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Protein

Ovostatin homolog 1

Gene

OVOS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Ovostatin homolog 1
Gene namesi
Name:OVOS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11851164Ovostatin homolog 1PRO_0000318965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IE37.
PRIDEiQ6IE37.

Expressioni

Gene expression databases

GenevestigatoriQ6IE37.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6IE37.
SMRiQ6IE37. Positions 63-1176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiNOG323265.
HOVERGENiHBG000039.
InParanoidiQ6IE37.
PhylomeDBiQ6IE37.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVHVCVCLC VCIYTSSCVC ACVHMCMRDA LLAEGRGGGL AAADDFLYLE
60 70 80 90 100
CCKCFSQESQ IAMVCQERSQ NETYEVKMNN DTEACRATLN LEERRSVAIR
110 120 130 140 150
SRENVVFVQT DKPTYKPGQK DVNGIAQFFL DTYTFTYPNI TLKDPQNNRI
160 170 180 190 200
FQRQNVTSFR NITQLSFQLI SEPMFGDYWI VVKRNSRETV THQFAVKRYV
210 220 230 240 250
LPKFEVTVNA PQTVTISDDE FQVDVCAYNF GQPVQGETQI RVCREYFSSS
260 270 280 290 300
NCEKNENEIC EQFIAQVQTN LDIFTLLCSS FLTVMQISEK TSVFITQLLG
310 320 330 340 350
TVNFENMDTF YRRGISYFGQ LKFSDPNNVP MVNKLLQLEL NDEFIGNYTT
360 370 380 390 400
DENGEAQFSI DTSDIFDPEF NLKVRHQRTE ECYLPSWLTP QYLDAHFLVS
410 420 430 440 450
RFYSRTNSFL KIVPEPKQLE CNQQKVVTVH YSLNSEAYED DSNVKFFYLN
460 470 480 490 500
GNFSFPISIS ADLAPAAVLF VYTLHPSGEI VADSVRFQVD KCFKHKVNIK
510 520 530 540 550
FSNEQGLPGS NASLCLQAAP VLFCALRAVD RNVLLLKSEQ QLSAESVSSL
560 570 580 590 600
YNMVPSIEPY GYFYHGLNLD DGKEDPCIPQ RDMFYNGLYY TPVSNYGDGD
610 620 630 640 650
IYNIVRVRSL RILENIIQTV RTNFPETWMW DLVSVSSSGS ANLSFLIPDT
660 670 680 690 700
ITQWEASGFC VNGDVGFGIS STTTLEVSQP FFIEIASPFS VVQNEQFDLI
710 720 730 740 750
VNVFSYRNTC VEVSYIWECL PGKVNITVVA ESKQSSACPN EGMEQQKLNW
760 770 780 790 800
KDTVVQSFLV EFLFLGDILG LALQNLVVLQ MPYGSGEQNA ALLASDTYVL
810 820 830 840 850
DYLKSTEQLT EEVQSKAFFL SILGYQRQLS FKNSDGSYSV FWQQSQKGSI
860 870 880 890 900
WLSALTFKTL ERMKKYVFID ENVQKQTLIW LSSQQKTSGC FKNDGQLFNH
910 920 930 940 950
ALRNALFCLE AALDSGVTNG YNHAILAYAF ALAGKEKQVE SLLQTLDQSA
960 970 980 990 1000
PKLSKRYYWE RERKPKTEEF PSFIPWAPSA QTEKSCYVLL AVISRKIPDL
1010 1020 1030 1040 1050
TYASKIVQWL AQRMNSHGGF SSNQVINVGL ILIAARGEEG LFSKDQNTVT
1060 1070 1080 1090 1100
FSSEGSSEIF QVNGHNRLLV QRSEVTQAPG EYTVDVEGHG CTFIQIFRYT
1110 1120 1130 1140 1150
GIRNKSSMVV IDVKMLSGFT PTMSSIEEVN NRSLIFQHKD SYIEYKRADS
1160 1170 1180
FPFSVEQSNL VFNIQPAPAM VYDYYEKGRQ ATAMP
Length:1,185
Mass (Da):134,499
Last modified:February 26, 2008 - v2
Checksum:i569DE9EA344240FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006432 Genomic DNA. No translation available.
AC092821 Genomic DNA. No translation available.
BN000356 mRNA. Translation: CAE51408.1.

Polymorphism databases

DMDMi182637456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006432 Genomic DNA. No translation available.
AC092821 Genomic DNA. No translation available.
BN000356 mRNA. Translation: CAE51408.1.

3D structure databases

ProteinModelPortaliQ6IE37.
SMRiQ6IE37. Positions 63-1176.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi182637456.

Proteomic databases

PaxDbiQ6IE37.
PRIDEiQ6IE37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

neXtProtiNX_Q6IE37.

Phylogenomic databases

eggNOGiNOG323265.
HOVERGENiHBG000039.
InParanoidiQ6IE37.
PhylomeDBiQ6IE37.

Miscellaneous databases

PROiQ6IE37.

Gene expression databases

GenevestigatoriQ6IE37.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A genomic analysis of rat proteases and protease inhibitors."
    Puente X.S., Lopez-Otin C.
    Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOVOS1_HUMAN
AccessioniPrimary (citable) accession number: Q6IE37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: January 7, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.