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Q6ID18

- LAC10_ARATH

UniProt

Q6ID18 - LAC10_ARATH

Protein

Laccase-10

Gene

LAC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Copper 1; type 2By similarity
    Metal bindingi82 – 821Copper 2; type 3By similarity
    Metal bindingi125 – 1251Copper 2; type 3By similarity
    Metal bindingi127 – 1271Copper 3; type 3By similarity
    Metal bindingi459 – 4591Copper 4; type 1By similarity
    Metal bindingi462 – 4621Copper 1; type 2By similarity
    Metal bindingi464 – 4641Copper 3; type 3By similarity
    Metal bindingi521 – 5211Copper 3; type 3By similarity
    Metal bindingi522 – 5221Copper 4; type 1By similarity
    Metal bindingi523 – 5231Copper 2; type 3By similarity
    Metal bindingi527 – 5271Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G01190-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-10 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 10
    Diphenol oxidase 10
    Urishiol oxidase 10
    Gene namesi
    Name:LAC10
    Ordered Locus Names:At5g01190
    ORF Names:F7J8.170
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G01190.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 558536Laccase-10PRO_0000283638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6ID18.

    Expressioni

    Tissue specificityi

    Ubiquitous, with lower levels in siliques.1 Publication

    Gene expression databases

    GenevestigatoriQ6ID18.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ID18.
    SMRiQ6ID18. Positions 22-537.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 146117Plastocyanin-like 1Add
    BLAST
    Domaini157 – 308152Plastocyanin-like 2Add
    BLAST
    Domaini408 – 542135Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ6ID18.
    OMAiTIYANED.
    PhylomeDBiQ6ID18.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6ID18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFPIRILVL FALLAFPACV HGAIRKYTFN VVTKQVTRIC STKQIVTVNG    50
    KFPGPTIYAN EDDTILVNVV NNVKYNVSIH WHGIRQLRTG WADGPAYITQ 100
    CPIKPGHSYV YNFTVTGQRG TLWWHAHVLW LRATVHGAIV ILPKLGLPYP 150
    FPKPHREEVI ILGEWWKSDT ETVVNEALKS GLAPNVSDAH VINGHPGFVP 200
    NCPSQGNFKL AVESGKTYML RLINAALNEE LFFKIAGHRF TVVEVDAVYV 250
    KPFNTDTILI APGQTTTALV SAARPSGQYL IAAAPFQDSA VVAVDNRTAT 300
    ATVHYSGTLS ATPTKTTSPP PQNATSVANT FVNSLRSLNS KTYPANVPIT 350
    VDHDLLFTVG LGINRCHSCK AGNFSRVVAA INNITFKMPK TALLQAHYFN 400
    LTGIYTTDFP AKPRRVFDFT GKPPSNLATM KATKLYKLPY NSTVQVVLQD 450
    TGNVAPENHP IHLHGFNFFV VGLGTGNYNS KKDSNKFNLV DPVERNTVGV 500
    PSGGWAAIRF RADNPGVWFM HCHLEVHTTW GLKMAFLVEN GKGPNQSIRP 550
    PPSDLPKC 558
    Length:558
    Mass (Da):61,298
    Last modified:July 5, 2004 - v1
    Checksum:i4F0CACDA7088ACBA
    GO

    Sequence cautioni

    The sequence CAB69847.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL137189 Genomic DNA. Translation: CAB69847.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED90308.1.
    BT014855 mRNA. Translation: AAT41838.1.
    PIRiT45959.
    RefSeqiNP_195739.2. NM_120197.3.
    UniGeneiAt.33933.
    At.67929.

    Genome annotation databases

    EnsemblPlantsiAT5G01190.1; AT5G01190.1; AT5G01190.
    GeneIDi831697.
    KEGGiath:AT5G01190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL137189 Genomic DNA. Translation: CAB69847.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED90308.1 .
    BT014855 mRNA. Translation: AAT41838.1 .
    PIRi T45959.
    RefSeqi NP_195739.2. NM_120197.3.
    UniGenei At.33933.
    At.67929.

    3D structure databases

    ProteinModelPortali Q6ID18.
    SMRi Q6ID18. Positions 22-537.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6ID18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G01190.1 ; AT5G01190.1 ; AT5G01190 .
    GeneIDi 831697.
    KEGGi ath:AT5G01190.

    Organism-specific databases

    TAIRi AT5G01190.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q6ID18.
    OMAi TIYANED.
    PhylomeDBi Q6ID18.

    Enzyme and pathway databases

    BioCyci ARA:AT5G01190-MONOMER.

    Gene expression databases

    Genevestigatori Q6ID18.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC10_ARATH
    AccessioniPrimary (citable) accession number: Q6ID18
    Secondary accession number(s): Q9LFB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3