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Q6IE06

- PRS58_RAT

UniProt

Q6IE06 - PRS58_RAT

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Protein
Putative inactive serine protease 58
Gene
Prss58, Tryx3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Charge relay system By similarity
Active sitei100 – 1001Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative inactive serine protease 58 (EC:3.4.21.4)
    Alternative name(s):
    Trypsin-X3
    Gene namesi
    Name:Prss58
    Synonyms:Tryx3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1303054. Prss58.

    Subcellular locationi

    Secreted Reviewed prediction

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616 Reviewed prediction
    Add
    BLAST
    Chaini17 – 240224Putative inactive serine protease 58
    PRO_5000096013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 56 By similarity
    Disulfide bondi132 ↔ 200 By similarity
    Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi164 ↔ 179 By similarity
    Disulfide bondi190 ↔ 214 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ6IE06.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6IE06.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017611.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IE06.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 238222Peptidase S1
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117405.
    HOVERGENiHBG013304.
    InParanoidiQ6IE06.
    OMAiVSTWAYN.
    OrthoDBiEOG7TBC32.
    PhylomeDBiQ6IE06.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6IE06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLVFCILST LLGTFAYNPD HIAGTTPPYL VYLKSDYLPC TGVLIHPLWV    50
    VTSAHCNLPD LRVILGITNP ADTTEHDVEV SDYEKMFRHP YFSVSSISYD 100
    LMLIKLRRGI KHSYYAKAVK LPQHTVPVNA MCSVSTWAYN LCDVTKEPDS 150
    LQTVNVSVIS KAECHNAYKA FDIRENMICV GIVPGRRLPC KEVTAAPAVC 200
    NGVLYGILSY ADGCVLRADV GIYASIFHYM PWIENIMKNN 240
    Length:240
    Mass (Da):26,812
    Last modified:July 5, 2004 - v1
    Checksum:i0A7841D62039FB8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC094798 Genomic DNA. No translation available.
    BN000387 mRNA. Translation: CAE51913.1.
    RefSeqiNP_001009174.1. NM_001009174.1.
    XP_006236428.1. XM_006236366.1.
    XP_006236429.1. XM_006236367.1.
    UniGeneiRn.125929.

    Genome annotation databases

    EnsembliENSRNOT00000017611; ENSRNOP00000017611; ENSRNOG00000013132.
    GeneIDi408204.
    KEGGirno:408204.
    UCSCiRGD:1303054. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC094798 Genomic DNA. No translation available.
    BN000387 mRNA. Translation: CAE51913.1 .
    RefSeqi NP_001009174.1. NM_001009174.1.
    XP_006236428.1. XM_006236366.1.
    XP_006236429.1. XM_006236367.1.
    UniGenei Rn.125929.

    3D structure databases

    ProteinModelPortali Q6IE06.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017611.

    Protein family/group databases

    MEROPSi S01.984.

    Proteomic databases

    PRIDEi Q6IE06.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017611 ; ENSRNOP00000017611 ; ENSRNOG00000013132 .
    GeneIDi 408204.
    KEGGi rno:408204.
    UCSCi RGD:1303054. rat.

    Organism-specific databases

    CTDi 136541.
    RGDi 1303054. Prss58.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117405.
    HOVERGENi HBG013304.
    InParanoidi Q6IE06.
    OMAi VSTWAYN.
    OrthoDBi EOG7TBC32.
    PhylomeDBi Q6IE06.
    TreeFami TF331065.

    Miscellaneous databases

    NextBioi 696400.
    PROi Q6IE06.

    Gene expression databases

    Genevestigatori Q6IE06.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "A genomic analysis of rat proteases and protease inhibitors."
      Puente X.S., Lopez-Otin C.
      Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiPRS58_RAT
    AccessioniPrimary (citable) accession number: Q6IE06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2004
    Last modified: May 14, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Thr-195 is present instead of the conserved Ser which is expected to be an active site residue. It is therefore unsure if this protein has kept its catalytic activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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