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Q6IE37 (OVOS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ovostatin homolog 1
Gene names
Name:OVOS1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Ontologies

Keywords
   Cellular componentSecreted
   DomainBait region
Signal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 11851164Ovostatin homolog 1
PRO_0000318965

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation4521N-linked (GlcNAc...) Potential
Glycosylation7251N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6IE37 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 569DE9EA344240FD

FASTA1,185134,499
        10         20         30         40         50         60 
MHVHVCVCLC VCIYTSSCVC ACVHMCMRDA LLAEGRGGGL AAADDFLYLE CCKCFSQESQ 

        70         80         90        100        110        120 
IAMVCQERSQ NETYEVKMNN DTEACRATLN LEERRSVAIR SRENVVFVQT DKPTYKPGQK 

       130        140        150        160        170        180 
DVNGIAQFFL DTYTFTYPNI TLKDPQNNRI FQRQNVTSFR NITQLSFQLI SEPMFGDYWI 

       190        200        210        220        230        240 
VVKRNSRETV THQFAVKRYV LPKFEVTVNA PQTVTISDDE FQVDVCAYNF GQPVQGETQI 

       250        260        270        280        290        300 
RVCREYFSSS NCEKNENEIC EQFIAQVQTN LDIFTLLCSS FLTVMQISEK TSVFITQLLG 

       310        320        330        340        350        360 
TVNFENMDTF YRRGISYFGQ LKFSDPNNVP MVNKLLQLEL NDEFIGNYTT DENGEAQFSI 

       370        380        390        400        410        420 
DTSDIFDPEF NLKVRHQRTE ECYLPSWLTP QYLDAHFLVS RFYSRTNSFL KIVPEPKQLE 

       430        440        450        460        470        480 
CNQQKVVTVH YSLNSEAYED DSNVKFFYLN GNFSFPISIS ADLAPAAVLF VYTLHPSGEI 

       490        500        510        520        530        540 
VADSVRFQVD KCFKHKVNIK FSNEQGLPGS NASLCLQAAP VLFCALRAVD RNVLLLKSEQ 

       550        560        570        580        590        600 
QLSAESVSSL YNMVPSIEPY GYFYHGLNLD DGKEDPCIPQ RDMFYNGLYY TPVSNYGDGD 

       610        620        630        640        650        660 
IYNIVRVRSL RILENIIQTV RTNFPETWMW DLVSVSSSGS ANLSFLIPDT ITQWEASGFC 

       670        680        690        700        710        720 
VNGDVGFGIS STTTLEVSQP FFIEIASPFS VVQNEQFDLI VNVFSYRNTC VEVSYIWECL 

       730        740        750        760        770        780 
PGKVNITVVA ESKQSSACPN EGMEQQKLNW KDTVVQSFLV EFLFLGDILG LALQNLVVLQ 

       790        800        810        820        830        840 
MPYGSGEQNA ALLASDTYVL DYLKSTEQLT EEVQSKAFFL SILGYQRQLS FKNSDGSYSV 

       850        860        870        880        890        900 
FWQQSQKGSI WLSALTFKTL ERMKKYVFID ENVQKQTLIW LSSQQKTSGC FKNDGQLFNH 

       910        920        930        940        950        960 
ALRNALFCLE AALDSGVTNG YNHAILAYAF ALAGKEKQVE SLLQTLDQSA PKLSKRYYWE 

       970        980        990       1000       1010       1020 
RERKPKTEEF PSFIPWAPSA QTEKSCYVLL AVISRKIPDL TYASKIVQWL AQRMNSHGGF 

      1030       1040       1050       1060       1070       1080 
SSNQVINVGL ILIAARGEEG LFSKDQNTVT FSSEGSSEIF QVNGHNRLLV QRSEVTQAPG 

      1090       1100       1110       1120       1130       1140 
EYTVDVEGHG CTFIQIFRYT GIRNKSSMVV IDVKMLSGFT PTMSSIEEVN NRSLIFQHKD 

      1150       1160       1170       1180 
SYIEYKRADS FPFSVEQSNL VFNIQPAPAM VYDYYEKGRQ ATAMP 

« Hide

References

« Hide 'large scale' references
[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"A genomic analysis of rat proteases and protease inhibitors."
Puente X.S., Lopez-Otin C.
Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006432 Genomic DNA. No translation available.
AC092821 Genomic DNA. No translation available.
BN000356 mRNA. Translation: CAE51408.1.

3D structure databases

ProteinModelPortalQ6IE37.
SMRQ6IE37. Positions 63-1176.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI39.002.

Polymorphism databases

DMDM182637456.

Proteomic databases

PaxDbQ6IE37.
PRIDEQ6IE37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

neXtProtNX_Q6IE37.

Phylogenomic databases

eggNOGNOG323265.
HOVERGENHBG000039.
InParanoidQ6IE37.
PhylomeDBQ6IE37.

Gene expression databases

GenevestigatorQ6IE37.

Family and domain databases

Gene3D1.50.10.20. 2 hits.
2.60.40.690. 1 hit.
InterProIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

PROQ6IE37.

Entry information

Entry nameOVOS1_HUMAN
AccessionPrimary (citable) accession number: Q6IE37
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM