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Protein

Retrotransposon Gag-like protein 6

Gene

RTL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

RTL6 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 6Imported
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells-like
Mammalian retrotransposon-derived protein 6By similarity
Protein LDOC1LCurated
Gene namesi
Name:RTL6Imported
Synonyms:LDOC1LCurated, MAR6, MART6By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000188636.3.
HGNCiHGNC:13343. RTL6.

Pathology & Biotechi

Organism-specific databases

DisGeNETi84247.
OpenTargetsiENSG00000188636.
PharmGKBiPA134971270.

Polymorphism and mutation databases

BioMutaiLDOC1L.
DMDMi74762303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890971 – 239Retrotransposon Gag-like protein 6Add BLAST239

Proteomic databases

MaxQBiQ6ICC9.
PaxDbiQ6ICC9.
PeptideAtlasiQ6ICC9.
PRIDEiQ6ICC9.

PTM databases

iPTMnetiQ6ICC9.

Expressioni

Gene expression databases

BgeeiENSG00000188636.
CleanExiHS_LDOC1L.
GenevisibleiQ6ICC9. HS.

Organism-specific databases

HPAiHPA005697.

Interactioni

Protein-protein interaction databases

BioGridi123975. 7 interactors.
IntActiQ6ICC9. 2 interactors.
STRINGi9606.ENSP00000340434.

Structurei

3D structure databases

ProteinModelPortaliQ6ICC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 69Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVFE. Eukaryota.
ENOG4111DVS. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000113308.
HOVERGENiHBG102708.
InParanoidiQ6ICC9.
OMAiLPTRARN.
OrthoDBiEOG091G02TH.
PhylomeDBiQ6ICC9.
TreeFamiTF337113.

Family and domain databases

InterProiView protein in InterPro
IPR032549. DUF4939.
IPR032567. LDOC1-rel.
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiView protein in Pfam
PF16297. DUF4939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ICC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQPQTSKAE SPALAASPNA QMDDVIDTLT SLRLTNSALR REASTLRAEK
60 70 80 90 100
ANLTNMLESV MAELTLLRTR ARIPGALQIT PPISSITSNG TRPMTTPPTS
110 120 130 140 150
LPEPFSGDPG RLAGFLMQMD RFMIFQASRF PGEAERVAFL VSRLTGEAEK
160 170 180 190 200
WAIPHMQPDS PLRNNYQGFL AELRRTYKSP LRHARRAQIR KTSASNRAVR
210 220 230
ERQMLCRQLA SAGTGPCPVH PASNGTSPAP ALPARARNL
Length:239
Mass (Da):26,154
Last modified:July 5, 2004 - v1
Checksum:iDEF1661C6F51FBD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456439 mRNA. Translation: CAG30325.1.
Z75407 Genomic DNA. No translation available.
BC030232 mRNA. Translation: AAH30232.1.
AK126304 mRNA. No translation available.
CCDSiCCDS33662.1.
RefSeqiNP_115663.2. NM_032287.2.
UniGeneiHs.744991.

Genome annotation databases

EnsembliENST00000341255; ENSP00000340434; ENSG00000188636.
GeneIDi84247.
KEGGihsa:84247.
UCSCiuc003beu.2. human.

Similar proteinsi

Entry informationi

Entry nameiRTL6_HUMAN
AccessioniPrimary (citable) accession number: Q6ICC9
Secondary accession number(s): Q6ZTR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families