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Q6IE36 (OVOS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ovostatin homolog 2
Gene names
Name:OVOS2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1432 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Sequence caution

The sequence CAE51409.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainBait region
Signal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 1432Ovostatin homolog 2PRO_0000318966

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation8581N-linked (GlcNAc...) Potential

Natural variations

Natural variant2111T → M.
Corresponds to variant rs7971718 [ dbSNP | Ensembl ].
VAR_055459
Natural variant5871L → V.
Corresponds to variant rs12309295 [ dbSNP | Ensembl ].
VAR_055460
Natural variant7891S → L.
Corresponds to variant rs11051266 [ dbSNP | Ensembl ].
VAR_055461
Natural variant13281V → A.
Corresponds to variant rs17418189 [ dbSNP | Ensembl ].
VAR_055462

Sequences

Sequence LengthMass (Da)Tools
Q6IE36 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 8A32EC146C3EFB80

FASTA1,432161,251
        10         20         30         40         50         60 
MTGSHLSHDS WQYVLLIPSV LQEGSLDKAC AQLFNLTESV VLTVSLNYGE VQTKIFEENV 

        70         80         90        100        110        120 
TGENFFKCIS FEVPQARSDP LAFITFSAKG ATLNLEERRS VAIRSRENVV FVQTDKPTYK 

       130        140        150        160        170        180 
PGQKDVNGIA QFFLDTYTFT YPNITLKDPQ NNRIFQWQNV TSFRNITQLS FQLISEPMFG 

       190        200        210        220        230        240 
DYWIVVKRNS RKTVTHQFAV KRYVLPKFEV TVNAPQTVTI SDDEFQVDVC AKYTFGQPVQ 

       250        260        270        280        290        300 
GKTQIRVCRE YFSSSNCEKN DNEICEQFIA QLENGCVSQI VNTKVFQLYR SGLFMTFHVA 

       310        320        330        340        350        360 
VIVTEFGTGN YCMQISEKTS VFITQLLGTV NFENMDTFYR RGISYFGTLK FSDPNNVPMV 

       370        380        390        400        410        420 
NKLLQLELND EFIGNYTTDE NGEAQFSIDT SDIFDPEFNL KATYVRPKSC YLPSWLTPQY 

       430        440        450        460        470        480 
LDAHFLVSRF YSRTNSFLKI VPEPKQLECN HQKVVTVHYS LNSEAYEDDS NVKFFYLVSL 

       490        500        510        520        530        540 
SHDSGNFQHR ISSSPIYTAW NGNFSFPLSI SADLAPAAVL FVYTLHPSGE IVADSVRFQV 

       550        560        570        580        590        600 
DKCFKHKVNI KFSNEQGLPG SNASLYLQAA PVLFCALGAV DGNVLLLKSE QQLSAESVYN 

       610        620        630        640        650        660 
MVPSIEPYGY FYHGLNLDDG KEDPCIPQRD MFYNGLYYTP VSNYGDGDIY NIVRNMGLKV 

       670        680        690        700        710        720 
FTNLHYRKPE VCVMERRLPL PKPLYLETEN YGPMHSVPSR IACRGENADY VEQAIIQTVR 

       730        740        750        760        770        780 
TNFPETWMWD LVSVDSSGSA NLSFLIPDTI TQWEASGFCV NGDVGFGISS TTTLEVSQPF 

       790        800        810        820        830        840 
FIEIASPFSV VQNEQFDLIV NAFSYLNTCV EISVQVEESQ NYEANINTWK INGSEVIQAG 

       850        860        870        880        890        900 
GRKTNIWTII PKKLGKVNIT VVAESKQSSA CPNEGMEQQK LNWKDTVVKS FLVEPEGIEK 

       910        920        930        940        950        960 
ERTQSFLICT EGAKASKQGV LDLPNDVVEG SARGFFTVVG DILGLAMQNL VVLQMPYGGG 

       970        980        990       1000       1010       1020 
EQNAALLASD TYVLDYLKST EQLTEEVQSK AFFLLSNGYQ RQLSFKNSDG SYSVFWQQNQ 

      1030       1040       1050       1060       1070       1080 
KGSIWLSALT FKTLERMKKF VFIDENVQKQ TLIWLSSQQK TSGCFKNDGQ LFNHAWEGGD 

      1090       1100       1110       1120       1130       1140 
EEDISLTAYV VGMFFEAGLN STFPALRNAL FCLEAALDSG VTNGYNHAIL AYAFALAGKE 

      1150       1160       1170       1180       1190       1200 
KQVESLLQTL DQSATKLNNV IYWERERKPK TEEFPSFIPW APSAQTEKSC YVLLAVISRK 

      1210       1220       1230       1240       1250       1260 
IPDLTYASKI VQWLAQQMNS HGGFSSNQVI NVGLILIAIC GEEGLFSKNQ NTVTFSSEGS 

      1270       1280       1290       1300       1310       1320 
SEIQFNGHNR LLVQRSEVTQ APGQYTVDVE GRGCTFIQAT LKYNVLLPKK ASGFSLSLEI 

      1330       1340       1350       1360       1370       1380 
VKNYSLTVFD LTVNLKYTGI RNKSSMVVID VKMLSGFTPT MSSIEELENK GQVMKTEVKN 

      1390       1400       1410       1420       1430 
DHVLFYLENV FGRADSFTFS VEQSNLVFNI QPAPGMVYDY YEKDGEAFLL TN 

« Hide

References

« Hide 'large scale' references
[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"A genomic analysis of rat proteases and protease inhibitors."
Puente X.S., Lopez-Otin C.
Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008010 Genomic DNA. No translation available.
AC008013 Genomic DNA. No translation available.
AC024940 Genomic DNA. No translation available.
BN000357 mRNA. Translation: CAE51409.1. Sequence problems.
UniGeneHs.524331.

3D structure databases

ProteinModelPortalQ6IE36.
SMRQ6IE36. Positions 13-247, 719-1424.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6IE36.

Polymorphism databases

DMDM182637457.

Proteomic databases

PaxDbQ6IE36.
PRIDEQ6IE36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc010sjy.1. human.

Organism-specific databases

GeneCardsGC12M031267.
neXtProtNX_Q6IE36.

Phylogenomic databases

eggNOGNOG241555.
HOGENOMHOG000220939.
HOVERGENHBG000039.
InParanoidQ6IE36.
PhylomeDBQ6IE36.

Gene expression databases

GenevestigatorQ6IE36.

Family and domain databases

Gene3D1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

PROQ6IE36.

Entry information

Entry nameOVOS2_HUMAN
AccessionPrimary (citable) accession number: Q6IE36
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM