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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene

NDUFS6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandUbiquinoneImported

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialUniRule annotation
Gene namesi
Name:NDUFS6Imported
ORF Names:hCG_21432Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31523.

PTM / Processingi

Proteomic databases

MaxQBiQ6IBC4.

Expressioni

Gene expression databases

BgeeiENSG00000145494.
ExpressionAtlasiQ6IBC4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274137.

Structurei

3D structure databases

ProteinModelPortaliQ6IBC4.
SMRiQ6IBC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 119zf-CHCCInterPro annotationAdd BLAST37

Sequence similaritiesi

Belongs to the complex I NDUFS6 subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
HOVERGENiHBG006549.
KOiK03939.
OMAiQTRVIAC.
PhylomeDBiQ6IBC4.

Family and domain databases

InterProiView protein in InterPro
IPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
PfamiView protein in Pfam
PF10276. zf-CHCC. 1 hit.
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IBC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAMTFCRL LNRCGEAARS LPLGARCFGV RVSPTGEKVT HTGQVYDDKD
60 70 80 90 100
YRRIRFVGRQ KEVNENFAID LIAEQPVSEV ETRVIACDGG GGALGHPKVY
110 120
INLDKETKTG TCGYCGLQFR QHHH
Length:124
Mass (Da):13,712
Last modified:May 10, 2005 - v1
Checksum:i0A1465160BCA772D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022503 mRNA. Translation: BAG51079.1.
CR456880 mRNA. Translation: CAG33161.1.
CH471102 Genomic DNA. Translation: EAX08142.1.
CH471102 Genomic DNA. Translation: EAX08143.1.
RefSeqiNP_004544.1. NM_004553.4.
UniGeneiHs.408257.

Genome annotation databases

GeneIDi4726.
KEGGihsa:4726.
UCSCiuc003jcy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022503 mRNA. Translation: BAG51079.1.
CR456880 mRNA. Translation: CAG33161.1.
CH471102 Genomic DNA. Translation: EAX08142.1.
CH471102 Genomic DNA. Translation: EAX08143.1.
RefSeqiNP_004544.1. NM_004553.4.
UniGeneiHs.408257.

3D structure databases

ProteinModelPortaliQ6IBC4.
SMRiQ6IBC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274137.

Proteomic databases

MaxQBiQ6IBC4.

Protocols and materials databases

DNASUi4726.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4726.
KEGGihsa:4726.
UCSCiuc003jcy.5. human.

Organism-specific databases

CTDi4726.
PharmGKBiPA31523.

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
HOVERGENiHBG006549.
KOiK03939.
OMAiQTRVIAC.
PhylomeDBiQ6IBC4.

Miscellaneous databases

ChiTaRSiNDUFS6. human.
GenomeRNAii4726.

Gene expression databases

BgeeiENSG00000145494.
ExpressionAtlasiQ6IBC4. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
PfamiView protein in Pfam
PF10276. zf-CHCC. 1 hit.
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IBC4_HUMAN
AccessioniPrimary (citable) accession number: Q6IBC4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 12, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.