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Q6ICL7

- S35E4_HUMAN

UniProt

Q6ICL7 - S35E4_HUMAN

Protein

Solute carrier family 35 member E4

Gene

SLC35E4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Putative transporter.By similarity

    Protein family/group databases

    TCDBi2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member E4
    Gene namesi
    Name:SLC35E4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:17058. SLC35E4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134883803.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Solute carrier family 35 member E4PRO_0000298927Add
    BLAST

    Proteomic databases

    PaxDbiQ6ICL7.
    PRIDEiQ6ICL7.

    PTM databases

    PhosphoSiteiQ6ICL7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ICL7.
    BgeeiQ6ICL7.
    CleanExiHS_SLC35E4.
    GenevestigatoriQ6ICL7.

    Organism-specific databases

    HPAiHPA049558.

    Interactioni

    Protein-protein interaction databases

    BioGridi130914. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ICL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 17955EamAAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi111 – 319209Leu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EamA domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG129799.
    HOGENOMiHOG000137347.
    HOVERGENiHBG095658.
    InParanoidiQ6ICL7.
    KOiK15286.
    OMAiKSVQQSA.
    OrthoDBiEOG7XWPP4.
    PhylomeDBiQ6ICL7.
    TreeFamiTF328788.

    Family and domain databases

    InterProiIPR000620. DMT.
    IPR004853. Tpt_PEP_trans_dom.
    [Graphical view]
    PfamiPF00892. EamA. 1 hit.
    PF03151. TPT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ICL7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA    50
    MAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR 100
    PMPGGTRCRV LLLSLTFGTS MACGNVGLRA VPLDLAQLVT TTTPLFTLAL 150
    SALLLGRRHH PLQLAAMGPL CLGAACSLAG EFRTPPTGCG FLLAATCLRG 200
    LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE AGVAPPPTAG 250
    DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR 300
    LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL 350
    Length:350
    Mass (Da):36,747
    Last modified:July 5, 2004 - v1
    Checksum:iC725DD27F32728B1
    GO
    Isoform 2 (identifier: Q6ICL7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
         235-350: Missing.

    Show »
    Length:234
    Mass (Da):24,654
    Checksum:i691D66E4BED7026F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei208 – 23427ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2. 1 PublicationVSP_027480Add
    BLAST
    Alternative sequencei235 – 350116Missing in isoform 2. 1 PublicationVSP_027481Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456351 mRNA. Translation: CAG30237.1.
    BC040191 mRNA. Translation: AAH40191.1.
    BC093099 mRNA. Translation: AAH93099.1.
    BC107119 mRNA. Translation: AAI07120.1.
    CCDSiCCDS13882.1. [Q6ICL7-1]
    RefSeqiNP_001001479.1. NM_001001479.2. [Q6ICL7-1]
    UniGeneiHs.660384.

    Genome annotation databases

    EnsembliENST00000343605; ENSP00000339626; ENSG00000100036. [Q6ICL7-1]
    ENST00000406566; ENSP00000384377; ENSG00000100036. [Q6ICL7-2]
    GeneIDi339665.
    KEGGihsa:339665.
    UCSCiuc003ais.1. human. [Q6ICL7-1]

    Polymorphism databases

    DMDMi74748762.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456351 mRNA. Translation: CAG30237.1 .
    BC040191 mRNA. Translation: AAH40191.1 .
    BC093099 mRNA. Translation: AAH93099.1 .
    BC107119 mRNA. Translation: AAI07120.1 .
    CCDSi CCDS13882.1. [Q6ICL7-1 ]
    RefSeqi NP_001001479.1. NM_001001479.2. [Q6ICL7-1 ]
    UniGenei Hs.660384.

    3D structure databases

    ProteinModelPortali Q6ICL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130914. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q6ICL7.

    Polymorphism databases

    DMDMi 74748762.

    Proteomic databases

    PaxDbi Q6ICL7.
    PRIDEi Q6ICL7.

    Protocols and materials databases

    DNASUi 339665.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343605 ; ENSP00000339626 ; ENSG00000100036 . [Q6ICL7-1 ]
    ENST00000406566 ; ENSP00000384377 ; ENSG00000100036 . [Q6ICL7-2 ]
    GeneIDi 339665.
    KEGGi hsa:339665.
    UCSCi uc003ais.1. human. [Q6ICL7-1 ]

    Organism-specific databases

    CTDi 339665.
    GeneCardsi GC22P031031.
    HGNCi HGNC:17058. SLC35E4.
    HPAi HPA049558.
    neXtProti NX_Q6ICL7.
    PharmGKBi PA134883803.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG129799.
    HOGENOMi HOG000137347.
    HOVERGENi HBG095658.
    InParanoidi Q6ICL7.
    KOi K15286.
    OMAi KSVQQSA.
    OrthoDBi EOG7XWPP4.
    PhylomeDBi Q6ICL7.
    TreeFami TF328788.

    Miscellaneous databases

    GenomeRNAii 339665.
    NextBioi 97481.
    PROi Q6ICL7.

    Gene expression databases

    ArrayExpressi Q6ICL7.
    Bgeei Q6ICL7.
    CleanExi HS_SLC35E4.
    Genevestigatori Q6ICL7.

    Family and domain databases

    InterProi IPR000620. DMT.
    IPR004853. Tpt_PEP_trans_dom.
    [Graphical view ]
    Pfami PF00892. EamA. 1 hit.
    PF03151. TPT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiS35E4_HUMAN
    AccessioniPrimary (citable) accession number: Q6ICL7
    Secondary accession number(s): Q567P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3