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Protein

Serine protease inhibitor Kazal-type 14

Gene

SPINK14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be a serine protease inhibitor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 14
Gene namesi
Name:SPINK14
Synonyms:SPINK5L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000196800.6.
HGNCiHGNC:33825. SPINK14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196800.
PharmGKBiPA165660569.

Polymorphism and mutation databases

BioMutaiSPINK14.
DMDMi74724705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500009599722 – 97Serine protease inhibitor Kazal-type 14Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 79PROSITE-ProRule annotation
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 76PROSITE-ProRule annotation
Disulfide bondi65 ↔ 97PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IE38.
PRIDEiQ6IE38.

Expressioni

Gene expression databases

BgeeiENSG00000196800.
ExpressionAtlasiQ6IE38. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349459.

Structurei

3D structure databases

ProteinModelPortaliQ6IE38.
SMRiQ6IE38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 97Kazal-likePROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFV9. Eukaryota.
ENOG41119H9. LUCA.
GeneTreeiENSGT00860000133862.
HOGENOMiHOG000090244.
HOVERGENiHBG097609.
InParanoidiQ6IE38.
OMAiCILCVES.
OrthoDBiEOG091G1BGL.
PhylomeDBiQ6IE38.

Family and domain databases

InterProiView protein in InterPro
IPR002350. Kazal_dom.
IPR036058. Kazal_dom_sf.
PfamiView protein in Pfam
PF00050. Kazal_1. 1 hit.
SMARTiView protein in SMART
SM00280. KAZAL. 1 hit.
SUPFAMiSSF100895. SSF100895. 1 hit.
PROSITEiView protein in PROSITE
PS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSFPVFSL LSFILIHLVL SSVSGPRHWW PPRGIIKVKC PYEKVNLSWY
60 70 80 90
NGTVNPCPGL YQPICGTNFI TYDNPCILCV ESLKSHGRIR FYHDGKC
Length:97
Mass (Da):11,057
Last modified:July 5, 2004 - v1
Checksum:i2D926A925057F508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116334 Genomic DNA. No translation available.
BN000355 mRNA. Translation: CAE51407.1.
CCDSiCCDS4288.1.
RefSeqiNP_001001325.1. NM_001001325.2.
XP_016864958.1. XM_017009469.1.
UniGeneiHs.553815.

Genome annotation databases

EnsembliENST00000356972; ENSP00000349459; ENSG00000196800.
GeneIDi408187.
KEGGihsa:408187.
UCSCiuc031sls.2. human.

Similar proteinsi

Entry informationi

Entry nameiISK14_HUMAN
AccessioniPrimary (citable) accession number: Q6IE38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM