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Protein

OTU domain-containing protein 6A

Gene

Otud6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150By similarity1
Active sitei153NucleophileBy similarity1
Active sitei269By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.008.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6A (EC:3.4.19.12)
Alternative name(s):
Hin-6 protease
Gene namesi
Name:Otud6a
Synonyms:Hin6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3644685. Otud6a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762781 – 290OTU domain-containing protein 6AAdd BLAST290

Proteomic databases

PaxDbiQ6IE21.
PRIDEiQ6IE21.

PTM databases

iPTMnetiQ6IE21.
PhosphoSitePlusiQ6IE21.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051582.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059861.

Structurei

3D structure databases

ProteinModelPortaliQ6IE21.
SMRiQ6IE21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 276OTUPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 153Cys-loopBy similarity7
Regioni211 – 221Variable-loopBy similarityAdd BLAST11
Regioni259 – 269His-loopBy similarityAdd BLAST11

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2606. Eukaryota.
COG5539. LUCA.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ6IE21.
KOiK18342.
OMAiWISYHRR.
OrthoDBiEOG091G0VVZ.
PhylomeDBiQ6IE21.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IE21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTEQELQR VIRRHYREKR ELQAHIQTLK ASVPKNDKGR RKQMLADISR
60 70 80 90 100
LEAEMEQRHK QELEKFGENP DSSVDSVTAD LEKMNLENMP PRPPKAQKRR
110 120 130 140 150
DRRAHQERRH QERMPAAQAE QLAANRREEE EKVAAILGAK NLEMKTIPAD
160 170 180 190 200
GHCMYRAIQD QLVFSVTIES LRYRTAYYMR KHIDDFLPFF TEPEAGNFYT
210 220 230 240 250
REDFLRYCDD IVHNASWGGQ LELRALSHVL QTPIEVVQAN SPTIVIGEEY
260 270 280 290
TRKPVTLVYL HYACDFGEHY NSVKPIEVAG AFGGMAPRLF
Length:290
Mass (Da):33,738
Last modified:July 5, 2004 - v1
Checksum:iDFCA5FACB71A6469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA. Translation: CAM19581.1.
BC153817 mRNA. Translation: AAI53818.1.
BN000372 mRNA. Translation: CAE51898.1.
CCDSiCCDS53146.1.
RefSeqiNP_001156663.1. NM_001163191.1.
UniGeneiMm.469910.

Genome annotation databases

EnsembliENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
GeneIDi408193.
KEGGimmu:408193.
UCSCiuc012hms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA. Translation: CAM19581.1.
BC153817 mRNA. Translation: AAI53818.1.
BN000372 mRNA. Translation: CAE51898.1.
CCDSiCCDS53146.1.
RefSeqiNP_001156663.1. NM_001163191.1.
UniGeneiMm.469910.

3D structure databases

ProteinModelPortaliQ6IE21.
SMRiQ6IE21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059861.

Protein family/group databases

MEROPSiC85.008.

PTM databases

iPTMnetiQ6IE21.
PhosphoSitePlusiQ6IE21.

Proteomic databases

PaxDbiQ6IE21.
PRIDEiQ6IE21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
GeneIDi408193.
KEGGimmu:408193.
UCSCiuc012hms.1. mouse.

Organism-specific databases

CTDi139562.
MGIiMGI:3644685. Otud6a.

Phylogenomic databases

eggNOGiKOG2606. Eukaryota.
COG5539. LUCA.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ6IE21.
KOiK18342.
OMAiWISYHRR.
OrthoDBiEOG091G0VVZ.
PhylomeDBiQ6IE21.
TreeFamiTF315010.

Miscellaneous databases

PROiQ6IE21.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051582.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTU6A_MOUSE
AccessioniPrimary (citable) accession number: Q6IE21
Secondary accession number(s): A2ADU1, A8E630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.