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Q6IE36

- OVOS2_HUMAN

UniProt

Q6IE36 - OVOS2_HUMAN

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Protein

Ovostatin homolog 2

Gene
OVOS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism By similarity.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Ovostatin homolog 2
Gene namesi
Name:OVOS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1432Ovostatin homolog 2PRO_0000318966
Signal peptidei1 – ? Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi858 – 8581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IE36.
PRIDEiQ6IE36.

PTM databases

PhosphoSiteiQ6IE36.

Expressioni

Gene expression databases

GenevestigatoriQ6IE36.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6IE36.
SMRiQ6IE36. Positions 13-247, 719-1424.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiNOG241555.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
InParanoidiQ6IE36.
PhylomeDBiQ6IE36.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE36-1 [UniParc]FASTAAdd to Basket

« Hide

MTGSHLSHDS WQYVLLIPSV LQEGSLDKAC AQLFNLTESV VLTVSLNYGE     50
VQTKIFEENV TGENFFKCIS FEVPQARSDP LAFITFSAKG ATLNLEERRS 100
VAIRSRENVV FVQTDKPTYK PGQKDVNGIA QFFLDTYTFT YPNITLKDPQ 150
NNRIFQWQNV TSFRNITQLS FQLISEPMFG DYWIVVKRNS RKTVTHQFAV 200
KRYVLPKFEV TVNAPQTVTI SDDEFQVDVC AKYTFGQPVQ GKTQIRVCRE 250
YFSSSNCEKN DNEICEQFIA QLENGCVSQI VNTKVFQLYR SGLFMTFHVA 300
VIVTEFGTGN YCMQISEKTS VFITQLLGTV NFENMDTFYR RGISYFGTLK 350
FSDPNNVPMV NKLLQLELND EFIGNYTTDE NGEAQFSIDT SDIFDPEFNL 400
KATYVRPKSC YLPSWLTPQY LDAHFLVSRF YSRTNSFLKI VPEPKQLECN 450
HQKVVTVHYS LNSEAYEDDS NVKFFYLVSL SHDSGNFQHR ISSSPIYTAW 500
NGNFSFPLSI SADLAPAAVL FVYTLHPSGE IVADSVRFQV DKCFKHKVNI 550
KFSNEQGLPG SNASLYLQAA PVLFCALGAV DGNVLLLKSE QQLSAESVYN 600
MVPSIEPYGY FYHGLNLDDG KEDPCIPQRD MFYNGLYYTP VSNYGDGDIY 650
NIVRNMGLKV FTNLHYRKPE VCVMERRLPL PKPLYLETEN YGPMHSVPSR 700
IACRGENADY VEQAIIQTVR TNFPETWMWD LVSVDSSGSA NLSFLIPDTI 750
TQWEASGFCV NGDVGFGISS TTTLEVSQPF FIEIASPFSV VQNEQFDLIV 800
NAFSYLNTCV EISVQVEESQ NYEANINTWK INGSEVIQAG GRKTNIWTII 850
PKKLGKVNIT VVAESKQSSA CPNEGMEQQK LNWKDTVVKS FLVEPEGIEK 900
ERTQSFLICT EGAKASKQGV LDLPNDVVEG SARGFFTVVG DILGLAMQNL 950
VVLQMPYGGG EQNAALLASD TYVLDYLKST EQLTEEVQSK AFFLLSNGYQ 1000
RQLSFKNSDG SYSVFWQQNQ KGSIWLSALT FKTLERMKKF VFIDENVQKQ 1050
TLIWLSSQQK TSGCFKNDGQ LFNHAWEGGD EEDISLTAYV VGMFFEAGLN 1100
STFPALRNAL FCLEAALDSG VTNGYNHAIL AYAFALAGKE KQVESLLQTL 1150
DQSATKLNNV IYWERERKPK TEEFPSFIPW APSAQTEKSC YVLLAVISRK 1200
IPDLTYASKI VQWLAQQMNS HGGFSSNQVI NVGLILIAIC GEEGLFSKNQ 1250
NTVTFSSEGS SEIQFNGHNR LLVQRSEVTQ APGQYTVDVE GRGCTFIQAT 1300
LKYNVLLPKK ASGFSLSLEI VKNYSLTVFD LTVNLKYTGI RNKSSMVVID 1350
VKMLSGFTPT MSSIEELENK GQVMKTEVKN DHVLFYLENV FGRADSFTFS 1400
VEQSNLVFNI QPAPGMVYDY YEKDGEAFLL TN 1432
Length:1,432
Mass (Da):161,251
Last modified:February 26, 2008 - v2
Checksum:i8A32EC146C3EFB80
GO

Sequence cautioni

The sequence CAE51409.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti211 – 2111T → M.
Corresponds to variant rs7971718 [ dbSNP | Ensembl ].
VAR_055459
Natural varianti587 – 5871L → V.
Corresponds to variant rs12309295 [ dbSNP | Ensembl ].
VAR_055460
Natural varianti789 – 7891S → L.
Corresponds to variant rs11051266 [ dbSNP | Ensembl ].
VAR_055461
Natural varianti1328 – 13281V → A.
Corresponds to variant rs17418189 [ dbSNP | Ensembl ].
VAR_055462

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008010 Genomic DNA. No translation available.
AC008013 Genomic DNA. No translation available.
AC024940 Genomic DNA. No translation available.
BN000357 mRNA. Translation: CAE51409.1. Sequence problems.
UniGeneiHs.524331.

Genome annotation databases

UCSCiuc010sjy.1. human.

Polymorphism databases

DMDMi182637457.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008010 Genomic DNA. No translation available.
AC008013 Genomic DNA. No translation available.
AC024940 Genomic DNA. No translation available.
BN000357 mRNA. Translation: CAE51409.1 . Sequence problems.
UniGenei Hs.524331.

3D structure databases

ProteinModelPortali Q6IE36.
SMRi Q6IE36. Positions 13-247, 719-1424.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6IE36.

Polymorphism databases

DMDMi 182637457.

Proteomic databases

PaxDbi Q6IE36.
PRIDEi Q6IE36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010sjy.1. human.

Organism-specific databases

GeneCardsi GC12M031267.
neXtProti NX_Q6IE36.

Phylogenomic databases

eggNOGi NOG241555.
HOGENOMi HOG000220939.
HOVERGENi HBG000039.
InParanoidi Q6IE36.
PhylomeDBi Q6IE36.

Miscellaneous databases

PROi Q6IE36.

Gene expression databases

Genevestigatori Q6IE36.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A genomic analysis of rat proteases and protease inhibitors."
    Puente X.S., Lopez-Otin C.
    Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOVOS2_HUMAN
AccessioniPrimary (citable) accession number: Q6IE36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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