Q6ICG8 (WBP2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Postacrosomal sheath WW domain-binding protein

Alternative name(s):
WW domain-binding protein 2-like

Gene names

Name:	WBP2NL
Synonyms:	PAWP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization By similarity.
Tissue specificity	Expressed in testis. Ref.5
Sequence similarities	Contains 1 GRAM domain.
Sequence caution	The sequence AAH22549.1 differs from that shown. Reason: Frameshift at position 159.

Ontologies

Keywords
Biological process	Meiosis
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	egg activation Inferred from sequence or structural similarity Ref.5. Source: HGNC male pronucleus assembly Inferred from sequence or structural similarity Ref.5. Source: HGNC meiosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	perinuclear theca Inferred from sequence or structural similarity Ref.5. Source: HGNC
Molecular function	WW domain binding Inferred from sequence or structural similarity Ref.5. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Postacrosomal sheath WW domain-binding protein		PRO_0000289127
Regions
	Domain	45 – 87	43	GRAM
	Repeat	175 – 181	7	1
	Repeat	182 – 188	7	2
	Repeat	189 – 195	7	3
	Repeat	217 – 223	7	4
	Repeat	224 – 230	7	5
	Repeat	231 – 237	7	6
	Repeat	238 – 244	7	7
	Repeat	245 – 251	7	8
	Repeat	252 – 258	7	9
	Repeat	259 – 265	7	10
	Region	175 – 265	91	10 X 7 AA tandem repeat of Y-G-X-P-P-X-G
	Motif	186 – 189	4	WW-binding
	Compositional bias	176 – 281	106	Gly-rich
Natural variations
	Natural variant	5	1	Q → E. Corresponds to variant rs17002790 [ dbSNP | Ensembl ].		VAR_032578
	Natural variant	121	1	D → G. Ref.4 Corresponds to variant rs133335 [ dbSNP | Ensembl ].		VAR_032579
	Natural variant	170	1	C → F. Corresponds to variant rs17002802 [ dbSNP | Ensembl ].		VAR_032580
	Natural variant	285	1	Q → H. Ref.4 Corresponds to variant rs2301521 [ dbSNP | Ensembl ].		VAR_032581
Experimental info
	Sequence conflict	136	1	A → V in AAQ02873. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q6ICG8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D09202E9A951DF48	FASTA	309	31,909
	10 20 30 40 50 60 MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT LFLTSYRVIF 70 80 90 100 110 120 ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ AAPYGGWEGQ ATFKLVFRNG 130 140 150 160 170 180 DAIEFAQLMV KAASAAARGF PLRTLNDWFS SMGIYVITGE GNMCTPQMPC SVIVYGAPPA 190 200 210 220 230 240 GYGAPPPGYG APPAGYGAQP VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA 250 260 270 280 290 300 PPLGYGTPPL GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP SASSSQVHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-121 AND HIS-285. Tissue: Brain.
[5]	"PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization." Wu A.T.H., Sutovsky P., Manandhar G., Xu W., Katayama M., Day B.N., Park K.-W., Yi Y.-J., Xi Y.W., Prather R.S., Oko R. J. Biol. Chem. 282:12164-12175(2007) [PubMed: 17289678] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-309, TISSUE SPECIFICITY, MOTIF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR456400 mRNA. Translation: CAG30286.1. AK128138 mRNA. Translation: BAG54636.1. Z99716 Genomic DNA. Translation: CAI41694.1. BC022546 mRNA. Translation: AAH22546.1. BC022549 mRNA. Translation: AAH22549.1. Frameshift. AF393575 mRNA. Translation: AAQ02873.1.
IPI	IPI00152200.
RefSeq	NP_689826.2. NM_152613.2.
UniGene	Hs.655541.
3D structure databases
ProteinModelPortal	Q6ICG8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ICG8.
Polymorphism databases
DMDM	74757724.
Proteomic databases
PRIDE	Q6ICG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328823; ENSP00000332983; ENSG00000183066. ENST00000329620; ENSP00000328800; ENSG00000183066. ENST00000436265; ENSP00000401002; ENSG00000183066.
GeneID	164684.
KEGG	hsa:164684.
UCSC	uc003bbt.1. human.
Organism-specific databases
CTD	164684.
GeneCards	GC22P042394.
H-InvDB	HIX0203182.
HGNC	HGNC:28389. WBP2NL.
MIM	610981. gene.
neXtProt	NX_Q6ICG8.
PharmGKB	PA145147710.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06987.
GeneTree	ENSGT00530000063718.
HOVERGEN	HBG027489.
InParanoid	Q6ICG8.
OMA	KNCTVEQ.
PhylomeDB	Q6ICG8.
Gene expression databases
ArrayExpress	Q6ICG8.
Bgee	Q6ICG8.
CleanEx	HS_WBP2NL.
Genevestigator	Q6ICG8.
Family and domain databases
InterPro	IPR004182. GRAM. IPR018826. WW-domain-binding. [Graphical view]
Pfam	PF02893. GRAM. 1 hit. PF10349. WWbp. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	88486.
SOURCE	Search...

Entry information

Entry name

WBP2L_HUMAN

Accession

Primary (citable) accession number: Q6ICG8
Secondary accession number(s): A3KFF7 , A8MSG5, B3KXX4, Q8TBF0, Q8TBF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.