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Protein
Submitted name:

TNFSF10 protein

Gene

TNFSF10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TNFSF10 proteinImported
Submitted name:
Tumor necrosis factor (Ligand) family, member 10Imported
Submitted name:
Tumor necrosis factor (Ligand) superfamily, member 10Imported
Submitted name:
Tumor necrosis factor (Ligand) superfamily, member 10, isoform CRA_aImported
Submitted name:
cDNA, FLJ93150, Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10), mRNAImported
Gene namesi
Name:TNFSF10Imported
ORF Names:hCG_20249Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3827HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36618.

PTM / Processingi

Proteomic databases

MaxQBiQ6IBA9.

Expressioni

Gene expression databases

BgeeiENSG00000121858.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000241261.

Structurei

3D structure databases

SMRiQ6IBA9. Positions 119-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 280158TNF_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IIX7. Eukaryota.
ENOG410YS4F. LUCA.
HOVERGENiHBG059007.
KOiK04721.
OMAiQTCVLIL.
OrthoDBiEOG091G0F3S.
PhylomeDBiQ6IBA9.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IBA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS
60 70 80 90 100
KSGIACFLKE DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI
110 120 130 140 150
STVQEKQQNI SPLVRERGPQ RVAAHITGTR GRSNTLSSPN SKNEKALGRK
160 170 180 190 200
INSWESSRSG HSFLSNLHLR NGELVIHEKG FYYIYSQTYF RFQEEIKENT
210 220 230 240 250
KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY SIYQGGIFEL
260 270 280
KENDRIFVSV TNEHLIDMDH EASFFGAFLV G
Length:281
Mass (Da):32,509
Last modified:May 10, 2005 - v1
Checksum:iDDAAAF78DAAB2F6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019564 mRNA. Translation: AAV38371.1.
EF064708 Genomic DNA. Translation: ABK41891.1.
AK312742 mRNA. Translation: BAG35612.1.
CR456895 mRNA. Translation: CAG33176.1.
CH471052 Genomic DNA. Translation: EAW78465.1.
RefSeqiNP_003801.1. NM_003810.3.
UniGeneiHs.478275.

Genome annotation databases

GeneIDi8743.
KEGGihsa:8743.
UCSCiuc003fid.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019564 mRNA. Translation: AAV38371.1.
EF064708 Genomic DNA. Translation: ABK41891.1.
AK312742 mRNA. Translation: BAG35612.1.
CR456895 mRNA. Translation: CAG33176.1.
CH471052 Genomic DNA. Translation: EAW78465.1.
RefSeqiNP_003801.1. NM_003810.3.
UniGeneiHs.478275.

3D structure databases

SMRiQ6IBA9. Positions 119-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000241261.

Proteomic databases

MaxQBiQ6IBA9.

Protocols and materials databases

DNASUi8743.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8743.
KEGGihsa:8743.
UCSCiuc003fid.3. human.

Organism-specific databases

CTDi8743.
PharmGKBiPA36618.

Phylogenomic databases

eggNOGiENOG410IIX7. Eukaryota.
ENOG410YS4F. LUCA.
HOVERGENiHBG059007.
KOiK04721.
OMAiQTCVLIL.
OrthoDBiEOG091G0F3S.
PhylomeDBiQ6IBA9.

Miscellaneous databases

ChiTaRSiTNFSF10. human.
GenomeRNAii8743.

Gene expression databases

BgeeiENSG00000121858.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IBA9_HUMAN
AccessioniPrimary (citable) accession number: Q6IBA9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.