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Protein

Tumor necrosis factor ligand superfamily member

Gene

TNFSF10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi230ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily memberUniRule annotation
Gene namesi
Name:TNFSF10Imported
ORF Names:hCG_20249Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000121858.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 38HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36618

PTM / Processingi

Proteomic databases

MaxQBiQ6IBA9

Expressioni

Gene expression databases

BgeeiENSG00000121858
ExpressionAtlasiQ6IBA9 baseline and differential

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6IBA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 280TNF_2InterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the tumor necrosis factor family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IIX7 Eukaryota
ENOG410YS4F LUCA
HOVERGENiHBG059007
KOiK04721
OMAiNKQMVQY
OrthoDBiEOG091G0F3S

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR017355 TNF_ligand_10/11
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF038013 TNF10_TNF11, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IBA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS
60 70 80 90 100
KSGIACFLKE DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI
110 120 130 140 150
STVQEKQQNI SPLVRERGPQ RVAAHITGTR GRSNTLSSPN SKNEKALGRK
160 170 180 190 200
INSWESSRSG HSFLSNLHLR NGELVIHEKG FYYIYSQTYF RFQEEIKENT
210 220 230 240 250
KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY SIYQGGIFEL
260 270 280
KENDRIFVSV TNEHLIDMDH EASFFGAFLV G
Length:281
Mass (Da):32,509
Last modified:May 10, 2005 - v1
Checksum:iDDAAAF78DAAB2F6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019564 mRNA Translation: AAV38371.1
EF064708 Genomic DNA Translation: ABK41891.1
AK312742 mRNA Translation: BAG35612.1
CR456895 mRNA Translation: CAG33176.1
CH471052 Genomic DNA Translation: EAW78465.1
RefSeqiNP_003801.1, NM_003810.3
UniGeneiHs.478275

Genome annotation databases

GeneIDi8743
KEGGihsa:8743
UCSCiuc003fid.3 human

Similar proteinsi

Entry informationi

Entry nameiQ6IBA9_HUMAN
AccessioniPrimary (citable) accession number: Q6IBA9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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