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Protein

Serine protease inhibitor Kazal-type 2

Gene

Spink2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 2
Gene namesi
Name:Spink2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1302956. Spink2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001656417 – 86Serine protease inhibitor Kazal-type 2Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 68PROSITE-ProRule annotation
Disulfide bondi46 ↔ 65PROSITE-ProRule annotation
Disulfide bondi54 ↔ 86PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6IE49.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031710.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067011.

Structurei

3D structure databases

ProteinModelPortaliQ6IE49.
SMRiQ6IE49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 86Kazal-likePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00530000064285.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiQ6IE49.
OMAiEDGSHIN.
OrthoDBiEOG091G1BGL.
PhylomeDBiQ6IE49.

Family and domain databases

InterProiView protein in InterPro
IPR002350. Kazal_dom.
PfamiView protein in Pfam
PF00050. Kazal_1. 1 hit.
SMARTiView protein in SMART
SM00280. KAZAL. 1 hit.
SUPFAMiSSF100895. SSF100895. 1 hit.
PROSITEiView protein in PROSITE
PS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLVLLLLA TDFAASDDSL DSSDSQLIKR SQFRTPDCHR FDYPVCSKHL
60 70 80
SPVCGTDMNT YGNECTLCMK IREDGSHINI IKDEPC
Length:86
Mass (Da):9,697
Last modified:July 5, 2004 - v1
Checksum:iAF84CB0046559333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097433 Genomic DNA. No translation available.
BN000344 mRNA. Translation: CAE51396.1.
RefSeqiNP_001008870.1. NM_001008870.2.
XP_003751398.1. XM_003751350.4.
UniGeneiRn.215227.

Genome annotation databases

EnsembliENSRNOT00000051031; ENSRNOP00000040692; ENSRNOG00000031710.
ENSRNOT00000075226; ENSRNOP00000067011; ENSRNOG00000047065.
GeneIDi100910138.
408234.
KEGGirno:100910138.
rno:408234.
UCSCiRGD:1302956. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097433 Genomic DNA. No translation available.
BN000344 mRNA. Translation: CAE51396.1.
RefSeqiNP_001008870.1. NM_001008870.2.
XP_003751398.1. XM_003751350.4.
UniGeneiRn.215227.

3D structure databases

ProteinModelPortaliQ6IE49.
SMRiQ6IE49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067011.

Protein family/group databases

MEROPSiI01.012.

Proteomic databases

PaxDbiQ6IE49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051031; ENSRNOP00000040692; ENSRNOG00000031710.
ENSRNOT00000075226; ENSRNOP00000067011; ENSRNOG00000047065.
GeneIDi100910138.
408234.
KEGGirno:100910138.
rno:408234.
UCSCiRGD:1302956. rat.

Organism-specific databases

CTDi6691.
RGDi1302956. Spink2.

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00530000064285.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiQ6IE49.
OMAiEDGSHIN.
OrthoDBiEOG091G1BGL.
PhylomeDBiQ6IE49.

Miscellaneous databases

PROiPR:Q6IE49.

Gene expression databases

BgeeiENSRNOG00000031710.

Family and domain databases

InterProiView protein in InterPro
IPR002350. Kazal_dom.
PfamiView protein in Pfam
PF00050. Kazal_1. 1 hit.
SMARTiView protein in SMART
SM00280. KAZAL. 1 hit.
SUPFAMiSSF100895. SSF100895. 1 hit.
PROSITEiView protein in PROSITE
PS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiISK2_RAT
AccessioniPrimary (citable) accession number: Q6IE49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.