Q6ICL7 (S35E4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member E4

Gene names

Name:

SLC35E4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative transporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TPT transporter family. SLC35E subfamily. Contains 1 EamA domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ICL7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ICL7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     208-234: ALLQEERLDAVTLLYATSLPSFCLLAG → LSFQICKMELMIPMERVRMRSAGQGQE
     235-350: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Solute carrier family 35 member E4		PRO_0000298927
Regions
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	73 – 93	21	Helical; Potential
	Transmembrane	110 – 132	23	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	258 – 278	21	Helical; Potential
	Transmembrane	279 – 299	21	Helical; Potential
	Transmembrane	312 – 332	21	Helical; Potential
	Domain	125 – 179	55	EamA
	Compositional bias	111 – 319	209	Leu-rich
Natural variations
	Alternative sequence	208 – 234	27	ALLQE…CLLAG → LSFQICKMELMIPMERVRMR SAGQGQE in isoform 2.		VSP_027480
	Alternative sequence	235 – 350	116	Missing in isoform 2.		VSP_027481

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C725DD27F32728B1	FASTA	350	36,747
	10 20 30 40 50 60 MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA MAALVWLLAG 70 80 90 100 110 120 ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR PMPGGTRCRV LLLSLTFGTS 130 140 150 160 170 180 MACGNVGLRA VPLDLAQLVT TTTPLFTLAL SALLLGRRHH PLQLAAMGPL CLGAACSLAG 190 200 210 220 230 240 EFRTPPTGCG FLLAATCLRG LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE 250 260 270 280 290 300 AGVAPPPTAG DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR 310 320 330 340 350 LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
	Isoform 2 [UniParc]. Checksum: 691D66E4BED7026F	FASTA	234	24,654
	10 20 30 40 50 60 MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA MAALVWLLAG 70 80 90 100 110 120 ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR PMPGGTRCRV LLLSLTFGTS 130 140 150 160 170 180 MACGNVGLRA VPLDLAQLVT TTTPLFTLAL SALLLGRRHH PLQLAAMGPL CLGAACSLAG 190 200 210 220 230 EFRTPPTGCG FLLAATCLRG LKSVQQSLSF QICKMELMIP MERVRMRSAG QGQE

References

[1]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR456351 mRNA. Translation: CAG30237.1. BC040191 mRNA. Translation: AAH40191.1. BC093099 mRNA. Translation: AAH93099.1. BC107119 mRNA. Translation: AAI07120.1.
IPI	IPI00086503. IPI00555706.
RefSeq	NP_001001479.1. NM_001001479.2.
UniGene	Hs.660384.
3D structure databases
ProteinModelPortal	Q6ICL7.
ModBase	Search...
Protein family/group databases
TCDB	2.A.7.24.7. drug/metabolite transporter (DMT) superfamily.
PTM databases
PhosphoSite	Q6ICL7.
Polymorphism databases
DMDM	74748762.
Proteomic databases
PaxDb	Q6ICL7.
PRIDE	Q6ICL7.
Protocols and materials databases
DNASU	339665.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300385; ENSP00000300385; ENSG00000100036. ENST00000343605; ENSP00000339626; ENSG00000100036. ENST00000406566; ENSP00000384377; ENSG00000100036.
GeneID	339665.
KEGG	hsa:339665.
UCSC	uc003ais.1. human.
Organism-specific databases
CTD	339665.
GeneCards	GC22P031031.
HGNC	HGNC:17058. SLC35E4.
HPA	HPA049558.
neXtProt	NX_Q6ICL7.
PharmGKB	PA134883803.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG129799.
HOGENOM	HOG000137347.
HOVERGEN	HBG095658.
InParanoid	Q6ICL7.
KO	K15286.
OMA	KSIQQSA.
OrthoDB	EOG4DV5MZ.
PhylomeDB	Q6ICL7.
Gene expression databases
ArrayExpress	Q6ICL7.
Bgee	Q6ICL7.
CleanEx	HS_SLC35E4.
Genevestigator	Q6ICL7.
Family and domain databases
InterPro	IPR000620. DMT. IPR004853. DUF250. [Graphical view]
Pfam	PF00892. EamA. 1 hit. PF03151. TPT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	339665.
NextBio	97481.

Entry information

Entry name

S35E4_HUMAN

Accession

Primary (citable) accession number: Q6ICL7
Secondary accession number(s): Q567P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.