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Protein
Submitted name:

DNMT2 protein

Gene

DNMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DNMT2 proteinImported
Submitted name:
HCG23994, isoform CRA_aImported
Submitted name:
cDNA FLJ76302, highly similar to Homo sapiens DNA (cytosine-5-)-methyltransferase 2 (DNMT2), transcript variant a, mRNAImported
Submitted name:
tRNA aspartic acid methyltransferase 1 variant 3Imported
Submitted name:
tRNA aspartic acid methyltransferase 1 variant 4Imported
Gene namesi
Name:DNMT2Imported
Synonyms:TRDMT1Imported
ORF Names:hCG_23994Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000107614.21.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406922.

PTM / Processingi

Proteomic databases

MaxQBiQ6ICS7.

Expressioni

Gene expression databases

BgeeiENSG00000107614.
ExpressionAtlasiQ6ICS7. baseline and differential.

Structurei

3D structure databases

SMRiQ6ICS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 388SAM-dependent_MTasesInterPro annotationAdd BLAST384

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0919. Eukaryota.
COG0270. LUCA.
HOVERGENiHBG051385.
KOiK15336.
OMAiLRYFTPK.
OrthoDBiEOG091G0FXV.

Family and domain databases

InterProiView protein in InterPro
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF00145. DNA_methylase. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiView protein in PROSITE
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6ICS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT
60 70 80 90 100
QLLAKTIEGI TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL
110 120 130 140 150
HILDILPRLQ KLPKYILLEN VKGFEVSSTR DLLIQTIENC GFQYQEFLLS
160 170 180 190 200
PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG QVLMEFPKIE SVHPQKYAMD
210 220 230 240 250
VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR KNQQDSDLSV
260 270 280 290 300
KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY
310 320 330 340 350
IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN
360 370 380 390
LLGFPPEFGF PEKITVKQRY RLLGNSLNVH VVAKLIKILY E
Length:391
Mass (Da):44,597
Last modified:May 10, 2005 - v1
Checksum:iBCA549E4EB2E6950
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei391Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF444974 Genomic DNA. Translation: ACA05983.1.
EF444974 Genomic DNA. Translation: ACA05987.1.
AK291417 mRNA. Translation: BAF84106.1.
CR450316 mRNA. Translation: CAG29312.1.
CH471072 Genomic DNA. Translation: EAW86217.1.
RefSeqiNP_004403.1. NM_004412.6.
UniGeneiHs.351665.
Hs.564140.
Hs.733857.

Genome annotation databases

GeneIDi1787.
KEGGihsa:1787.
UCSCiuc001iop.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6ICS7_HUMAN
AccessioniPrimary (citable) accession number: Q6ICS7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.