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Protein
Submitted name:

PGRMC1 protein

Gene

PGRMC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
PGRMC1 proteinImported
Submitted name:
Progesterone receptor membrane component 1Imported
Submitted name:
Progesterone receptor membrane component 1, isoform CRA_aImported
Submitted name:
cDNA, FLJ94602, Homo sapiens progesterone receptor membrane component 1 (PGRMC1),mRNAImported
Gene namesi
Name:PGRMC1Imported
ORF Names:hCG_23188Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33248.

Expressioni

Gene expression databases

BgeeiENSG00000101856.

Interactioni

Protein-protein interaction databases

MINTiMINT-5003213.
STRINGi9606.ENSP00000217971.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 171Cytochrome b5 heme-bindingInterPro annotationAdd BLAST99

Sequence similaritiesi

Belongs to the cytochrome b5 family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
HOVERGENiHBG059971.
KOiK17278.
OMAiAYDKEIG.
OrthoDBiEOG091G0PXT.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IB11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVVATG ADPSDLESGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PAASGDSDDD EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV
110 120 130 140 150
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTAAQQ
160 170 180 190
ETLSDWESQF TFKYHHVGKL LKEGEEPTVY SDEEEPKDES ARKND
Length:195
Mass (Da):21,671
Last modified:May 10, 2005 - v1
Checksum:iCCD5E802E1C9E604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ496104 Genomic DNA. Translation: ABF47093.1.
AK313956 mRNA. Translation: BAG36672.1.
CR456993 mRNA. Translation: CAG33274.1.
CH471161 Genomic DNA. Translation: EAW89879.1.
CH471161 Genomic DNA. Translation: EAW89882.1.
RefSeqiNP_006658.1. NM_006667.4.
UniGeneiHs.90061.

Genome annotation databases

GeneIDi10857.
KEGGihsa:10857.
UCSCiuc004erb.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ496104 Genomic DNA. Translation: ABF47093.1.
AK313956 mRNA. Translation: BAG36672.1.
CR456993 mRNA. Translation: CAG33274.1.
CH471161 Genomic DNA. Translation: EAW89879.1.
CH471161 Genomic DNA. Translation: EAW89882.1.
RefSeqiNP_006658.1. NM_006667.4.
UniGeneiHs.90061.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5003213.
STRINGi9606.ENSP00000217971.

Protocols and materials databases

DNASUi10857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10857.
KEGGihsa:10857.
UCSCiuc004erb.5. human.

Organism-specific databases

CTDi10857.
PharmGKBiPA33248.

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
HOVERGENiHBG059971.
KOiK17278.
OMAiAYDKEIG.
OrthoDBiEOG091G0PXT.

Miscellaneous databases

ChiTaRSiPGRMC1. human.
GenomeRNAii10857.

Gene expression databases

BgeeiENSG00000101856.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IB11_HUMAN
AccessioniPrimary (citable) accession number: Q6IB11
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 5, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.