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Q6IE21

- OTU6A_MOUSE

UniProt

Q6IE21 - OTU6A_MOUSE

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Protein

OTU domain-containing protein 6A

Gene

Otud6a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501By similarity
Active sitei153 – 1531NucleophileBy similarity
Active sitei269 – 2691By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K11-linked deubiquitination Source: UniProtKB
  2. protein K27-linked deubiquitination Source: UniProtKB
  3. protein K29-linked deubiquitination Source: UniProtKB
  4. protein K33-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6A (EC:3.4.19.12)
Alternative name(s):
Hin-6 protease
Gene namesi
Name:Otud6a
Synonyms:Hin6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:3644685. Otud6a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290OTU domain-containing protein 6APRO_0000076278Add
BLAST

Proteomic databases

PaxDbiQ6IE21.
PRIDEiQ6IE21.

PTM databases

PhosphoSiteiQ6IE21.

Expressioni

Gene expression databases

BgeeiQ6IE21.
GenevestigatoriQ6IE21.

Structurei

3D structure databases

ProteinModelPortaliQ6IE21.
SMRiQ6IE21. Positions 137-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 276135OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni147 – 1537Cys-loopBy similarity
Regioni211 – 22111Variable-loopBy similarityAdd
BLAST
Regioni259 – 26911His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5539.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ6IE21.
KOiK18342.
OMAiKHVDDFL.
OrthoDBiEOG7WT42W.
PhylomeDBiQ6IE21.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IE21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTEQELQR VIRRHYREKR ELQAHIQTLK ASVPKNDKGR RKQMLADISR
60 70 80 90 100
LEAEMEQRHK QELEKFGENP DSSVDSVTAD LEKMNLENMP PRPPKAQKRR
110 120 130 140 150
DRRAHQERRH QERMPAAQAE QLAANRREEE EKVAAILGAK NLEMKTIPAD
160 170 180 190 200
GHCMYRAIQD QLVFSVTIES LRYRTAYYMR KHIDDFLPFF TEPEAGNFYT
210 220 230 240 250
REDFLRYCDD IVHNASWGGQ LELRALSHVL QTPIEVVQAN SPTIVIGEEY
260 270 280 290
TRKPVTLVYL HYACDFGEHY NSVKPIEVAG AFGGMAPRLF
Length:290
Mass (Da):33,738
Last modified:July 5, 2004 - v1
Checksum:iDFCA5FACB71A6469
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL671299 Genomic DNA. Translation: CAM19581.1.
BC153817 mRNA. Translation: AAI53818.1.
BN000372 mRNA. Translation: CAE51898.1.
CCDSiCCDS53146.1.
RefSeqiNP_001156663.1. NM_001163191.1.
UniGeneiMm.469910.

Genome annotation databases

EnsembliENSMUST00000060241; ENSMUSP00000059861; ENSMUSG00000051582.
GeneIDi408193.
KEGGimmu:408193.
UCSCiuc012hms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL671299 Genomic DNA. Translation: CAM19581.1 .
BC153817 mRNA. Translation: AAI53818.1 .
BN000372 mRNA. Translation: CAE51898.1 .
CCDSi CCDS53146.1.
RefSeqi NP_001156663.1. NM_001163191.1.
UniGenei Mm.469910.

3D structure databases

ProteinModelPortali Q6IE21.
SMRi Q6IE21. Positions 137-276.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6IE21.

Proteomic databases

PaxDbi Q6IE21.
PRIDEi Q6IE21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060241 ; ENSMUSP00000059861 ; ENSMUSG00000051582 .
GeneIDi 408193.
KEGGi mmu:408193.
UCSCi uc012hms.1. mouse.

Organism-specific databases

CTDi 139562.
MGIi MGI:3644685. Otud6a.

Phylogenomic databases

eggNOGi COG5539.
GeneTreei ENSGT00390000012840.
HOGENOMi HOG000192906.
HOVERGENi HBG080227.
InParanoidi Q6IE21.
KOi K18342.
OMAi KHVDDFL.
OrthoDBi EOG7WT42W.
PhylomeDBi Q6IE21.
TreeFami TF315010.

Miscellaneous databases

NextBioi 407405.
PROi Q6IE21.
SOURCEi Search...

Gene expression databases

Bgeei Q6IE21.
Genevestigatori Q6IE21.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "A genomic analysis of rat proteases and protease inhibitors."
    Puente X.S., Lopez-Otin C.
    Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOTU6A_MOUSE
AccessioniPrimary (citable) accession number: Q6IE21
Secondary accession number(s): A2ADU1, A8E630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3