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Reviewed, UniProtKB/Swiss-Prot Q6ICL3 (CV025_HUMAN)

Last modified October 13, 2009. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Uncharacterized protein C22orf25
Gene names
Name: C22orf25
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ICL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ICL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-151: Missing.
Isoform 3 (identifier: Q6ICL3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MCIIFFKFDP...FWGNNNEILS → MPLGAGTPVN...FWGNNNEILS
     190-197: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Uncharacterized protein C22orf25
PRO_0000253891

Natural variations

Alternative sequence1 – 4848MCIIF…NEILS → MPLGAGTPVNVQRREDSATE GSHRLILAANRDEFYSRPSK LADFWGNNNEILS in isoform 3.
VSP_021137
Alternative sequence90 – 15162Missing in isoform 2.
VSP_021139
Alternative sequence190 – 1978Missing in isoform 3.
VSP_021138
Natural variant1251D → N: dbSNP rs17855650. Ref.3
VAR_028742
Natural variant2001E → K: dbSNP rs17854107. Ref.3
VAR_028743
Natural variant2451D → E: dbSNP rs16982614.
VAR_028744

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 99D55353FD1B74E4

FASTA27630,937
        10         20         30         40         50         60 
MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL DMEEGKEGGT 

        70         80         90        100        110        120 
WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV DSLSYLKKVS MEGHLYNGFN 

       130        140        150        160        170        180 
LIAADLSTAK GDVICYYGNR GEPDPIVLTP GTYGLSNALL ETPWRKLCFG KQLFLEAVER 

       190        200        210        220        230        240 
SQALPKDVLI ASLLDVLNNE EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT 

       250        260        270 
IILVDADGHV TFTERSMMDK DLSHWETRTY EFTLQS 

« Hide

Isoform 2.

Checksum: 6E2207E4F3CA29A2
Show »

FASTA21424,194
Isoform 3.

Checksum: 7AAF915CEB57393A
Show »

FASTA27330,345

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Placenta and Testis.
[2]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-125 AND LYS-200.
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-276 (ISOFORM 1).
Tissue: Amygdala.

Cross-references

Sequence databases

AK057461 mRNA. Translation: BAB71498.1.
AK092484 mRNA. Translation: BAC03902.1.
CR456355 mRNA. Translation: CAG30241.1.
BC041339 mRNA. Translation: AAH41339.1.
AL713640 mRNA. Translation: CAD28454.1.
IPIIPI00168034.
IPI00384646.
IPI00395547.
RefSeqNP_690870.3.
UniGeneHs.474233

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ6ICL3.

Genome annotation databases

EnsemblENST00000327374; ENSP00000332721; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000398042; ENSP00000381122; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000399807; ENSP00000382706; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000401833; ENSP00000384827; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000401886; ENSP00000385662; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000411907; ENSP00000387931; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000420290; ENSP00000396182; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000420446; ENSP00000392311; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000430807; ENSP00000403432; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000432198; ENSP00000413850; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000432883; ENSP00000402926; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000434168; ENSP00000411602; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000434570; ENSP00000391262; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000444651; ENSP00000395816; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000447208; ENSP00000389797; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000450019; ENSP00000402966; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000450664; ENSP00000415450; ENSG00000183597; Homo sapiens. [Genome view]
ENST00000456048; ENSP00000403645; ENSG00000183597; Homo sapiens. [Genome view]
GeneID128989.
KEGGhsa:128989.
NMPDRfig|9606.3.peg.21248.
UCSCuc002zrb.1. human.
uc002zrc.1. human.

Organism-specific databases

CTD128989.
GeneCardsGC22P018384.
HGNCHGNC:25439. C22orf25.
HPAHPA003080.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ6ICL3.

Gene expression databases

ArrayExpressQ6ICL3.
BgeeQ6ICL3.
CleanExHS_C22orf25.
GenevestigatorQ6ICL3.
GermOnlineENSG00000183597. Homo sapiens.

Family and domain databases

InterProIPR008551. DUF833.
[Graphical view]
PANTHERPTHR17985. DUF833. 1 hit.
PfamPF05742. DUF833. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio82526.

Entry information

Entry nameCV025_HUMAN
AccessionPrimary (citable) accession number: Q6ICL3
Secondary accession number(s): Q8IW05 expand/collapse secondary AC list , Q8NAL0, Q8TCS0, Q96M16
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 13, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Names and origin · Protein attributes · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents