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Q6ICL3

- TNG2_HUMAN

UniProt

Q6ICL3 - TNG2_HUMAN

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Protein

Transport and Golgi organization protein 2 homolog

Gene
TANGO2, C22orf25
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 2 homolog
Gene namesi
Name:TANGO2
Synonyms:C22orf25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:25439. TANGO2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Transport and Golgi organization protein 2 homologPRO_0000253891Add
BLAST

Proteomic databases

MaxQBiQ6ICL3.
PaxDbiQ6ICL3.
PRIDEiQ6ICL3.

PTM databases

PhosphoSiteiQ6ICL3.

Expressioni

Gene expression databases

ArrayExpressiQ6ICL3.
BgeeiQ6ICL3.
CleanExiHS_C22orf25.
GenevestigatoriQ6ICL3.

Organism-specific databases

HPAiHPA003080.

Interactioni

Protein-protein interaction databases

BioGridi126178. 4 interactions.
STRINGi9606.ENSP00000332721.

Structurei

3D structure databases

ProteinModelPortaliQ6ICL3.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tango2 family.

Phylogenomic databases

eggNOGiCOG3332.
HOGENOMiHOG000261311.
HOVERGENiHBG017881.
OMAiHTVHYQI.
OrthoDBiEOG7S2208.
PhylomeDBiQ6ICL3.
TreeFamiTF315064.

Family and domain databases

InterProiIPR008551. DUF833.
[Graphical view]
PANTHERiPTHR17985. PTHR17985. 1 hit.
PfamiPF05742. NRDE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ICL3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL    50
DMEEGKEGGT WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV 100
DSLSYLKKVS MEGHLYNGFN LIAADLSTAK GDVICYYGNR GEPDPIVLTP 150
GTYGLSNALL ETPWRKLCFG KQLFLEAVER SQALPKDVLI ASLLDVLNNE 200
EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT IILVDADGHV 250
TFTERSMMDK DLSHWETRTY EFTLQS 276
Length:276
Mass (Da):30,937
Last modified:July 5, 2004 - v1
Checksum:i99D55353FD1B74E4
GO
Isoform 2 (identifier: Q6ICL3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-151: Missing.

Show »
Length:214
Mass (Da):24,194
Checksum:i6E2207E4F3CA29A2
GO
Isoform 3 (identifier: Q6ICL3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MCIIFFKFDP...FWGNNNEILS → MPLGAGTPVN...FWGNNNEILS
     190-197: Missing.

Note: No experimental confirmation available.

Show »
Length:273
Mass (Da):30,345
Checksum:i7AAF915CEB57393A
GO
Isoform 4 (identifier: Q6ICL3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCIIFFKFDPRPVSKNAY → MPPKLLCAGR...REDSATEGSH

Show »
Length:317
Mass (Da):34,952
Checksum:i49895A717C4830F2
GO
Isoform 5 (identifier: Q6ICL3-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: MCIIFFKFDP...NGFNLIAADL → MAGHQHTWQAGSTHQLPAAAAGLAGPRA

Show »
Length:178
Mass (Da):19,467
Checksum:i399C2DF473F24294
GO
Isoform 6 (identifier: Q6ICL3-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCIIFFKFDPRPVSKNAY → MPPKLLCAGR...REDSATEGSH
     151-157: GTYGLSN → EPTLSSW
     158-276: Missing.

Show »
Length:198
Mass (Da):21,628
Checksum:iC4BF2CDFE87CD2B0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251D → N.1 Publication
Corresponds to variant rs17855650 [ dbSNP | Ensembl ].
VAR_028742
Natural varianti200 – 2001E → K.1 Publication
Corresponds to variant rs17854107 [ dbSNP | Ensembl ].
VAR_028743
Natural varianti245 – 2451D → E.
Corresponds to variant rs16982614 [ dbSNP | Ensembl ].
VAR_028744

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 126126MCIIF…IAADL → MAGHQHTWQAGSTHQLPAAA AGLAGPRA in isoform 5. VSP_055604Add
BLAST
Alternative sequencei1 – 4848MCIIF…NEILS → MPLGAGTPVNVQRREDSATE GSHRLILAANRDEFYSRPSK LADFWGNNNEILS in isoform 3. VSP_021137Add
BLAST
Alternative sequencei1 – 1818MCIIF…SKNAY → MPPKLLCAGRCVGQDGAAQA WHCPPGQGHSVWDAVRMPLG AGTPVNVQRREDSATEGSH in isoform 4 and isoform 6. VSP_055605Add
BLAST
Alternative sequencei90 – 15162Missing in isoform 2. VSP_021139Add
BLAST
Alternative sequencei151 – 1577GTYGLSN → EPTLSSW in isoform 6. VSP_055606
Alternative sequencei158 – 276119Missing in isoform 6. VSP_055607Add
BLAST
Alternative sequencei190 – 1978Missing in isoform 3. VSP_021138

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057461 mRNA. Translation: BAB71498.1.
AK092484 mRNA. Translation: BAC03902.1.
AK295210 mRNA. Translation: BAH12013.1.
AK298593 mRNA. Translation: BAH12819.1.
AK301366 mRNA. Translation: BAH13466.1.
AK316056 mRNA. Translation: BAH14427.1.
CR456355 mRNA. Translation: CAG30241.1.
AC005663 Genomic DNA. No translation available.
AC006547 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03001.1.
CH471176 Genomic DNA. Translation: EAX03003.1.
CH471176 Genomic DNA. Translation: EAX03005.1.
BC041339 mRNA. Translation: AAH41339.1.
AL713640 mRNA. Translation: CAD28454.1.
CCDSiCCDS13772.1. [Q6ICL3-1]
CCDS63404.1. [Q6ICL3-2]
RefSeqiNP_001270035.1. NM_001283106.1. [Q6ICL3-1]
NP_001270045.1. NM_001283116.1. [Q6ICL3-1]
NP_001270058.1. NM_001283129.1.
NP_001270077.1. NM_001283148.1.
NP_001270083.1. NM_001283154.1.
NP_001270108.1. NM_001283179.1. [Q6ICL3-2]
NP_001270115.1. NM_001283186.1. [Q6ICL3-2]
NP_001270128.1. NM_001283199.1.
NP_001270144.1. NM_001283215.1.
NP_001270164.1. NM_001283235.1.
NP_001270177.1. NM_001283248.1.
NP_690870.3. NM_152906.5. [Q6ICL3-1]
XP_005261280.1. XM_005261223.2. [Q6ICL3-2]
UniGeneiHs.474233.

Genome annotation databases

EnsembliENST00000327374; ENSP00000332721; ENSG00000183597. [Q6ICL3-1]
ENST00000398042; ENSP00000381122; ENSG00000183597. [Q6ICL3-2]
ENST00000401833; ENSP00000384827; ENSG00000183597.
ENST00000401886; ENSP00000385662; ENSG00000183597. [Q6ICL3-2]
ENST00000420290; ENSP00000396182; ENSG00000183597.
ENST00000432883; ENSP00000402926; ENSG00000183597. [Q6ICL3-2]
ENST00000434570; ENSP00000391262; ENSG00000183597.
ENST00000447208; ENSP00000389797; ENSG00000183597. [Q6ICL3-1]
GeneIDi128989.
KEGGihsa:128989.
UCSCiuc002zrc.1. human. [Q6ICL3-1]
uc002zrf.2. human. [Q6ICL3-2]

