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Protein

Aspartate beta-hydroxylase domain-containing protein 2

Gene

ASPHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as 2-oxoglutarate-dependent dioxygenase.By similarity

Cofactori

Fe cationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei2282-oxoglutarateBy similarity1
Binding sitei2722-oxoglutarateBy similarity1
Metal bindingi283IronBy similarity1
Metal bindingi328IronBy similarity1
Binding sitei3412-oxoglutarateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate beta-hydroxylase domain-containing protein 2 (EC:1.14.11.-)
Gene namesi
Name:ASPHD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:30437. ASPHD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 369LumenalSequence analysisAdd BLAST290

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57168.
OpenTargetsiENSG00000128203.
PharmGKBiPA143485314.

Polymorphism and mutation databases

BioMutaiASPHD2.
DMDMi74757726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541621 – 369Aspartate beta-hydroxylase domain-containing protein 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6ICH7.
MaxQBiQ6ICH7.
PaxDbiQ6ICH7.
PeptideAtlasiQ6ICH7.
PRIDEiQ6ICH7.

PTM databases

iPTMnetiQ6ICH7.
PhosphoSitePlusiQ6ICH7.

Expressioni

Gene expression databases

BgeeiENSG00000128203.
CleanExiHS_ASPHD2.
ExpressionAtlasiQ6ICH7. baseline and differential.
GenevisibleiQ6ICH7. HS.

Organism-specific databases

HPAiHPA000820.

Interactioni

Protein-protein interaction databases

BioGridi121421. 23 interactors.
STRINGi9606.ENSP00000215906.

Structurei

3D structure databases

ProteinModelPortaliQ6ICH7.
SMRiQ6ICH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni292 – 2942-oxoglutarate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3696. Eukaryota.
COG3555. LUCA.
GeneTreeiENSGT00530000063281.
HOGENOMiHOG000233597.
HOVERGENiHBG079419.
InParanoidiQ6ICH7.
OMAiEWVTFYL.
OrthoDBiEOG091G08T9.
PhylomeDBiQ6ICH7.
TreeFamiTF312799.

Family and domain databases

Gene3Di2.60.120.330. 1 hit.
InterProiIPR007803. Asp/Arg/Pro-Hydrxlase.
IPR027443. IPNS-like.
[Graphical view]
PfamiPF05118. Asp_Arg_Hydrox. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ICH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWAPLGPPR TDCLTLLHTP SKDSPKMSLE WLVAWSWSLD GLRDCIATGI
60 70 80 90 100
QSVRDCDTTA VITVACLLVL FVWYCYHVGR EQPRPYVSVN SLMQAADANG
110 120 130 140 150
LQNGYVYCQS PECVRCTHNE GLNQKLYHNL QEYAKRYSWS GMGRIHKGIR
160 170 180 190 200
EQGRYLNSRP SIQKPEVFFL PDLPTTPYFS RDAQKHDVEV LERNFQTILC
210 220 230 240 250
EFETLYKAFS NCSLPQGWKM NSTPSGEWFT FYLVNQGVCV PRNCRKCPRT
260 270 280 290 300
YRLLGSLRTC IGNNVFGNAC ISVLSPGTVI TEHYGPTNIR IRCHLGLKTP
310 320 330 340 350
NGCELVVGGE PQCWAEGRCL LFDDSFLHAA FHEGSAEDGP RVVFMVDLWH
360
PNVAAAERQA LDFIFAPGR
Length:369
Mass (Da):41,699
Last modified:July 5, 2004 - v1
Checksum:iAE28ED71AC770ACF
GO

Sequence cautioni

The sequence AAH36753 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060123235N → S.Corresponds to variant rs34902186dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456391 mRNA. Translation: CAG30277.1.
AK315112 mRNA. Translation: BAG37570.1. Different initiation.
Z99714 Genomic DNA. Translation: CAI17879.1.
BC036753 mRNA. Translation: AAH36753.1. Different initiation.
AL161993 mRNA. Translation: CAB82325.1.
CCDSiCCDS13834.2.
PIRiT47148.
RefSeqiNP_065170.2. NM_020437.4.
UniGeneiHs.567547.

Genome annotation databases

EnsembliENST00000215906; ENSP00000215906; ENSG00000128203.
GeneIDi57168.
KEGGihsa:57168.
UCSCiuc003acg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456391 mRNA. Translation: CAG30277.1.
AK315112 mRNA. Translation: BAG37570.1. Different initiation.
Z99714 Genomic DNA. Translation: CAI17879.1.
BC036753 mRNA. Translation: AAH36753.1. Different initiation.
AL161993 mRNA. Translation: CAB82325.1.
CCDSiCCDS13834.2.
PIRiT47148.
RefSeqiNP_065170.2. NM_020437.4.
UniGeneiHs.567547.

3D structure databases

ProteinModelPortaliQ6ICH7.
SMRiQ6ICH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121421. 23 interactors.
STRINGi9606.ENSP00000215906.

PTM databases

iPTMnetiQ6ICH7.
PhosphoSitePlusiQ6ICH7.

Polymorphism and mutation databases

BioMutaiASPHD2.
DMDMi74757726.

Proteomic databases

EPDiQ6ICH7.
MaxQBiQ6ICH7.
PaxDbiQ6ICH7.
PeptideAtlasiQ6ICH7.
PRIDEiQ6ICH7.

Protocols and materials databases

DNASUi57168.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215906; ENSP00000215906; ENSG00000128203.
GeneIDi57168.
KEGGihsa:57168.
UCSCiuc003acg.3. human.

Organism-specific databases

CTDi57168.
DisGeNETi57168.
GeneCardsiASPHD2.
HGNCiHGNC:30437. ASPHD2.
HPAiHPA000820.
neXtProtiNX_Q6ICH7.
OpenTargetsiENSG00000128203.
PharmGKBiPA143485314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3696. Eukaryota.
COG3555. LUCA.
GeneTreeiENSGT00530000063281.
HOGENOMiHOG000233597.
HOVERGENiHBG079419.
InParanoidiQ6ICH7.
OMAiEWVTFYL.
OrthoDBiEOG091G08T9.
PhylomeDBiQ6ICH7.
TreeFamiTF312799.

Miscellaneous databases

GenomeRNAii57168.
PROiQ6ICH7.

Gene expression databases

BgeeiENSG00000128203.
CleanExiHS_ASPHD2.
ExpressionAtlasiQ6ICH7. baseline and differential.
GenevisibleiQ6ICH7. HS.

Family and domain databases

Gene3Di2.60.120.330. 1 hit.
InterProiIPR007803. Asp/Arg/Pro-Hydrxlase.
IPR027443. IPNS-like.
[Graphical view]
PfamiPF05118. Asp_Arg_Hydrox. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASPH2_HUMAN
AccessioniPrimary (citable) accession number: Q6ICH7
Secondary accession number(s): B2RCH3, Q7L0W3, Q9NSN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.