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Protein

Transmembrane protease serine 11B-like protein

Gene

Tmprss11bnl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serine protease.By similarity

Enzyme regulationi

Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei229Charge relay systemBy similarity1
Active sitei274Charge relay systemBy similarity1
Active sitei370Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.321.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11B-like protein (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 5
Transmembrane protease serine 11B
Gene namesi
Name:Tmprss11bnl
Synonyms:Hatl5, Tmprss11b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1303278. Tmprss11bnl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini41 – 420ExtracellularSequence analysisAdd BLAST380

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993211 – 420Transmembrane protease serine 11B-like proteinAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi214 ↔ 230PROSITE-ProRule annotation
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi339 ↔ 355PROSITE-ProRule annotation
Disulfide bondi366 ↔ 395PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IE14.
PRIDEiQ6IE14.

Structurei

3D structure databases

ProteinModelPortaliQ6IE14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 165SEAPROSITE-ProRule annotationAdd BLAST118
Domaini189 – 419Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6IE14.
KOiK09751.
OMAiIINNRCG.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ6IE14.
TreeFamiTF351684.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IE14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSKLRPVI ASRKSFPPWM IILGVLGVLA ILGLIIGLLV HFLAVENKIY
60 70 80 90 100
YYQGSFKVLN IPYDRNYERE TSLESNYLSK ILEIKMVDAF ESSNIYKQYI
110 120 130 140 150
NSQIITLVPE NNSVTAHIWL VFKDPWSNKE NLRRRIESIL HQMLENNSGS
160 170 180 190 200
LTTDPGSLKL TEITKVDAEK IINNRCGRRP RMSATYDRIT GGSTAQKGEW
210 220 230 240 250
PWQASLRVNG KHHCGASLIG ERFLLTAAHC FLRTNNPKNL TVSFGTRVTP
260 270 280 290 300
AYMQHYVEEV IIHEDYVKGQ HHDDVAIIKL TEKVSFRNDV HRVCLPEATQ
310 320 330 340 350
VFPPGEGVVV TGWGSLSYNG KSPLLLQKAS IKIIDTNACN SEEAYGGRIM
360 370 380 390 400
DTMLCAGYME GYVDACQGDS GGPLVHPNSR DIWYLVGIVS WGHECGRVNK
410 420
PGVYMRVTSY RDWIASKTGI
Length:420
Mass (Da):47,242
Last modified:July 5, 2004 - v1
Checksum:iBC0D61CB9761AD2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03092659 Genomic DNA. No translation available.
AABR03092237 Genomic DNA. No translation available.
BN000379 mRNA. Translation: CAE51905.1.
RefSeqiNP_001004020.1. NM_001004020.1.
UniGeneiRn.138998.

Genome annotation databases

EnsembliENSRNOT00000002743; ENSRNOP00000002743; ENSRNOG00000002002.
GeneIDi365265.
KEGGirno:365265.
UCSCiRGD:1303278. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03092659 Genomic DNA. No translation available.
AABR03092237 Genomic DNA. No translation available.
BN000379 mRNA. Translation: CAE51905.1.
RefSeqiNP_001004020.1. NM_001004020.1.
UniGeneiRn.138998.

3D structure databases

ProteinModelPortaliQ6IE14.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.321.

Proteomic databases

PaxDbiQ6IE14.
PRIDEiQ6IE14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002743; ENSRNOP00000002743; ENSRNOG00000002002.
GeneIDi365265.
KEGGirno:365265.
UCSCiRGD:1303278. rat.

Organism-specific databases

CTDi132724.
RGDi1303278. Tmprss11bnl.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6IE14.
KOiK09751.
OMAiIINNRCG.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ6IE14.
TreeFamiTF351684.

Miscellaneous databases

PROiQ6IE14.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM11L_RAT
AccessioniPrimary (citable) accession number: Q6IE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.