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Protein

Condensin-2 complex subunit H2

Gene

NCAPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a role in lineage-specific role in T-cell development (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Enzyme and pathway databases

ReactomeiR-HSA-2299718. Condensation of Prophase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit H2
Alternative name(s):
Chromosome-associated protein H2
Short name:
hCAP-H2
Kleisin-beta
Non-SMC condensin II complex subunit H2
Gene namesi
Name:NCAPH2
Synonyms:CAPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:25071. NCAPH2.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication

  • Note: Distributed along the arms of chromosomes assembled in vivo and in vitro.

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000025770.
PharmGKBiPA162397314.

Polymorphism and mutation databases

BioMutaiNCAPH2.
DMDMi74709496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262411 – 605Condensin-2 complex subunit H2Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei282PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IBW4.
MaxQBiQ6IBW4.
PaxDbiQ6IBW4.
PeptideAtlasiQ6IBW4.
PRIDEiQ6IBW4.

PTM databases

iPTMnetiQ6IBW4.
PhosphoSitePlusiQ6IBW4.

Expressioni

Gene expression databases

BgeeiENSG00000025770.
CleanExiHS_NCAPH2.
ExpressionAtlasiQ6IBW4. baseline and differential.
GenevisibleiQ6IBW4. HS.

Organism-specific databases

HPAiHPA067932.
HPA069056.

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGLN3Q9H6Z93EBI-10247000,EBI-1175354
NCAPD3P426953EBI-2548296,EBI-722805
NCAPG2Q86XI22EBI-2548296,EBI-1047404
SMC2O953472EBI-2548296,EBI-355822
SNRPCQ5TAL43EBI-10247000,EBI-10246938
USHBP1Q8N6Y03EBI-10247000,EBI-739895

Protein-protein interaction databases

BioGridi118913. 101 interactors.
DIPiDIP-43901N.
IntActiQ6IBW4. 16 interactors.
MINTiMINT-4329914.
STRINGi9606.ENSP00000299821.

Structurei

3D structure databases

ProteinModelPortaliQ6IBW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2359. Eukaryota.
ENOG4111BR3. LUCA.
GeneTreeiENSGT00390000014443.
HOVERGENiHBG098083.
InParanoidiQ6IBW4.
KOiK11490.
OMAiASCVKET.
OrthoDBiEOG091G0TAX.
PhylomeDBiQ6IBW4.
TreeFamiTF101164.

Family and domain databases

InterProiIPR031737. CNDH2_C.
IPR009378. H2_N.
IPR031739. Ncaph2.
[Graphical view]
PANTHERiPTHR14324:SF3. PTHR14324:SF3. 1 hit.
PfamiPF16858. CNDH2_C. 1 hit.
PF06278. CNDH2_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IBW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT
60 70 80 90 100
MNFIEAALLI QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED
110 120 130 140 150
RANGVASSGV PQEAENEFLS LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM
160 170 180 190 200
ALVAPDEMEK NNNPLYSRQG EVLASRKDFR MNTCVPHPRG AFMLEPEGMS
210 220 230 240 250
PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS QEPGPSPEGP
260 270 280 290 300
MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
310 320 330 340 350
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK
360 370 380 390 400
RKRKGAAKLQ DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ
410 420 430 440 450
LETLRKLQRR EVAEQWLRPA EEDHLEDSLE DLGAADDFLE PEEYMEPEGA
460 470 480 490 500
DPREAADLDA VPMSLSYEEL VRRNVELFIA TSQKFVQETE LSQRIRDWED
510 520 530 540 550
TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL VAGQPAFEVC
560 570 580 590 600
RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP

SMAQP
Length:605
Mass (Da):68,227
Last modified:July 5, 2004 - v1
Checksum:i2C8A1070C27B4547
GO
Isoform 2 (identifier: Q6IBW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-188: Missing.

Note: Gene prediction based on EST data.
Show »
Length:583
Mass (Da):65,716
Checksum:i21B93C7E157E1E5C
GO
Isoform 3 (identifier: Q6IBW4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-299: SAALPRRYMLRE → VGPTWRPAEPEL
     300-605: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,819
Checksum:iC47577DA567D7AAA
GO
Isoform 4 (identifier: Q6IBW4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: A → AA

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):68,298
Checksum:i9D6FAEBA6500B608
GO

Sequence cautioni

The sequence AAB03345 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH00473 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01509 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01833 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01937 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH09441 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA16670 differs from that shown. Reason: Frameshift at positions 56 and 429.Curated
The sequence EAW73552 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36E → D in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti61Q → H in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti76S → W in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti161N → I in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti190G → R in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti215K → N in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti249G → R in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti282S → F in AAH09441 (PubMed:15489334).Curated1
Sequence conflicti316P → L in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti323 – 324FD → LN in CAA16670 (PubMed:12529303).Curated2
Sequence conflicti368A → V in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti474N → K in CAA16670 (PubMed:12529303).Curated1
Sequence conflicti486V → I in CAA16670 (PubMed:12529303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032636167 – 188Missing in isoform 2. CuratedAdd BLAST22
Alternative sequenceiVSP_032637288 – 299SAALP…YMLRE → VGPTWRPAEPEL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_032638300 – 605Missing in isoform 3. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_032639435A → AA in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021682 mRNA. Translation: CAA16670.1. Frameshift.
CR456604 mRNA. Translation: CAG30490.1.
U62317 Genomic DNA. Translation: AAB03345.1. Sequence problems.
CH471138 Genomic DNA. Translation: EAW73554.1.
CH471138 Genomic DNA. Translation: EAW73556.1.
CH471138 Genomic DNA. Translation: EAW73552.1. Sequence problems.
BC000473 mRNA. Translation: AAH00473.1. Different initiation.
BC001509 mRNA. Translation: AAH01509.1. Different initiation.
BC001833 mRNA. Translation: AAH01833.1. Different initiation.
BC001937 mRNA. Translation: AAH01937.1. Different initiation.
BC009441 mRNA. Translation: AAH09441.1. Different initiation.
BC014939 mRNA. Translation: AAH14939.2.
CCDSiCCDS14094.2. [Q6IBW4-1]
CCDS43038.1. [Q6IBW4-5]
CCDS54546.1. [Q6IBW4-4]
RefSeqiNP_001171940.1. NM_001185011.1. [Q6IBW4-4]
NP_055366.3. NM_014551.4. [Q6IBW4-5]
NP_689512.2. NM_152299.3. [Q6IBW4-1]
UniGeneiHs.730607.

