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Protein

Serine protease inhibitor Kazal-type 2

Gene

Spink2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.012

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 2
Gene namesi
Name:Spink2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1302956 Spink2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001656417 – 86Serine protease inhibitor Kazal-type 2Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 68PROSITE-ProRule annotation
Disulfide bondi46 ↔ 65PROSITE-ProRule annotation
Disulfide bondi54 ↔ 86PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6IE49

Expressioni

Gene expression databases

BgeeiENSRNOG00000031710

Structurei

3D structure databases

ProteinModelPortaliQ6IE49
SMRiQ6IE49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 86Kazal-likePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00530000064285
HOGENOMiHOG000090244
HOVERGENiHBG006182
InParanoidiQ6IE49
OMAiHNIKIIR
OrthoDBiEOG091G1BGL
PhylomeDBiQ6IE49

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLVLLLLA TDFAASDDSL DSSDSQLIKR SQFRTPDCHR FDYPVCSKHL
60 70 80
SPVCGTDMNT YGNECTLCMK IREDGSHINI IKDEPC
Length:86
Mass (Da):9,697
Last modified:July 5, 2004 - v1
Checksum:iAF84CB0046559333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097433 Genomic DNA No translation available.
BN000344 mRNA Translation: CAE51396.1
RefSeqiNP_001008870.1, NM_001008870.2
XP_003751398.1, XM_003751350.4
UniGeneiRn.215227

Genome annotation databases

EnsembliENSRNOT00000051031; ENSRNOP00000040692; ENSRNOG00000031710
ENSRNOT00000075226; ENSRNOP00000067011; ENSRNOG00000047065
GeneIDi100910138
408234
KEGGirno:100910138
rno:408234
UCSCiRGD:1302956 rat

Similar proteinsi

Entry informationi

Entry nameiISK2_RAT
AccessioniPrimary (citable) accession number: Q6IE49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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