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Reviewed, UniProtKB/Swiss-Prot Q6IE81 (JADE1_HUMAN)

Last modified December 16, 2008. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein Jade-1
Alternative name(s):
    PHD finger protein 17
Gene names
Name: PHF17
Synonyms: JADE1, KIAA1807
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transcriptional coactivator which seems to act by promoting acetylation of nucleosomal histone H4 by HTATIP. Promotes apoptosis. May act as a renal tumor suppressor. Ref.7 Ref.8

Subunit structure

Isoform 3 interacts with VHL and HTATIP. Ref.7 Ref.1

Subcellular location

Cytoplasm. Nucleus. Ref.7 Ref.1

Tissue specificity

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. Ref.8 Ref.1

Domain

The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similarities

Belongs to the JADE family.

Contains 2 PHD-type zinc fingers.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6IE81-1)

Also known as: JADE1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6IE81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: Missing.
Notes: No experimental confirmation available.
Isoform 3 (identifier: Q6IE81-3)

Also known as: JADE1S;

The sequence of this isoform differs from the canonical sequence as follows:
     503-509: RNLTYMV → MIDTDTL
     510-842: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842Protein Jade-1
PRO_0000253529

Regions

Zinc finger203 – 25351PHD-type 1
Zinc finger312 – 37160PHD-type 2; atypical
Compositional bias544 – 5507Poly-Ser

Amino acid modifications

Modified residue81Phosphoserine Ref.9
Modified residue91Phosphoserine Ref.9
Modified residue101Phosphoserine Ref.9
Modified residue131Phosphoserine Ref.9
Modified residue891Phosphoserine Ref.10
Modified residue921Phosphothreonine Ref.10

Natural variations

Alternative sequence99 – 11012Missing in isoform 2.
VSP_021045
Alternative sequence503 – 5097RNLTYMV → MIDTDTL in isoform 3.
VSP_021046
Alternative sequence510 – 842333Missing in isoform 3.
VSP_021047
Natural variant6621N → S: dbSNP rs6855813.
VAR_053777

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (JADE1L) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 239FC2229CE25FFD

FASTA84295,533
        10         20         30         40         50         60 
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD 

        70         80         90        100        110        120 
SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV VSEEKSLMFI RPKKYIVSSG 

       130        140        150        160        170        180 
SEPPELGYVD IRTLADSVCR YDLNDMDAAW LELTNEEFKE MGMPELDEYT MERVLEEFEQ 

       190        200        210        220        230        240 
RCYDNMNHAI ETEEGLGIEY DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV 

       250        260        270        280        290        300 
PEGSWLCRTC ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI 

       310        320        330        340        350        360 
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK TILAENDEVK 

       370        380        390        400        410        420 
FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF ASLEQNREEA HRVSVRKQKL 

       430        440        450        460        470        480 
QQLEDEFYTF VNLLDVARAL RLPEEVVDFL YQYWKLKRKV NFNKPLITPK KDEEDNLAKR 

       490        500        510        520        530        540 
EQDVLFRRLQ LFTHLRQDLE RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS 

       550        560        570        580        590        600 
GVPSSCSSSS LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL 

       610        620        630        640        650        660 
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG VVMPDHGKRR 

       670        680        690        700        710        720 
DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA ATSPGVGQSA PGTRKEIVPK 

       730        740        750        760        770        780 
CNGSLIKVNY NQTAVKVPTT PASPVKNWGG FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG 

       790        800        810        820        830        840 
LGRVPAKERA KSKLKSDNEN DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL 


AS 

« Hide

Isoform 2.

Checksum: 3F136EE584113837
Show »

83094,114
Isoform 3 (JADE1S).

Checksum: ED47BFCFAE89A24F
Show »

50958,370

References

« Hide 'large scale' references
[1]"The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
Zhou M.I., Wang H., Ross J.J., Kuzmin I., Xu C., Cohen H.T.
J. Biol. Chem. 277:39887-39898(2002) [PubMed: 12169691] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH VHL, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Hippocampus.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Cervix.
[5]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-842.
Tissue: Brain.
[6]"Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
Tzouanacou E., Tweedie S., Wilson V.
Mol. Cell. Biol. 23:8553-8562(2003) [PubMed: 14612400] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1).
[7]"von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."
Panchenko M.V., Zhou M.I., Cohen H.T.
J. Biol. Chem. 279:56032-56041(2004) [PubMed: 15502158] [Abstract]
Cited for: INTERACTION WITH HTATIP, SUBCELLULAR LOCATION, FUNCTION.
[8]"Jade-1, a candidate renal tumor suppressor that promotes apoptosis."
Zhou M.I., Foy R.L., Chitalia V.C., Zhao J., Panchenko M.V., Wang H., Cohen H.T.
Proc. Natl. Acad. Sci. U.S.A. 102:11035-11040(2005) [PubMed: 16046545] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8; SER-9; SER-10 AND SER-13, MASS SPECTROMETRY.
Tissue: Epithelium.
[10]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND THR-92, MASS SPECTROMETRY.

Cross-references

Sequence databases

AF520952 mRNA. Translation: AAM95612.1.
AK027620 mRNA. Translation: BAB55239.1.
AK026132 mRNA. Translation: BAB15371.1. Different initiation.
AK074986 mRNA. Translation: BAC11335.1. Different initiation.
AK127326 mRNA. Translation: BAC86931.1.
AC108024 Genomic DNA. Translation: AAY40997.1.
AC093783 Genomic DNA. No translation available.
BC032376 mRNA. Translation: AAH32376.1.
AB058710 mRNA. Translation: BAB47436.1.
BN000287 mRNA. Translation: CAE30500.1.
RefSeqNP_079176.2.
NP_955352.1.
UniGeneHs.12420

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ6IE81. 1 interaction.

PTM databases

PhosphoSiteQ6IE81.

Proteomic databases

PRIDEQ6IE81.

Genome annotation databases

EnsemblENSG00000077684. Homo sapiens. [Contig view]
GeneID79960.
KEGGhsa:79960.

Organism-specific databases

GeneCardsGC04P129950.
H-InvDBHIX0004498.
HGNCHGNC:30027. PHF17.
MIM610514. gene.
PharmGKBPA134925124.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ6IE81.

Gene expression databases

ArrayExpressQ6IE81.
CleanExHS_PHF17.
GermOnlineENSG00000077684. Homo sapiens.

Family and domain databases

InterProIPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
PfamPF00628. PHD. 2 hits.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
[Graphical view]
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio69955.
SOURCESearch...

Entry information

Entry nameJADE1_HUMAN
AccessionPrimary (citable) accession number: Q6IE81
Secondary accession number(s): Q4W5D5 expand/collapse secondary AC list , Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: December 16, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents