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Protein

Solute carrier family 35 member E4

Gene

SLC35E4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

Protein family/group databases

TCDBi2.A.7.9.11 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E4
Gene namesi
Name:SLC35E4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100036.12
HGNCiHGNC:17058 SLC35E4
neXtProtiNX_Q6ICL7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei110 – 132HelicalSequence analysisAdd BLAST23
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100036
PharmGKBiPA134883803

Polymorphism and mutation databases

BioMutaiSLC35E4
DMDMi74748762

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989271 – 350Solute carrier family 35 member E4Add BLAST350

Proteomic databases

PaxDbiQ6ICL7
PeptideAtlasiQ6ICL7
PRIDEiQ6ICL7

PTM databases

iPTMnetiQ6ICL7
PhosphoSitePlusiQ6ICL7

Expressioni

Gene expression databases

BgeeiENSG00000100036
CleanExiHS_SLC35E4
ExpressionAtlasiQ6ICL7 baseline and differential
GenevisibleiQ6ICL7 HS

Organism-specific databases

HPAiHPA049558

Interactioni

Protein-protein interaction databases

IntActiQ6ICL7, 2 interactors
STRINGi9606.ENSP00000339626

Structurei

3D structure databases

ProteinModelPortaliQ6ICL7
SMRiQ6ICL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 179EamAAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 319Leu-richAdd BLAST209

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441 Eukaryota
ENOG410XP1S LUCA
GeneTreeiENSGT00730000111291
HOGENOMiHOG000137347
HOVERGENiHBG095658
InParanoidiQ6ICL7
KOiK15286
OMAiALACHWG
OrthoDBiEOG091G09DK
PhylomeDBiQ6ICL7
TreeFamiTF328788

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ICL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA
60 70 80 90 100
MAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR
110 120 130 140 150
PMPGGTRCRV LLLSLTFGTS MACGNVGLRA VPLDLAQLVT TTTPLFTLAL
160 170 180 190 200
SALLLGRRHH PLQLAAMGPL CLGAACSLAG EFRTPPTGCG FLLAATCLRG
210 220 230 240 250
LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE AGVAPPPTAG
260 270 280 290 300
DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
310 320 330 340 350
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
Length:350
Mass (Da):36,747
Last modified:July 5, 2004 - v1
Checksum:iC725DD27F32728B1
GO
Isoform 2 (identifier: Q6ICL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
     235-350: Missing.

Show »
Length:234
Mass (Da):24,654
Checksum:i691D66E4BED7026F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027480208 – 234ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_027481235 – 350Missing in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456351 mRNA Translation: CAG30237.1
BC040191 mRNA Translation: AAH40191.1
BC093099 mRNA Translation: AAH93099.1
BC107119 mRNA Translation: AAI07120.1
CCDSiCCDS13882.1 [Q6ICL7-1]
CCDS82708.1 [Q6ICL7-2]
RefSeqiNP_001001479.1, NM_001001479.3 [Q6ICL7-1]
NP_001305299.1, NM_001318370.1 [Q6ICL7-2]
NP_001305300.1, NM_001318371.1
XP_016884283.1, XM_017028794.1 [Q6ICL7-1]
XP_016884284.1, XM_017028795.1 [Q6ICL7-1]
UniGeneiHs.660384

Genome annotation databases

EnsembliENST00000343605; ENSP00000339626; ENSG00000100036 [Q6ICL7-1]
ENST00000406566; ENSP00000384377; ENSG00000100036 [Q6ICL7-2]
GeneIDi339665
KEGGihsa:339665
UCSCiuc003ais.2 human [Q6ICL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35E4_HUMAN
AccessioniPrimary (citable) accession number: Q6ICL7
Secondary accession number(s): Q567P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: December 20, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health