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Protein

Uncharacterized protein KIAA0930

Gene

KIAA0930

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA0930
Gene namesi
Name:KIAA0930
Synonyms:C22orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1314. KIAA0930.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394623.

Polymorphism and mutation databases

BioMutaiKIAA0930.
DMDMi74748760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Uncharacterized protein KIAA0930PRO_0000255938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671PhosphoserineCombined sources
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei279 – 2791PhosphoserineCombined sources
Modified residuei290 – 2901PhosphothreonineCombined sources
Modified residuei293 – 2931PhosphothreonineCombined sources
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei324 – 3241PhosphoserineCombined sources
Modified residuei358 – 3581PhosphoserineBy similarity
Modified residuei362 – 3621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ICG6.
MaxQBiQ6ICG6.
PaxDbiQ6ICG6.
PRIDEiQ6ICG6.

PTM databases

iPTMnetiQ6ICG6.
PhosphoSiteiQ6ICG6.

Expressioni

Gene expression databases

BgeeiQ6ICG6.
CleanExiHS_C22orf9.
ExpressionAtlasiQ6ICG6. baseline and differential.
GenevisibleiQ6ICG6. HS.

Organism-specific databases

HPAiHPA038091.

Interactioni

Protein-protein interaction databases

BioGridi116904. 16 interactions.
IntActiQ6ICG6. 3 interactions.
MINTiMINT-1630728.
STRINGi9606.ENSP00000251993.

Structurei

3D structure databases

ProteinModelPortaliQ6ICG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2465. Eukaryota.
ENOG410ZRJN. LUCA.
GeneTreeiENSGT00390000004190.
HOVERGENiHBG061712.
InParanoidiQ6ICG6.
OMAiKTNTFQG.
OrthoDBiEOG7K6PTZ.
PhylomeDBiQ6ICG6.
TreeFamiTF313801.

Family and domain databases

InterProiIPR019141. DUF2045.
[Graphical view]
PfamiPF09741. DUF2045. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ICG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRAIAEERG RLSLRREVCG LGCFKDDRIV FWTWMFSTYF MEKWAPRQDD
60 70 80 90 100
MLFYVRRKLA YSGSESGADG RKAAEPEVEV EVYRRDSKKL PGLGDPDIDW
110 120 130 140 150
EESVCLNLIL QKLDYMVTCA VCTRADGGDI HIHKKKSQQV FASPSKHPMD
160 170 180 190 200
SKGEESKISY PNIFFMIDSF EEVFSDMTVG EGEMVCVELV ASDKTNTFQG
210 220 230 240 250
VIFQGSIRYE ALKKVYDNRV SVAARMAQKM SFGFYKYSNM EFVRMKGPQG
260 270 280 290 300
KGHAEMAVSR VSTGDTSPCG TEEDSSPASP MHERVTSFST PPTPERNNRP
310 320 330 340 350
AFFSPSLKRK VPRNRIAEMK KSHSANDSEE FFREDDGGAD LHNATNLRSR
360 370 380 390 400
SLSGTGRSLV GSWLKLNRAD GNFLLYAHLT YVTLPLHRIL TDILEVRQKP

ILMT
Length:404
Mass (Da):45,794
Last modified:July 5, 2004 - v1
Checksum:i293D43C8E862E4A2
GO
Isoform 2 (identifier: Q6ICG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MLRAIAEERGRLSLRREVCGL → MGSQAAAEWRNWASWEVSSSLSGCSM

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):46,184
Checksum:i5CD3F3FCEDD00BA9
GO
Isoform 3 (identifier: Q6ICG6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):41,728
Checksum:i6DB08AEA04178A0F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3434Missing in isoform 3. 1 PublicationVSP_021310Add
BLAST
Alternative sequencei1 – 2121MLRAI…EVCGL → MGSQAAAEWRNWASWEVSSS LSGCSM in isoform 2. 1 PublicationVSP_021309Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456402 mRNA. Translation: CAG30288.1.
AK094937 mRNA. Translation: BAG52960.1.
AK124648 mRNA. Translation: BAC85917.1.
AL008718 Genomic DNA. Translation: CAI17946.1.
AL008718 Genomic DNA. Translation: CAQ08665.1.
AL008718 Genomic DNA. Translation: CAQ08667.1.
CH471138 Genomic DNA. Translation: EAW73376.1.
BC016882 mRNA. Translation: AAH16882.1.
BC053595 mRNA. Translation: AAH53595.1.
AB023147 mRNA. Translation: BAA76774.1.
CCDSiCCDS33665.1. [Q6ICG6-1]
CCDS33666.1. [Q6ICG6-2]
RefSeqiNP_001009880.1. NM_001009880.1. [Q6ICG6-1]
NP_056079.1. NM_015264.1. [Q6ICG6-2]
XP_011528319.1. XM_011530017.1. [Q6ICG6-3]
UniGeneiHs.592207.