Polymorphism databases

DMDMi74709518.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057461 mRNA. Translation: BAB71498.1 .
AK092484 mRNA. Translation: BAC03902.1 .
AK295210 mRNA. Translation: BAH12013.1 .
AK298593 mRNA. Translation: BAH12819.1 .
AK301366 mRNA. Translation: BAH13466.1 .
AK316056 mRNA. Translation: BAH14427.1 .
CR456355 mRNA. Translation: CAG30241.1 .
AC005663 Genomic DNA. No translation available.
AC006547 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03001.1 .
CH471176 Genomic DNA. Translation: EAX03003.1 .
CH471176 Genomic DNA. Translation: EAX03005.1 .
BC041339 mRNA. Translation: AAH41339.1 .
AL713640 mRNA. Translation: CAD28454.1 .
CCDSi CCDS13772.1. [Q6ICL3-1 ]
CCDS63404.1. [Q6ICL3-2 ]
RefSeqi NP_001270035.1. NM_001283106.1. [Q6ICL3-1 ]
NP_001270045.1. NM_001283116.1. [Q6ICL3-1 ]
NP_001270058.1. NM_001283129.1.
NP_001270077.1. NM_001283148.1.
NP_001270083.1. NM_001283154.1.
NP_001270108.1. NM_001283179.1. [Q6ICL3-2 ]
NP_001270115.1. NM_001283186.1. [Q6ICL3-2 ]
NP_001270128.1. NM_001283199.1.
NP_001270144.1. NM_001283215.1.
NP_001270164.1. NM_001283235.1.
NP_001270177.1. NM_001283248.1.
NP_690870.3. NM_152906.5. [Q6ICL3-1 ]
XP_005261280.1. XM_005261223.2. [Q6ICL3-2 ]
UniGenei Hs.474233.

3D structure databases

ProteinModelPortali Q6ICL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126178. 4 interactions.
STRINGi 9606.ENSP00000332721.

PTM databases

PhosphoSitei Q6ICL3.

Polymorphism databases

DMDMi 74709518.

Proteomic databases

MaxQBi Q6ICL3.
PaxDbi Q6ICL3.
PRIDEi Q6ICL3.

Protocols and materials databases

DNASUi 128989.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327374 ; ENSP00000332721 ; ENSG00000183597 . [Q6ICL3-1 ]
ENST00000398042 ; ENSP00000381122 ; ENSG00000183597 . [Q6ICL3-2 ]
ENST00000401833 ; ENSP00000384827 ; ENSG00000183597 .
ENST00000401886 ; ENSP00000385662 ; ENSG00000183597 . [Q6ICL3-2 ]
ENST00000420290 ; ENSP00000396182 ; ENSG00000183597 .
ENST00000432883 ; ENSP00000402926 ; ENSG00000183597 . [Q6ICL3-2 ]
ENST00000434570 ; ENSP00000391262 ; ENSG00000183597 .
ENST00000447208 ; ENSP00000389797 ; ENSG00000183597 . [Q6ICL3-1 ]
GeneIDi 128989.
KEGGi hsa:128989.
UCSCi uc002zrc.1. human. [Q6ICL3-1 ]
uc002zrf.2. human. [Q6ICL3-2 ]

Organism-specific databases

CTDi 128989.
GeneCardsi GC22P020005.
H-InvDB HIX0016248.
HGNCi HGNC:25439. TANGO2.
HPAi HPA003080.
neXtProti NX_Q6ICL3.
PharmGKBi PA143485406.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3332.
HOGENOMi HOG000261311.
HOVERGENi HBG017881.
OMAi HTVHYQI.
OrthoDBi EOG7S2208.
PhylomeDBi Q6ICL3.
TreeFami TF315064.

Miscellaneous databases

ChiTaRSi C22orf25. human.
GeneWikii C22orf25.
GenomeRNAii 128989.
NextBioi 82526.
PROi Q6ICL3.

Gene expression databases

ArrayExpressi Q6ICL3.
Bgeei Q6ICL3.
CleanExi HS_C22orf25.
Genevestigatori Q6ICL3.

Family and domain databases

InterProi IPR008551. DUF833.
[Graphical view ]
PANTHERi PTHR17985. PTHR17985. 1 hit.
Pfami PF05742. NRDE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4; 5 AND 6).
    Tissue: Caudate nucleus, Hippocampus, Mesangial cell, Placenta, Synovium and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-125 AND LYS-200.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-276 (ISOFORM 1).
    Tissue: Amygdala.

Entry informationi

Entry nameiTNG2_HUMAN
AccessioniPrimary (citable) accession number: Q6ICL3
Secondary accession number(s): A8MUE9
, B7WNV6, B7Z583, B7Z730, D3DX23, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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