Reviewed, UniProtKB/Swiss-Prot Q6ICG6 (CV009_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C22orf9

Gene names

Name:	C22orf9
Synonyms:	KIAA0930

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAG	P61981	1	EBI-1053969,EBI-359832
YWHAQ	P27348	1	EBI-1053969,EBI-359854
YWHAZ	P63104	1	EBI-1053969,EBI-347088

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ICG6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ICG6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MLRAIAEERGRLSLRREVCGL → MGSQAAAEWRNWASWEVSSSLSGCSM

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q6ICG6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Uncharacterized protein C22orf9		PRO_0000255938
Amino acid modifications
	Modified residue	290	1	Phosphothreonine Ref.6
	Modified residue	293	1	Phosphothreonine Ref.6
	Modified residue	324	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 34	34	Missing in isoform 3.		VSP_021310
	Alternative sequence	1 – 21	21	MLRAI…EVCGL → MGSQAAAEWRNWASWEVSSS LSGCSM in isoform 2.		VSP_021309

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 293D43C8E862E4A2	FASTA	404	45,794
	10 20 30 40 50 60 MLRAIAEERG RLSLRREVCG LGCFKDDRIV FWTWMFSTYF MEKWAPRQDD MLFYVRRKLA 70 80 90 100 110 120 YSGSESGADG RKAAEPEVEV EVYRRDSKKL PGLGDPDIDW EESVCLNLIL QKLDYMVTCA 130 140 150 160 170 180 VCTRADGGDI HIHKKKSQQV FASPSKHPMD SKGEESKISY PNIFFMIDSF EEVFSDMTVG 190 200 210 220 230 240 EGEMVCVELV ASDKTNTFQG VIFQGSIRYE ALKKVYDNRV SVAARMAQKM SFGFYKYSNM 250 260 270 280 290 300 EFVRMKGPQG KGHAEMAVSR VSTGDTSPCG TEEDSSPASP MHERVTSFST PPTPERNNRP 310 320 330 340 350 360 AFFSPSLKRK VPRNRIAEMK KSHSANDSEE FFREDDGGAD LHNATNLRSR SLSGTGRSLV 370 380 390 400 GSWLKLNRAD GNFLLYAHLT YVTLPLHRIL TDILEVRQKP ILMT
	Isoform 2. Checksum: 5CD3F3FCEDD00BA9		409	46,184
	10 20 30 40 50 60 MGSQAAAEWR NWASWEVSSS LSGCSMGCFK DDRIVFWTWM FSTYFMEKWA PRQDDMLFYV 70 80 90 100 110 120 RRKLAYSGSE SGADGRKAAE PEVEVEVYRR DSKKLPGLGD PDIDWEESVC LNLILQKLDY 130 140 150 160 170 180 MVTCAVCTRA DGGDIHIHKK KSQQVFASPS KHPMDSKGEE SKISYPNIFF MIDSFEEVFS 190 200 210 220 230 240 DMTVGEGEMV CVELVASDKT NTFQGVIFQG SIRYEALKKV YDNRVSVAAR MAQKMSFGFY 250 260 270 280 290 300 KYSNMEFVRM KGPQGKGHAE MAVSRVSTGD TSPCGTEEDS SPASPMHERV TSFSTPPTPE 310 320 330 340 350 360 RNNRPAFFSP SLKRKVPRNR IAEMKKSHSA NDSEEFFRED DGGADLHNAT NLRSRSLSGT 370 380 390 400 GRSLVGSWLK LNRADGNFLL YAHLTYVTLP LHRILTDILE VRQKPILMT
	Isoform 3. Checksum: 6DB08AEA04178A0F		370	41,728
	10 20 30 40 50 60 MFSTYFMEKW APRQDDMLFY VRRKLAYSGS ESGADGRKAA EPEVEVEVYR RDSKKLPGLG 70 80 90 100 110 120 DPDIDWEESV CLNLILQKLD YMVTCAVCTR ADGGDIHIHK KKSQQVFASP SKHPMDSKGE 130 140 150 160 170 180 ESKISYPNIF FMIDSFEEVF SDMTVGEGEM VCVELVASDK TNTFQGVIFQ GSIRYEALKK 190 200 210 220 230 240 VYDNRVSVAA RMAQKMSFGF YKYSNMEFVR MKGPQGKGHA EMAVSRVSTG DTSPCGTEED 250 260 270 280 290 300 SSPASPMHER VTSFSTPPTP ERNNRPAFFS PSLKRKVPRN RIAEMKKSHS ANDSEEFFRE 310 320 330 340 350 360 DDGGADLHNA TNLRSRSLSG TGRSLVGSWL KLNRADGNFL LYAHLTYVTL PLHRILTDIL 370 EVRQKPILMT

References

[1]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-404 (ISOFORMS 1/2/3). Tissue: Brain and Uterus.
[5]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-404. Tissue: Brain.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-290; THR-293 AND SER-324, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR456402 mRNA. Translation: CAG30288.1. AK124648 mRNA. Translation: BAC85917.1. AL008718 Genomic DNA. Translation: CAI17946.1. AL008718 Genomic DNA. Translation: CAQ08665.1. AL008718 Genomic DNA. Translation: CAQ08667.1. BC016882 mRNA. Translation: AAH16882.1. BC053595 mRNA. Translation: AAH53595.1. AB023147 mRNA. Translation: BAA76774.1.
RefSeq	NP_001009880.1. NP_056079.1.
UniGene	Hs.592207
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ICG6. 4 interactions.
Proteomic databases
PRIDE	Q6ICG6.
Genome annotation databases
Ensembl	ENSG00000100364. Homo sapiens. [Contig view]
GeneID	23313.
KEGG	hsa:23313.
Organism-specific databases
GeneCards	GC22M043912.
HGNC	HGNC:1314. C22orf9.
PharmGKB	PA128394623.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6ICG6.
Gene expression databases
ArrayExpress	Q6ICG6.
CleanEx	HS_C22orf9.
GermOnline	ENSG00000100364. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	45186.

Entry information

Entry name

CV009_HUMAN

Accession

Primary (citable) accession number: Q6ICG6
Secondary accession number(s): B0QY17 , B0QY19, Q6ZVE5, Q7Z6K9, Q8IZ76, Q9Y2E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	December 16, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)