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Protein

Epoxide hydrolase 4

Gene

Ephx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671NucleophileBy similarity
Active sitei279 – 2791Proton donorBy similarity
Active sitei334 – 3341Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERimouse-ephx4. Epoxide_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 4 (EC:3.3.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 7
Epoxide hydrolase-related protein
Gene namesi
Name:Ephx4
Synonyms:Abhd7, Ephxrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2686228. Ephx4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Epoxide hydrolase 4PRO_0000281379Add
BLAST

Proteomic databases

MaxQBiQ6IE26.
PaxDbiQ6IE26.
PRIDEiQ6IE26.

PTM databases

PhosphoSiteiQ6IE26.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033805.
CleanExiMM_ABHD7.
ExpressionAtlasiQ6IE26. baseline and differential.
GenevisibleiQ6IE26. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043764.

Structurei

3D structure databases

ProteinModelPortaliQ6IE26.
SMRiQ6IE26. Positions 74-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INND. Eukaryota.
ENOG410XRPK. LUCA.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
InParanoidiQ6IE26.
OMAiWRHQIPE.
OrthoDBiEOG091G0ASI.
TreeFamiTF314403.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IE26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPRPPRLL PALRALLYWS LVYGYCGLCA SVHLLKLLWS IGRAPAQTFR
60 70 80 90 100
RAARANPPAC LNDPSLGTHC YVRIKDSGLR FHYVAAGERG KPLMLLLHGF
110 120 130 140 150
PEFWYSWRHQ LREFKSEYRV VALDLRGYGE SDAPAHQESY KLDCLIADIK
160 170 180 190 200
DILDSLGYSK CVLIGHDWGG MIAWLIAVCY PEMIMKLIVI NFPHPSVFTE
210 220 230 240 250
YILRHPAQLF RSSFYYFFQI PRFPEFMFSI NDFKALKHLF TSQSTGIGRK
260 270 280 290 300
GRQLTTEDLE AYVYVFSQPG ALSGPINHYR NIFSCLPLKH HMVTTPTLLL
310 320 330 340 350
WGEEDAFMEV EMAEVTKIYV KNYFRLTILS EGSHWLQQDQ PDIVNGLIWA

FLKEETRRD
Length:359
Mass (Da):41,477
Last modified:October 3, 2012 - v2
Checksum:i27871F1D051BAA5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126598 Genomic DNA. No translation available.
BN000367 mRNA. Translation: CAE51855.1.
CCDSiCCDS19501.1.
RefSeqiNP_001001804.2. NM_001001804.2.
UniGeneiMm.489863.

Genome annotation databases

EnsembliENSMUST00000049146; ENSMUSP00000043764; ENSMUSG00000033805.
GeneIDi384214.
KEGGimmu:384214.
UCSCiuc008yme.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126598 Genomic DNA. No translation available.
BN000367 mRNA. Translation: CAE51855.1.
CCDSiCCDS19501.1.
RefSeqiNP_001001804.2. NM_001001804.2.
UniGeneiMm.489863.

3D structure databases

ProteinModelPortaliQ6IE26.
SMRiQ6IE26. Positions 74-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043764.

Protein family/group databases

ESTHERimouse-ephx4. Epoxide_hydrolase.

PTM databases

PhosphoSiteiQ6IE26.

Proteomic databases

MaxQBiQ6IE26.
PaxDbiQ6IE26.
PRIDEiQ6IE26.

Protocols and materials databases

DNASUi384214.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049146; ENSMUSP00000043764; ENSMUSG00000033805.
GeneIDi384214.
KEGGimmu:384214.
UCSCiuc008yme.1. mouse.

Organism-specific databases

CTDi253152.
MGIiMGI:2686228. Ephx4.

Phylogenomic databases

eggNOGiENOG410INND. Eukaryota.
ENOG410XRPK. LUCA.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
InParanoidiQ6IE26.
OMAiWRHQIPE.
OrthoDBiEOG091G0ASI.
TreeFamiTF314403.

Miscellaneous databases

PROiQ6IE26.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033805.
CleanExiMM_ABHD7.
ExpressionAtlasiQ6IE26. baseline and differential.
GenevisibleiQ6IE26. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPHX4_MOUSE
AccessioniPrimary (citable) accession number: Q6IE26
Secondary accession number(s): F8VQ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.