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Q6IE21 (OTU6A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 6A

EC=3.4.19.12
Alternative name(s):
Hin-6 protease
Gene names
Name:Otud6a
Synonyms:Hin6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Contains 1 OTU domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290OTU domain-containing protein 6A
PRO_0000076278

Regions

Domain142 – 276135OTU
Region147 – 1537Cys-loop By similarity
Region211 – 22111Variable-loop By similarity
Region259 – 26911His-loop By similarity

Sites

Active site1501 By similarity
Active site1531Nucleophile By similarity
Active site2691 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IE21 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: DFCA5FACB71A6469

FASTA29033,738
        10         20         30         40         50         60 
MSDTEQELQR VIRRHYREKR ELQAHIQTLK ASVPKNDKGR RKQMLADISR LEAEMEQRHK 

        70         80         90        100        110        120 
QELEKFGENP DSSVDSVTAD LEKMNLENMP PRPPKAQKRR DRRAHQERRH QERMPAAQAE 

       130        140        150        160        170        180 
QLAANRREEE EKVAAILGAK NLEMKTIPAD GHCMYRAIQD QLVFSVTIES LRYRTAYYMR 

       190        200        210        220        230        240 
KHIDDFLPFF TEPEAGNFYT REDFLRYCDD IVHNASWGGQ LELRALSHVL QTPIEVVQAN 

       250        260        270        280        290 
SPTIVIGEEY TRKPVTLVYL HYACDFGEHY NSVKPIEVAG AFGGMAPRLF 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"A genomic analysis of rat proteases and protease inhibitors."
Puente X.S., Lopez-Otin C.
Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL671299 Genomic DNA. Translation: CAM19581.1.
BC153817 mRNA. Translation: AAI53818.1.
BN000372 mRNA. Translation: CAE51898.1.
RefSeqNP_001156663.1. NM_001163191.1.
UniGeneMm.469910.

3D structure databases

ProteinModelPortalQ6IE21.
SMRQ6IE21. Positions 137-276.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6IE21.

Proteomic databases

PaxDbQ6IE21.
PRIDEQ6IE21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
GeneID408193.
KEGGmmu:408193.
UCSCuc012hms.1. mouse.

Organism-specific databases

CTD139562.
MGIMGI:3644685. Otud6a.

Phylogenomic databases

eggNOGCOG5539.
GeneTreeENSGT00390000012840.
HOGENOMHOG000192906.
HOVERGENHBG080227.
InParanoidA8E630.
OMAKHVDDFL.
OrthoDBEOG7WT42W.
PhylomeDBQ6IE21.
TreeFamTF315010.

Gene expression databases

BgeeQ6IE21.
GenevestigatorQ6IE21.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio407405.
PROQ6IE21.
SOURCESearch...

Entry information

Entry nameOTU6A_MOUSE
AccessionPrimary (citable) accession number: Q6IE21
Secondary accession number(s): A2ADU1, A8E630
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot