Q6ICL3 (TNG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transport and Golgi organization 2 homolog

Gene names

Name:	TANGO2
Synonyms:	C22orf25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the tango2 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ICL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ICL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-151: Missing.

Isoform 3 (identifier: Q6ICL3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MCIIFFKFDP...FWGNNNEILS → MPLGAGTPVN...FWGNNNEILS
     190-197: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Transport and Golgi organization 2 homolog		PRO_0000253891
Natural variations
	Alternative sequence	1 – 48	48	MCIIF…NEILS → MPLGAGTPVNVQRREDSATE GSHRLILAANRDEFYSRPSK LADFWGNNNEILS in isoform 3.		VSP_021137
	Alternative sequence	90 – 151	62	Missing in isoform 2.		VSP_021139
	Alternative sequence	190 – 197	8	Missing in isoform 3.		VSP_021138
	Natural variant	125	1	D → N. Ref.5 Corresponds to variant rs17855650 [ dbSNP | Ensembl ].		VAR_028742
	Natural variant	200	1	E → K. Ref.5 Corresponds to variant rs17854107 [ dbSNP | Ensembl ].		VAR_028743
	Natural variant	245	1	D → E. Corresponds to variant rs16982614 [ dbSNP | Ensembl ].		VAR_028744

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 99D55353FD1B74E4	FASTA	276	30,937
	10 20 30 40 50 60 MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL DMEEGKEGGT 70 80 90 100 110 120 WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV DSLSYLKKVS MEGHLYNGFN 130 140 150 160 170 180 LIAADLSTAK GDVICYYGNR GEPDPIVLTP GTYGLSNALL ETPWRKLCFG KQLFLEAVER 190 200 210 220 230 240 SQALPKDVLI ASLLDVLNNE EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT 250 260 270 IILVDADGHV TFTERSMMDK DLSHWETRTY EFTLQS
	Isoform 2 [UniParc]. Checksum: 6E2207E4F3CA29A2	FASTA	214	24,194
	10 20 30 40 50 60 MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL DMEEGKEGGT 70 80 90 100 110 120 WLGISTRGKL AALTNYLQPQ LDWQARGRGT YGLSNALLET PWRKLCFGKQ LFLEAVERSQ 130 140 150 160 170 180 ALPKDVLIAS LLDVLNNEEA QLPDPAIEDQ GGEYVQPMLS KYAAVCVRCP GYGTRTNTII 190 200 210 LVDADGHVTF TERSMMDKDL SHWETRTYEF TLQS
	Isoform 3 [UniParc]. Checksum: 7AAF915CEB57393A	FASTA	273	30,345
	10 20 30 40 50 60 MPLGAGTPVN VQRREDSATE GSHRLILAAN RDEFYSRPSK LADFWGNNNE ILSGLDMEEG 70 80 90 100 110 120 KEGGTWLGIS TRGKLAALTN YLQPQLDWQA RGRGELVTHF LTTDVDSLSY LKKVSMEGHL 130 140 150 160 170 180 YNGFNLIAAD LSTAKGDVIC YYGNRGEPDP IVLTPGTYGL SNALLETPWR KLCFGKQLFL 190 200 210 220 230 240 EAVERSQALP KDVLNNEEAQ LPDPAIEDQG GEYVQPMLSK YAAVCVRCPG YGTRTNTIIL 250 260 270 VDADGHVTFT ERSMMDKDLS HWETRTYEFT LQS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Placenta and Testis.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-125 AND LYS-200. Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-276 (ISOFORM 1). Tissue: Amygdala.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057461 mRNA. Translation: BAB71498.1. AK092484 mRNA. Translation: BAC03902.1. CR456355 mRNA. Translation: CAG30241.1. AC005663 Genomic DNA. No translation available. AC006547 Genomic DNA. No translation available. CH471176 Genomic DNA. Translation: EAX03001.1. CH471176 Genomic DNA. Translation: EAX03005.1. BC041339 mRNA. Translation: AAH41339.1. AL713640 mRNA. Translation: CAD28454.1.
IPI	IPI00168034. IPI00384646. IPI00395547.
RefSeq	NP_690870.3. NM_152906.4.
UniGene	Hs.474233.
3D structure databases
ProteinModelPortal	Q6ICL3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332721.
PTM databases
PhosphoSite	Q6ICL3.
Polymorphism databases
DMDM	74709518.
Proteomic databases
PaxDb	Q6ICL3.
PRIDE	Q6ICL3.
Protocols and materials databases
DNASU	128989.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327374; ENSP00000332721; ENSG00000183597. ENST00000398042; ENSP00000381122; ENSG00000183597. ENST00000401886; ENSP00000385662; ENSG00000183597. ENST00000432883; ENSP00000402926; ENSG00000183597. ENST00000447208; ENSP00000389797; ENSG00000183597.
GeneID	128989.
KEGG	hsa:128989.
UCSC	uc002zrc.1. human. uc002zrf.2. human.
Organism-specific databases
CTD	128989.
GeneCards	GC22P020004.
H-InvDB	HIX0016248.
HGNC	HGNC:25439. TANGO2.
HPA	HPA003080.
neXtProt	NX_Q6ICL3.
PharmGKB	PA143485406.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG3332.
HOVERGEN	HBG017881.
OrthoDB	EOG45X7WW.
PhylomeDB	Q6ICL3.
Gene expression databases
ArrayExpress	Q6ICL3.
Bgee	Q6ICL3.
CleanEx	HS_C22orf25.
Genevestigator	Q6ICL3.
GermOnline	ENSG00000183597. Homo sapiens.
Family and domain databases
InterPro	IPR008551. DUF833. [Graphical view]
PANTHER	PTHR17985. PTHR17985. 1 hit.
Pfam	PF05742. NRDE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C22orf25. human.
GenomeRNAi	128989.
NextBio	82526.

Entry information

Entry name

TNG2_HUMAN

Accession

Primary (citable) accession number: Q6ICL3
Secondary accession number(s): A8MUE9 , D3DX23, Q8IW05, Q8NAL0, Q8TCS0, Q96M16

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.