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Protein
Submitted name:

HLA-DMA protein

Gene

HLA-DMA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-DMA proteinImported
Gene namesi
Name:HLA-DMAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 261235Sequence analysisPRO_5004274595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Combined sourcesCAR_5005389958
Disulfide bondi50 ↔ 105Combined sources
Disulfide bondi147 ↔ 202Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ6ICR9.
PRIDEiQ6ICR9.

Expressioni

Gene expression databases

BgeeiENSG00000204257.
ExpressionAtlasiQ6ICR9. baseline and differential.
GenevisibleiQ6ICR9. HS.

Interactioni

Protein-protein interaction databases

DIPiDIP-60118N.
STRINGi9606.ENSP00000363976.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20A/E39-226[»]
ProteinModelPortaliQ6ICR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 21595Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOVERGENiHBG001688.
KOiK06752.
OMAiEEDAPIF.
OrthoDBiEOG091G0LMN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6ICR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC
60 70 80 90 100
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF
110 120 130 140 150
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS
160 170 180 190 200
NLFPPMLTVN WQHHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF
210 220 230 240 250
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL
260
IIYFRKPCSG D
Length:261
Mass (Da):29,207
Last modified:July 5, 2004 - v1
Checksum:iBAAB2528874DFFC6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei261 – 2611Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450324 mRNA. Translation: CAG29320.1.
RefSeqiNP_006111.2. NM_006120.3.
UniGeneiHs.728759.

Genome annotation databases

GeneIDi3108.
KEGGihsa:3108.
UCSCiuc003ocm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450324 mRNA. Translation: CAG29320.1.
RefSeqiNP_006111.2. NM_006120.3.
UniGeneiHs.728759.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20A/E39-226[»]
ProteinModelPortaliQ6ICR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60118N.
STRINGi9606.ENSP00000363976.

Proteomic databases

PaxDbiQ6ICR9.
PRIDEiQ6ICR9.

Protocols and materials databases

DNASUi3108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3108.
KEGGihsa:3108.
UCSCiuc003ocm.3. human.

Organism-specific databases

CTDi3108.
PharmGKBiPA35058.

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOVERGENiHBG001688.
KOiK06752.
OMAiEEDAPIF.
OrthoDBiEOG091G0LMN.

Miscellaneous databases

ChiTaRSiHLA-DMA. human.
GenomeRNAii3108.

Gene expression databases

BgeeiENSG00000204257.
ExpressionAtlasiQ6ICR9. baseline and differential.
GenevisibleiQ6ICR9. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6ICR9_HUMAN
AccessioniPrimary (citable) accession number: Q6ICR9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.