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Protein

Gamma-glutamyltransferase 6

Gene

Ggt6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Glutathione biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyltransferase 6 (EC:2.3.2.2)
Short name:
GGT 6
Alternative name(s):
Gamma-glutamyltranspeptidase 6
Glutathione hydrolase 6 (EC:3.4.19.13)
Cleaved into the following 2 chains:
Gene namesi
Name:Ggt6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1303335. Ggt6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini71 – 498428ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 498Gamma-glutamyltransferase 6 light chainPRO_0000314959
Chaini1 – ?Gamma-glutamyltransferase 6 heavy chainPRO_0000314958

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6IE08.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015210.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039691.

Structurei

3D structure databases

ProteinModelPortaliQ6IE08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 3010Poly-Glu

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6IE08.
KOiK00681.
OMAiCPLLCHA.
OrthoDBiEOG091G0EVC.
PhylomeDBiQ6IE08.
TreeFamiTF338758.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 2 hits.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IE08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATTGAVLY QKLQLWEPGM ESEEEEEEEE IAEPLVLSLR RLQNTPGNKV
60 70 80 90 100
GGLPGAWTRL LAGLLLLAVS SSLALRQLQG RNSPKGNLGP VDLPASRHSH
110 120 130 140 150
HPGVYHHSAV ISPAATCSRL GQELLVAGGN VVDAGVGAAL CLAVVHPHAT
160 170 180 190 200
GLGATFWGLF YNSSSGNSTA LTAGPAQILA PGLGLPTALP ALHLLHTHFG
210 220 230 240 250
RLPWSHLLAK PAMLAQKGFE VDAPLASALA AQGTEGLCPL FCHTNGTPLG
260 270 280 290 300
LGAQVTNPNL AAVLLREALA SSPDLVGNAL LNLLVRDLGL ELPSVQPKPS
310 320 330 340 350
LEPALQLLLP QGVLFTTPGP SAGPELMGLL ESTLHSKTPS PASCSSLLQT
360 370 380 390 400
AETPVSSALA TVDSHGSMLL LTSSLNSSFG SGHLSPSTGV LLSNLEASSV
410 420 430 440 450
PSTWACPLIL RGNLDDTEDD MLGLVASGIP RGAKAMACTL FNHLTTPQTQ
460 470 480 490
QQVQHQAQQR PTESPGICGK EALLQVVVHA EHAQVSSIPS GCCPFQGY
Length:498
Mass (Da):51,559
Last modified:July 5, 2004 - v1
Checksum:iD88B4463EE6BE62F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095632 Genomic DNA. No translation available.
BN000385 mRNA. Translation: CAE51911.1.
RefSeqiNP_001002820.1. NM_001002820.1.
UniGeneiRn.113458.

Genome annotation databases

EnsembliENSRNOT00000045100; ENSRNOP00000039691; ENSRNOG00000015210.
GeneIDi408206.
KEGGirno:408206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095632 Genomic DNA. No translation available.
BN000385 mRNA. Translation: CAE51911.1.
RefSeqiNP_001002820.1. NM_001002820.1.
UniGeneiRn.113458.

3D structure databases

ProteinModelPortaliQ6IE08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039691.

Protein family/group databases

MEROPSiT03.022.

Proteomic databases

PaxDbiQ6IE08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045100; ENSRNOP00000039691; ENSRNOG00000015210.
GeneIDi408206.
KEGGirno:408206.

Organism-specific databases

CTDi124975.
RGDi1303335. Ggt6.

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6IE08.
KOiK00681.
OMAiCPLLCHA.
OrthoDBiEOG091G0EVC.
PhylomeDBiQ6IE08.
TreeFamiTF338758.

Enzyme and pathway databases

UniPathwayiUPA00204.

Miscellaneous databases

PROiQ6IE08.

Gene expression databases

BgeeiENSRNOG00000015210.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 2 hits.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGT6_RAT
AccessioniPrimary (citable) accession number: Q6IE08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.