Unreviewed,
UniProtKB/TrEMBL Q6ICN0 (Q6ICN0_HUMAN)
Last modified
January 19, 2010.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Third-party data |
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Names and origin
| Protein names | Submitted name: GRB2 protein EMBL CAG29359.1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) EMBL CAG29359.1 | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 217 AA. |
| Sequence status | Fragment. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Sequence similarities | Contains 1 SH2 domain. Contains 2 SH3 domains. |
Ontologies
| Keywords | |
|---|---|
| Domain | SH3 domain RuleBase RU003338V3 |
| Gene Ontology (GO) | |
| Biological process | MAPKKK cascade Inferred from electronic annotation. Source: Compara agingInferred from electronic annotation. Source: Compara cell differentiationInferred from electronic annotation. Source: Compara protein heterooligomerizationInferred from electronic annotation. Source: Compara |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: Compara protein complexInferred from electronic annotation. Source: Compara vesicle membraneInferred from electronic annotation. Source: Compara |
| Molecular function | SH3/SH2 adaptor activity Inferred from electronic annotation. Source: Compara insulin receptor substrate bindingInferred from electronic annotation. Source: Compara phosphotyrosine bindingInferred from electronic annotation. Source: Compara protein domain specific bindingInferred from electronic annotation. Source: Compara |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Experimental info | ||||||||
|---|---|---|---|---|---|---|---|---|
| Non-terminal residue | 217 | 1 | EMBL CAG29359.1 | |||||
Sequences
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References
| [1] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR450363 mRNA. Translation: CAG29359.1. |
| IPI | IPI00021327. |
| UniGene | Hs.444356 Hs.708119 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1K76 based on UniProtKB P29355. |
| SMR | Q6ICN0. Positions 1-217. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6ICN0. |
Genome annotation databases | |
| Ensembl | ENST00000316804; ENSP00000339007; ENSG00000177885; Homo sapiens. [Genome view] ENST00000392562; ENSP00000376345; ENSG00000177885; Homo sapiens. [Genome view] ENST00000392564; ENSP00000376347; ENSG00000177885; Homo sapiens. [Genome view] |
Organism-specific databases | |
| HGNC | HGNC:4566. GRB2. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q6ICN0. |
Gene expression databases | |
| ArrayExpress | Q6ICN0. |
| Bgee | Q6ICN0. |
Family and domain databases | |
| InterPro | IPR000108. Neu_cyt_fact_2. IPR000980. SH2. IPR001452. SH3_domain. IPR020473. SH3_region. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| Pfam | PF00017. SH2. 1 hit. PF00018. SH3_1. 2 hits. [Graphical view] |
| PRINTS | PR00499. P67PHOX. PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. |
| SMART | SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view] |
| PROSITE | PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | Q6ICN0_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6ICN0 | ||||||||
| Entry history |
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| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||

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