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Protein

Solute carrier family 35 member E4

Gene

SLC35E4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E4
Gene namesi
Name:SLC35E4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:17058. SLC35E4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13223HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883803.

Polymorphism and mutation databases

BioMutaiSLC35E4.
DMDMi74748762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Solute carrier family 35 member E4PRO_0000298927Add
BLAST

Proteomic databases

PaxDbiQ6ICL7.
PRIDEiQ6ICL7.

PTM databases

PhosphoSiteiQ6ICL7.

Expressioni

Gene expression databases

BgeeiQ6ICL7.
CleanExiHS_SLC35E4.
ExpressionAtlasiQ6ICL7. baseline and differential.
GenevisibleiQ6ICL7. HS.

Organism-specific databases

HPAiHPA049558.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000339626.

Structurei

3D structure databases

ProteinModelPortaliQ6ICL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 17955EamAAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 319209Leu-richAdd
BLAST

Sequence similaritiesi

Contains 1 EamA domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG129799.
GeneTreeiENSGT00730000111291.
HOGENOMiHOG000137347.
HOVERGENiHBG095658.
InParanoidiQ6ICL7.
KOiK15286.
OMAiKSVQQSA.
OrthoDBiEOG7XWPP4.
PhylomeDBiQ6ICL7.
TreeFamiTF328788.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ICL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA
60 70 80 90 100
MAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR
110 120 130 140 150
PMPGGTRCRV LLLSLTFGTS MACGNVGLRA VPLDLAQLVT TTTPLFTLAL
160 170 180 190 200
SALLLGRRHH PLQLAAMGPL CLGAACSLAG EFRTPPTGCG FLLAATCLRG
210 220 230 240 250
LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE AGVAPPPTAG
260 270 280 290 300
DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
310 320 330 340 350
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
Length:350
Mass (Da):36,747
Last modified:July 5, 2004 - v1
Checksum:iC725DD27F32728B1
GO
Isoform 2 (identifier: Q6ICL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
     235-350: Missing.

Show »
Length:234
Mass (Da):24,654
Checksum:i691D66E4BED7026F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 23427ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2. 1 PublicationVSP_027480Add
BLAST
Alternative sequencei235 – 350116Missing in isoform 2. 1 PublicationVSP_027481Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456351 mRNA. Translation: CAG30237.1.
BC040191 mRNA. Translation: AAH40191.1.
BC093099 mRNA. Translation: AAH93099.1.
BC107119 mRNA. Translation: AAI07120.1.
CCDSiCCDS13882.1. [Q6ICL7-1]
RefSeqiNP_001001479.1. NM_001001479.2. [Q6ICL7-1]
UniGeneiHs.660384.

Genome annotation databases

EnsembliENST00000343605; ENSP00000339626; ENSG00000100036.
ENST00000406566; ENSP00000384377; ENSG00000100036. [Q6ICL7-2]
GeneIDi339665.
KEGGihsa:339665.
UCSCiuc003ais.1. human. [Q6ICL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456351 mRNA. Translation: CAG30237.1.
BC040191 mRNA. Translation: AAH40191.1.
BC093099 mRNA. Translation: AAH93099.1.
BC107119 mRNA. Translation: AAI07120.1.
CCDSiCCDS13882.1. [Q6ICL7-1]
RefSeqiNP_001001479.1. NM_001001479.2. [Q6ICL7-1]
UniGeneiHs.660384.

3D structure databases

ProteinModelPortaliQ6ICL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000339626.

Protein family/group databases

TCDBi2.A.7.9.11. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ6ICL7.

Polymorphism and mutation databases

BioMutaiSLC35E4.
DMDMi74748762.

Proteomic databases

PaxDbiQ6ICL7.
PRIDEiQ6ICL7.

Protocols and materials databases

DNASUi339665.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343605; ENSP00000339626; ENSG00000100036.
ENST00000406566; ENSP00000384377; ENSG00000100036. [Q6ICL7-2]
GeneIDi339665.
KEGGihsa:339665.
UCSCiuc003ais.1. human. [Q6ICL7-1]

Organism-specific databases

CTDi339665.
GeneCardsiGC22P031031.
HGNCiHGNC:17058. SLC35E4.
HPAiHPA049558.
neXtProtiNX_Q6ICL7.
PharmGKBiPA134883803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG129799.
GeneTreeiENSGT00730000111291.
HOGENOMiHOG000137347.
HOVERGENiHBG095658.
InParanoidiQ6ICL7.
KOiK15286.
OMAiKSVQQSA.
OrthoDBiEOG7XWPP4.
PhylomeDBiQ6ICL7.
TreeFamiTF328788.

Miscellaneous databases

ChiTaRSiSLC35E4. human.
GenomeRNAii339665.
NextBioi97481.
PROiQ6ICL7.

Gene expression databases

BgeeiQ6ICL7.
CleanExiHS_SLC35E4.
ExpressionAtlasiQ6ICL7. baseline and differential.
GenevisibleiQ6ICL7. HS.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiS35E4_HUMAN
AccessioniPrimary (citable) accession number: Q6ICL7
Secondary accession number(s): Q567P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.