nameJADE1_HUMAN
AccessionPrimary (citable) accession number: Q6IE81
Secondary accession number(s): D3DNY0 expand/collapse secondary AC list , D3DNY1, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM