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Protein

Laccase-10

Gene

LAC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Copper 1; type 2By similarity1
Metal bindingi82Copper 2; type 3By similarity1
Metal bindingi125Copper 2; type 3By similarity1
Metal bindingi127Copper 3; type 3By similarity1
Metal bindingi459Copper 4; type 1By similarity1
Metal bindingi462Copper 1; type 2By similarity1
Metal bindingi464Copper 3; type 3By similarity1
Metal bindingi521Copper 3; type 3By similarity1
Metal bindingi522Copper 4; type 1By similarity1
Metal bindingi523Copper 2; type 3By similarity1
Metal bindingi527Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01190-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-10 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 10
Diphenol oxidase 10
Urishiol oxidase 10
Gene namesi
Name:LAC10
Ordered Locus Names:At5g01190
ORF Names:F7J8.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G01190.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000028363823 – 558Laccase-10Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ID18.
PRIDEiQ6ID18.

Expressioni

Tissue specificityi

Ubiquitous, with lower levels in siliques.1 Publication

Gene expression databases

GenevisibleiQ6ID18. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G01190.1.

Structurei

3D structure databases

ProteinModelPortaliQ6ID18.
SMRiQ6ID18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 146Plastocyanin-like 1Add BLAST117
Domaini157 – 308Plastocyanin-like 2Add BLAST152
Domaini408 – 542Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ6ID18.
KOiK05909.
OMAiPTIYANE.
OrthoDBiEOG093605NS.
PhylomeDBiQ6ID18.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ID18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPIRILVL FALLAFPACV HGAIRKYTFN VVTKQVTRIC STKQIVTVNG
60 70 80 90 100
KFPGPTIYAN EDDTILVNVV NNVKYNVSIH WHGIRQLRTG WADGPAYITQ
110 120 130 140 150
CPIKPGHSYV YNFTVTGQRG TLWWHAHVLW LRATVHGAIV ILPKLGLPYP
160 170 180 190 200
FPKPHREEVI ILGEWWKSDT ETVVNEALKS GLAPNVSDAH VINGHPGFVP
210 220 230 240 250
NCPSQGNFKL AVESGKTYML RLINAALNEE LFFKIAGHRF TVVEVDAVYV
260 270 280 290 300
KPFNTDTILI APGQTTTALV SAARPSGQYL IAAAPFQDSA VVAVDNRTAT
310 320 330 340 350
ATVHYSGTLS ATPTKTTSPP PQNATSVANT FVNSLRSLNS KTYPANVPIT
360 370 380 390 400
VDHDLLFTVG LGINRCHSCK AGNFSRVVAA INNITFKMPK TALLQAHYFN
410 420 430 440 450
LTGIYTTDFP AKPRRVFDFT GKPPSNLATM KATKLYKLPY NSTVQVVLQD
460 470 480 490 500
TGNVAPENHP IHLHGFNFFV VGLGTGNYNS KKDSNKFNLV DPVERNTVGV
510 520 530 540 550
PSGGWAAIRF RADNPGVWFM HCHLEVHTTW GLKMAFLVEN GKGPNQSIRP

PPSDLPKC
Length:558
Mass (Da):61,298
Last modified:July 5, 2004 - v1
Checksum:i4F0CACDA7088ACBA
GO

Sequence cautioni

The sequence CAB69847 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137189 Genomic DNA. Translation: CAB69847.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90308.1.
BT014855 mRNA. Translation: AAT41838.1.
PIRiT45959.
RefSeqiNP_195739.2. NM_120197.4.
UniGeneiAt.33933.
At.67929.

Genome annotation databases

EnsemblPlantsiAT5G01190.1; AT5G01190.1; AT5G01190.
GeneIDi831697.
GrameneiAT5G01190.1; AT5G01190.1; AT5G01190.
KEGGiath:AT5G01190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137189 Genomic DNA. Translation: CAB69847.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90308.1.
BT014855 mRNA. Translation: AAT41838.1.
PIRiT45959.
RefSeqiNP_195739.2. NM_120197.4.
UniGeneiAt.33933.
At.67929.

3D structure databases

ProteinModelPortaliQ6ID18.
SMRiQ6ID18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G01190.1.

Proteomic databases

PaxDbiQ6ID18.
PRIDEiQ6ID18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G01190.1; AT5G01190.1; AT5G01190.
GeneIDi831697.
GrameneiAT5G01190.1; AT5G01190.1; AT5G01190.
KEGGiath:AT5G01190.

Organism-specific databases

TAIRiAT5G01190.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ6ID18.
KOiK05909.
OMAiPTIYANE.
OrthoDBiEOG093605NS.
PhylomeDBiQ6ID18.

Enzyme and pathway databases

BioCyciARA:AT5G01190-MONOMER.

Miscellaneous databases

PROiQ6ID18.

Gene expression databases

GenevisibleiQ6ID18. AT.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC10_ARATH
AccessioniPrimary (citable) accession number: Q6ID18
Secondary accession number(s): Q9LFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.