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Protein

OTU domain-containing protein 6A

Gene

Otud6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501By similarity
Active sitei153 – 1531NucleophileBy similarity
Active sitei269 – 2691By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6A (EC:3.4.19.12)
Alternative name(s):
Hin-6 protease
Gene namesi
Name:Otud6a
Synonyms:Hin6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3644685. Otud6a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290OTU domain-containing protein 6APRO_0000076278Add
BLAST

Proteomic databases

PaxDbiQ6IE21.
PRIDEiQ6IE21.

PTM databases

PhosphoSiteiQ6IE21.

Expressioni

Gene expression databases

BgeeiQ6IE21.
GenevestigatoriQ6IE21.

Structurei

3D structure databases

ProteinModelPortaliQ6IE21.
SMRiQ6IE21. Positions 137-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 276135OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni147 – 1537Cys-loopBy similarity
Regioni211 – 22111Variable-loopBy similarityAdd
BLAST
Regioni259 – 26911His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5539.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ6IE21.
KOiK18342.
OMAiMRKHVDD.
OrthoDBiEOG7WT42W.
PhylomeDBiQ6IE21.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IE21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTEQELQR VIRRHYREKR ELQAHIQTLK ASVPKNDKGR RKQMLADISR
60 70 80 90 100
LEAEMEQRHK QELEKFGENP DSSVDSVTAD LEKMNLENMP PRPPKAQKRR
110 120 130 140 150
DRRAHQERRH QERMPAAQAE QLAANRREEE EKVAAILGAK NLEMKTIPAD
160 170 180 190 200
GHCMYRAIQD QLVFSVTIES LRYRTAYYMR KHIDDFLPFF TEPEAGNFYT
210 220 230 240 250
REDFLRYCDD IVHNASWGGQ LELRALSHVL QTPIEVVQAN SPTIVIGEEY
260 270 280 290
TRKPVTLVYL HYACDFGEHY NSVKPIEVAG AFGGMAPRLF
Length:290
Mass (Da):33,738
Last modified:July 5, 2004 - v1
Checksum:iDFCA5FACB71A6469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA. Translation: CAM19581.1.
BC153817 mRNA. Translation: AAI53818.1.
BN000372 mRNA. Translation: CAE51898.1.
CCDSiCCDS53146.1.
RefSeqiNP_001156663.1. NM_001163191.1.
UniGeneiMm.469910.

Genome annotation databases

EnsembliENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
GeneIDi408193.
KEGGimmu:408193.
UCSCiuc012hms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA. Translation: CAM19581.1.
BC153817 mRNA. Translation: AAI53818.1.
BN000372 mRNA. Translation: CAE51898.1.
CCDSiCCDS53146.1.
RefSeqiNP_001156663.1. NM_001163191.1.
UniGeneiMm.469910.

3D structure databases

ProteinModelPortaliQ6IE21.
SMRiQ6IE21. Positions 137-276.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6IE21.

Proteomic databases

PaxDbiQ6IE21.
PRIDEiQ6IE21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
GeneIDi408193.
KEGGimmu:408193.
UCSCiuc012hms.1. mouse.

Organism-specific databases

CTDi139562.
MGIiMGI:3644685. Otud6a.

Phylogenomic databases

eggNOGiCOG5539.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ6IE21.
KOiK18342.
OMAiMRKHVDD.
OrthoDBiEOG7WT42W.
PhylomeDBiQ6IE21.
TreeFamiTF315010.

Miscellaneous databases

NextBioi407405.
PROiQ6IE21.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IE21.
GenevestigatoriQ6IE21.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "A genomic analysis of rat proteases and protease inhibitors."
    Puente X.S., Lopez-Otin C.
    Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOTU6A_MOUSE
AccessioniPrimary (citable) accession number: Q6IE21
Secondary accession number(s): A2ADU1, A8E630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.