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Q6ICL7

- S35E4_HUMAN

UniProt

Q6ICL7 - S35E4_HUMAN

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Protein
Solute carrier family 35 member E4
Gene
SLC35E4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative transporter By similarity.

Protein family/group databases

TCDBi2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E4
Gene namesi
Name:SLC35E4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:17058. SLC35E4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Transmembranei110 – 13223Helical; Reviewed prediction
Add
BLAST
Transmembranei135 – 15521Helical; Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Reviewed prediction
Add
BLAST
Transmembranei279 – 29921Helical; Reviewed prediction
Add
BLAST
Transmembranei312 – 33221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Solute carrier family 35 member E4
PRO_0000298927Add
BLAST

Proteomic databases

PaxDbiQ6ICL7.
PRIDEiQ6ICL7.

PTM databases

PhosphoSiteiQ6ICL7.

Expressioni

Gene expression databases

ArrayExpressiQ6ICL7.
BgeeiQ6ICL7.
CleanExiHS_SLC35E4.
GenevestigatoriQ6ICL7.

Organism-specific databases

HPAiHPA049558.

Interactioni

Protein-protein interaction databases

BioGridi130914. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6ICL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 17955EamA
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 319209Leu-rich
Add
BLAST

Sequence similaritiesi

Contains 1 EamA domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG129799.
HOGENOMiHOG000137347.
HOVERGENiHBG095658.
InParanoidiQ6ICL7.
KOiK15286.
OMAiKSVQQSA.
OrthoDBiEOG7XWPP4.
PhylomeDBiQ6ICL7.
TreeFamiTF328788.

Family and domain databases

InterProiIPR000620. DMT.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ICL7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA    50
MAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR 100
PMPGGTRCRV LLLSLTFGTS MACGNVGLRA VPLDLAQLVT TTTPLFTLAL 150
SALLLGRRHH PLQLAAMGPL CLGAACSLAG EFRTPPTGCG FLLAATCLRG 200
LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE AGVAPPPTAG 250
DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR 300
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL 350
Length:350
Mass (Da):36,747
Last modified:July 5, 2004 - v1
Checksum:iC725DD27F32728B1
GO
Isoform 2 (identifier: Q6ICL7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
     235-350: Missing.

Show »
Length:234
Mass (Da):24,654
Checksum:i691D66E4BED7026F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 23427ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2.
VSP_027480Add
BLAST
Alternative sequencei235 – 350116Missing in isoform 2.
VSP_027481Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR456351 mRNA. Translation: CAG30237.1.
BC040191 mRNA. Translation: AAH40191.1.
BC093099 mRNA. Translation: AAH93099.1.
BC107119 mRNA. Translation: AAI07120.1.
CCDSiCCDS13882.1. [Q6ICL7-1]
RefSeqiNP_001001479.1. NM_001001479.2. [Q6ICL7-1]
UniGeneiHs.660384.

Genome annotation databases

EnsembliENST00000300385; ENSP00000300385; ENSG00000100036. [Q6ICL7-2]
ENST00000343605; ENSP00000339626; ENSG00000100036. [Q6ICL7-1]
ENST00000406566; ENSP00000384377; ENSG00000100036. [Q6ICL7-2]
GeneIDi339665.
KEGGihsa:339665.
UCSCiuc003ais.1. human. [Q6ICL7-1]

Polymorphism databases

DMDMi74748762.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR456351 mRNA. Translation: CAG30237.1 .
BC040191 mRNA. Translation: AAH40191.1 .
BC093099 mRNA. Translation: AAH93099.1 .
BC107119 mRNA. Translation: AAI07120.1 .
CCDSi CCDS13882.1. [Q6ICL7-1 ]
RefSeqi NP_001001479.1. NM_001001479.2. [Q6ICL7-1 ]
UniGenei Hs.660384.

3D structure databases

ProteinModelPortali Q6ICL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130914. 1 interaction.

Protein family/group databases

TCDBi 2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q6ICL7.

Polymorphism databases

DMDMi 74748762.

Proteomic databases

PaxDbi Q6ICL7.
PRIDEi Q6ICL7.

Protocols and materials databases

DNASUi 339665.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300385 ; ENSP00000300385 ; ENSG00000100036 . [Q6ICL7-2 ]
ENST00000343605 ; ENSP00000339626 ; ENSG00000100036 . [Q6ICL7-1 ]
ENST00000406566 ; ENSP00000384377 ; ENSG00000100036 . [Q6ICL7-2 ]
GeneIDi 339665.
KEGGi hsa:339665.
UCSCi uc003ais.1. human. [Q6ICL7-1 ]

Organism-specific databases

CTDi 339665.
GeneCardsi GC22P031031.
HGNCi HGNC:17058. SLC35E4.
HPAi HPA049558.
neXtProti NX_Q6ICL7.
PharmGKBi PA134883803.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG129799.
HOGENOMi HOG000137347.
HOVERGENi HBG095658.
InParanoidi Q6ICL7.
KOi K15286.
OMAi KSVQQSA.
OrthoDBi EOG7XWPP4.
PhylomeDBi Q6ICL7.
TreeFami TF328788.

Miscellaneous databases

GenomeRNAii 339665.
NextBioi 97481.
PROi Q6ICL7.

Gene expression databases

ArrayExpressi Q6ICL7.
Bgeei Q6ICL7.
CleanExi HS_SLC35E4.
Genevestigatori Q6ICL7.

Family and domain databases

InterProi IPR000620. DMT.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view ]
Pfami PF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiS35E4_HUMAN
AccessioniPrimary (citable) accession number: Q6ICL7
Secondary accession number(s): Q567P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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