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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene

NDUFS6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

UbiquinoneImported

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialUniRule annotation
Gene namesi
Name:NDUFS6Imported
ORF Names:hCG_21432Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31523.

PTM / Processingi

Proteomic databases

MaxQBiQ6IBC4.

Expressioni

Gene expression databases

BgeeiENSG00000145494.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274137.

Structurei

3D structure databases

SMRiQ6IBC4. Positions 59-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 11937zf-CHCCInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I NDUFS6 subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
HOVERGENiHBG006549.
KOiK03939.
OMAiQTRVIAC.
PhylomeDBiQ6IBC4.

Family and domain databases

Gene3Di2.60.260.40. 1 hit.
InterProiIPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
[Graphical view]
PfamiPF10276. zf-CHCC. 1 hit.
[Graphical view]
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IBC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAMTFCRL LNRCGEAARS LPLGARCFGV RVSPTGEKVT HTGQVYDDKD
60 70 80 90 100
YRRIRFVGRQ KEVNENFAID LIAEQPVSEV ETRVIACDGG GGALGHPKVY
110 120
INLDKETKTG TCGYCGLQFR QHHH
Length:124
Mass (Da):13,712
Last modified:May 10, 2005 - v1
Checksum:i0A1465160BCA772D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022503 mRNA. Translation: BAG51079.1.
CR456880 mRNA. Translation: CAG33161.1.
CH471102 Genomic DNA. Translation: EAX08142.1.
CH471102 Genomic DNA. Translation: EAX08143.1.
RefSeqiNP_004544.1. NM_004553.4.
UniGeneiHs.408257.

Genome annotation databases

GeneIDi4726.
KEGGihsa:4726.
UCSCiuc003jcy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022503 mRNA. Translation: BAG51079.1.
CR456880 mRNA. Translation: CAG33161.1.
CH471102 Genomic DNA. Translation: EAX08142.1.
CH471102 Genomic DNA. Translation: EAX08143.1.
RefSeqiNP_004544.1. NM_004553.4.
UniGeneiHs.408257.

3D structure databases

SMRiQ6IBC4. Positions 59-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274137.

Proteomic databases

MaxQBiQ6IBC4.

Protocols and materials databases

DNASUi4726.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4726.
KEGGihsa:4726.
UCSCiuc003jcy.5. human.

Organism-specific databases

CTDi4726.
PharmGKBiPA31523.

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
HOVERGENiHBG006549.
KOiK03939.
OMAiQTRVIAC.
PhylomeDBiQ6IBC4.

Miscellaneous databases

ChiTaRSiNDUFS6. human.
GenomeRNAii4726.

Gene expression databases

BgeeiENSG00000145494.

Family and domain databases

Gene3Di2.60.260.40. 1 hit.
InterProiIPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
[Graphical view]
PfamiPF10276. zf-CHCC. 1 hit.
[Graphical view]
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IBC4_HUMAN
AccessioniPrimary (citable) accession number: Q6IBC4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.