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Q6ICL7 (S35E4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member E4
Gene names
Name:SLC35E4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative transporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TPT transporter family. SLC35E subfamily.

Contains 1 EamA domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ICL7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ICL7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
     235-350: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Solute carrier family 35 member E4
PRO_0000298927

Regions

Transmembrane51 – 7121Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane110 – 13223Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane312 – 33221Helical; Potential
Domain125 – 17955EamA
Compositional bias111 – 319209Leu-rich

Natural variations

Alternative sequence208 – 23427ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2.
VSP_027480
Alternative sequence235 – 350116Missing in isoform 2.
VSP_027481

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C725DD27F32728B1

FASTA35036,747
        10         20         30         40         50         60 
MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA MAALVWLLAG 

        70         80         90        100        110        120 
ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR PMPGGTRCRV LLLSLTFGTS 

       130        140        150        160        170        180 
MACGNVGLRA VPLDLAQLVT TTTPLFTLAL SALLLGRRHH PLQLAAMGPL CLGAACSLAG 

       190        200        210        220        230        240 
EFRTPPTGCG FLLAATCLRG LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE 

       250        260        270        280        290        300 
AGVAPPPTAG DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR 

       310        320        330        340        350 
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL 

« Hide

Isoform 2 [UniParc].

Checksum: 691D66E4BED7026F
Show »

FASTA23424,654

References

[1]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR456351 mRNA. Translation: CAG30237.1.
BC040191 mRNA. Translation: AAH40191.1.
BC093099 mRNA. Translation: AAH93099.1.
BC107119 mRNA. Translation: AAI07120.1.
CCDSCCDS13882.1. [Q6ICL7-1]
RefSeqNP_001001479.1. NM_001001479.2. [Q6ICL7-1]
UniGeneHs.660384.

3D structure databases

ProteinModelPortalQ6ICL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130914. 1 interaction.

Protein family/group databases

TCDB2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ6ICL7.

Polymorphism databases

DMDM74748762.

Proteomic databases

PaxDbQ6ICL7.
PRIDEQ6ICL7.

Protocols and materials databases

DNASU339665.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300385; ENSP00000300385; ENSG00000100036. [Q6ICL7-2]
ENST00000343605; ENSP00000339626; ENSG00000100036. [Q6ICL7-1]
ENST00000406566; ENSP00000384377; ENSG00000100036. [Q6ICL7-2]
GeneID339665.
KEGGhsa:339665.
UCSCuc003ais.1. human. [Q6ICL7-1]

Organism-specific databases

CTD339665.
GeneCardsGC22P031031.
HGNCHGNC:17058. SLC35E4.
HPAHPA049558.
neXtProtNX_Q6ICL7.
PharmGKBPA134883803.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG129799.
HOGENOMHOG000137347.
HOVERGENHBG095658.
InParanoidQ6ICL7.
KOK15286.
OMAKSVQQSA.
OrthoDBEOG7XWPP4.
PhylomeDBQ6ICL7.
TreeFamTF328788.

Gene expression databases

ArrayExpressQ6ICL7.
BgeeQ6ICL7.
CleanExHS_SLC35E4.
GenevestigatorQ6ICL7.

Family and domain databases

InterProIPR000620. DMT.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339665.
NextBio97481.
PROQ6ICL7.

Entry information

Entry nameS35E4_HUMAN
AccessionPrimary (citable) accession number: Q6ICL7
Secondary accession number(s): Q567P0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM