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Protein

Desumoylating isopeptidase 1

Gene

DESI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38By similarity1
Active sitei108By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiC97.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Desumoylating isopeptidase 1 (EC:3.4.-.-)
Short name:
DeSI-1
Alternative name(s):
PPPDE peptidase domain-containing protein 2
Protein FAM152B
Gene namesi
Name:DESI1
Synonyms:FAM152B, PPPDE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:24577. DESI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100418.
PharmGKBiPA164725008.

Polymorphism and mutation databases

BioMutaiDESI1.
DMDMi74757716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181501 – 168Desumoylating isopeptidase 1Add BLAST168

Proteomic databases

EPDiQ6ICB0.
MaxQBiQ6ICB0.
PaxDbiQ6ICB0.
PeptideAtlasiQ6ICB0.
PRIDEiQ6ICB0.
TopDownProteomicsiQ6ICB0.

PTM databases

iPTMnetiQ6ICB0.
PhosphoSitePlusiQ6ICB0.

Expressioni

Gene expression databases

BgeeiENSG00000100418.
GenevisibleiQ6ICB0. HS.

Organism-specific databases

HPAiHPA053415.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi118163. 5 interactors.
IntActiQ6ICB0. 14 interactors.
STRINGi9606.ENSP00000263256.

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Turni16 – 19Combined sources4
Helixi20 – 29Combined sources10
Beta strandi37 – 43Combined sources7
Beta strandi46 – 49Combined sources4
Beta strandi55 – 59Combined sources5
Beta strandi69 – 77Combined sources9
Helixi81 – 92Combined sources12
Turni93 – 95Combined sources3
Helixi98 – 100Combined sources3
Turni103 – 105Combined sources3
Helixi108 – 120Combined sources13
Helixi126 – 129Combined sources4
Helixi131 – 136Combined sources6
Helixi139 – 144Combined sources6
Turni145 – 147Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EBQX-ray1.90A1-168[»]
ProteinModelPortaliQ6ICB0.
SMRiQ6ICB0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6ICB0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 149PPPDE peptidaseAdd BLAST143

Sequence similaritiesi

Belongs to the DeSI family.Curated
Contains 1 PPPDE peptidase domain.Curated

Phylogenomic databases

eggNOGiKOG0324. Eukaryota.
ENOG4111H3Z. LUCA.
GeneTreeiENSGT00730000111100.
HOGENOMiHOG000012722.
InParanoidiQ6ICB0.
OMAiFRSEAYN.
OrthoDBiEOG091G0PEG.
PhylomeDBiQ6ICB0.
TreeFamiTF328492.

Family and domain databases

InterProiIPR008580. PPPDE_dom.
[Graphical view]
PfamiPF05903. Peptidase_C97. 1 hit.
[Graphical view]
SMARTiSM01179. DUF862. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ICB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPNLYPVK LYVYDLSKGL ARRLSPIMLG KQLEGIWHTS IVVHKDEFFF
60 70 80 90 100
GSGGISSCPP GGTLLGPPDS VVDVGSTEVT EEIFLEYLSS LGESLFRGEA
110 120 130 140 150
YNLFEHNCNT FSNEVAQFLT GRKIPSYITD LPSEVLSTPF GQALRPLLDS
160
IQIQPPGGSS VGRPNGQS
Length:168
Mass (Da):18,263
Last modified:July 5, 2004 - v1
Checksum:iD902AF6FE5DDA31A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456458 mRNA. Translation: CAG30344.1.
Z83840, AL023553 Genomic DNA. Translation: CAI17917.1.
AL023553, Z83840 Genomic DNA. Translation: CAI20277.1.
CH471095 Genomic DNA. Translation: EAW60445.1.
BC093956 mRNA. Translation: AAH93956.1.
BC112179 mRNA. Translation: AAI12180.1.
CCDSiCCDS33652.1.
RefSeqiNP_056519.1. NM_015704.2.
UniGeneiHs.570455.

Genome annotation databases

EnsembliENST00000263256; ENSP00000263256; ENSG00000100418.
GeneIDi27351.
KEGGihsa:27351.
UCSCiuc003bam.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456458 mRNA. Translation: CAG30344.1.
Z83840, AL023553 Genomic DNA. Translation: CAI17917.1.
AL023553, Z83840 Genomic DNA. Translation: CAI20277.1.
CH471095 Genomic DNA. Translation: EAW60445.1.
BC093956 mRNA. Translation: AAH93956.1.
BC112179 mRNA. Translation: AAI12180.1.
CCDSiCCDS33652.1.
RefSeqiNP_056519.1. NM_015704.2.
UniGeneiHs.570455.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EBQX-ray1.90A1-168[»]
ProteinModelPortaliQ6ICB0.
SMRiQ6ICB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118163. 5 interactors.
IntActiQ6ICB0. 14 interactors.
STRINGi9606.ENSP00000263256.

Protein family/group databases

MEROPSiC97.001.

PTM databases

iPTMnetiQ6ICB0.
PhosphoSitePlusiQ6ICB0.

Polymorphism and mutation databases

BioMutaiDESI1.
DMDMi74757716.

Proteomic databases

EPDiQ6ICB0.
MaxQBiQ6ICB0.
PaxDbiQ6ICB0.
PeptideAtlasiQ6ICB0.
PRIDEiQ6ICB0.
TopDownProteomicsiQ6ICB0.

Protocols and materials databases

DNASUi27351.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263256; ENSP00000263256; ENSG00000100418.
GeneIDi27351.
KEGGihsa:27351.
UCSCiuc003bam.3. human.

Organism-specific databases

CTDi27351.
GeneCardsiDESI1.
H-InvDBHIX0041118.
HGNCiHGNC:24577. DESI1.
HPAiHPA053415.
MIMi614637. gene.
neXtProtiNX_Q6ICB0.
OpenTargetsiENSG00000100418.
PharmGKBiPA164725008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0324. Eukaryota.
ENOG4111H3Z. LUCA.
GeneTreeiENSGT00730000111100.
HOGENOMiHOG000012722.
InParanoidiQ6ICB0.
OMAiFRSEAYN.
OrthoDBiEOG091G0PEG.
PhylomeDBiQ6ICB0.
TreeFamiTF328492.

Miscellaneous databases

EvolutionaryTraceiQ6ICB0.
GenomeRNAii27351.
PROiQ6ICB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100418.
GenevisibleiQ6ICB0. HS.

Family and domain databases

InterProiIPR008580. PPPDE_dom.
[Graphical view]
PfamiPF05903. Peptidase_C97. 1 hit.
[Graphical view]
SMARTiSM01179. DUF862. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDESI1_HUMAN
AccessioniPrimary (citable) accession number: Q6ICB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.