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Protein

Postacrosomal sheath WW domain-binding protein

Gene

WBP2NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.By similarity

GO - Molecular functioni

  • WW domain binding Source: HGNC

GO - Biological processi

  • egg activation Source: HGNC
  • male pronucleus assembly Source: HGNC
  • meiotic cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Postacrosomal sheath WW domain-binding protein
Alternative name(s):
WW domain-binding protein 2-like
Gene namesi
Name:WBP2NL
Synonyms:PAWP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28389. WBP2NL.

Subcellular locationi

GO - Cellular componenti

  • perinuclear theca Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147710.

Polymorphism and mutation databases

BioMutaiWBP2NL.
DMDMi74757724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Postacrosomal sheath WW domain-binding proteinPRO_0000289127Add
BLAST

Proteomic databases

PaxDbiQ6ICG8.
PRIDEiQ6ICG8.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiQ6ICG8.
CleanExiHS_WBP2NL.
ExpressionAtlasiQ6ICG8. baseline and differential.
GenevisibleiQ6ICG8. HS.

Organism-specific databases

HPAiHPA048557.

Interactioni

GO - Molecular functioni

  • WW domain binding Source: HGNC

Protein-protein interaction databases

BioGridi127900. 6 interactions.
STRINGi9606.ENSP00000328800.

Structurei

3D structure databases

ProteinModelPortaliQ6ICG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 8743GRAMAdd
BLAST
Repeati175 – 18171
Repeati182 – 18872
Repeati189 – 19573
Repeati217 – 22374
Repeati224 – 23075
Repeati231 – 23776
Repeati238 – 24477
Repeati245 – 25178
Repeati252 – 25879
Repeati259 – 265710

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 2659110 X 7 AA tandem repeat of Y-G-X-P-P-X-GAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi186 – 1894WW-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi176 – 281106Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 GRAM domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiQ6ICG8.
OMAiEGPPVGY.
PhylomeDBiQ6ICG8.
TreeFamiTF314141.

Family and domain databases

InterProiIPR004182. GRAM.
IPR011993. PH_dom-like.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ICG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT
60 70 80 90 100
LFLTSYRVIF ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ
110 120 130 140 150
AAPYGGWEGQ ATFKLVFRNG DAIEFAQLMV KAASAAARGF PLRTLNDWFS
160 170 180 190 200
SMGIYVITGE GNMCTPQMPC SVIVYGAPPA GYGAPPPGYG APPAGYGAQP
210 220 230 240 250
VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA PPLGYGTPPL
260 270 280 290 300
GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP

SASSSQVHS
Length:309
Mass (Da):31,909
Last modified:July 5, 2004 - v1
Checksum:iD09202E9A951DF48
GO

Sequence cautioni

The sequence AAH22549.1 differs from that shown. Reason: Frameshift at position 159. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361A → V in AAQ02873 (PubMed:17289678).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51Q → E.
Corresponds to variant rs17002790 [ dbSNP | Ensembl ].
VAR_032578
Natural varianti121 – 1211D → G.1 Publication
Corresponds to variant rs133335 [ dbSNP | Ensembl ].
VAR_032579
Natural varianti170 – 1701C → F.
Corresponds to variant rs17002802 [ dbSNP | Ensembl ].
VAR_032580
Natural varianti285 – 2851Q → H.1 Publication
Corresponds to variant rs2301521 [ dbSNP | Ensembl ].
VAR_032581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456400 mRNA. Translation: CAG30286.1.
AK128138 mRNA. Translation: BAG54636.1.
Z99716 Genomic DNA. Translation: CAI41694.1.
BC022546 mRNA. Translation: AAH22546.1.
BC022549 mRNA. Translation: AAH22549.1. Frameshift.
AF393575 mRNA. Translation: AAQ02873.1.
CCDSiCCDS14029.1.
RefSeqiNP_689826.2. NM_152613.2.
UniGeneiHs.655541.

Genome annotation databases

EnsembliENST00000328823; ENSP00000332983; ENSG00000183066.
ENST00000329620; ENSP00000328800; ENSG00000183066.
ENST00000436265; ENSP00000401002; ENSG00000183066.
GeneIDi164684.
KEGGihsa:164684.
UCSCiuc003bbt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456400 mRNA. Translation: CAG30286.1.
AK128138 mRNA. Translation: BAG54636.1.
Z99716 Genomic DNA. Translation: CAI41694.1.
BC022546 mRNA. Translation: AAH22546.1.
BC022549 mRNA. Translation: AAH22549.1. Frameshift.
AF393575 mRNA. Translation: AAQ02873.1.
CCDSiCCDS14029.1.
RefSeqiNP_689826.2. NM_152613.2.
UniGeneiHs.655541.

3D structure databases

ProteinModelPortaliQ6ICG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127900. 6 interactions.
STRINGi9606.ENSP00000328800.

Polymorphism and mutation databases

BioMutaiWBP2NL.
DMDMi74757724.

Proteomic databases

PaxDbiQ6ICG8.
PRIDEiQ6ICG8.

Protocols and materials databases

DNASUi164684.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328823; ENSP00000332983; ENSG00000183066.
ENST00000329620; ENSP00000328800; ENSG00000183066.
ENST00000436265; ENSP00000401002; ENSG00000183066.
GeneIDi164684.
KEGGihsa:164684.
UCSCiuc003bbt.4. human.

Organism-specific databases

CTDi164684.
GeneCardsiWBP2NL.
HGNCiHGNC:28389. WBP2NL.
HPAiHPA048557.
MIMi610981. gene.
neXtProtiNX_Q6ICG8.
PharmGKBiPA145147710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiQ6ICG8.
OMAiEGPPVGY.
PhylomeDBiQ6ICG8.
TreeFamiTF314141.

Miscellaneous databases

ChiTaRSiWBP2NL. human.
GenomeRNAii164684.
NextBioi88486.
PROiQ6ICG8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ICG8.
CleanExiHS_WBP2NL.
ExpressionAtlasiQ6ICG8. baseline and differential.
GenevisibleiQ6ICG8. HS.

Family and domain databases

InterProiIPR004182. GRAM.
IPR011993. PH_dom-like.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-121 AND HIS-285.
    Tissue: Brain.
  5. "PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization."
    Wu A.T.H., Sutovsky P., Manandhar G., Xu W., Katayama M., Day B.N., Park K.-W., Yi Y.-J., Xi Y.W., Prather R.S., Oko R.
    J. Biol. Chem. 282:12164-12175(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-309, TISSUE SPECIFICITY, MOTIF.

Entry informationi

Entry nameiWBP2L_HUMAN
AccessioniPrimary (citable) accession number: Q6ICG8
Secondary accession number(s): A3KFF7
, A8MSG5, B3KXX4, Q8TBF0, Q8TBF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.