Genome annotation databases

EnsembliENST00000299821; ENSP00000299821; ENSG00000025770. [Q6IBW4-4]
ENST00000395698; ENSP00000379050; ENSG00000025770. [Q6IBW4-5]
ENST00000420993; ENSP00000410088; ENSG00000025770. [Q6IBW4-1]
GeneIDi29781.
KEGGihsa:29781.
UCSCiuc003blq.5. human. [Q6IBW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021682 mRNA. Translation: CAA16670.1. Frameshift.
CR456604 mRNA. Translation: CAG30490.1.
U62317 Genomic DNA. Translation: AAB03345.1. Sequence problems.
CH471138 Genomic DNA. Translation: EAW73554.1.
CH471138 Genomic DNA. Translation: EAW73556.1.
CH471138 Genomic DNA. Translation: EAW73552.1. Sequence problems.
BC000473 mRNA. Translation: AAH00473.1. Different initiation.
BC001509 mRNA. Translation: AAH01509.1. Different initiation.
BC001833 mRNA. Translation: AAH01833.1. Different initiation.
BC001937 mRNA. Translation: AAH01937.1. Different initiation.
BC009441 mRNA. Translation: AAH09441.1. Different initiation.
BC014939 mRNA. Translation: AAH14939.2.
CCDSiCCDS14094.2. [Q6IBW4-1]
CCDS43038.1. [Q6IBW4-5]
CCDS54546.1. [Q6IBW4-4]
RefSeqiNP_001171940.1. NM_001185011.1. [Q6IBW4-4]
NP_055366.3. NM_014551.4. [Q6IBW4-5]
NP_689512.2. NM_152299.3. [Q6IBW4-1]
UniGeneiHs.730607.

3D structure databases

ProteinModelPortaliQ6IBW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118913. 101 interactors.
DIPiDIP-43901N.
IntActiQ6IBW4. 16 interactors.
MINTiMINT-4329914.
STRINGi9606.ENSP00000299821.

PTM databases

iPTMnetiQ6IBW4.
PhosphoSitePlusiQ6IBW4.

Polymorphism and mutation databases

BioMutaiNCAPH2.
DMDMi74709496.

Proteomic databases

EPDiQ6IBW4.
MaxQBiQ6IBW4.
PaxDbiQ6IBW4.
PeptideAtlasiQ6IBW4.
PRIDEiQ6IBW4.

Protocols and materials databases

DNASUi29781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299821; ENSP00000299821; ENSG00000025770. [Q6IBW4-4]
ENST00000395698; ENSP00000379050; ENSG00000025770. [Q6IBW4-5]
ENST00000420993; ENSP00000410088; ENSG00000025770. [Q6IBW4-1]
GeneIDi29781.
KEGGihsa:29781.
UCSCiuc003blq.5. human. [Q6IBW4-1]

Organism-specific databases

CTDi29781.
GeneCardsiNCAPH2.
H-InvDBHIX0016615.
HGNCiHGNC:25071. NCAPH2.
HPAiHPA067932.
HPA069056.
MIMi611230. gene.
neXtProtiNX_Q6IBW4.
OpenTargetsiENSG00000025770.
PharmGKBiPA162397314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2359. Eukaryota.
ENOG4111BR3. LUCA.
GeneTreeiENSGT00390000014443.
HOVERGENiHBG098083.
InParanoidiQ6IBW4.
KOiK11490.
OMAiASCVKET.
OrthoDBiEOG091G0TAX.
PhylomeDBiQ6IBW4.
TreeFamiTF101164.

Enzyme and pathway databases

ReactomeiR-HSA-2299718. Condensation of Prophase Chromosomes.

Miscellaneous databases

ChiTaRSiNCAPH2. human.
GeneWikiiNCAPH2.
GenomeRNAii29781.
PROiQ6IBW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025770.
CleanExiHS_NCAPH2.
ExpressionAtlasiQ6IBW4. baseline and differential.
GenevisibleiQ6IBW4. HS.

Family and domain databases

InterProiIPR031737. CNDH2_C.
IPR009378. H2_N.
IPR031739. Ncaph2.
[Graphical view]
PANTHERiPTHR14324:SF3. PTHR14324:SF3. 1 hit.
PfamiPF16858. CNDH2_C. 1 hit.
PF06278. CNDH2_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNDH2_HUMAN
AccessioniPrimary (citable) accession number: Q6IBW4
Secondary accession number(s): B7WPH1
, O43788, Q13391, Q96C14, Q96GJ0, Q9BQ71, Q9BUT3, Q9BVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.