Genome annotation databases

EnsembliENST00000251993; ENSP00000251993; ENSG00000100364. [Q6ICG6-2]
ENST00000336156; ENSP00000336720; ENSG00000100364. [Q6ICG6-1]
ENST00000391627; ENSP00000375485; ENSG00000100364. [Q6ICG6-3]
GeneIDi23313.
KEGGihsa:23313.
UCSCiuc003bfw.2. human. [Q6ICG6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456402 mRNA. Translation: CAG30288.1.
AK094937 mRNA. Translation: BAG52960.1.
AK124648 mRNA. Translation: BAC85917.1.
AL008718 Genomic DNA. Translation: CAI17946.1.
AL008718 Genomic DNA. Translation: CAQ08665.1.
AL008718 Genomic DNA. Translation: CAQ08667.1.
CH471138 Genomic DNA. Translation: EAW73376.1.
BC016882 mRNA. Translation: AAH16882.1.
BC053595 mRNA. Translation: AAH53595.1.
AB023147 mRNA. Translation: BAA76774.1.
CCDSiCCDS33665.1. [Q6ICG6-1]
CCDS33666.1. [Q6ICG6-2]
RefSeqiNP_001009880.1. NM_001009880.1. [Q6ICG6-1]
NP_056079.1. NM_015264.1. [Q6ICG6-2]
XP_011528319.1. XM_011530017.1. [Q6ICG6-3]
UniGeneiHs.592207.

3D structure databases

ProteinModelPortaliQ6ICG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116904. 16 interactions.
IntActiQ6ICG6. 3 interactions.
MINTiMINT-1630728.
STRINGi9606.ENSP00000251993.

PTM databases

iPTMnetiQ6ICG6.
PhosphoSiteiQ6ICG6.

Polymorphism and mutation databases

BioMutaiKIAA0930.
DMDMi74748760.

Proteomic databases

EPDiQ6ICG6.
MaxQBiQ6ICG6.
PaxDbiQ6ICG6.
PRIDEiQ6ICG6.

Protocols and materials databases

DNASUi23313.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251993; ENSP00000251993; ENSG00000100364. [Q6ICG6-2]
ENST00000336156; ENSP00000336720; ENSG00000100364. [Q6ICG6-1]
ENST00000391627; ENSP00000375485; ENSG00000100364. [Q6ICG6-3]
GeneIDi23313.
KEGGihsa:23313.
UCSCiuc003bfw.2. human. [Q6ICG6-1]

Organism-specific databases

CTDi23313.
GeneCardsiKIAA0930.
HGNCiHGNC:1314. KIAA0930.
HPAiHPA038091.
neXtProtiNX_Q6ICG6.
PharmGKBiPA128394623.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2465. Eukaryota.
ENOG410ZRJN. LUCA.
GeneTreeiENSGT00390000004190.
HOVERGENiHBG061712.
InParanoidiQ6ICG6.
OMAiKTNTFQG.
OrthoDBiEOG7K6PTZ.
PhylomeDBiQ6ICG6.
TreeFamiTF313801.

Miscellaneous databases

ChiTaRSiKIAA0930. human.
GeneWikiiC22orf9.
GenomeRNAii23313.
NextBioi45186.
PROiQ6ICG6.

Gene expression databases

BgeeiQ6ICG6.
CleanExiHS_C22orf9.
ExpressionAtlasiQ6ICG6. baseline and differential.
GenevisibleiQ6ICG6. HS.

Family and domain databases

InterProiIPR019141. DUF2045.
[Graphical view]
PfamiPF09741. DUF2045. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Corpus callosum.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-404 (ISOFORMS 1/2/3).
    Tissue: Brain and Uterus.
  6. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-404.
    Tissue: Brain.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-290; THR-293 AND SER-324, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiK0930_HUMAN
AccessioniPrimary (citable) accession number: Q6ICG6
Secondary accession number(s): B0QY17
, B0QY19, B3KT48, Q6ZVE5, Q7Z6K9, Q8IZ76, Q9Y2E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.