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Protein
Submitted name:

PGRMC1 protein

Gene

PGRMC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
PGRMC1 proteinImported
Submitted name:
Progesterone receptor membrane component 1Imported
Submitted name:
Progesterone receptor membrane component 1, isoform CRA_aImported
Submitted name:
cDNA, FLJ94602, Homo sapiens progesterone receptor membrane component 1 (PGRMC1),mRNAImported
Gene namesi
Name:PGRMC1Imported
ORF Names:hCG_23188Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000101856.9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33248

PTM / Processingi

Proteomic databases

MaxQBiQ6IB11
PRIDEiQ6IB11

Expressioni

Gene expression databases

BgeeiENSG00000101856
ExpressionAtlasiQ6IB11 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-10249941,EBI-6942903

Protein-protein interaction databases

IntActiQ6IB11, 1 interactor

Structurei

3D structure databases

SMRiQ6IB11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 171Cytochrome b5 heme-bindingInterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 152Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the cytochrome b5 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1110 Eukaryota
ENOG4111UG0 LUCA
HOVERGENiHBG059971
KOiK17278
OMAiEWETQFT
OrthoDBiEOG091G0PXT

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IB11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVVATG ADPSDLESGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PAASGDSDDD EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV
110 120 130 140 150
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTAAQQ
160 170 180 190
ETLSDWESQF TFKYHHVGKL LKEGEEPTVY SDEEEPKDES ARKND
Length:195
Mass (Da):21,671
Last modified:May 10, 2005 - v1
Checksum:iCCD5E802E1C9E604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ496104 Genomic DNA Translation: ABF47093.1
AK313956 mRNA Translation: BAG36672.1
CR456993 mRNA Translation: CAG33274.1
CH471161 Genomic DNA Translation: EAW89879.1
CH471161 Genomic DNA Translation: EAW89882.1
RefSeqiNP_006658.1, NM_006667.4
UniGeneiHs.90061

Genome annotation databases

GeneIDi10857
KEGGihsa:10857
UCSCiuc004erb.5 human

Similar proteinsi

Entry informationi

Entry nameiQ6IB11_HUMAN
AccessioniPrimary (citable) accession number: Q6IB11
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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