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Q6ID18

- LAC10_ARATH

UniProt

Q6ID18 - LAC10_ARATH

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Protein

Laccase-10

Gene

LAC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Copper 1; type 2By similarity
Metal bindingi82 – 821Copper 2; type 3By similarity
Metal bindingi125 – 1251Copper 2; type 3By similarity
Metal bindingi127 – 1271Copper 3; type 3By similarity
Metal bindingi459 – 4591Copper 4; type 1By similarity
Metal bindingi462 – 4621Copper 1; type 2By similarity
Metal bindingi464 – 4641Copper 3; type 3By similarity
Metal bindingi521 – 5211Copper 3; type 3By similarity
Metal bindingi522 – 5221Copper 4; type 1By similarity
Metal bindingi523 – 5231Copper 2; type 3By similarity
Metal bindingi527 – 5271Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01190-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-10 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 10
Diphenol oxidase 10
Urishiol oxidase 10
Gene namesi
Name:LAC10
Ordered Locus Names:At5g01190
ORF Names:F7J8.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G01190.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 558536Laccase-10PRO_0000283638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6ID18.

Expressioni

Tissue specificityi

Ubiquitous, with lower levels in siliques.1 Publication

Gene expression databases

GenevestigatoriQ6ID18.

Structurei

3D structure databases

ProteinModelPortaliQ6ID18.
SMRiQ6ID18. Positions 22-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 146117Plastocyanin-like 1Add
BLAST
Domaini157 – 308152Plastocyanin-like 2Add
BLAST
Domaini408 – 542135Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ6ID18.
OMAiTIYANED.
PhylomeDBiQ6ID18.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ID18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFPIRILVL FALLAFPACV HGAIRKYTFN VVTKQVTRIC STKQIVTVNG
60 70 80 90 100
KFPGPTIYAN EDDTILVNVV NNVKYNVSIH WHGIRQLRTG WADGPAYITQ
110 120 130 140 150
CPIKPGHSYV YNFTVTGQRG TLWWHAHVLW LRATVHGAIV ILPKLGLPYP
160 170 180 190 200
FPKPHREEVI ILGEWWKSDT ETVVNEALKS GLAPNVSDAH VINGHPGFVP
210 220 230 240 250
NCPSQGNFKL AVESGKTYML RLINAALNEE LFFKIAGHRF TVVEVDAVYV
260 270 280 290 300
KPFNTDTILI APGQTTTALV SAARPSGQYL IAAAPFQDSA VVAVDNRTAT
310 320 330 340 350
ATVHYSGTLS ATPTKTTSPP PQNATSVANT FVNSLRSLNS KTYPANVPIT
360 370 380 390 400
VDHDLLFTVG LGINRCHSCK AGNFSRVVAA INNITFKMPK TALLQAHYFN
410 420 430 440 450
LTGIYTTDFP AKPRRVFDFT GKPPSNLATM KATKLYKLPY NSTVQVVLQD
460 470 480 490 500
TGNVAPENHP IHLHGFNFFV VGLGTGNYNS KKDSNKFNLV DPVERNTVGV
510 520 530 540 550
PSGGWAAIRF RADNPGVWFM HCHLEVHTTW GLKMAFLVEN GKGPNQSIRP

PPSDLPKC
Length:558
Mass (Da):61,298
Last modified:July 5, 2004 - v1
Checksum:i4F0CACDA7088ACBA
GO

Sequence cautioni

The sequence CAB69847.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137189 Genomic DNA. Translation: CAB69847.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90308.1.
BT014855 mRNA. Translation: AAT41838.1.
PIRiT45959.
RefSeqiNP_195739.2. NM_120197.3.
UniGeneiAt.33933.
At.67929.

Genome annotation databases

EnsemblPlantsiAT5G01190.1; AT5G01190.1; AT5G01190.
GeneIDi831697.
KEGGiath:AT5G01190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137189 Genomic DNA. Translation: CAB69847.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED90308.1 .
BT014855 mRNA. Translation: AAT41838.1 .
PIRi T45959.
RefSeqi NP_195739.2. NM_120197.3.
UniGenei At.33933.
At.67929.

3D structure databases

ProteinModelPortali Q6ID18.
SMRi Q6ID18. Positions 22-537.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6ID18.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G01190.1 ; AT5G01190.1 ; AT5G01190 .
GeneIDi 831697.
KEGGi ath:AT5G01190.

Organism-specific databases

TAIRi AT5G01190.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q6ID18.
OMAi TIYANED.
PhylomeDBi Q6ID18.

Enzyme and pathway databases

BioCyci ARA:AT5G01190-MONOMER.

Gene expression databases

Genevestigatori Q6ID18.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC10_ARATH
AccessioniPrimary (citable) accession number: Q6ID18
Secondary accession number(s): Q9LFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3