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Q6IE37

- OVOS1_HUMAN

UniProt

Q6IE37 - OVOS1_HUMAN

Protein

Ovostatin homolog 1

Gene

OVOS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI39.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovostatin homolog 1
    Gene namesi
    Name:OVOS1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11851164Ovostatin homolog 1PRO_0000318965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6IE37.
    PRIDEiQ6IE37.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6IE37.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IE37.
    SMRiQ6IE37. Positions 63-1176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiNOG323265.
    HOVERGENiHBG000039.
    InParanoidiQ6IE37.
    PhylomeDBiQ6IE37.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6IE37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVHVCVCLC VCIYTSSCVC ACVHMCMRDA LLAEGRGGGL AAADDFLYLE     50
    CCKCFSQESQ IAMVCQERSQ NETYEVKMNN DTEACRATLN LEERRSVAIR 100
    SRENVVFVQT DKPTYKPGQK DVNGIAQFFL DTYTFTYPNI TLKDPQNNRI 150
    FQRQNVTSFR NITQLSFQLI SEPMFGDYWI VVKRNSRETV THQFAVKRYV 200
    LPKFEVTVNA PQTVTISDDE FQVDVCAYNF GQPVQGETQI RVCREYFSSS 250
    NCEKNENEIC EQFIAQVQTN LDIFTLLCSS FLTVMQISEK TSVFITQLLG 300
    TVNFENMDTF YRRGISYFGQ LKFSDPNNVP MVNKLLQLEL NDEFIGNYTT 350
    DENGEAQFSI DTSDIFDPEF NLKVRHQRTE ECYLPSWLTP QYLDAHFLVS 400
    RFYSRTNSFL KIVPEPKQLE CNQQKVVTVH YSLNSEAYED DSNVKFFYLN 450
    GNFSFPISIS ADLAPAAVLF VYTLHPSGEI VADSVRFQVD KCFKHKVNIK 500
    FSNEQGLPGS NASLCLQAAP VLFCALRAVD RNVLLLKSEQ QLSAESVSSL 550
    YNMVPSIEPY GYFYHGLNLD DGKEDPCIPQ RDMFYNGLYY TPVSNYGDGD 600
    IYNIVRVRSL RILENIIQTV RTNFPETWMW DLVSVSSSGS ANLSFLIPDT 650
    ITQWEASGFC VNGDVGFGIS STTTLEVSQP FFIEIASPFS VVQNEQFDLI 700
    VNVFSYRNTC VEVSYIWECL PGKVNITVVA ESKQSSACPN EGMEQQKLNW 750
    KDTVVQSFLV EFLFLGDILG LALQNLVVLQ MPYGSGEQNA ALLASDTYVL 800
    DYLKSTEQLT EEVQSKAFFL SILGYQRQLS FKNSDGSYSV FWQQSQKGSI 850
    WLSALTFKTL ERMKKYVFID ENVQKQTLIW LSSQQKTSGC FKNDGQLFNH 900
    ALRNALFCLE AALDSGVTNG YNHAILAYAF ALAGKEKQVE SLLQTLDQSA 950
    PKLSKRYYWE RERKPKTEEF PSFIPWAPSA QTEKSCYVLL AVISRKIPDL 1000
    TYASKIVQWL AQRMNSHGGF SSNQVINVGL ILIAARGEEG LFSKDQNTVT 1050
    FSSEGSSEIF QVNGHNRLLV QRSEVTQAPG EYTVDVEGHG CTFIQIFRYT 1100
    GIRNKSSMVV IDVKMLSGFT PTMSSIEEVN NRSLIFQHKD SYIEYKRADS 1150
    FPFSVEQSNL VFNIQPAPAM VYDYYEKGRQ ATAMP 1185
    Length:1,185
    Mass (Da):134,499
    Last modified:February 26, 2008 - v2
    Checksum:i569DE9EA344240FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006432 Genomic DNA. No translation available.
    AC092821 Genomic DNA. No translation available.
    BN000356 mRNA. Translation: CAE51408.1.

    Polymorphism databases

    DMDMi182637456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006432 Genomic DNA. No translation available.
    AC092821 Genomic DNA. No translation available.
    BN000356 mRNA. Translation: CAE51408.1 .

    3D structure databases

    ProteinModelPortali Q6IE37.
    SMRi Q6IE37. Positions 63-1176.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I39.002.

    Polymorphism databases

    DMDMi 182637456.

    Proteomic databases

    PaxDbi Q6IE37.
    PRIDEi Q6IE37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    neXtProti NX_Q6IE37.

    Phylogenomic databases

    eggNOGi NOG323265.
    HOVERGENi HBG000039.
    InParanoidi Q6IE37.
    PhylomeDBi Q6IE37.

    Miscellaneous databases

    PROi Q6IE37.

    Gene expression databases

    Genevestigatori Q6IE37.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "A genomic analysis of rat proteases and protease inhibitors."
      Puente X.S., Lopez-Otin C.
      Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiOVOS1_HUMAN
    AccessioniPrimary (citable) accession number: Q6IE37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3