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Protein

C-C motif chemokine

Gene

CCL19

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:CCL19Imported
ORF Names:hCG_20476Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_500999893122 – 98C-C motif chemokineUniRule annotationAdd BLAST77

Expressioni

Gene expression databases

BgeeiENSG00000172724.
ExpressionAtlasiQ6IBD6. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6IBD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 86SCYInterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J4UG. Eukaryota.
ENOG410ZG6G. LUCA.
HOVERGENiHBG017871.
KOiK05512.

Family and domain databases

CDDicd01119. Chemokine_CC_DCCL. 1 hit.
InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR034133. Chemokine_CC_DCCL.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IBD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL
60 70 80 90
IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS
Length:98
Mass (Da):10,993
Last modified:May 10, 2005 - v1
Checksum:i0D2516DB2EB1C81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064766 Genomic DNA. Translation: ABK41949.1.
AK311945 mRNA. Translation: BAG34886.1.
CR456868 mRNA. Translation: CAG33149.1.
CH471071 Genomic DNA. Translation: EAW58416.1.
RefSeqiNP_006265.1. NM_006274.2.
UniGeneiHs.50002.

Genome annotation databases

GeneIDi6363.
KEGGihsa:6363.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6IBD6_HUMAN
AccessioniPrimary (citable) accession number: Q6IBD6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 5, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.