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Q6IE36

- OVOS2_HUMAN

UniProt

Q6IE36 - OVOS2_HUMAN

Protein

Ovostatin homolog 2

Gene

OVOS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovostatin homolog 2
    Gene namesi
    Name:OVOS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 1432Ovostatin homolog 2PRO_0000318966
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi858 – 8581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6IE36.
    PRIDEiQ6IE36.

    PTM databases

    PhosphoSiteiQ6IE36.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6IE36.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IE36.
    SMRiQ6IE36. Positions 13-247, 719-1424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiNOG241555.
    HOGENOMiHOG000220939.
    HOVERGENiHBG000039.
    InParanoidiQ6IE36.
    PhylomeDBiQ6IE36.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6IE36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGSHLSHDS WQYVLLIPSV LQEGSLDKAC AQLFNLTESV VLTVSLNYGE     50
    VQTKIFEENV TGENFFKCIS FEVPQARSDP LAFITFSAKG ATLNLEERRS 100
    VAIRSRENVV FVQTDKPTYK PGQKDVNGIA QFFLDTYTFT YPNITLKDPQ 150
    NNRIFQWQNV TSFRNITQLS FQLISEPMFG DYWIVVKRNS RKTVTHQFAV 200
    KRYVLPKFEV TVNAPQTVTI SDDEFQVDVC AKYTFGQPVQ GKTQIRVCRE 250
    YFSSSNCEKN DNEICEQFIA QLENGCVSQI VNTKVFQLYR SGLFMTFHVA 300
    VIVTEFGTGN YCMQISEKTS VFITQLLGTV NFENMDTFYR RGISYFGTLK 350
    FSDPNNVPMV NKLLQLELND EFIGNYTTDE NGEAQFSIDT SDIFDPEFNL 400
    KATYVRPKSC YLPSWLTPQY LDAHFLVSRF YSRTNSFLKI VPEPKQLECN 450
    HQKVVTVHYS LNSEAYEDDS NVKFFYLVSL SHDSGNFQHR ISSSPIYTAW 500
    NGNFSFPLSI SADLAPAAVL FVYTLHPSGE IVADSVRFQV DKCFKHKVNI 550
    KFSNEQGLPG SNASLYLQAA PVLFCALGAV DGNVLLLKSE QQLSAESVYN 600
    MVPSIEPYGY FYHGLNLDDG KEDPCIPQRD MFYNGLYYTP VSNYGDGDIY 650
    NIVRNMGLKV FTNLHYRKPE VCVMERRLPL PKPLYLETEN YGPMHSVPSR 700
    IACRGENADY VEQAIIQTVR TNFPETWMWD LVSVDSSGSA NLSFLIPDTI 750
    TQWEASGFCV NGDVGFGISS TTTLEVSQPF FIEIASPFSV VQNEQFDLIV 800
    NAFSYLNTCV EISVQVEESQ NYEANINTWK INGSEVIQAG GRKTNIWTII 850
    PKKLGKVNIT VVAESKQSSA CPNEGMEQQK LNWKDTVVKS FLVEPEGIEK 900
    ERTQSFLICT EGAKASKQGV LDLPNDVVEG SARGFFTVVG DILGLAMQNL 950
    VVLQMPYGGG EQNAALLASD TYVLDYLKST EQLTEEVQSK AFFLLSNGYQ 1000
    RQLSFKNSDG SYSVFWQQNQ KGSIWLSALT FKTLERMKKF VFIDENVQKQ 1050
    TLIWLSSQQK TSGCFKNDGQ LFNHAWEGGD EEDISLTAYV VGMFFEAGLN 1100
    STFPALRNAL FCLEAALDSG VTNGYNHAIL AYAFALAGKE KQVESLLQTL 1150
    DQSATKLNNV IYWERERKPK TEEFPSFIPW APSAQTEKSC YVLLAVISRK 1200
    IPDLTYASKI VQWLAQQMNS HGGFSSNQVI NVGLILIAIC GEEGLFSKNQ 1250
    NTVTFSSEGS SEIQFNGHNR LLVQRSEVTQ APGQYTVDVE GRGCTFIQAT 1300
    LKYNVLLPKK ASGFSLSLEI VKNYSLTVFD LTVNLKYTGI RNKSSMVVID 1350
    VKMLSGFTPT MSSIEELENK GQVMKTEVKN DHVLFYLENV FGRADSFTFS 1400
    VEQSNLVFNI QPAPGMVYDY YEKDGEAFLL TN 1432
    Length:1,432
    Mass (Da):161,251
    Last modified:February 26, 2008 - v2
    Checksum:i8A32EC146C3EFB80
    GO

    Sequence cautioni

    The sequence CAE51409.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti211 – 2111T → M.
    Corresponds to variant rs7971718 [ dbSNP | Ensembl ].
    VAR_055459
    Natural varianti587 – 5871L → V.
    Corresponds to variant rs12309295 [ dbSNP | Ensembl ].
    VAR_055460
    Natural varianti789 – 7891S → L.
    Corresponds to variant rs11051266 [ dbSNP | Ensembl ].
    VAR_055461
    Natural varianti1328 – 13281V → A.
    Corresponds to variant rs17418189 [ dbSNP | Ensembl ].
    VAR_055462

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008010 Genomic DNA. No translation available.
    AC008013 Genomic DNA. No translation available.
    AC024940 Genomic DNA. No translation available.
    BN000357 mRNA. Translation: CAE51409.1. Sequence problems.
    UniGeneiHs.524331.

    Genome annotation databases

    UCSCiuc010sjy.1. human.

    Polymorphism databases

    DMDMi182637457.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008010 Genomic DNA. No translation available.
    AC008013 Genomic DNA. No translation available.
    AC024940 Genomic DNA. No translation available.
    BN000357 mRNA. Translation: CAE51409.1 . Sequence problems.
    UniGenei Hs.524331.

    3D structure databases

    ProteinModelPortali Q6IE36.
    SMRi Q6IE36. Positions 13-247, 719-1424.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6IE36.

    Polymorphism databases

    DMDMi 182637457.

    Proteomic databases

    PaxDbi Q6IE36.
    PRIDEi Q6IE36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010sjy.1. human.

    Organism-specific databases

    GeneCardsi GC12M031267.
    neXtProti NX_Q6IE36.

    Phylogenomic databases

    eggNOGi NOG241555.
    HOGENOMi HOG000220939.
    HOVERGENi HBG000039.
    InParanoidi Q6IE36.
    PhylomeDBi Q6IE36.

    Miscellaneous databases

    PROi Q6IE36.

    Gene expression databases

    Genevestigatori Q6IE36.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "A genomic analysis of rat proteases and protease inhibitors."
      Puente X.S., Lopez-Otin C.
      Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiOVOS2_HUMAN
    AccessioniPrimary (citable) accession number: Q6IE36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3