Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6IE36

- OVOS2_HUMAN

UniProt

Q6IE36 - OVOS2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ovostatin homolog 2

Gene

OVOS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI39.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovostatin homolog 2
Gene namesi
Name:OVOS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1432Ovostatin homolog 2PRO_0000318966
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi858 – 8581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IE36.
PRIDEiQ6IE36.

PTM databases

PhosphoSiteiQ6IE36.

Expressioni

Gene expression databases

GenevestigatoriQ6IE36.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6IE36.
SMRiQ6IE36. Positions 13-247, 719-1424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiNOG241555.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
InParanoidiQ6IE36.
PhylomeDBiQ6IE36.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGSHLSHDS WQYVLLIPSV LQEGSLDKAC AQLFNLTESV VLTVSLNYGE
60 70 80 90 100
VQTKIFEENV TGENFFKCIS FEVPQARSDP LAFITFSAKG ATLNLEERRS
110 120 130 140 150
VAIRSRENVV FVQTDKPTYK PGQKDVNGIA QFFLDTYTFT YPNITLKDPQ
160 170 180 190 200
NNRIFQWQNV TSFRNITQLS FQLISEPMFG DYWIVVKRNS RKTVTHQFAV
210 220 230 240 250
KRYVLPKFEV TVNAPQTVTI SDDEFQVDVC AKYTFGQPVQ GKTQIRVCRE
260 270 280 290 300
YFSSSNCEKN DNEICEQFIA QLENGCVSQI VNTKVFQLYR SGLFMTFHVA
310 320 330 340 350
VIVTEFGTGN YCMQISEKTS VFITQLLGTV NFENMDTFYR RGISYFGTLK
360 370 380 390 400
FSDPNNVPMV NKLLQLELND EFIGNYTTDE NGEAQFSIDT SDIFDPEFNL
410 420 430 440 450
KATYVRPKSC YLPSWLTPQY LDAHFLVSRF YSRTNSFLKI VPEPKQLECN
460 470 480 490 500
HQKVVTVHYS LNSEAYEDDS NVKFFYLVSL SHDSGNFQHR ISSSPIYTAW
510 520 530 540 550
NGNFSFPLSI SADLAPAAVL FVYTLHPSGE IVADSVRFQV DKCFKHKVNI
560 570 580 590 600
KFSNEQGLPG SNASLYLQAA PVLFCALGAV DGNVLLLKSE QQLSAESVYN
610 620 630 640 650
MVPSIEPYGY FYHGLNLDDG KEDPCIPQRD MFYNGLYYTP VSNYGDGDIY
660 670 680 690 700
NIVRNMGLKV FTNLHYRKPE VCVMERRLPL PKPLYLETEN YGPMHSVPSR
710 720 730 740 750
IACRGENADY VEQAIIQTVR TNFPETWMWD LVSVDSSGSA NLSFLIPDTI
760 770 780 790 800
TQWEASGFCV NGDVGFGISS TTTLEVSQPF FIEIASPFSV VQNEQFDLIV
810 820 830 840 850
NAFSYLNTCV EISVQVEESQ NYEANINTWK INGSEVIQAG GRKTNIWTII
860 870 880 890 900
PKKLGKVNIT VVAESKQSSA CPNEGMEQQK LNWKDTVVKS FLVEPEGIEK
910 920 930 940 950
ERTQSFLICT EGAKASKQGV LDLPNDVVEG SARGFFTVVG DILGLAMQNL
960 970 980 990 1000
VVLQMPYGGG EQNAALLASD TYVLDYLKST EQLTEEVQSK AFFLLSNGYQ
1010 1020 1030 1040 1050
RQLSFKNSDG SYSVFWQQNQ KGSIWLSALT FKTLERMKKF VFIDENVQKQ
1060 1070 1080 1090 1100
TLIWLSSQQK TSGCFKNDGQ LFNHAWEGGD EEDISLTAYV VGMFFEAGLN
1110 1120 1130 1140 1150
STFPALRNAL FCLEAALDSG VTNGYNHAIL AYAFALAGKE KQVESLLQTL
1160 1170 1180 1190 1200
DQSATKLNNV IYWERERKPK TEEFPSFIPW APSAQTEKSC YVLLAVISRK
1210 1220 1230 1240 1250
IPDLTYASKI VQWLAQQMNS HGGFSSNQVI NVGLILIAIC GEEGLFSKNQ
1260 1270 1280 1290 1300
NTVTFSSEGS SEIQFNGHNR LLVQRSEVTQ APGQYTVDVE GRGCTFIQAT
1310 1320 1330 1340 1350
LKYNVLLPKK ASGFSLSLEI VKNYSLTVFD LTVNLKYTGI RNKSSMVVID
1360 1370 1380 1390 1400
VKMLSGFTPT MSSIEELENK GQVMKTEVKN DHVLFYLENV FGRADSFTFS
1410 1420 1430
VEQSNLVFNI QPAPGMVYDY YEKDGEAFLL TN
Length:1,432
Mass (Da):161,251
Last modified:February 26, 2008 - v2
Checksum:i8A32EC146C3EFB80
GO

Sequence cautioni

The sequence CAE51409.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti211 – 2111T → M.
Corresponds to variant rs7971718 [ dbSNP | Ensembl ].
VAR_055459
Natural varianti587 – 5871L → V.
Corresponds to variant rs12309295 [ dbSNP | Ensembl ].
VAR_055460
Natural varianti789 – 7891S → L.
Corresponds to variant rs11051266 [ dbSNP | Ensembl ].
VAR_055461
Natural varianti1328 – 13281V → A.
Corresponds to variant rs17418189 [ dbSNP | Ensembl ].
VAR_055462

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008010 Genomic DNA. No translation available.
AC008013 Genomic DNA. No translation available.
AC024940 Genomic DNA. No translation available.
BN000357 mRNA. Translation: CAE51409.1. Sequence problems.
UniGeneiHs.524331.

Genome annotation databases

UCSCiuc010sjy.1. human.

Polymorphism databases

DMDMi182637457.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008010 Genomic DNA. No translation available.
AC008013 Genomic DNA. No translation available.
AC024940 Genomic DNA. No translation available.
BN000357 mRNA. Translation: CAE51409.1 . Sequence problems.
UniGenei Hs.524331.

3D structure databases

ProteinModelPortali Q6IE36.
SMRi Q6IE36. Positions 13-247, 719-1424.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I39.002.

PTM databases

PhosphoSitei Q6IE36.

Polymorphism databases

DMDMi 182637457.

Proteomic databases

PaxDbi Q6IE36.
PRIDEi Q6IE36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010sjy.1. human.

Organism-specific databases

GeneCardsi GC12M031267.
neXtProti NX_Q6IE36.

Phylogenomic databases

eggNOGi NOG241555.
HOGENOMi HOG000220939.
HOVERGENi HBG000039.
InParanoidi Q6IE36.
PhylomeDBi Q6IE36.

Miscellaneous databases

PROi Q6IE36.

Gene expression databases

Genevestigatori Q6IE36.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A genomic analysis of rat proteases and protease inhibitors."
    Puente X.S., Lopez-Otin C.
    Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOVOS2_HUMAN
AccessioniPrimary (citable) accession number: Q6IE36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3