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Protein

Mediator of RNA polymerase II transcription subunit 7

Gene

CRSP9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 7UniRule annotation
Gene namesi
Name:CRSP9Imported
ORF Names:hCG_14744Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395669.

PTM / Processingi

Proteomic databases

MaxQBiQ6IAZ5.

Expressioni

Gene expression databases

BgeeiENSG00000155868.
ExpressionAtlasiQ6IAZ5. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HAUS1Q96CS23EBI-10283772,EBI-2514791

Protein-protein interaction databases

IntActiQ6IAZ5. 1 interactor.

Structurei

3D structure databases

SMRiQ6IAZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 7 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0570. Eukaryota.
ENOG410ZFRU. LUCA.
HOVERGENiHBG002997.
KOiK15148.
OMAiKRLYPQH.
OrthoDBiEOG091G0N9D.

Family and domain databases

InterProiView protein in InterPro
IPR009244. Mediatior_Med7.
PfamiView protein in Pfam
PF05983. Med7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IAZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ
60 70 80 90 100
CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP
110 120 130 140 150
GSIKREEKLE DLKLLFVHVH HLINEYRPHQ ARETLRVMME VQKRQRLETA
160 170 180 190 200
ERFQKHLERV IEMIQNCLAS LPDDLPHSEA GMRVKTEPMD ADDSNNCTGQ
210 220 230
NEHQRENSGH RRDQIIEKDA ALCVLIDEMN ERP
Length:233
Mass (Da):27,245
Last modified:May 10, 2005 - v1
Checksum:i9D95A2A8360B9C62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei233Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007368 mRNA. Translation: AAP36032.1.
CR457009 mRNA. Translation: CAG33290.1.
CR541696 mRNA. Translation: CAG46497.1.
CH471062 Genomic DNA. Translation: EAW61610.1.
CH471062 Genomic DNA. Translation: EAW61611.1.
RefSeqiNP_001094286.1. NM_001100816.1.
NP_004261.1. NM_004270.4.
UniGeneiHs.279902.
Hs.744244.

Genome annotation databases

GeneIDi9443.
KEGGihsa:9443.
UCSCiuc003lwm.5. human.

Similar proteinsi

Entry informationi

Entry nameiQ6IAZ5_HUMAN
AccessioniPrimary (citable) accession number: Q6IAZ5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: August 30, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.