Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione hydrolase 6

Gene

Ggt6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processGlutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-174403. Glutathione synthesis and recycling.
R-RNO-5423646. Aflatoxin activation and detoxification.
UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase 6 (EC:3.4.19.13)
Alternative name(s):
Gamma-glutamyltransferase 6 (EC:2.3.2.2)
Short name:
GGT 6
Gamma-glutamyltranspeptidase 6
Cleaved into the following 2 chains:
Gene namesi
Name:Ggt6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1303335. Ggt6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini71 – 498ExtracellularSequence analysisAdd BLAST428

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000314959? – 498Glutathione hydrolase 6 light chain
ChainiPRO_00003149581 – ?Glutathione hydrolase 6 heavy chain

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6IE08.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015210.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039691.

Structurei

3D structure databases

ProteinModelPortaliQ6IE08.
SMRiQ6IE08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 30Poly-Glu10

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6IE08.
KOiK00681.
OMAiCPLLCHA.
OrthoDBiEOG091G0EVC.
PhylomeDBiQ6IE08.
TreeFamiTF338758.

Family and domain databases

InterProiView protein in InterPro
IPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
PANTHERiPTHR11686. PTHR11686. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATTGAVLY QKLQLWEPGM ESEEEEEEEE IAEPLVLSLR RLQNTPGNKV
60 70 80 90 100
GGLPGAWTRL LAGLLLLAVS SSLALRQLQG RNSPKGNLGP VDLPASRHSH
110 120 130 140 150
HPGVYHHSAV ISPAATCSRL GQELLVAGGN VVDAGVGAAL CLAVVHPHAT
160 170 180 190 200
GLGATFWGLF YNSSSGNSTA LTAGPAQILA PGLGLPTALP ALHLLHTHFG
210 220 230 240 250
RLPWSHLLAK PAMLAQKGFE VDAPLASALA AQGTEGLCPL FCHTNGTPLG
260 270 280 290 300
LGAQVTNPNL AAVLLREALA SSPDLVGNAL LNLLVRDLGL ELPSVQPKPS
310 320 330 340 350
LEPALQLLLP QGVLFTTPGP SAGPELMGLL ESTLHSKTPS PASCSSLLQT
360 370 380 390 400
AETPVSSALA TVDSHGSMLL LTSSLNSSFG SGHLSPSTGV LLSNLEASSV
410 420 430 440 450
PSTWACPLIL RGNLDDTEDD MLGLVASGIP RGAKAMACTL FNHLTTPQTQ
460 470 480 490
QQVQHQAQQR PTESPGICGK EALLQVVVHA EHAQVSSIPS GCCPFQGY
Length:498
Mass (Da):51,559
Last modified:July 5, 2004 - v1
Checksum:iD88B4463EE6BE62F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095632 Genomic DNA. No translation available.
BN000385 mRNA. Translation: CAE51911.1.
RefSeqiNP_001002820.1. NM_001002820.1.
UniGeneiRn.113458.

Genome annotation databases

EnsembliENSRNOT00000045100; ENSRNOP00000039691; ENSRNOG00000015210.
GeneIDi408206.
KEGGirno:408206.

Similar proteinsi

Entry informationi

Entry nameiGGT6_RAT
AccessioniPrimary (citable) accession number: Q6IE08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome