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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene

NDUFS6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandUbiquinoneImported

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialUniRule annotation
Gene namesi
Name:NDUFS6Imported
ORF Names:hCG_21432Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000145494.11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31523

Expressioni

Gene expression databases

BgeeiENSG00000145494

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 119zf-CHCCInterPro annotationAdd BLAST37

Sequence similaritiesi

Belongs to the complex I NDUFS6 subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3456 Eukaryota
ENOG4111W6X LUCA
HOVERGENiHBG006549
KOiK03939
OMAiGNHICGY

Family and domain databases

InterProiView protein in InterPro
IPR016668 NDUFS6
IPR019401 Znf_CHCC
PfamiView protein in Pfam
PF10276 zf-CHCC, 1 hit
PIRSFiPIRSF016564 CI-13KD-A, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IBC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAMTFCRL LNRCGEAARS LPLGARCFGV RVSPTGEKVT HTGQVYDDKD
60 70 80 90 100
YRRIRFVGRQ KEVNENFAID LIAEQPVSEV ETRVIACDGG GGALGHPKVY
110 120
INLDKETKTG TCGYCGLQFR QHHH
Length:124
Mass (Da):13,712
Last modified:May 10, 2005 - v1
Checksum:i0A1465160BCA772D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022503 mRNA Translation: BAG51079.1
CR456880 mRNA Translation: CAG33161.1
CH471102 Genomic DNA Translation: EAX08142.1
CH471102 Genomic DNA Translation: EAX08143.1
RefSeqiNP_004544.1, NM_004553.4
UniGeneiHs.408257

Genome annotation databases

GeneIDi4726
KEGGihsa:4726
UCSCiuc003jcy.5 human

Similar proteinsi

Entry informationi

Entry nameiQ6IBC4_HUMAN
AccessioniPrimary (citable) accession number: Q6IBC4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health