ID   S35E4_HUMAN             Reviewed;         350 AA.
AC   Q6ICL7; Q567P0;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 134.
DE   RecName: Full=Solute carrier family 35 member E4;
GN   Name=SLC35E4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q6ICL7; Q13520: AQP6; NbExp=3; IntAct=EBI-12867720, EBI-13059134;
CC       Q6ICL7; P34972: CNR2; NbExp=3; IntAct=EBI-12867720, EBI-2835940;
CC       Q6ICL7; Q96P66: GPR101; NbExp=3; IntAct=EBI-12867720, EBI-17935713;
CC       Q6ICL7; O15529: GPR42; NbExp=3; IntAct=EBI-12867720, EBI-18076404;
CC       Q6ICL7; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12867720, EBI-18053395;
CC       Q6ICL7; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-12867720, EBI-6163737;
CC       Q6ICL7; P15941-11: MUC1; NbExp=3; IntAct=EBI-12867720, EBI-17263240;
CC       Q6ICL7; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12867720, EBI-17247926;
CC       Q6ICL7; Q14973: SLC10A1; NbExp=3; IntAct=EBI-12867720, EBI-3923031;
CC       Q6ICL7; Q9UKG4: SLC13A4; NbExp=3; IntAct=EBI-12867720, EBI-12808018;
CC       Q6ICL7; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12867720, EBI-6268651;
CC       Q6ICL7; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12867720, EBI-8638294;
CC       Q6ICL7; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12867720, EBI-10982110;
CC       Q6ICL7; Q86WB7-2: UNC93A; NbExp=3; IntAct=EBI-12867720, EBI-13356252;
CC       Q6ICL7; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-12867720, EBI-1055364;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ICL7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ICL7-2; Sequence=VSP_027480, VSP_027481;
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR456351; CAG30237.1; -; mRNA.
DR   EMBL; BC040191; AAH40191.1; -; mRNA.
DR   EMBL; BC093099; AAH93099.1; -; mRNA.
DR   EMBL; BC107119; AAI07120.1; -; mRNA.
DR   CCDS; CCDS13882.1; -. [Q6ICL7-1]
DR   CCDS; CCDS82708.1; -. [Q6ICL7-2]
DR   RefSeq; NP_001001479.1; NM_001001479.3. [Q6ICL7-1]
DR   RefSeq; NP_001305299.1; NM_001318370.1. [Q6ICL7-2]
DR   RefSeq; NP_001305300.1; NM_001318371.1.
DR   RefSeq; XP_016884283.1; XM_017028794.1.
DR   RefSeq; XP_016884284.1; XM_017028795.1.
DR   AlphaFoldDB; Q6ICL7; -.
DR   SMR; Q6ICL7; -.
DR   BioGRID; 130914; 17.
DR   IntAct; Q6ICL7; 15.
DR   STRING; 9606.ENSP00000339626; -.
DR   TCDB; 2.A.7.9.11; the drug/metabolite transporter (dmt) superfamily.
DR   iPTMnet; Q6ICL7; -.
DR   PhosphoSitePlus; Q6ICL7; -.
DR   BioMuta; SLC35E4; -.
DR   DMDM; 74748762; -.
DR   jPOST; Q6ICL7; -.
DR   MassIVE; Q6ICL7; -.
DR   PaxDb; 9606-ENSP00000339626; -.
DR   PeptideAtlas; Q6ICL7; -.
DR   ProteomicsDB; 66400; -. [Q6ICL7-1]
DR   Antibodypedia; 62513; 19 antibodies from 10 providers.
DR   DNASU; 339665; -.
DR   Ensembl; ENST00000343605.5; ENSP00000339626.4; ENSG00000100036.13. [Q6ICL7-1]
DR   Ensembl; ENST00000406566.1; ENSP00000384377.1; ENSG00000100036.13. [Q6ICL7-2]
DR   GeneID; 339665; -.
DR   KEGG; hsa:339665; -.
DR   MANE-Select; ENST00000343605.5; ENSP00000339626.4; NM_001001479.4; NP_001001479.1.
DR   UCSC; uc003ais.2; human. [Q6ICL7-1]
DR   AGR; HGNC:17058; -.
DR   CTD; 339665; -.
DR   DisGeNET; 339665; -.
DR   GeneCards; SLC35E4; -.
DR   HGNC; HGNC:17058; SLC35E4.
DR   HPA; ENSG00000100036; Tissue enhanced (testis).
DR   neXtProt; NX_Q6ICL7; -.
DR   OpenTargets; ENSG00000100036; -.
DR   PharmGKB; PA134883803; -.
DR   VEuPathDB; HostDB:ENSG00000100036; -.
DR   eggNOG; KOG1441; Eukaryota.
DR   GeneTree; ENSGT00730000111291; -.
DR   HOGENOM; CLU_022332_2_0_1; -.
DR   InParanoid; Q6ICL7; -.
DR   OMA; QAGCCFL; -.
DR   OrthoDB; 5264806at2759; -.
DR   PhylomeDB; Q6ICL7; -.
DR   TreeFam; TF328788; -.
DR   PathwayCommons; Q6ICL7; -.
DR   SignaLink; Q6ICL7; -.
DR   BioGRID-ORCS; 339665; 13 hits in 1152 CRISPR screens.
DR   ChiTaRS; SLC35E4; human.
DR   GenomeRNAi; 339665; -.
DR   Pharos; Q6ICL7; Tdark.
DR   PRO; PR:Q6ICL7; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q6ICL7; Protein.
DR   Bgee; ENSG00000100036; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 107 other cell types or tissues.
DR   ExpressionAtlas; Q6ICL7; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   PANTHER; PTHR11132; SOLUTE CARRIER FAMILY 35; 1.
DR   PANTHER; PTHR11132:SF347; SOLUTE CARRIER FAMILY 35 MEMBER E4; 1.
DR   Pfam; PF03151; TPT; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
DR   Genevisible; Q6ICL7; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..350
FT                   /note="Solute carrier family 35 member E4"
FT                   /id="PRO_0000298927"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          125..179
FT                   /note="EamA"
FT   REGION          19..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         208..234
FT                   /note="ALLQEERLDAVTLLYATSLPSFCLLAG -> LSFQICKMELMIPMERVRMRS
FT                   AGQGQE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027480"
FT   VAR_SEQ         235..350
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027481"
SQ   SEQUENCE   350 AA;  36747 MW;  C725DD27F32728B1 CRC64;
     MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA MAALVWLLAG
     ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR PMPGGTRCRV LLLSLTFGTS
     MACGNVGLRA VPLDLAQLVT TTTPLFTLAL SALLLGRRHH PLQLAAMGPL CLGAACSLAG
     EFRTPPTGCG FLLAATCLRG LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE
     AGVAPPPTAG DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
     LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
//