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Protein

Laccase-10

Gene

LAC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Copper 1; type 2By similarity1
Metal bindingi82Copper 2; type 3By similarity1
Metal bindingi125Copper 2; type 3By similarity1
Metal bindingi127Copper 3; type 3By similarity1
Metal bindingi459Copper 4; type 1By similarity1
Metal bindingi462Copper 1; type 2By similarity1
Metal bindingi464Copper 3; type 3By similarity1
Metal bindingi521Copper 3; type 3By similarity1
Metal bindingi522Copper 4; type 1By similarity1
Metal bindingi523Copper 2; type 3By similarity1
Metal bindingi527Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01190-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-10 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 10
Diphenol oxidase 10
Urishiol oxidase 10
Gene namesi
Name:LAC10
Ordered Locus Names:At5g01190
ORF Names:F7J8.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G01190
TAIRilocus:2150139 AT5G01190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000028363823 – 558Laccase-10Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ID18
PRIDEiQ6ID18

Expressioni

Tissue specificityi

Ubiquitous, with lower levels in siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ6ID18 baseline and differential
GenevisibleiQ6ID18 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G01190.1

Structurei

3D structure databases

ProteinModelPortaliQ6ID18
SMRiQ6ID18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 146Plastocyanin-like 1Add BLAST117
Domaini157 – 308Plastocyanin-like 2Add BLAST152
Domaini408 – 542Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ6ID18
KOiK05909
OMAiNSKTYPA
OrthoDBiEOG093605NS
PhylomeDBiQ6ID18

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ID18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPIRILVL FALLAFPACV HGAIRKYTFN VVTKQVTRIC STKQIVTVNG
60 70 80 90 100
KFPGPTIYAN EDDTILVNVV NNVKYNVSIH WHGIRQLRTG WADGPAYITQ
110 120 130 140 150
CPIKPGHSYV YNFTVTGQRG TLWWHAHVLW LRATVHGAIV ILPKLGLPYP
160 170 180 190 200
FPKPHREEVI ILGEWWKSDT ETVVNEALKS GLAPNVSDAH VINGHPGFVP
210 220 230 240 250
NCPSQGNFKL AVESGKTYML RLINAALNEE LFFKIAGHRF TVVEVDAVYV
260 270 280 290 300
KPFNTDTILI APGQTTTALV SAARPSGQYL IAAAPFQDSA VVAVDNRTAT
310 320 330 340 350
ATVHYSGTLS ATPTKTTSPP PQNATSVANT FVNSLRSLNS KTYPANVPIT
360 370 380 390 400
VDHDLLFTVG LGINRCHSCK AGNFSRVVAA INNITFKMPK TALLQAHYFN
410 420 430 440 450
LTGIYTTDFP AKPRRVFDFT GKPPSNLATM KATKLYKLPY NSTVQVVLQD
460 470 480 490 500
TGNVAPENHP IHLHGFNFFV VGLGTGNYNS KKDSNKFNLV DPVERNTVGV
510 520 530 540 550
PSGGWAAIRF RADNPGVWFM HCHLEVHTTW GLKMAFLVEN GKGPNQSIRP

PPSDLPKC
Length:558
Mass (Da):61,298
Last modified:July 5, 2004 - v1
Checksum:i4F0CACDA7088ACBA
GO

Sequence cautioni

The sequence CAB69847 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137189 Genomic DNA Translation: CAB69847.1 Sequence problems.
CP002688 Genomic DNA Translation: AED90308.1
BT014855 mRNA Translation: AAT41838.1
PIRiT45959
RefSeqiNP_195739.2, NM_120197.4
UniGeneiAt.33933
At.67929

Genome annotation databases

EnsemblPlantsiAT5G01190.1; AT5G01190.1; AT5G01190
GeneIDi831697
GrameneiAT5G01190.1; AT5G01190.1; AT5G01190
KEGGiath:AT5G01190

Similar proteinsi

Entry informationi

Entry nameiLAC10_ARATH
AccessioniPrimary (citable) accession number: Q6ID18
Secondary accession number(s): Q9LFB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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