Q6IE36 (OVOS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ovostatin homolog 2

Gene names

Name:

OVOS2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]
Sequence caution	The sequence CAE51409.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Bait region Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of endopeptidase activity Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular space Inferred from electronic annotation. Source: InterPro
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Chain	? – 1432		Ovostatin homolog 2		PRO_0000318966
Amino acid modifications
	Glycosylation	35	1	N-linked (GlcNAc...) Potential
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	858	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	211	1	T → M. Corresponds to variant rs7971718 [ dbSNP | Ensembl ].		VAR_055459
	Natural variant	587	1	L → V. Corresponds to variant rs12309295 [ dbSNP | Ensembl ].		VAR_055460
	Natural variant	789	1	S → L. Corresponds to variant rs11051266 [ dbSNP | Ensembl ].		VAR_055461
	Natural variant	1328	1	V → A. Corresponds to variant rs17418189 [ dbSNP | Ensembl ].		VAR_055462

Sequences

	Sequence		Length	Mass (Da)
	Q6IE36 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 8A32EC146C3EFB80	FASTA	1,432	161,251
	10 20 30 40 50 60 MTGSHLSHDS WQYVLLIPSV LQEGSLDKAC AQLFNLTESV VLTVSLNYGE VQTKIFEENV 70 80 90 100 110 120 TGENFFKCIS FEVPQARSDP LAFITFSAKG ATLNLEERRS VAIRSRENVV FVQTDKPTYK 130 140 150 160 170 180 PGQKDVNGIA QFFLDTYTFT YPNITLKDPQ NNRIFQWQNV TSFRNITQLS FQLISEPMFG 190 200 210 220 230 240 DYWIVVKRNS RKTVTHQFAV KRYVLPKFEV TVNAPQTVTI SDDEFQVDVC AKYTFGQPVQ 250 260 270 280 290 300 GKTQIRVCRE YFSSSNCEKN DNEICEQFIA QLENGCVSQI VNTKVFQLYR SGLFMTFHVA 310 320 330 340 350 360 VIVTEFGTGN YCMQISEKTS VFITQLLGTV NFENMDTFYR RGISYFGTLK FSDPNNVPMV 370 380 390 400 410 420 NKLLQLELND EFIGNYTTDE NGEAQFSIDT SDIFDPEFNL KATYVRPKSC YLPSWLTPQY 430 440 450 460 470 480 LDAHFLVSRF YSRTNSFLKI VPEPKQLECN HQKVVTVHYS LNSEAYEDDS NVKFFYLVSL 490 500 510 520 530 540 SHDSGNFQHR ISSSPIYTAW NGNFSFPLSI SADLAPAAVL FVYTLHPSGE IVADSVRFQV 550 560 570 580 590 600 DKCFKHKVNI KFSNEQGLPG SNASLYLQAA PVLFCALGAV DGNVLLLKSE QQLSAESVYN 610 620 630 640 650 660 MVPSIEPYGY FYHGLNLDDG KEDPCIPQRD MFYNGLYYTP VSNYGDGDIY NIVRNMGLKV 670 680 690 700 710 720 FTNLHYRKPE VCVMERRLPL PKPLYLETEN YGPMHSVPSR IACRGENADY VEQAIIQTVR 730 740 750 760 770 780 TNFPETWMWD LVSVDSSGSA NLSFLIPDTI TQWEASGFCV NGDVGFGISS TTTLEVSQPF 790 800 810 820 830 840 FIEIASPFSV VQNEQFDLIV NAFSYLNTCV EISVQVEESQ NYEANINTWK INGSEVIQAG 850 860 870 880 890 900 GRKTNIWTII PKKLGKVNIT VVAESKQSSA CPNEGMEQQK LNWKDTVVKS FLVEPEGIEK 910 920 930 940 950 960 ERTQSFLICT EGAKASKQGV LDLPNDVVEG SARGFFTVVG DILGLAMQNL VVLQMPYGGG 970 980 990 1000 1010 1020 EQNAALLASD TYVLDYLKST EQLTEEVQSK AFFLLSNGYQ RQLSFKNSDG SYSVFWQQNQ 1030 1040 1050 1060 1070 1080 KGSIWLSALT FKTLERMKKF VFIDENVQKQ TLIWLSSQQK TSGCFKNDGQ LFNHAWEGGD 1090 1100 1110 1120 1130 1140 EEDISLTAYV VGMFFEAGLN STFPALRNAL FCLEAALDSG VTNGYNHAIL AYAFALAGKE 1150 1160 1170 1180 1190 1200 KQVESLLQTL DQSATKLNNV IYWERERKPK TEEFPSFIPW APSAQTEKSC YVLLAVISRK 1210 1220 1230 1240 1250 1260 IPDLTYASKI VQWLAQQMNS HGGFSSNQVI NVGLILIAIC GEEGLFSKNQ NTVTFSSEGS 1270 1280 1290 1300 1310 1320 SEIQFNGHNR LLVQRSEVTQ APGQYTVDVE GRGCTFIQAT LKYNVLLPKK ASGFSLSLEI 1330 1340 1350 1360 1370 1380 VKNYSLTVFD LTVNLKYTGI RNKSSMVVID VKMLSGFTPT MSSIEELENK GQVMKTEVKN 1390 1400 1410 1420 1430 DHVLFYLENV FGRADSFTFS VEQSNLVFNI QPAPGMVYDY YEKDGEAFLL TN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"A genomic analysis of rat proteases and protease inhibitors." Puente X.S., Lopez-Otin C. Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008010 Genomic DNA. No translation available. AC008013 Genomic DNA. No translation available. AC024940 Genomic DNA. No translation available. BN000357 mRNA. Translation: CAE51409.1. Sequence problems.
IPI	IPI00456958.
UniGene	Hs.524331.
3D structure databases
HSSP	HSSP built from PDB template 1EDY based on UniProtKB Q63332.
ProteinModelPortal	Q6IE36.
ModBase	Search...
PTM databases
PhosphoSite	Q6IE36.
Polymorphism databases
DMDM	182637457.
Proteomic databases
PaxDb	Q6IE36.
PRIDE	Q6IE36.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010sjy.1. human.
Organism-specific databases
GeneCards	GC12M031267.
neXtProt	NX_Q6IE36.
Phylogenomic databases
eggNOG	NOG241555.
HOGENOM	HOG000220939.
HOVERGEN	HBG000039.
InParanoid	Q6IE36.
OrthoDB	EOG4WSW8S.
Gene expression databases
Genevestigator	Q6IE36.
Family and domain databases
Gene3D	2.60.40.690. 1 hit.
InterPro	IPR009048. A-macroglobulin_rcpt-bd. IPR011626. A2M_comp. IPR002890. A2M_N. IPR011625. A2M_N_2. IPR001599. Macroglobln_a2. IPR019565. MacrogloblnA2_thiol-ester-bond. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
Pfam	PF00207. A2M. 1 hit. PF07678. A2M_comp. 1 hit. PF01835. A2M_N. 1 hit. PF07703. A2M_N_2. 1 hit. PF07677. A2M_recep. 1 hit. PF10569. Thiol-ester_cl. 1 hit. [Graphical view]
SUPFAM	SSF49410. AM_receptor_bind. 1 hit. SSF48239. Terp_cyc_toroid. 1 hit.
PROSITE	PS00477. ALPHA_2_MACROGLOBULIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OVOS2_HUMAN

Accession

Primary (citable) accession number: Q6IE36

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.