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Q6ICH7

- ASPH2_HUMAN

UniProt

Q6ICH7 - ASPH2_HUMAN

Protein

Aspartate beta-hydroxylase domain-containing protein 2

Gene

ASPHD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May function as 2-oxoglutarate-dependent dioxygenase.By similarity

    Cofactori

    Iron.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 22812-oxoglutarateBy similarity
    Binding sitei272 – 27212-oxoglutarateBy similarity
    Metal bindingi283 – 2831IronBy similarity
    Metal bindingi328 – 3281IronBy similarity
    Binding sitei341 – 34112-oxoglutarateBy similarity

    GO - Molecular functioni

    1. dioxygenase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidyl-amino acid modification Source: InterPro

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate beta-hydroxylase domain-containing protein 2 (EC:1.14.11.-)
    Gene namesi
    Name:ASPHD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:30437. ASPHD2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485314.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Aspartate beta-hydroxylase domain-containing protein 2PRO_0000254162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6ICH7.
    PaxDbiQ6ICH7.
    PRIDEiQ6ICH7.

    PTM databases

    PhosphoSiteiQ6ICH7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ICH7.
    BgeeiQ6ICH7.
    CleanExiHS_ASPHD2.
    GenevestigatoriQ6ICH7.

    Organism-specific databases

    HPAiHPA000820.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000215906.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ICH7.
    SMRiQ6ICH7. Positions 188-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5858CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini80 – 369290LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni292 – 29432-oxoglutarate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3555.
    HOGENOMiHOG000233597.
    HOVERGENiHBG079419.
    InParanoidiQ6ICH7.
    OMAiEWVTFYL.
    OrthoDBiEOG7JMGDJ.
    PhylomeDBiQ6ICH7.
    TreeFamiTF312799.

    Family and domain databases

    Gene3Di2.60.120.330. 1 hit.
    InterProiIPR007803. Asp_Arg_Pro-Hydrxlase.
    IPR027443. IPNS-like.
    [Graphical view]
    PfamiPF05118. Asp_Arg_Hydrox. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ICH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVWAPLGPPR TDCLTLLHTP SKDSPKMSLE WLVAWSWSLD GLRDCIATGI    50
    QSVRDCDTTA VITVACLLVL FVWYCYHVGR EQPRPYVSVN SLMQAADANG 100
    LQNGYVYCQS PECVRCTHNE GLNQKLYHNL QEYAKRYSWS GMGRIHKGIR 150
    EQGRYLNSRP SIQKPEVFFL PDLPTTPYFS RDAQKHDVEV LERNFQTILC 200
    EFETLYKAFS NCSLPQGWKM NSTPSGEWFT FYLVNQGVCV PRNCRKCPRT 250
    YRLLGSLRTC IGNNVFGNAC ISVLSPGTVI TEHYGPTNIR IRCHLGLKTP 300
    NGCELVVGGE PQCWAEGRCL LFDDSFLHAA FHEGSAEDGP RVVFMVDLWH 350
    PNVAAAERQA LDFIFAPGR 369
    Length:369
    Mass (Da):41,699
    Last modified:July 5, 2004 - v1
    Checksum:iAE28ED71AC770ACF
    GO

    Sequence cautioni

    The sequence AAH36753.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG37570.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351N → S.
    Corresponds to variant rs34902186 [ dbSNP | Ensembl ].
    VAR_060123

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456391 mRNA. Translation: CAG30277.1.
    AK315112 mRNA. Translation: BAG37570.1. Different initiation.
    Z99714 Genomic DNA. Translation: CAI17879.1.
    BC036753 mRNA. Translation: AAH36753.1. Different initiation.
    AL161993 mRNA. Translation: CAB82325.1.
    CCDSiCCDS13834.2.
    PIRiT47148.
    RefSeqiNP_065170.2. NM_020437.4.
    UniGeneiHs.567547.

    Genome annotation databases

    EnsembliENST00000215906; ENSP00000215906; ENSG00000128203.
    GeneIDi57168.
    KEGGihsa:57168.
    UCSCiuc003acg.2. human.

    Polymorphism databases

    DMDMi74757726.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456391 mRNA. Translation: CAG30277.1 .
    AK315112 mRNA. Translation: BAG37570.1 . Different initiation.
    Z99714 Genomic DNA. Translation: CAI17879.1 .
    BC036753 mRNA. Translation: AAH36753.1 . Different initiation.
    AL161993 mRNA. Translation: CAB82325.1 .
    CCDSi CCDS13834.2.
    PIRi T47148.
    RefSeqi NP_065170.2. NM_020437.4.
    UniGenei Hs.567547.

    3D structure databases

    ProteinModelPortali Q6ICH7.
    SMRi Q6ICH7. Positions 188-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000215906.

    PTM databases

    PhosphoSitei Q6ICH7.

    Polymorphism databases

    DMDMi 74757726.

    Proteomic databases

    MaxQBi Q6ICH7.
    PaxDbi Q6ICH7.
    PRIDEi Q6ICH7.

    Protocols and materials databases

    DNASUi 57168.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000215906 ; ENSP00000215906 ; ENSG00000128203 .
    GeneIDi 57168.
    KEGGi hsa:57168.
    UCSCi uc003acg.2. human.

    Organism-specific databases

    CTDi 57168.
    GeneCardsi GC22P026825.
    HGNCi HGNC:30437. ASPHD2.
    HPAi HPA000820.
    neXtProti NX_Q6ICH7.
    PharmGKBi PA143485314.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3555.
    HOGENOMi HOG000233597.
    HOVERGENi HBG079419.
    InParanoidi Q6ICH7.
    OMAi EWVTFYL.
    OrthoDBi EOG7JMGDJ.
    PhylomeDBi Q6ICH7.
    TreeFami TF312799.

    Miscellaneous databases

    GenomeRNAii 57168.
    NextBioi 63181.
    PROi Q6ICH7.

    Gene expression databases

    ArrayExpressi Q6ICH7.
    Bgeei Q6ICH7.
    CleanExi HS_ASPHD2.
    Genevestigatori Q6ICH7.

    Family and domain databases

    Gene3Di 2.60.120.330. 1 hit.
    InterProi IPR007803. Asp_Arg_Pro-Hydrxlase.
    IPR027443. IPNS-like.
    [Graphical view ]
    Pfami PF05118. Asp_Arg_Hydrox. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-369.
      Tissue: Amygdala.

    Entry informationi

    Entry nameiASPH2_HUMAN
    AccessioniPrimary (citable) accession number: Q6ICH7
    Secondary accession number(s): B2RCH3, Q7L0W3, Q9NSN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3