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Q6IE21

- OTU6A_MOUSE

UniProt

Q6IE21 - OTU6A_MOUSE

Protein

OTU domain-containing protein 6A

Gene

Otud6a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501By similarity
    Active sitei153 – 1531NucleophileBy similarity
    Active sitei269 – 2691By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K11-linked deubiquitination Source: UniProtKB
    2. protein K27-linked deubiquitination Source: UniProtKB
    3. protein K29-linked deubiquitination Source: UniProtKB
    4. protein K33-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6A (EC:3.4.19.12)
    Alternative name(s):
    Hin-6 protease
    Gene namesi
    Name:Otud6a
    Synonyms:Hin6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:3644685. Otud6a.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290OTU domain-containing protein 6APRO_0000076278Add
    BLAST

    Proteomic databases

    PaxDbiQ6IE21.
    PRIDEiQ6IE21.

    PTM databases

    PhosphoSiteiQ6IE21.

    Expressioni

    Gene expression databases

    BgeeiQ6IE21.
    GenevestigatoriQ6IE21.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IE21.
    SMRiQ6IE21. Positions 137-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini142 – 276135OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni147 – 1537Cys-loopBy similarity
    Regioni211 – 22111Variable-loopBy similarityAdd
    BLAST
    Regioni259 – 26911His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    GeneTreeiENSGT00390000012840.
    HOGENOMiHOG000192906.
    HOVERGENiHBG080227.
    InParanoidiA8E630.
    KOiK18342.
    OMAiKHVDDFL.
    OrthoDBiEOG7WT42W.
    PhylomeDBiQ6IE21.
    TreeFamiTF315010.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IE21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTEQELQR VIRRHYREKR ELQAHIQTLK ASVPKNDKGR RKQMLADISR    50
    LEAEMEQRHK QELEKFGENP DSSVDSVTAD LEKMNLENMP PRPPKAQKRR 100
    DRRAHQERRH QERMPAAQAE QLAANRREEE EKVAAILGAK NLEMKTIPAD 150
    GHCMYRAIQD QLVFSVTIES LRYRTAYYMR KHIDDFLPFF TEPEAGNFYT 200
    REDFLRYCDD IVHNASWGGQ LELRALSHVL QTPIEVVQAN SPTIVIGEEY 250
    TRKPVTLVYL HYACDFGEHY NSVKPIEVAG AFGGMAPRLF 290
    Length:290
    Mass (Da):33,738
    Last modified:July 5, 2004 - v1
    Checksum:iDFCA5FACB71A6469
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671299 Genomic DNA. Translation: CAM19581.1.
    BC153817 mRNA. Translation: AAI53818.1.
    BN000372 mRNA. Translation: CAE51898.1.
    CCDSiCCDS53146.1.
    RefSeqiNP_001156663.1. NM_001163191.1.
    UniGeneiMm.469910.

    Genome annotation databases

    EnsembliENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
    GeneIDi408193.
    KEGGimmu:408193.
    UCSCiuc012hms.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671299 Genomic DNA. Translation: CAM19581.1 .
    BC153817 mRNA. Translation: AAI53818.1 .
    BN000372 mRNA. Translation: CAE51898.1 .
    CCDSi CCDS53146.1.
    RefSeqi NP_001156663.1. NM_001163191.1.
    UniGenei Mm.469910.

    3D structure databases

    ProteinModelPortali Q6IE21.
    SMRi Q6IE21. Positions 137-276.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6IE21.

    Proteomic databases

    PaxDbi Q6IE21.
    PRIDEi Q6IE21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060241 ; ENSMUSP00000059861 ; ENSMUSG00000051582 .
    GeneIDi 408193.
    KEGGi mmu:408193.
    UCSCi uc012hms.1. mouse.

    Organism-specific databases

    CTDi 139562.
    MGIi MGI:3644685. Otud6a.

    Phylogenomic databases

    eggNOGi COG5539.
    GeneTreei ENSGT00390000012840.
    HOGENOMi HOG000192906.
    HOVERGENi HBG080227.
    InParanoidi A8E630.
    KOi K18342.
    OMAi KHVDDFL.
    OrthoDBi EOG7WT42W.
    PhylomeDBi Q6IE21.
    TreeFami TF315010.

    Miscellaneous databases

    NextBioi 407405.
    PROi Q6IE21.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6IE21.
    Genevestigatori Q6IE21.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "A genomic analysis of rat proteases and protease inhibitors."
      Puente X.S., Lopez-Otin C.
      Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiOTU6A_MOUSE
    AccessioniPrimary (citable) accession number: Q6IE21
    Secondary accession number(s): A2ADU1, A8E630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3